Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0041 | 0.1302 | 0.3201 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 1 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0258 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.5583 | 0.5583 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.4067 | 0.4067 |
Brugia malayi | hypothetical protein | 0.011 | 0.4067 | 0.4067 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0162 | 0.1028 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0044 | 0.1418 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.5583 | 0.5583 |
Brugia malayi | LBP/BPI | 0.011 | 0.4067 | 0.4067 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0258 | 1 | 1 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0162 | 0.1145 |
Onchocerca volvulus | 0.0258 | 1 | 1 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0048 | 0.158 | 1 |
Onchocerca volvulus | 0.0258 | 1 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.011 | 0.4067 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.4067 | 0.4067 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0162 | 0.0162 |
Onchocerca volvulus | 0.0258 | 1 | 1 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0162 | 0.1028 |
Brugia malayi | hypothetical protein | 0.0148 | 0.5583 | 0.5583 |
Onchocerca volvulus | 0.0258 | 1 | 1 | |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0044 | 0.1418 | 0.1418 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.5583 | 0.5583 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0148 | 0.5583 | 0.5583 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0162 | 0.1145 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.5583 | 0.5583 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.4067 | 0.4067 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0258 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0148 | 0.5583 | 0.5583 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.4067 | 0.4067 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0041 | 0.1302 | 0.3201 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0044 | 0.1418 | 1 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0148 | 0.5583 | 0.5583 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0162 | 0.1145 |
Onchocerca volvulus | 0.0148 | 0.5583 | 0.2556 | |
Onchocerca volvulus | 0.0258 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.5583 | 0.5583 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0162 | 0.0162 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0048 | 0.158 | 1 |
Onchocerca volvulus | 0.0258 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1185 | 0.1185 |
Onchocerca volvulus | 0.0148 | 0.5583 | 0.2556 | |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0162 | 0.1145 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0044 | 0.1418 | 0.1418 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0148 | 0.5583 | 0.5583 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0148 | 0.5583 | 0.5583 |
Onchocerca volvulus | 0.0258 | 1 | 1 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0148 | 0.5583 | 0.5583 |
Onchocerca volvulus | 0.0258 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Concentration (functional) | = 3.5 mM | Concentration which reduced survival to 1% following incubation 3 hours with V79 mammalian cells under hypoxic (Cnitrogen) conditions | ChEMBL. | 2391699 |
Concentration (functional) | = 70 mM | Concentration which reduced survival to 1% following incubation 3 hours with V79 mammalian cells under aerobic (Cair) conditions | ChEMBL. | 2391699 |
Ratio (functional) | = 20 | Ratio of concentration which reduced V79 cell survival to 1% under aerobic conditions to that of hypoxic conditions | ChEMBL. | 2391699 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.