Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-1 | 0.0464 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.1697 | 0.1697 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0464 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0049 | 0.0511 | 0.1432 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0065 | 0.0882 | 0.0882 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E type 5, putative | 0.0055 | 0.0651 | 0.0171 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0464 | 1 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0065 | 0.0882 | 0.0882 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0118 | 0.2082 | 0.1676 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0065 | 0.0882 | 0.0882 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0065 | 0.0882 | 0.0882 |
Leishmania major | hypothetical protein, conserved | 0.0049 | 0.0511 | 0.0025 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0101 | 0.1697 | 0.1697 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0521 | 0.0521 |
Echinococcus multilocularis | geminin | 0.0184 | 0.3593 | 0.3593 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0101 | 0.1697 | 0.1697 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0065 | 0.0882 | 0.0882 |
Echinococcus granulosus | carbonic anhydrase II | 0.0118 | 0.2082 | 0.2082 |
Schistosoma mansoni | hypothetical protein | 0.0218 | 0.4381 | 0.4381 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0049 | 0.0511 | 0.7856 |
Echinococcus multilocularis | eukaryotic translation initiation factor 4E | 0.0464 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0521 | 0.0521 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0101 | 0.1697 | 0.1697 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0521 | 0.0521 |
Loa Loa (eye worm) | hypothetical protein | 0.0328 | 0.6892 | 0.6892 |
Leishmania major | eukaryotic translation initiation factor eIF-4E, putative | 0.0464 | 1 | 1 |
Giardia lamblia | Translation elongation factor | 0.0055 | 0.0651 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0118 | 0.2082 | 0.2082 |
Leishmania major | eukaryotic translation initiation factor-like | 0.0464 | 1 | 1 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-2 | 0.0055 | 0.0651 | 0.0171 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0118 | 0.2082 | 0.2082 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E type 5, putative | 0.0055 | 0.0651 | 0.0171 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0118 | 0.2082 | 0.1676 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0049 | 0.0511 | 0.0511 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.4381 | 0.4381 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E | 0.0055 | 0.0651 | 1 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-3 | 0.0055 | 0.0651 | 0.0171 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.0464 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0521 | 0.0521 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0319 | 0.6693 | 0.6693 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0118 | 0.2082 | 0.2082 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0065 | 0.0882 | 0.0882 |
Trypanosoma cruzi | eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative | 0.0055 | 0.0651 | 0.0171 |
Brugia malayi | Isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Brugia malayi | Eukaryotic translation initiation factor 4E type 3, putative | 0.0055 | 0.0651 | 0.0651 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0118 | 0.2082 | 0.1676 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0882 | 0.0882 |
Giardia lamblia | Hypothetical protein | 0.0055 | 0.0651 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0521 | 0.0521 |
Leishmania major | eukaryotic translation initiation factor, putative | 0.0055 | 0.0651 | 0.0171 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0049 | 0.0511 | 0.0025 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0364 | 0.7727 | 0.7727 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-3 | 0.0055 | 0.0651 | 0.0171 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.0055 | 0.0651 | 0.0651 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.1697 | 0.1697 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0118 | 0.2082 | 0.2082 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0101 | 0.1697 | 0.1697 |
Echinococcus granulosus | geminin | 0.0184 | 0.3593 | 0.3593 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0049 | 0.0511 | 0.0025 |
Leishmania major | eukaryotic translation initiation factor 4e, putative | 0.0055 | 0.0651 | 0.0171 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0464 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0521 | 0.0521 |
Loa Loa (eye worm) | translation initiation factor 4E | 0.0464 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-4 | 0.0055 | 0.0651 | 0.0171 |
Brugia malayi | MH2 domain containing protein | 0.0364 | 0.7727 | 0.7727 |
Leishmania major | eukaryotic translation initiation factor-like protein | 0.0464 | 1 | 1 |
Trypanosoma cruzi | eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative | 0.0055 | 0.0651 | 0.0171 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1697 | 0.1697 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0049 | 0.0511 | 0.7856 |
Plasmodium vivax | translation initiation factor 4E, putative | 0.0055 | 0.0651 | 1 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0464 | 1 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0882 | 0.0882 |
Brugia malayi | hypothetical protein | 0.0049 | 0.0511 | 0.0511 |
Onchocerca volvulus | 0.0328 | 0.6892 | 1 | |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0464 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0101 | 0.1697 | 0.1697 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0464 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0364 | 0.7727 | 0.7727 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0112 | 0.0112 |
Giardia lamblia | Hypothetical protein | 0.0055 | 0.0651 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0521 | 0.0521 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E | 0.0464 | 1 | 1 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0464 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.3593 | 0.3593 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0048 | 0.0488 | 0.0488 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0464 | 1 | 1 |
Onchocerca volvulus | Deterin homolog | 0.0065 | 0.0882 | 0.0371 |
Toxoplasma gondii | hypothetical protein | 0.0055 | 0.0651 | 0.0651 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0319 | 0.6693 | 0.6693 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0048 | 0.0488 | 0.7498 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0118 | 0.2082 | 0.2082 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0521 | 0.0521 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.1697 | 0.1697 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-4 | 0.0055 | 0.0651 | 0.0171 |
Onchocerca volvulus | 0.0065 | 0.0882 | 0.0371 | |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0118 | 0.2082 | 0.2082 |
Leishmania major | hypothetical protein, conserved | 0.0055 | 0.0651 | 0.0171 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E type 5 | 0.0055 | 0.0651 | 0.0171 |
Brugia malayi | eukaryotic translation initiation factor 4E-1 | 0.0055 | 0.0651 | 0.0651 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.1697 | 0.1697 |
Brugia malayi | isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Leishmania major | carbonic anhydrase-like protein | 0.0118 | 0.2082 | 0.1676 |
Schistosoma mansoni | eukaryotic translation initiation factor 4e | 0.0464 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0055 | 0.0651 | 0.0171 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.3593 | 0.3593 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0049 | 0.0511 | 0.0025 |
Giardia lamblia | hypothetical protein | 0.0055 | 0.0651 | 0.5 |
Loa Loa (eye worm) | eukaryotic translation initiation factor 4E-1 | 0.0055 | 0.0651 | 0.0651 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0218 | 0.4381 | 0.4381 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-4 | 0.0055 | 0.0651 | 0.0171 |
Echinococcus multilocularis | GPCR, family 2 | 0.0101 | 0.1697 | 0.1697 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0521 | 0.0521 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E type | 0.0055 | 0.0651 | 0.0651 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.6693 | 0.6693 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0065 | 0.0882 | 0.0882 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0882 | 0.0882 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0118 | 0.2082 | 0.2082 |
Brugia malayi | hypothetical protein | 0.0328 | 0.6892 | 0.6892 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Plasmodium vivax | hypothetical protein, conserved | 0.0055 | 0.0651 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | eukaryotic translation initiation factor 4E type 3 | 0.0055 | 0.0651 | 0.0651 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0065 | 0.0882 | 0.0882 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0101 | 0.1697 | 0.1697 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0511 | 0.0511 |
Echinococcus granulosus | GPCR family 2 | 0.0101 | 0.1697 | 0.1697 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E, putative | 0.0055 | 0.0651 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0319 | 0.6693 | 0.6693 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0101 | 0.1697 | 0.1697 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0048 | 0.0488 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | PUBCHEM_BIOASSAY: SAR analysis of Antagonists of IAP-family anti-apoptotic proteins. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1018, AID1449, AID1513, AID1514, AID1638] | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | PUBCHEM_BIOASSAY: SAR analysis of Antagonists of XIAP-Bir3 domain of IAP-family anti-apoptotic proteins. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1018, AID1449, AID1513, AID1514, AID1638] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.