Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | eukaryotic translation initiation factor, putative | 0.0055 | 0.0651 | 0.0171 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.4381 | 0.4381 |
Loa Loa (eye worm) | eukaryotic translation initiation factor 4E-1 | 0.0055 | 0.0651 | 0.0651 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0521 | 0.0521 |
Plasmodium vivax | translation initiation factor 4E, putative | 0.0055 | 0.0651 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0101 | 0.1697 | 0.1697 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0118 | 0.2082 | 0.2082 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-4 | 0.0055 | 0.0651 | 0.0171 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0118 | 0.2082 | 0.1676 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0882 | 0.0882 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E type 5, putative | 0.0055 | 0.0651 | 0.0171 |
Onchocerca volvulus | 0.0065 | 0.0882 | 0.0371 | |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0065 | 0.0882 | 0.0882 |
Plasmodium vivax | hypothetical protein, conserved | 0.0055 | 0.0651 | 1 |
Loa Loa (eye worm) | translation initiation factor 4E | 0.0464 | 1 | 1 |
Leishmania major | eukaryotic translation initiation factor-like protein | 0.0464 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0882 | 0.0882 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0048 | 0.0488 | 0.5 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0065 | 0.0882 | 0.0882 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0118 | 0.2082 | 0.2082 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0464 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0055 | 0.0651 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0218 | 0.4381 | 0.4381 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0065 | 0.0882 | 0.0882 |
Brugia malayi | MH2 domain containing protein | 0.0364 | 0.7727 | 0.7727 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E type 5, putative | 0.0055 | 0.0651 | 0.0171 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0464 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1697 | 0.1697 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.3593 | 0.3593 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0049 | 0.0511 | 0.7856 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0521 | 0.0521 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-3 | 0.0055 | 0.0651 | 0.0171 |
Giardia lamblia | Hypothetical protein | 0.0055 | 0.0651 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0118 | 0.2082 | 0.2082 |
Brugia malayi | Isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.1697 | 0.1697 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0464 | 1 | 1 |
Leishmania major | eukaryotic translation initiation factor 4e, putative | 0.0055 | 0.0651 | 0.0171 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0065 | 0.0882 | 0.0882 |
Echinococcus multilocularis | geminin | 0.0184 | 0.3593 | 0.3593 |
Loa Loa (eye worm) | hypothetical protein | 0.0319 | 0.6693 | 0.6693 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0364 | 0.7727 | 0.7727 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0101 | 0.1697 | 0.1697 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E, putative | 0.0055 | 0.0651 | 1 |
Onchocerca volvulus | Deterin homolog | 0.0065 | 0.0882 | 0.0371 |
Plasmodium falciparum | eukaryotic translation initiation factor 4E | 0.0055 | 0.0651 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0048 | 0.0488 | 0.7498 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-4 | 0.0055 | 0.0651 | 0.0171 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0112 | 0.0112 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0511 | 0.0511 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0118 | 0.2082 | 0.2082 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E type | 0.0055 | 0.0651 | 0.0651 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.1697 | 0.1697 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0521 | 0.0521 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0364 | 0.7727 | 0.7727 |
Echinococcus granulosus | eukaryotic translation initiation factor 4E | 0.0464 | 1 | 1 |
Schistosoma mansoni | eukaryotic translation initiation factor 4e | 0.0464 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0101 | 0.1697 | 0.1697 |
Schistosoma mansoni | hypothetical protein | 0.0218 | 0.4381 | 0.4381 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.3593 | 0.3593 |
Leishmania major | hypothetical protein, conserved | 0.0055 | 0.0651 | 0.0171 |
Trypanosoma cruzi | eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative | 0.0055 | 0.0651 | 0.0171 |
Echinococcus granulosus | carbonic anhydrase II | 0.0118 | 0.2082 | 0.2082 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0464 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0118 | 0.2082 | 0.2082 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.0055 | 0.0651 | 0.0651 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0049 | 0.0511 | 0.0511 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0521 | 0.0521 |
Echinococcus multilocularis | GPCR, family 2 | 0.0101 | 0.1697 | 0.1697 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0101 | 0.1697 | 0.1697 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Entamoeba histolytica | eukaryotic translation initiation factor 4E, putative | 0.0464 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0118 | 0.2082 | 0.2082 |
Brugia malayi | Eukaryotic translation initiation factor 4E type 3, putative | 0.0055 | 0.0651 | 0.0651 |
Trypanosoma cruzi | eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative | 0.0055 | 0.0651 | 0.0171 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0521 | 0.0521 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0319 | 0.6693 | 0.6693 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0319 | 0.6693 | 0.6693 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0118 | 0.2082 | 0.1676 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0049 | 0.0511 | 0.0025 |
Leishmania major | hypothetical protein, conserved | 0.0055 | 0.0651 | 0.0171 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0101 | 0.1697 | 0.1697 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0118 | 0.2082 | 0.2082 |
Brugia malayi | hypothetical protein | 0.0328 | 0.6892 | 0.6892 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-4 | 0.0055 | 0.0651 | 0.0171 |
Leishmania major | carbonic anhydrase-like protein | 0.0118 | 0.2082 | 0.1676 |
Toxoplasma gondii | hypothetical protein | 0.0055 | 0.0651 | 0.0651 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0464 | 1 | 1 |
Trypanosoma cruzi | Eukaryotic translation initiation factor 4E-1 | 0.0464 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.1697 | 0.1697 |
Leishmania major | hypothetical protein, conserved | 0.0049 | 0.0511 | 0.0025 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-3 | 0.0055 | 0.0651 | 0.0171 |
Brugia malayi | eukaryotic translation initiation factor 4E-1 | 0.0055 | 0.0651 | 0.0651 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-2 | 0.0055 | 0.0651 | 0.0171 |
Onchocerca volvulus | 0.0328 | 0.6892 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.1697 | 0.1697 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E-1 | 0.0464 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0049 | 0.0511 | 0.0025 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0049 | 0.0511 | 0.1432 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0065 | 0.0882 | 0.0882 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0521 | 0.0521 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0101 | 0.1697 | 0.1697 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0049 | 0.0511 | 0.0025 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0101 | 0.1697 | 0.1697 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0882 | 0.0882 |
Leishmania major | eukaryotic translation initiation factor eIF-4E, putative | 0.0464 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0319 | 0.6693 | 0.6693 |
Giardia lamblia | hypothetical protein | 0.0055 | 0.0651 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Echinococcus multilocularis | eukaryotic translation initiation factor 4E | 0.0464 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0048 | 0.0488 | 0.0488 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0048 | 0.0488 | 0.0488 |
Trypanosoma brucei | Eukaryotic translation initiation factor 4E type 5 | 0.0055 | 0.0651 | 0.0171 |
Loa Loa (eye worm) | eukaryotic translation initiation factor 4E type 3 | 0.0055 | 0.0651 | 0.0651 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0521 | 0.0521 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0521 | 0.0521 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0065 | 0.0882 | 0.0882 |
Brugia malayi | hypothetical protein | 0.0049 | 0.0511 | 0.0511 |
Trichomonas vaginalis | eukaryotic translation initiation factor 4E, putative | 0.0464 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0101 | 0.1697 | 0.1697 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0065 | 0.0882 | 0.0882 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0118 | 0.2082 | 0.1676 |
Echinococcus granulosus | geminin | 0.0184 | 0.3593 | 0.3593 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0521 | 0.0521 |
Toxoplasma gondii | eukaryotic initiation factor-4E, putative | 0.0464 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0049 | 0.0511 | 0.7856 |
Leishmania major | eukaryotic translation initiation factor-like | 0.0464 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0328 | 0.6892 | 0.6892 |
Giardia lamblia | Translation elongation factor | 0.0055 | 0.0651 | 0.5 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0065 | 0.0882 | 0.0882 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | PUBCHEM_BIOASSAY: SAR analysis of Antagonists of IAP-family anti-apoptotic proteins. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1018, AID1449, AID1513, AID1514, AID1638] | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | PUBCHEM_BIOASSAY: SAR analysis of Antagonists of XIAP-Bir3 domain of IAP-family anti-apoptotic proteins. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1018, AID1449, AID1513, AID1514, AID1638] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.