Detailed information for compound 1427241

Basic information

Technical information
  • TDR Targets ID: 1427241
  • Name: ethyl 1-[2-[3-(3-methylpiperidin-1-yl)propyla mino]-3,4-dioxo-1-cyclobutenyl]piperidine-3-c arboxylate
  • MW: 391.504 | Formula: C21H33N3O4
  • H donors: 1 H acceptors: 3 LogP: 2.49 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1CCCN(C1)C1=C(C(=O)C1=O)NCCCN1CCCC(C1)C
  • InChi: 1S/C21H33N3O4/c1-3-28-21(27)16-8-5-12-24(14-16)18-17(19(25)20(18)26)22-9-6-11-23-10-4-7-15(2)13-23/h15-16,22H,3-14H2,1-2H3
  • InChiKey: SOCHCNNLOCIOAF-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • ethyl 1-[2-[3-(3-methyl-1-piperidyl)propylamino]-3,4-dioxo-1-cyclobutenyl]piperidine-3-carboxylate
  • 1-[2-[3-(3-methyl-1-piperidinyl)propylamino]-3,4-dioxo-1-cyclobutenyl]-3-piperidinecarboxylic acid ethyl ester
  • 1-[3,4-diketo-2-[3-(3-methyl-1-piperidyl)propylamino]-1-cyclobutenyl]nipecotic acid ethyl ester
  • MLS000119333
  • SMR000096254

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens snurportin 1 No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica alkyl sulfatase, putative 0.0049 0.053 0.0747
Mycobacterium leprae conserved hypothetical protein 0.0049 0.053 0.0335
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0077 0.0013
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.057 0.013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0147 0.2 0.3121
Schistosoma mansoni cpg binding protein 0.0033 0.0285 0.0293
Leishmania major hypothetical protein, conserved 0.0043 0.0447 0.059
Schistosoma mansoni hypothetical protein 0.0058 0.0672 0.0815
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0068 0.0108
Loa Loa (eye worm) hypothetical protein 0.0043 0.0447 0.0713
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.068 1 1
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0077 0.0013
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0049 0.053 0.0624
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0077 0.0013
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0049 0.053 0.072
Brugia malayi carbohydrate phosphorylase 0.0431 0.6261 1
Trichomonas vaginalis beta lactamase domain, putative 0.0049 0.053 0.0747
Mycobacterium leprae Beta-lactamase-like protein 0.0049 0.053 0.0335
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0147 0.2 0.3121
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.053 0.0747
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0231 0.0368
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.194 0.3098
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0049 0.053 0.0847
Chlamydia trachomatis glycogen phosphorylase 0.0431 0.6261 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0077 0.0013
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.118 0.1797
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.0979 1
Schistosoma mansoni hypothetical protein 0.0049 0.053 0.0624
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0884 0.1413
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.057 0.0678
Loa Loa (eye worm) glycogen phosphorylase 0.0431 0.6261 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0109 0.0174
Entamoeba histolytica hypothetical protein 0.0035 0.0322 0.041
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0049 0.053 0.0847
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0447 0.0713
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.0111 0.0372
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.118 0.1797
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.194 0.2526
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0068 0.0001
Echinococcus multilocularis expressed protein 0.0034 0.0309 0.0326
Brugia malayi metallo-beta-lactamase superfamily protein 0.0049 0.053 0.0847
Plasmodium falciparum phd finger protein, putative 0.0058 0.0672 0.6596
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.0672 0.0815
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0077 0.0103
Schistosoma mansoni hypothetical protein 0.0019 0.0081 0.0017
Echinococcus multilocularis zinc phosphodiesterase 0.0049 0.053 0.0624
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.194 0.2526
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.053 0.0747
Brugia malayi beta-lactamase 0.0043 0.0447 0.0713
Schistosoma mansoni rotamase 0.0034 0.0309 0.0326
Loa Loa (eye worm) hypothetical protein 0.0058 0.0672 0.1073
Echinococcus granulosus ETHE1 protein 0.0049 0.053 0.0624
Brugia malayi beta-lactamase family protein 0.0043 0.0447 0.0713
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.068 1 1
Brugia malayi PHD-finger family protein 0.0058 0.0672 0.1073
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0077 0.0013
Mycobacterium tuberculosis Conserved protein 0.0049 0.053 0.0087
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.118 0.1733
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0229 0.3227 0.4262
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0049 0.053 0.0747
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0077 0.0013
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0856 0.1064
Brugia malayi MH2 domain containing protein 0.0025 0.0167 0.0266
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.194 0.2526
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0077 0.0103
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0049 0.053 0.0747
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.057 0.0376
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.048 0.0666
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.017 0.0272
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0049 0.053 0.0624
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0049 0.053 0.5024
Onchocerca volvulus 0.0049 0.053 0.0411
Brugia malayi hypothetical protein 0.0049 0.053 0.0847
Mycobacterium ulcerans hypothetical protein 0.0049 0.053 0.0087
Brugia malayi jmjC domain containing protein 0.0019 0.0077 0.0123
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.0979 0.1229
Trichomonas vaginalis glycogen phosphorylase, putative 0.0431 0.6261 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0189 0.1237
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0189 0.0188
Trichomonas vaginalis rotamase, putative 0.0034 0.0309 0.039
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0979 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.0672 0.0815
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0049 0.053 0.0624
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0068 0.0108
Brugia malayi hypothetical protein 0.0017 0.0049 0.0078
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0229 0.3227 0.4262
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0447 0.059
Brugia malayi Probable ClpP-like protease 0.0079 0.0979 0.1563
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0049 0.053 0.072
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.118 0.1885
Mycobacterium tuberculosis Conserved hypothetical protein 0.0049 0.053 0.0087
Schistosoma mansoni hypothetical protein 0.0049 0.053 0.0624
Brugia malayi MH2 domain containing protein 0.0025 0.0167 0.0266
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0167 0.0134
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0835 0.1036
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0049 0.053 0.0624
Trichomonas vaginalis glycogen phosphorylase, putative 0.0431 0.6261 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0218 0.0242
Brugia malayi beta-lactamase family protein 0.0043 0.0447 0.0713
Leishmania major importin beta-1 subunit, putative 0.0028 0.0218 0.0234
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0077 0.0013
Trypanosoma brucei glyoxalase II 0.0049 0.053 0.072
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.0979 0.1229
Schistosoma mansoni cpg binding protein 0.0035 0.0313 0.0331
Loa Loa (eye worm) hypothetical protein 0.0229 0.3227 0.5154
Leishmania major metallo-beta-lactamase family-like protein 0.0049 0.053 0.072
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.118 0.1885
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0049 0.053 0.072
Echinococcus granulosus glycogen phosphorylase 0.0431 0.6261 0.8356
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0147 0.2 0.3121
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0105 0.005
Schistosoma mansoni glycogen phosphorylase 0.0186 0.259 0.3403
Loa Loa (eye worm) hypothetical protein 0.0043 0.0447 0.0713
Entamoeba histolytica glycogenphosphorylase, putative 0.0186 0.259 0.4072
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0189 0.0188
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0049 0.053 0.0411
Echinococcus granulosus zinc phosphodiesterase 0.0049 0.053 0.0624
Onchocerca volvulus 0.0043 0.0447 0.0271
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0297 0.2519
Mycobacterium tuberculosis Possible hydrolase 0.0049 0.053 0.0087
Echinococcus granulosus smad 0.0025 0.0167 0.0134
Onchocerca volvulus 0.0043 0.0447 0.0271
Entamoeba histolytica hypothetical protein 0.0025 0.017 0.0165
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0203 0.0182
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0077 0.0123
Entamoeba histolytica glycogen phosphorylase, putative 0.0431 0.6261 1
Echinococcus multilocularis ETHE1 protein 0.0049 0.053 0.0624
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.118 0.1797
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0202 0.1385
Echinococcus granulosus peregrin 0.0058 0.0672 0.0815
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0167 0.0134
Plasmodium falciparum importin beta, putative 0.0035 0.0317 0.2656
Loa Loa (eye worm) hypothetical protein 0.0043 0.0447 0.0713
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.194 0.3098
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0446 0.6487 1
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0218 0.0242
Trichomonas vaginalis beta lactamase domain, putative 0.0049 0.053 0.0747
Brugia malayi ethe1-prov protein 0.0049 0.053 0.0847
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.194 0.2526
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.053 0.0747
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0724 0.7204
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0049 0.053 0.072
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0147 0.2 0.3121
Entamoeba histolytica glycogen phosphorylase, putative 0.0186 0.259 0.4072
Entamoeba histolytica hypothetical protein 0.0035 0.0322 0.041
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.0979 0.0793
Echinococcus multilocularis dnaJ subfamily B 0.0466 0.6787 0.9066
Plasmodium vivax unspecified product 0.0049 0.053 0.5024
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0884 0.1102
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.053 0.0747
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.0672 0.0815
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0186 0.259 0.2243
Schistosoma mansoni smad1 5 8 and 0.0025 0.0167 0.0134
Loa Loa (eye worm) hypothetical protein 0.0049 0.053 0.0847
Entamoeba histolytica glycogen phosphorylase, putative 0.0186 0.259 0.4072
Brugia malayi jmjC domain containing protein 0.0192 0.2669 0.4264
Schistosoma mansoni hypothetical protein 0.0035 0.0322 0.0343
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0189 0.0188
Loa Loa (eye worm) hypothetical protein 0.0035 0.0317 0.0506
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0447 0.0511
Loa Loa (eye worm) hypothetical protein 0.0121 0.1617 0.2583
Giardia lamblia Glycogen phosphorylase 0.0431 0.6261 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.194 0.2526
Brugia malayi CXXC zinc finger family protein 0.0033 0.0285 0.0455
Loa Loa (eye worm) hypothetical protein 0.0079 0.0979 0.1563
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.053 0.0747
Echinococcus multilocularis geminin 0.0512 0.7479 1
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0049 0.053 0.0747
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0049 0.053 0.0747
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0167 0.0266
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0446 0.6487 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.057 0.0678
Brugia malayi PHD-finger family protein 0.0021 0.0109 0.0174
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0049 0.053 0.072
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.017 0.0138
Plasmodium falciparum cytosolic glyoxalase II 0.0049 0.053 0.5024
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0297 0.0371
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.057 0.013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0077 0.0123
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.194 0.2526
Mycobacterium ulcerans hydrolase 0.0049 0.053 0.0087
Echinococcus multilocularis jumonji domain containing protein 0.0081 0.1016 0.1279
Mycobacterium ulcerans beta lactamase-like protein 0.0049 0.053 0.0087
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.118 0.1501
Trichomonas vaginalis A-type flavoprotein 0.0049 0.053 0.0747
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0192 0.2669 0.351
Schistosoma mansoni zinc phosphodiesterase 0.0049 0.053 0.0624
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.1607 0.2566
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0147 0.2 0.3121
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0979 0.4319
Trypanosoma cruzi glyoxalase II 0.0049 0.053 0.072
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.0979 0.1229
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.0672 0.1073
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0077 0.0123
Trichomonas vaginalis esterase, putative 0.0043 0.0447 0.0612
Echinococcus granulosus Smad4 0.0025 0.0167 0.0134
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0111 0.0372
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0297 0.0357
Mycobacterium tuberculosis Beta lactamase like protein 0.0049 0.053 0.0087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.194 0.2526
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0049 0.053 0.0747
Schistosoma mansoni hypothetical protein 0.0512 0.7479 1
Echinococcus granulosus glycogen phosphorylase 0.0431 0.6261 0.8356
Schistosoma mansoni zinc phosphodiesterase 0.0049 0.053 0.0624
Onchocerca volvulus 0.0043 0.0447 0.0271
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0447 0.0612
Onchocerca volvulus 0.0049 0.053 0.0411
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0147 0.2 0.3121
Onchocerca volvulus Alhambra homolog 0.0058 0.0672 0.0648
Brugia malayi MH2 domain containing protein 0.0365 0.5269 0.8416
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0309 0.039
Schistosoma mansoni peptidylglycine monooxygenase 0.0121 0.1617 0.209
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0218 0.0234
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0121 0.1617 0.2583
Echinococcus multilocularis Smad4 0.0025 0.0167 0.0134
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0049 0.053 0.5076
Loa Loa (eye worm) Smad1 0.0025 0.0167 0.0266
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0049 0.053 0.072
Brugia malayi MH1 domain containing protein 0.0025 0.0167 0.0266
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0147 0.2 0.3121
Echinococcus granulosus phd:f box containing protein 0.0019 0.0077 0.0013
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0447 0.0511
Toxoplasma gondii FATC domain-containing protein 0.0025 0.017 0.1124
Mycobacterium tuberculosis Conserved hypothetical protein 0.0049 0.053 0.0087
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0077 0.0013
Trypanosoma brucei polo-like protein kinase 0.0092 0.118 0.1733
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0049 0.053 0.0087
Mycobacterium ulcerans hydrolase 0.0049 0.053 0.0087
Echinococcus granulosus snurportin 1 0.0372 0.5376 0.7162
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0297 0.0357
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0447 0.4098
Echinococcus multilocularis smad 0.0025 0.0167 0.0134
Leishmania major metallo-beta-lactamase family protein-like protein 0.0049 0.053 0.072
Echinococcus granulosus jumonji domain containing protein 0.0081 0.1016 0.1279
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0049 0.053 0.072
Onchocerca volvulus Glycogen phosphorylase homolog 0.0431 0.6261 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.017 0.0159
Loa Loa (eye worm) hypothetical protein 0.0043 0.0447 0.0713
Mycobacterium leprae Probable lipase LipE 0.0043 0.0447 0.025
Mycobacterium tuberculosis Conserved protein 0.0049 0.053 0.0087
Giardia lamblia PHD finger protein 15 0.0058 0.0672 0.0975
Entamoeba histolytica alkyl sulfatase, putative 0.0049 0.053 0.0747
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.3965 0.3683
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0167 0.0134
Loa Loa (eye worm) hypothetical protein 0.0043 0.0447 0.0713
Echinococcus granulosus serine protein kinase ATM 0.0025 0.017 0.0138
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.0979 1
Mycobacterium tuberculosis Possible hydrolase 0.0049 0.053 0.0087
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.5376 0.8586
Loa Loa (eye worm) hypothetical protein 0.0049 0.053 0.0847
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0189 0.1237
Trichomonas vaginalis beta lactamase domain, putative 0.0049 0.053 0.0747
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0309 0.0494
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0147 0.2 0.3121
Schistosoma mansoni Smad4 0.0025 0.0167 0.0134
Schistosoma mansoni hypothetical protein 0.0049 0.053 0.0624
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0081 0.002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0147 0.2 0.3121
Schistosoma mansoni glycogen phosphorylase 0.0431 0.6261 0.8356
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0077 0.0013
Echinococcus multilocularis Glycosyl transferase, family 35 0.0431 0.6261 0.8356
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0322 0.0343
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0317 0.2732
Brugia malayi hypothetical protein 0.0035 0.0322 0.0514
Echinococcus multilocularis glycogen phosphorylase 0.0431 0.6261 0.8356
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0049 0.053 0.0847
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0186 0.259 0.2243
Loa Loa (eye worm) transcription factor SMAD2 0.0365 0.5269 0.8416
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0189 0.1237
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0068 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0147 0.2 0.3121
Schistosoma mansoni importin beta-1 0.0035 0.0317 0.0336
Mycobacterium ulcerans hypothetical protein 0.0049 0.053 0.0087
Brugia malayi RNA, U transporter 1 0.0099 0.1281 0.2045
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0192 0.2669 0.351
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0077 0.0015
Brugia malayi Importin beta-1 subunit 0.0035 0.0317 0.0506
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.017 0.0165
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0229 0.3227 0.5154
Echinococcus granulosus Glycosyl transferase family 35 0.0431 0.6261 0.8356
Echinococcus granulosus dnaJ subfamily B 0.0466 0.6787 0.9066
Treponema pallidum ribonuclease Z 0.0049 0.053 0.1824
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0077 0.0015
Echinococcus granulosus expressed protein 0.0034 0.0309 0.0326
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.118 0.1797
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0447 0.059
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.118 0.1501
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0317 0.0388
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0081 0.0142
Mycobacterium tuberculosis Conserved hypothetical protein 0.0049 0.053 0.0087
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0447 0.0713
Schistosoma mansoni cpg binding protein 0.0035 0.0313 0.0331
Leishmania major hypothetical protein, conserved 0.0019 0.0077 0.0015
Echinococcus granulosus geminin 0.0512 0.7479 1
Schistosoma mansoni smad1 5 8 and 0.0025 0.0167 0.0134
Entamoeba histolytica metallo-beta-lactamase family protein 0.0049 0.053 0.0747
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0446 0.6487 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0447 0.0612
Mycobacterium leprae POSSIBLE HYDROLASE 0.0049 0.053 0.0335
Entamoeba histolytica glycogen phosphorylase, putative 0.0431 0.6261 1
Trichomonas vaginalis beta lactamase domain, putative 0.0049 0.053 0.0747
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0447 0.025
Schistosoma mansoni kinase 0.0047 0.0498 0.0581
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.118 0.1733
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0672 0.6631
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0322 0.0343
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.006 0.0692 0.1105
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0979 0.0783
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0446 0.6487 0.6323
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0077 0.0013
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0297 0.0357
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0167 0.0266
Brugia malayi hypothetical protein 0.0026 0.0189 0.0301
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0077 0.0015
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0077 0.0013
Schistosoma mansoni glycogen phosphorylase 0.0431 0.6261 0.8356
Echinococcus granulosus cpg binding protein 0.0035 0.0313 0.0331
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0447 0.0612
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.118 0.1797
Brugia malayi metallo-beta-lactamase superfamily protein 0.0049 0.053 0.0847
Loa Loa (eye worm) MH2 domain-containing protein 0.0365 0.5269 0.8416
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0117 0.0077
Loa Loa (eye worm) hypothetical protein 0.0043 0.0447 0.0713
Treponema pallidum fructose-bisphosphate aldolase 0.0147 0.2 1
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0049 0.053 0.0624
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0049 0.053 0.0747
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0167 0.0134
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.017 0.0138
Leishmania major hypothetical protein, conserved 0.0049 0.053 0.072
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0189 0.1327
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0979 0.0557
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0068 0.0108
Loa Loa (eye worm) hypothetical protein 0.0049 0.053 0.0847
Schistosoma mansoni hypothetical protein 0.0466 0.6787 0.9066
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0317 0.0336
Brugia malayi Smad1 0.0025 0.0167 0.0266
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0322 0.0343
Schistosoma mansoni smad 0.0025 0.0167 0.0134
Trichomonas vaginalis apoptosis inducing factor, putative 0.0049 0.053 0.0747
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0105 0.005
Schistosoma mansoni dopamine-beta-monooxygenase 0.0121 0.1617 0.209
Entamoeba histolytica hypothetical protein 0.0028 0.0218 0.0242
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0285 0.0455
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0081 0.0142
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.118 0.1797
Mycobacterium ulcerans glyoxalase II, GloB 0.0049 0.053 0.0087
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.017 0.0159
Leishmania major hypothetical protein, conserved 0.0026 0.0189 0.0188
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0672 0.6596
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0049 0.053 0.0624
Trypanosoma cruzi glyoxalase II 0.0049 0.053 0.072
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0049 0.053 0.072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0077 0.0123
Giardia lamblia Kinase, PLK 0.0092 0.118 0.1797
Toxoplasma gondii ABC1 family protein 0.0043 0.0447 0.4159
Trichomonas vaginalis beta lactamase domain, putative 0.0049 0.053 0.0747
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0081 0.002
Brugia malayi jmjC domain containing protein 0.0019 0.0077 0.0123
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0317 0.0388
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0202 0.1385
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0229 0.3227 0.4262
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0446 0.6487 1
Plasmodium vivax importin-beta 2, putative 0.0035 0.0317 0.2656
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.118 0.1501
Mycobacterium ulcerans hypothetical protein 0.0049 0.053 0.0087
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.0979 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.118 0.1733
Mycobacterium leprae conserved hypothetical protein 0.0049 0.053 0.0335
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0447 0.0612
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0077 0.0123
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0884 0.1102
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0297 0.0357
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0672 0.6631
Toxoplasma gondii hypothetical protein 0.0027 0.0202 0.1473
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.0979 0.0557
Brugia malayi jmjC domain containing protein 0.0073 0.0884 0.1413
Echinococcus multilocularis cpg binding protein 0.0035 0.0313 0.0331
Brugia malayi AF-10 protein 0.0019 0.0081 0.0129
Echinococcus multilocularis glycogen phosphorylase 0.0431 0.6261 0.8356
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0309 0.0494
Loa Loa (eye worm) hypothetical protein 0.0026 0.0189 0.0301
Schistosoma mansoni smad1 5 8 and 0.0025 0.0167 0.0134
Echinococcus multilocularis snurportin 1 0.0372 0.5376 0.7162
Echinococcus multilocularis peregrin 0.0058 0.0672 0.0815
Loa Loa (eye worm) beta-lactamase 0.0043 0.0447 0.0713
Schistosoma mansoni jumonji domain containing protein 0.0152 0.2078 0.2713
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.118 0.1797
Loa Loa (eye worm) hypothetical protein 0.0049 0.053 0.0847
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0062 0.0719 0.1148
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0068 0.0108
Trypanosoma cruzi glyoxalase II 0.0049 0.053 0.072
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0446 0.6487 0.6323
Mycobacterium ulcerans hydrolase 0.0049 0.053 0.0087
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0049 0.053 0.072
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.0979 0.0783
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0077 0.0013
Entamoeba histolytica hypothetical protein, conserved 0.0049 0.053 0.0747
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.053 0.0747
Entamoeba histolytica type A flavoprotein, putative 0.0049 0.053 0.0747
Brugia malayi jmjC domain containing protein 0.0019 0.0077 0.0123
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0049 0.053 0.0847
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0447 0.0612
Loa Loa (eye worm) hypothetical protein 0.01 0.1299 0.2075
Brugia malayi jmjC domain containing protein 0.0019 0.0077 0.0123
Entamoeba histolytica hypothetical protein 0.0035 0.0322 0.041
Trichomonas vaginalis rotamase, putative 0.0034 0.0297 0.0371
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0049 0.053 0.072
Entamoeba histolytica type A flavoprotein, putative 0.0049 0.053 0.0747
Mycobacterium tuberculosis Conserved protein 0.0049 0.053 0.0087
Trichomonas vaginalis beta lactamase domain, putative 0.0049 0.053 0.0747
Mycobacterium ulcerans hypothetical protein 0.0049 0.053 0.0087
Onchocerca volvulus Putative hydrolase PNKD 0.0049 0.053 0.0411
Schistosoma mansoni hypothetical protein 0.0512 0.7479 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.118 0.1499
Schistosoma mansoni hypothetical protein 0.0372 0.5376 0.7162
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0447 0.0511
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0049 0.053 0.0624
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.048 0.0666
Entamoeba histolytica metallo-beta-lactamase family protein 0.0049 0.053 0.0747
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0167 0.0134
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0447 0.059
Entamoeba histolytica metallo-beta-lactamase family protein 0.0049 0.053 0.0747
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0049 0.053 0.072
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.0979 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0218 0.0242
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0049 0.053 0.5076
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.118 0.1797
Giardia lamblia Fructose-bisphosphate aldolase 0.0147 0.2 0.3121
Brugia malayi Bromodomain containing protein 0.0058 0.0672 0.1073
Echinococcus granulosus importin subunit beta 1 0.0035 0.0317 0.0336
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0447 0.0511
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.0884 0.1102
Loa Loa (eye worm) hypothetical protein 0.0022 0.0117 0.0187
Entamoeba histolytica hypothetical protein 0.0035 0.0322 0.041
Brugia malayi MH1 domain containing protein 0.0025 0.0167 0.0266

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0037 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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