Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | holo [acyl-carrier protein] synthase | 0.0052 | 0.0549 | 0.5 |
Brugia malayi | maoC like domain containing protein | 0.0088 | 0.308 | 0.308 |
Mycobacterium ulcerans | hypothetical protein | 0.0088 | 0.308 | 1 |
Mycobacterium tuberculosis | Probable 3-hydroxyacyl-thioester dehydratase HtdY | 0.0088 | 0.308 | 1 |
Mycobacterium ulcerans | 4'-phosphopantetheinyl transferase | 0.0052 | 0.0549 | 0.1781 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 1 | 1 |
Leishmania major | phosphopantetheinyl transferase-like protein | 0.0052 | 0.0549 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.1477 | 0.1477 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0186 | 1 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0065 | 0.1477 | 0.1477 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.1477 | 0.1477 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0052 | 0.0549 | 0.5 |
Plasmodium vivax | holo-[acyl-carrier-protein] synthase, putative | 0.0052 | 0.0549 | 0.5 |
Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0079 | 0.2441 | 1 |
Onchocerca volvulus | 0.0186 | 1 | 1 | |
Mycobacterium ulcerans | phosphopantetheinyl transferase, PptII | 0.0052 | 0.0549 | 0.1781 |
Mycobacterium leprae | conserved hypothetical protein | 0.0052 | 0.0549 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.308 | 0.308 |
Entamoeba histolytica | hypothetical protein | 0.0052 | 0.0549 | 0.5 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0065 | 0.1477 | 0.1477 |
Toxoplasma gondii | MaoC family domain-containing protein | 0.0053 | 0.063 | 0.0432 |
Treponema pallidum | 4'-phosphopantetheinyl transferase | 0.0052 | 0.0549 | 0.5 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0186 | 1 | 1 |
Mycobacterium ulcerans | dehydratase | 0.0088 | 0.308 | 1 |
Plasmodium falciparum | holo-[acyl-carrier-protein] synthase, putative | 0.0052 | 0.0549 | 0.5 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0186 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | 4'-phosphopantetheinyl transferase | 0.0052 | 0.0549 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase. Possible 2-enoyl acyl-CoA hydratase. | 0.0088 | 0.308 | 1 |
Mycobacterium tuberculosis | holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie | 0.0052 | 0.0549 | 0.1781 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.8 uM | PUBCHEM_BIOASSAY: SAR analysis of Antagonists of IAP-family anti-apoptotic proteins. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1018, AID1449, AID1513, AID1514, AID1638] | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | PUBCHEM_BIOASSAY: SAR analysis of Antagonists of XIAP-Bir3 domain of IAP-family anti-apoptotic proteins. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1018, AID1449, AID1513, AID1514, AID1638] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.