Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | LCK proto-oncogene, Src family tyrosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.001 | 0.004 | 0.0614 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0009 | 0.0009 | 0.0142 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (probably LuxR/UhpA-family) | 0.0547 | 0.9852 | 0.9852 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.004 | 0.0555 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.001 | 0.004 | 0.0614 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0017 | 0.0166 | 0.2564 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0017 | 0.0166 | 0.2564 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.004 | 0.0555 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0009 | 0.0018 | 0.0275 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0017 | 0.0166 | 0.2564 |
Brugia malayi | nuclear receptor RXR | 0.0009 | 0.0018 | 0.0275 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0018 | 0.0275 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0009 | 0.0009 | 0.0142 |
Echinococcus granulosus | c src tyrosine kinase | 0.001 | 0.004 | 0.0614 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0009 | 0.0017 | 0.0253 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.001 | 0.004 | 0.0614 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0017 | 0.0166 | 0.2564 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0009 | 0.0009 | 0.0142 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0043 | 0.0646 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0017 | 0.0166 | 0.2564 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0018 | 0.0275 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0017 | 0.0166 | 0.2564 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0017 | 0.0166 | 0.2564 |
Mycobacterium tuberculosis | Possible transcriptional regulatory protein | 0.0547 | 0.9852 | 0.9852 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0082 | 0.1271 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0018 | 0.0275 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.001 | 0.004 | 0.0614 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0009 | 0.0009 | 0.0142 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0166 | 0.2564 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.001 | 0.004 | 0.0614 |
Wolbachia endosymbiont of Brugia malayi | signal transduction histidine kinase and receiver | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0017 | 0.0166 | 0.2564 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.0718 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0009 | 0.0018 | 0.025 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0017 | 0.0166 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0017 | 0.0166 | 0.2564 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0166 | 0.2564 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.004 | 0.0555 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein | 0.0547 | 0.9852 | 0.9852 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0009 | 0.0018 | 0.0275 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0009 | 0.0009 | 0.0142 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0017 | 0.0166 | 0.2306 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0009 | 0.0009 | 0.0159 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0082 | 0.1271 |
Brugia malayi | ecdysteroid receptor | 0.0017 | 0.0166 | 0.2564 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0017 | 0.0166 | 0.2564 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0017 | 0.0166 | 0.2306 |
Wolbachia endosymbiont of Brugia malayi | response regulator | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0017 | 0.0166 | 0.2564 |
Schistosoma mansoni | nuclear hormone receptor | 0.0017 | 0.0166 | 0.2306 |
Brugia malayi | nuclear hormone receptor | 0.0017 | 0.0166 | 0.2564 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0043 | 0.0646 | 1 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0009 | 0.0009 | 0.0142 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0017 | 0.0166 | 0.2564 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0017 | 0.0166 | 0.2564 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0017 | 0.0166 | 0.2564 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.001 | 0.004 | 0.0614 |
Loa Loa (eye worm) | SRC-1 | 0.001 | 0.004 | 0.0614 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0018 | 0.0275 |
Schistosoma mansoni | tyrosine kinase | 0.001 | 0.004 | 0.0555 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0017 | 0.0166 | 0.2306 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.001 | 0.004 | 0.0614 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.001 | 0.004 | 0.0614 |
Treponema pallidum | protein-glutamate methylesterase (cheB) | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0009 | 0.0009 | 0.0142 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0166 | 0.2564 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0017 | 0.0166 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0009 | 0.0142 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.001 | 0.004 | 0.0614 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.001 | 0.004 | 0.0614 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0009 | 0.0009 | 0.0131 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.001 | 0.004 | 0.0555 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0166 | 0.2564 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.001 | 0.004 | 0.0614 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0009 | 0.0017 | 0.0253 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0009 | 0.0018 | 0.0275 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0009 | 0.0017 | 0.0253 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0166 | 0.2564 |
Mycobacterium ulcerans | nitrate/nitrite response regulator protein NarL | 0.0555 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0017 | 0.0253 |
Brugia malayi | Variant SH3 domain containing protein | 0.0009 | 0.0017 | 0.0253 |
Schistosoma mansoni | thyroid hormone receptor | 0.0017 | 0.0166 | 0.2306 |
Wolbachia endosymbiont of Brugia malayi | response regulator PleD | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0017 | 0.0166 | 0.2564 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0009 | 0.0009 | 0.0142 |
Mycobacterium ulcerans | hypothetical protein | 0.0547 | 0.9852 | 0.9852 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0166 | 0.2564 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.001 | 0.004 | 0.0614 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0017 | 0.0166 | 0.2564 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0082 | 0.1271 |
Mycobacterium tuberculosis | Possible two component transcriptional regulatory protein (probably LuxR-family) | 0.0547 | 0.9852 | 0.9852 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0017 | 0.0166 | 0.2564 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0008 | 0 | 0.0003 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.001 | 0.004 | 0.0614 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (LuxR-family) | 0.0547 | 0.9852 | 0.9852 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0041 | 0.0593 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0166 | 0.2564 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.0009 | 0.0131 |
Mycobacterium ulcerans | two component transcriptional regulator | 0.0555 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0018 | 0.0275 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0017 | 0.0166 | 0.2306 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.0009 | 0.0131 |
Echinococcus multilocularis | c src tyrosine kinase | 0.001 | 0.004 | 0.0614 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.001 | 0.004 | 0.0614 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0017 | 0.0166 | 0.2564 |
Schistosoma mansoni | nuclear receptor | 0.0008 | 0 | 0.0003 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0009 | 0.0018 | 0.025 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0082 | 0.1271 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0018 | 0.0275 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0017 | 0.0166 | 0.2564 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0017 | 0.0166 | 0.2564 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0009 | 0.0017 | 0.023 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0017 | 0.0166 | 0.2564 |
Chlamydia trachomatis | two component regulatory system response regulator/ATPase | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor | 0.0008 | 0 | 0.0003 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0041 | 0.0593 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0017 | 0.0166 | 0.2564 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0017 | 0.0166 | 0.2564 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0009 | 0.0009 | 0.0142 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0017 | 0.0166 | 0.2564 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.001 | 0.004 | 0.0614 |
Schistosoma mansoni | adapter molecule crk | 0.0009 | 0.0017 | 0.023 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0009 | 0.0009 | 0.0131 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0009 | 0.0017 | 0.023 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0008 | 0 | 0.0003 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0017 | 0.0166 | 0.2564 |
Echinococcus multilocularis | NCK adaptor protein | 0.0009 | 0.0017 | 0.0253 |
Schistosoma mansoni | thyroid hormone receptor | 0.0017 | 0.0166 | 0.2306 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0009 | 0.0009 | 0.0131 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0082 | 0.1271 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0017 | 0.0166 | 0.2564 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0009 | 0.0009 | 0.0131 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0009 | 0.0009 | 0.0142 |
Mycobacterium ulcerans | two component transcriptional regulatory protein DevR | 0.0555 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0017 | 0.0166 | 0.2306 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0082 | 0.1271 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0017 | 0.0166 | 0.2564 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0009 | 0.0009 | 0.0142 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0017 | 0.0166 | 0.2564 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0009 | 0.0017 | 0.023 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0017 | 0.0166 | 0.2564 |
Treponema pallidum | response regulatory protein (atoC) | 0.0008 | 0 | 0.5 |
Treponema pallidum | chemotaxis response regulator (cheY) | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0009 | 0.0018 | 0.0275 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.0718 | 1 |
Brugia malayi | Variant SH3 domain containing protein | 0.0009 | 0.0017 | 0.0253 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.001 | 0.004 | 0.0614 |
Brugia malayi | steroid hormone receptor | 0.0017 | 0.0166 | 0.2564 |
Mycobacterium leprae | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN | 0.0547 | 0.9852 | 1 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0009 | 0.0009 | 0.0142 |
Brugia malayi | nuclear receptor NHR-88 | 0.0017 | 0.0166 | 0.2564 |
Schistosoma mansoni | nuclear hormone receptor | 0.0008 | 0 | 0.0003 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0017 | 0.0166 | 0.2564 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0017 | 0.0166 | 0.2564 |
Schistosoma mansoni | nuclear hormone receptor | 0.0008 | 0 | 0.0003 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0017 | 0.0166 | 0.2564 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0082 | 0.1145 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0017 | 0.0166 | 0.2564 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0043 | 0.0646 | 1 |
Brugia malayi | SRC-1 | 0.001 | 0.004 | 0.0614 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.001 | 0.004 | 0.0614 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0017 | 0.0166 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0017 | 0.0166 | 0.2564 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0017 | 0.0166 | 0.2306 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0017 | 0.0166 | 0.2564 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.001 | 0.004 | 0.0614 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0017 | 0.0166 | 0.2306 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0017 | 0.0166 | 0.2564 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0017 | 0.0166 | 0.2564 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0017 | 0.0166 | 0.2306 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0017 | 0.0166 | 0.2564 |
Schistosoma mansoni | zinc finger protein | 0.0008 | 0 | 0.0003 |
Brugia malayi | hypothetical protein | 0.0009 | 0.0018 | 0.0275 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0017 | 0.0166 | 0.2564 |
Onchocerca volvulus | 0.0017 | 0.0166 | 1 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0043 | 0.0646 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0008 | 0 | 0.0003 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.001 | 0.004 | 0.0614 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0009 | 0.0009 | 0.0142 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0009 | 0.0017 | 0.0253 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0009 | 0.0018 | 0.0275 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0009 | 0.0017 | 0.0253 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0166 | 0.2564 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0017 | 0.0166 | 0.2564 |
Mycobacterium ulcerans | putative regulatory protein | 0.0547 | 0.9852 | 0.9852 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0082 | 0.1145 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.001 | 0.004 | 0.0614 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0017 | 0.0166 | 0.2564 |
Echinococcus granulosus | NCK adaptor protein | 0.0009 | 0.0017 | 0.0253 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0017 | 0.0166 | 0.2564 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0017 | 0.0166 | 0.2306 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.001 | 0.004 | 0.0614 |
Schistosoma mansoni | nck2/grb4 | 0.0009 | 0.0017 | 0.023 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0009 | 0.0009 | 0.0142 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0017 | 0.0166 | 0.2306 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0541 | 0.8377 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0009 | 0.0009 | 0.0159 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.