Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Schistosoma japonicum | ko:K04380 microtubule-associated protein tau, putative | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Echinococcus granulosus | microtubule associated protein 2 | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Schistosoma mansoni | microtubule-associated protein tau | Get druggable targets OG5_133504 | All targets in OG5_133504 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0154 | 0.1201 | 0.1201 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0926 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.1341 | 0.1341 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0154 | 0.1201 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0833 | 0.8943 | 0.8943 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0105 | 0.0645 | 0.5371 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0926 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0154 | 0.1201 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0328 | 0.3181 | 0.3181 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0926 | 1 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 0.8943 | 0.8943 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0926 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.0645 | 0.0645 |
Echinococcus multilocularis | geminin | 0.0166 | 0.1341 | 0.1341 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0796 | 0.8521 | 0.8521 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.1201 | 0.1201 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 0.8943 | 0.8943 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0645 | 0.0645 |
Echinococcus multilocularis | tumor protein p63 | 0.0328 | 0.3181 | 0.3181 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0232 | 0.2091 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0926 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.1341 | 0.1341 |
Echinococcus granulosus | geminin | 0.0166 | 0.1341 | 0.1341 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (binding) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.