Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed), beta | Starlite/ChEMBL | No references |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | polymerase (DNA directed), beta | 335 aa | 303 aa | 32.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0365 | 0.3516 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 0.3516 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0342 | 0.3204 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0196 | 0.1179 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 1 | 0.5 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0342 | 0.3204 | 1 |
Mycobacterium ulcerans | acetolactate synthase | 0.0196 | 0.1179 | 0.368 |
Mycobacterium ulcerans | hypothetical protein | 0.0192 | 0.1128 | 0.3519 |
Loa Loa (eye worm) | ILVBL protein | 0.0207 | 0.1337 | 1 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0196 | 0.1179 | 0.368 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0173 | 0.0858 | 0.244 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 1 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0196 | 0.1179 | 0.5 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0365 | 0.3516 | 1 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0342 | 0.3204 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0173 | 0.0858 | 0.244 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0173 | 0.0858 | 0.244 |
Brugia malayi | Thiamine pyrophosphate enzyme, central domain containing protein | 0.0342 | 0.3204 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0192 | 0.1128 | 0.2335 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0342 | 0.3204 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0342 | 0.3204 | 1 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0342 | 0.3204 | 0.5 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0196 | 0.1179 | 0.368 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 0.3516 | 1 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0342 | 0.3204 | 1 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0196 | 0.1179 | 0.3353 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (binding) | = 100 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.