Detailed information for compound 1433751

Basic information

Technical information
  • TDR Targets ID: 1433751
  • Name: 3-[2-(2-chlorophenoxy)ethylsulfanyl]-4-methyl -5-thiophen-2-yl-1,2,4-triazole
  • MW: 351.874 | Formula: C15H14ClN3OS2
  • H donors: 0 H acceptors: 2 LogP: 3.94 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccccc1OCCSc1nnc(n1C)c1cccs1
  • InChi: 1S/C15H14ClN3OS2/c1-19-14(13-7-4-9-21-13)17-18-15(19)22-10-8-20-12-6-3-2-5-11(12)16/h2-7,9H,8,10H2,1H3
  • InChiKey: OEOUFFBFFSWZCJ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 3-[2-(2-chlorophenoxy)ethylsulfanyl]-4-methyl-5-(2-thienyl)-1,2,4-triazole
  • 3-[2-(2-chlorophenoxy)ethylthio]-4-methyl-5-(2-thienyl)-1,2,4-triazole
  • 3-{[2-(2-chlorophenoxy)ethyl]sulfanyl}-4-methyl-5-(2-thienyl)-4H-1,2,4-triazole
  • MLS000547212
  • SMR000115161
  • ZINC02126883
  • AN-023/42399223

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.0285 0.5897 0.5819
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.5897 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0187 1
Leishmania major cathepsin L-like protease 0.0285 0.5897 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0285 0.5897 1
Brugia malayi Papain family cysteine protease containing protein 0.0153 0.2955 0.2821
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.5897 1
Loa Loa (eye worm) hypothetical protein 0.009 0.1556 0.1534
Brugia malayi Cathepsin L-like precursor 0.0285 0.5897 0.5819
Schistosoma mansoni cathepsin F (C01 family) 0.0285 0.5897 0.5467
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0063 0.0949 0.0926
Echinococcus granulosus cathepsin b 0.0469 1 1
Echinococcus granulosus cysteine protease 0.0153 0.2955 0.2216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0195 0.3891 0.5946
Leishmania major cathepsin L-like protease 0.0285 0.5897 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0949 0.0926
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0285 0.5897 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.5897 1
Echinococcus multilocularis cathepsin L 0.0153 0.2955 0.2216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.5897 1
Brugia malayi Papain family cysteine protease containing protein 0.0285 0.5897 0.5819
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0063 0.0949 0.1573
Onchocerca volvulus 0.0063 0.0949 0.1335
Entamoeba histolytica cysteine proteinase, putative 0.0285 0.5897 1
Brugia malayi Papain family cysteine protease containing protein 0.0153 0.2955 0.2821
Brugia malayi Cathepsin L-like precursor 0.0285 0.5897 0.5819
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0187 1
Entamoeba histolytica cysteine protease, putative 0.0153 0.2955 0.4848
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.5897 1
Onchocerca volvulus 0.0285 0.5897 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0469 1 1
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0063 0.0949 0.1573
Echinococcus granulosus cathepsin b 0.0469 1 1
Plasmodium falciparum serine repeat antigen 5 0.0063 0.0949 0.1573
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0063 0.0949 0.1573
Leishmania major cathepsin L-like protease 0.0285 0.5897 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.5897 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.5897 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.5897 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0189 0.3749 0.5658
Plasmodium vivax unspecified product 0.0063 0.0949 0.1573
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0285 0.5897 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0187 1
Brugia malayi Cathepsin L-like precursor 0.0285 0.5897 0.5819
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0285 0.5897 1
Trypanosoma cruzi cysteine peptidase, putative 0.0285 0.5897 0.5467
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0063 0.0949 0.1573
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0285 0.5897 1
Trypanosoma cruzi cysteine peptidase, putative 0.0153 0.2955 0.2216
Entamoeba histolytica cysteine protease, putative 0.0153 0.2955 0.4848
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0153 0.2955 0.2216
Plasmodium falciparum serine repeat antigen 7 0.0063 0.0949 0.1573
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0285 0.5897 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0153 0.2955 0.4848
Entamoeba histolytica cysteine protease, putative 0.0153 0.2955 0.4848
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0187 0.5
Loa Loa (eye worm) hypothetical protein 0.009 0.1556 0.1534
Trypanosoma cruzi cruzipain precursor, putative 0.0285 0.5897 0.5467
Echinococcus granulosus cathepsin l1 0.0285 0.5897 0.5467
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0469 1 1
Onchocerca volvulus 0.0285 0.5897 1
Entamoeba histolytica cysteine protease, putative 0.0063 0.0949 0.1335
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0469 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0153 0.2955 0.4848
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0189 0.3749 0.3093
Plasmodium falciparum serine repeat antigen 1 0.0063 0.0949 0.1573
Entamoeba histolytica cysteine protease, putative 0.0153 0.2955 0.4848
Brugia malayi Cathepsin L-like precursor 0.009 0.1556 0.1395
Loa Loa (eye worm) hypothetical protein 0.0063 0.0949 0.0926
Schistosoma mansoni cathepsin F (C01 family) 0.0285 0.5897 0.5467
Entamoeba histolytica cysteine protease, putative 0.0153 0.2955 0.4848
Brugia malayi cathepsin Z-like cysteine proteinase 0.0063 0.0949 0.0777
Echinococcus granulosus cathepsin l cysteine peptidase 0.0285 0.5897 0.5467
Loa Loa (eye worm) ctsf protein 0.0285 0.5897 0.5886
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.5897 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0285 0.5897 0.5467
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0195 0.3891 0.5946
Entamoeba histolytica cysteine proteinase, putative 0.0153 0.2955 0.4848
Entamoeba histolytica hypothetical protein 0.0063 0.0949 0.1335
Loa Loa (eye worm) hypothetical protein 0.0063 0.0949 0.0926
Loa Loa (eye worm) hypothetical protein 0.0029 0.0187 0.0162
Onchocerca volvulus 0.0285 0.5897 1
Plasmodium falciparum serine repeat antigen 4 0.0063 0.0949 0.1573
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.5897 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.5897 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0063 0.0949 0.1573
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0063 0.0949 0.1335
Entamoeba histolytica cysteine protease, putative 0.0153 0.2955 0.4848
Entamoeba histolytica cysteine protease, putative 0.0063 0.0949 0.1335
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0063 0.0949 0.1573
Entamoeba histolytica cysteine protease, putative 0.0063 0.0949 0.1335
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0063 0.0949 0.1335
Onchocerca volvulus Cathepsin L homolog 0.0063 0.0949 0.1335
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0063 0.0949 0.0926
Schistosoma mansoni cathepsin s 0.009 0.1556 0.067
Plasmodium falciparum serine repeat antigen 3 0.0063 0.0949 0.1573
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0285 0.5897 1
Plasmodium falciparum serine repeat antigen 8 0.0063 0.0949 0.1573
Brugia malayi cathepsin F-like cysteine proteinase 0.0063 0.0949 0.0777
Trypanosoma cruzi cysteine peptidase, putative 0.0285 0.5897 0.5467
Onchocerca volvulus Cathepsin L homolog 0.0285 0.5897 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0063 0.0949 0.1573
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0285 0.5897 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0189 0.3749 0.2697
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0063 0.0949 0.1573
Loa Loa (eye worm) hypothetical protein 0.0285 0.5897 0.5886
Loa Loa (eye worm) hypothetical protein 0.0063 0.0949 0.0926
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0153 0.2955 0.4054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0153 0.2955 0.2216
Loa Loa (eye worm) cathepsin B 0.0189 0.3749 0.3732
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.5897 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.5897 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.5897 1
Entamoeba histolytica cysteine protease, putative 0.0285 0.5897 1
Entamoeba histolytica cysteine protease, putative 0.0153 0.2955 0.4848
Entamoeba histolytica cysteine protease, putative 0.0153 0.2955 0.4848
Brugia malayi Cathepsin L-like cysteine proteinase 0.0195 0.3891 0.3775
Entamoeba histolytica cysteine protease, putative 0.0063 0.0949 0.1335
Brugia malayi cathepsin L-like precursor 0.0195 0.3891 0.3775
Loa Loa (eye worm) papain family cysteine protease containing protein 0.009 0.1556 0.1534
Plasmodium falciparum serine repeat antigen 9 0.0063 0.0949 0.1573
Echinococcus multilocularis cysteine protease 0.0285 0.5897 0.5467
Plasmodium falciparum cysteine proteinase falcipain 3 0.0285 0.5897 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0189 0.3749 0.6237
Brugia malayi Cathepsin L-like precursor 0.0285 0.5897 0.5819
Entamoeba histolytica cysteine protease, putative 0.0153 0.2955 0.4848
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0285 0.5897 1
Onchocerca volvulus 0.0195 0.3891 0.6487
Entamoeba histolytica cysteine proteinase, putative 0.0153 0.2955 0.4848
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0153 0.2955 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0063 0.0949 0.0777
Onchocerca volvulus Cathepsin L homolog 0.0285 0.5897 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0187 1
Entamoeba histolytica cysteine protease, putative 0.0153 0.2955 0.4848
Brugia malayi Cathepsin L-like precursor 0.0195 0.3891 0.3775
Loa Loa (eye worm) hypothetical protein 0.0195 0.3891 0.3875
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0285 0.5897 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0187 1
Leishmania major cathepsin L-like protease 0.0285 0.5897 1
Echinococcus granulosus cathepsin L cysteine protease 0.0153 0.2955 0.2216
Brugia malayi fibroinase precursor 0.0063 0.0949 0.0777
Toxoplasma gondii cathepsin CPL 0.0285 0.5897 1
Onchocerca volvulus 0.0285 0.5897 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0063 0.0949 0.0777
Giardia lamblia Cathepsin B precursor 0.0189 0.3749 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0063 0.0949 0.1573
Plasmodium vivax unspecified product 0.009 0.1556 0.2605
Brugia malayi Cathepsin L-like precursor 0.0195 0.3891 0.3775
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0153 0.2955 0.2216
Echinococcus multilocularis cathepsin b 0.0469 1 1
Leishmania major cysteine peptidase A (CPA) 0.0285 0.5897 1
Loa Loa (eye worm) cysteine protease 0.0285 0.5897 0.5886
Trypanosoma cruzi cysteine protease, putative 0.0153 0.2955 0.2216
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0063 0.0949 0.1573
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0285 0.5897 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0189 0.3749 0.3093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.5897 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0063 0.0949 0.1573
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.5897 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0195 0.3891 0.325
Entamoeba histolytica cysteine protease, putative 0.0063 0.0949 0.1335
Trypanosoma cruzi cysteine proteinase, putative 0.0153 0.2955 0.2216
Plasmodium falciparum cysteine proteinase falcipain 1 0.0153 0.2955 0.4989
Plasmodium vivax vivapain-2 0.0285 0.5897 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0187 1
Loa Loa (eye worm) hypothetical protein 0.0195 0.3891 0.3875
Loa Loa (eye worm) hypothetical protein 0.0029 0.0187 0.0162
Onchocerca volvulus 0.0285 0.5897 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0285 0.5897 0.5467
Trypanosoma cruzi cysteine peptidase, putative 0.0285 0.5897 0.5467
Trypanosoma cruzi cruzipain precursor, putative 0.009 0.1556 0.067
Loa Loa (eye worm) hypothetical protein 0.009 0.1556 0.1534
Leishmania major cathepsin L-like protease 0.0285 0.5897 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0285 0.5897 1
Trypanosoma cruzi cysteine proteinase, putative 0.0153 0.2955 0.2216
Leishmania major cathepsin L-like protease 0.0285 0.5897 1
Onchocerca volvulus 0.0285 0.5897 1
Plasmodium vivax unspecified product 0.0153 0.2955 0.4989
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0026 0.5
Loa Loa (eye worm) hypothetical protein 0.0195 0.3891 0.3875
Plasmodium vivax vivapain-2 0.0285 0.5897 1
Plasmodium vivax vivapain-1 0.0153 0.2955 0.4989
Entamoeba histolytica cysteine proteinase, putative 0.0153 0.2955 0.4848
Entamoeba histolytica cysteine proteinase, putative 0.0285 0.5897 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0285 0.5897 0.5886
Leishmania major cathepsin L-like protease 0.0285 0.5897 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0285 0.5897 0.5467
Leishmania major cathepsin L-like protease 0.0285 0.5897 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0187 0.5
Loa Loa (eye worm) hypothetical protein 0.0063 0.0949 0.0926
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0026 0.139
Giardia lamblia Cathepsin B precursor 0.0189 0.3749 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0063 0.0949 0.0777
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.5897 1
Entamoeba histolytica cysteine proteinase, putative 0.0195 0.3891 0.6487
Onchocerca volvulus Cathepsin F homolog 0.0285 0.5897 1
Echinococcus granulosus cathepsin L 0.0153 0.2955 0.2216
Brugia malayi cathepsin L precursor 0.0063 0.0949 0.0777
Giardia lamblia Cathepsin B precursor 0.0189 0.3749 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0063 0.0949 0.1573
Brugia malayi Cathepsin L-like precursor 0.0285 0.5897 0.5819
Echinococcus multilocularis cathepsin L cysteine protease 0.0285 0.5897 0.5467
Entamoeba histolytica cysteine protease, putative 0.0153 0.2955 0.4848
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0469 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0187 1
Entamoeba histolytica cysteine protease, putative 0.0153 0.2955 0.4848
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0153 0.2955 0.2216
Mycobacterium ulcerans hypothetical protein 0.0029 0.0187 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0063 0.0949 0.0777
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0187 1
Onchocerca volvulus 0.0285 0.5897 1
Plasmodium vivax vivapain-3 0.0153 0.2955 0.4989
Brugia malayi Papain family cysteine protease containing protein 0.0063 0.0949 0.0777
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.009 0.1556 0.1395
Plasmodium falciparum serine repeat antigen 6 0.0063 0.0949 0.1573
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0285 0.5897 1
Echinococcus multilocularis cysteine protease 0.0285 0.5897 0.5467
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0187 1
Echinococcus multilocularis cathepsin b 0.0469 1 1
Toxoplasma gondii cathepsin B 0.0189 0.3749 0.5658
Plasmodium falciparum serine repeat antigen 2 0.0063 0.0949 0.1573
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.5897 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0285 0.5897 1
Echinococcus granulosus cathepsin l1 0.0195 0.3891 0.325
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0063 0.0949 0.1573
Entamoeba histolytica cysteine protease, putative 0.0063 0.0949 0.1335
Brugia malayi cathepsin F-like cysteine proteinase 0.009 0.1556 0.1395
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.5897 1
Loa Loa (eye worm) hypothetical protein 0.0469 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0469 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0285 0.5897 0.5467
Trypanosoma cruzi cysteine peptidase, putative 0.0285 0.5897 0.5467
Plasmodium vivax serine-repeat antigen (SERA) 0.0063 0.0949 0.1573
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0063 0.0949 0.0926
Loa Loa (eye worm) hypothetical protein 0.0063 0.0949 0.0926
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0063 0.0949 0.1573
Trypanosoma cruzi cysteine peptidase, putative 0.009 0.1556 0.067
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0285 0.5897 0.5886
Brugia malayi Papain family cysteine protease containing protein 0.0063 0.0949 0.0777
Schistosoma mansoni cathepsin F (C01 family) 0.0195 0.3891 0.325
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0285 0.5897 1
Loa Loa (eye worm) fibroinase 0.0285 0.5897 0.5886
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.5897 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0285 0.5897 1
Entamoeba histolytica cysteine proteinase 2 0.0153 0.2955 0.4848
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.5897 1
Entamoeba histolytica cysteine protease, putative 0.0153 0.2955 0.4848
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0285 0.5897 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0187 0.0162

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3981 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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