Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | neuropeptide S receptor 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | neuropeptide s receptor | Get druggable targets OG5_136011 | All targets in OG5_136011 |
Echinococcus multilocularis | neuropeptide receptor A26 | Get druggable targets OG5_136011 | All targets in OG5_136011 |
Schistosoma japonicum | IPR000276,Rhodopsin-like GPCR superfamily,domain-containing | Get druggable targets OG5_136011 | All targets in OG5_136011 |
Echinococcus granulosus | neuropeptide receptor A26 | Get druggable targets OG5_136011 | All targets in OG5_136011 |
Echinococcus multilocularis | neuropeptide s receptor | Get druggable targets OG5_136011 | All targets in OG5_136011 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0466 | 0.7964 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1095 | 0.1374 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0156 | 0.1095 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0156 | 0.1095 | 0.1374 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0558 | 1 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0558 | 1 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0558 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0466 | 0.7964 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0466 | 0.7964 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0466 | 0.7964 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0156 | 0.1095 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0063 um | PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.