TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 314.379 | Formula: C18H22N2O3
H donors: 3 H acceptors: 4 LogP: 4.53 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1c(O)nc2c(c1O)cccc2)NC1CCCCCCC1
InChi: 1S/C18H22N2O3/c21-16-13-10-6-7-11-14(13)20-18(23)15(16)17(22)19-12-8-4-2-1-3-5-9-12/h6-7,10-12H,1-5,8-9H2,(H,19,22)(H2,20,21,23)
InChiKey: UZUFXRDBMNZRDM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	tumor protein p53	Starlite/ChEMBL	No references
Homo sapiens	Niemann-Pick disease, type C1	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Trypanosoma cruzi	cysteine peptidase, putative	Starlite/ChEMBL	No references
Homo sapiens	RAB9A, member RAS oncogene family	Starlite/ChEMBL	No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	breast cancer 1, early onset	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K07003 Niemann Pick type C1, putative	Get druggable targets OG5_128206	All targets in OG5_128206
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	niemann-pick C1 (NPC1)	Get druggable targets OG5_128206	All targets in OG5_128206
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	Niemann Pick C1 protein	Get druggable targets OG5_128206	All targets in OG5_128206
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128206	All targets in OG5_128206
Echinococcus granulosus	Niemann Pick C1 protein	Get druggable targets OG5_128206	All targets in OG5_128206
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Candida albicans	potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home	Get druggable targets OG5_128206	All targets in OG5_128206
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128206	All targets in OG5_128206
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	expressed conserved protein	Get druggable targets OG5_128206	All targets in OG5_128206
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Niemann-Pick C1 protein precursor, putative	Get druggable targets OG5_128206	All targets in OG5_128206
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Niemann-Pick C1 protein precursor	Get druggable targets OG5_128206	All targets in OG5_128206
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	Niemann Pick C1 protein	Get druggable targets OG5_128206	All targets in OG5_128206
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	Niemann-Pick C1 protein, putative	Get druggable targets OG5_128206	All targets in OG5_128206
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Niemann-Pick C1 protein precursor, putative	Get druggable targets OG5_128206	All targets in OG5_128206
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Echinococcus multilocularis	expressed conserved protein	Get druggable targets OG5_128206	All targets in OG5_128206
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	Niemann Pick C1 protein	Get druggable targets OG5_128206	All targets in OG5_128206
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	ras-related protein Rab-5B	RAB9A, member RAS oncogene family	201 aa	165 aa	30.9 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.002	0.0083	0.1687
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0083	0.1783
Leishmania major	cathepsin L-like protease	0.002	0.0083	0.0536
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0166	0.159	0.159
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.005	0.005
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0017	0.005	0.0108
Brugia malayi	Cathepsin L-like precursor	0.002	0.0083	0.0406
Loa Loa (eye worm)	hypothetical protein	0.002	0.0083	0.0181
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0066	0.056	0.1221
Leishmania major	cysteine peptidase A (CPA)	0.002	0.0083	0.0536
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0665	0.3256
Leishmania major	cathepsin L-like protease	0.0077	0.067	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0066	0.056	0.1221
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.002	0.0083	0.0216
Brugia malayi	Probable ClpP-like protease	0.0166	0.159	0.7786
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0166	0.159	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0083	0.1783
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0083	0.1783
Leishmania major	cathepsin L-like protease	0.0077	0.067	1
Brugia malayi	isocitrate dehydrogenase	0.0017	0.005	0.0243
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0057	0.0465	0.2697
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0109	0.0999	0.4744
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0083	0.1783
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0083	0.0181
Schistosoma mansoni	hypothetical protein	0.0066	0.056	0.1221
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0083	0.1783
Echinococcus granulosus	Niemann Pick C1 protein	0.0119	0.1103	0.2406
Entamoeba histolytica	hypothetical protein	0.0043	0.0323	0.2839
Onchocerca volvulus		0.002	0.0083	0.1687
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.067	1
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0083	0.1687
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0456	0.4585	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0083	0.1783
Brugia malayi	Calcitonin receptor-like protein seb-1	0.021	0.2042	1
Echinococcus granulosus	Niemann Pick C1 protein	0.017	0.1631	0.3557
Loa Loa (eye worm)	ctsf protein	0.002	0.0083	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0066	0.056	0.1221
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0166	0.159	0.3468
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0066	0.056	0.1221
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0014	0.003
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0166	0.159	1
Onchocerca volvulus		0.002	0.0083	0.1687
Plasmodium vivax	vivapain-2	0.002	0.0083	0.0216
Echinococcus granulosus	hormone sensitive lipase	0.0456	0.4585	1
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1356	0.2957
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0017	0.005	0.0108
Echinococcus multilocularis	cysteine protease	0.002	0.0083	0.0083
Onchocerca volvulus		0.006	0.0491	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0119	0.1103	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0014	0.003
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0083	0.0083
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0017	0.005	0.005
Schistosoma mansoni	hypothetical protein	0.0143	0.1356	0.2957
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0083	0.1783
Brugia malayi	RNA binding protein	0.0076	0.0665	0.3256
Brugia malayi	latrophilin 2 splice variant baaae	0.0143	0.1356	0.664
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.0491	0.1072
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0401	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0109	0.0999	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0066	0.056	0.056
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0166	0.159	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0665	0.145
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0323	0.0705
Trypanosoma cruzi	major cysteine proteinase, putative	0.0061	0.05	0.7254
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0665	0.0665
Schistosoma mansoni	hypothetical protein	0.0205	0.199	0.434
Schistosoma mansoni	cathepsin F (C01 family)	0.0014	0.0014	0.003
Trypanosoma cruzi	cruzipain precursor, putative	0.0077	0.067	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.067	1
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0083	0.0406
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0665	0.145
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0017	0.005	0.0108
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0665	0.145
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0083	0.1783
Brugia malayi	Cathepsin L-like precursor	0.0014	0.0014	0.0067
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0323	0.0705
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0456	0.4585	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.067	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.002	0.0083	0.0216
Echinococcus multilocularis	geminin	0.0205	0.199	0.199
Onchocerca volvulus		0.002	0.0083	0.1687
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0083	0.1783
Echinococcus multilocularis	cysteine protease	0.002	0.0083	0.0083
Echinococcus granulosus	expressed conserved protein	0.0112	0.1029	0.2244
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0083	0.1783
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0083	0.1783
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0665	0.145
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0166	0.159	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0083	0.1783
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0166	0.159	1
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0665	0.145
Loa Loa (eye worm)	hypothetical protein	0.006	0.0491	0.1072
Onchocerca volvulus		0.002	0.0083	0.1687
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0083	0.1783
Schistosoma mansoni	hypothetical protein	0.0066	0.056	0.1221
Echinococcus multilocularis	protein patched	0.0051	0.0401	0.0401
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0665	0.145
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0083	0.1783
Schistosoma mansoni	hypothetical protein	0.0049	0.0382	0.0834
Brugia malayi	Cathepsin L-like precursor	0.002	0.0083	0.0406
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0083	0.1687
Echinococcus granulosus	tumor protein p63	0.0408	0.4093	0.8928
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0166	0.159	0.5
Brugia malayi	Cathepsin L-like precursor	0.002	0.0083	0.0406
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.067	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0083	0.1783
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0014	0.0014	0.0067
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0083	0.0181
Onchocerca volvulus		0.0014	0.0014	0.028
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.067	1
Loa Loa (eye worm)	fibroinase	0.002	0.0083	0.0181
Echinococcus multilocularis	Niemann Pick C1 protein	0.0119	0.1103	0.1103
Echinococcus granulosus	geminin	0.0205	0.199	0.434
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0083	0.1783
Echinococcus multilocularis	isocitrate dehydrogenase	0.0017	0.005	0.005
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.067	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0066	0.056	0.2742
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0083	0.1783
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0109	0.0999	0.0999
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.002	0.0083	0.0181
Echinococcus granulosus	cathepsin l1	0.0014	0.0014	0.003
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0166	0.159	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.017	0.1631	0.1631
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0083	0.1783
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0083	0.1783
Entamoeba histolytica	hypothetical protein	0.0043	0.0323	0.2839
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0665	0.145
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0083	0.0083
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0083	0.0634
Brugia malayi	Cathepsin L-like precursor	0.002	0.0083	0.0406
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0057	0.0465	0.2697
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0066	0.056	0.056
Echinococcus multilocularis	sterol regulatory element binding protein	0.0051	0.0401	0.0401
Toxoplasma gondii	hypothetical protein	0.0057	0.0465	0.2697
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0665	0.145
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0083	0.0634
Leishmania major	cathepsin L-like protease	0.002	0.0083	0.0536
Echinococcus granulosus	GPCR family 2	0.0066	0.056	0.1221
Entamoeba histolytica	hypothetical protein	0.0043	0.0323	0.2839
Plasmodium vivax	vivapain-2	0.002	0.0083	0.0216
Loa Loa (eye worm)	hypothetical protein	0.021	0.2042	0.4454
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0323	0.0323
Brugia malayi	Isocitrate dehydrogenase	0.0017	0.005	0.0243
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.021	0.2042	1
Toxoplasma gondii	cathepsin CPL	0.002	0.0083	0.0216
Brugia malayi	Cathepsin L-like precursor	0.002	0.0083	0.0406
Brugia malayi	CHE-14 protein	0.0051	0.0401	0.1966
Echinococcus multilocularis	expressed conserved protein	0.0112	0.1029	0.1029
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.067	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0083	0.1783
Leishmania major	cathepsin L-like protease	0.0077	0.067	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.021	0.2042	0.4454
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0401	0.0876
Echinococcus granulosus	cathepsin l cysteine peptidase	0.002	0.0083	0.0181
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.005	0.005
Schistosoma mansoni	peptidase Clp (S14 family)	0.0166	0.159	0.3468
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0083	0.0181
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.067	1
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0166	0.159	1
Echinococcus multilocularis	tumor protein p63	0.0408	0.4093	0.4093
Schistosoma mansoni	hypothetical protein	0.0066	0.056	0.1221
Leishmania major	cathepsin L-like protease	0.002	0.0083	0.0536
Schistosoma mansoni	hypothetical protein	0.0049	0.0382	0.0834
Brugia malayi	cathepsin L-like precursor	0.0014	0.0014	0.0067
Loa Loa (eye worm)	cysteine protease	0.002	0.0083	0.0181
Brugia malayi	Cathepsin L-like precursor	0.002	0.0083	0.0406
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.002	0.0083	0.0216
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.067	1
Entamoeba histolytica	hypothetical protein	0.0043	0.0323	0.2839
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0083	0.1783
Schistosoma mansoni	patched 1	0.0051	0.0401	0.0876
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.067	1
Loa Loa (eye worm)	hypothetical protein	0.0166	0.159	0.3468
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0166	0.159	0.5
Echinococcus granulosus	Protein patched homolog 1	0.0051	0.0401	0.0876
Brugia malayi	Niemann-Pick C1 protein precursor	0.0119	0.1103	0.5403
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0051	0.0401	0.0876
Echinococcus granulosus	peptidase Clp S14 family	0.0109	0.0999	0.2178
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0083	0.1783
Brugia malayi	TAR-binding protein	0.0076	0.0665	0.3256
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0665	0.145
Schistosoma mansoni	hypothetical protein	0.0205	0.199	0.434
Onchocerca volvulus		0.002	0.0083	0.1687
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.007	0.0601	0.8887
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0166	0.159	0.5
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0121	0.1122	0.2448
Echinococcus granulosus	cathepsin l1	0.002	0.0083	0.0181
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0083	0.1783
Schistosoma mansoni	hypothetical protein	0.0066	0.056	0.1221
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.005	0.005
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.067	1
Entamoeba histolytica	cysteine protease, putative	0.002	0.0083	0.0634
Brugia malayi	Latrophilin receptor protein 2	0.0066	0.056	0.2742
Echinococcus multilocularis	protein dispatched 1	0.0058	0.0476	0.0476
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0083	0.1783
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0109	0.0999	1
Schistosoma mansoni	hypothetical protein	0.0049	0.0382	0.0834
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0456	0.4585	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1103	0.2406
Loa Loa (eye worm)	hypothetical protein	0.0062	0.052	0.1134
Echinococcus multilocularis	hormone sensitive lipase	0.0456	0.4585	0.4585
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0083	0.1783
Brugia malayi	Cathepsin L-like precursor	0.0014	0.0014	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0456	0.4585	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.067	1
Leishmania major	cathepsin L-like protease	0.002	0.0083	0.0536
Echinococcus multilocularis	GPCR, family 2	0.0066	0.056	0.056
Onchocerca volvulus		0.002	0.0083	0.1687
Echinococcus granulosus	cathepsin L cysteine proteinase	0.002	0.0083	0.0181
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0166	0.159	0.5
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0083	0.0083
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0083	0.0083
Onchocerca volvulus	Cathepsin F homolog	0.002	0.0083	0.1687
Schistosoma mansoni	hypothetical protein	0.0049	0.0382	0.0834
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.067	1
Brugia malayi	hypothetical protein	0.0043	0.0323	0.1582
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0014	0.003
Schistosoma mansoni	hypothetical protein	0.0043	0.0323	0.0705
Leishmania major	cathepsin L-like protease	0.002	0.0083	0.0536
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.067	1
Trypanosoma cruzi	cysteine peptidase, putative	0.002	0.0083	0.0536
Echinococcus granulosus	sterol regulatory element binding protein	0.0051	0.0401	0.0876

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 1.2589 um	PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	1.8356 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143]	ChEMBL.	No reference
Potency (functional)	= 3.1623 um	PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 3.5481 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.6964 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	6.5131 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	7.0795 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	9.2 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))]	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	14.1254 uM	PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 22.3872 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 89.1251 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1558469

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1424229