Detailed information for compound 1443744

Basic information

Technical information
  • TDR Targets ID: 1443744
  • Name: N-(3-imidazol-1-ylpropyl)-2-oxochromene-3-car boxamide
  • MW: 297.309 | Formula: C16H15N3O3
  • H donors: 1 H acceptors: 3 LogP: 2.03 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cc2ccccc2oc1=O)NCCCn1cncc1
  • InChi: 1S/C16H15N3O3/c20-15(18-6-3-8-19-9-7-17-11-19)13-10-12-4-1-2-5-14(12)22-16(13)21/h1-2,4-5,7,9-11H,3,6,8H2,(H,18,20)
  • InChiKey: SCEWFLIAMZCARX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-imidazol-1-ylpropyl)-2-oxo-chromene-3-carboxamide
  • N-[3-(1-imidazolyl)propyl]-2-oxo-3-chromenecarboxamide
  • N-(3-imidazol-1-ylpropyl)-2-keto-chromene-3-carboxamide
  • ZINC02115661
  • EU-0083452
  • MLS000578877
  • N-[3-(1H-imidazol-1-yl)propyl]-2-oxo-2H-chromene-3-carboxamide
  • SMR000197863
  • IDI1_007037
  • AK-968/41927615
  • IVK/9328549
  • Enamine_002690

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0298 0.1695 0.1695
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0465 0.5
Plasmodium vivax serine-repeat antigen (SERA) 0.0212 0.1173 0.2044
Echinococcus granulosus cathepsin L cysteine protease 0.051 0.2973 0.2951
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0212 0.1173 0.2044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0948 0.5614 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0212 0.1173 0.2044
Toxoplasma gondii cathepsin CPC2 0.0212 0.1173 0.2044
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0212 0.1173 0.2044
Plasmodium falciparum cysteine proteinase falcipain 3 0.0948 0.5614 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0649 0.3814 0.3794
Leishmania major cathepsin L-like protease 0.0948 0.5614 1
Entamoeba histolytica cysteine proteinase, putative 0.0948 0.5614 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0948 0.5614 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.051 0.2973 0.5269
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0212 0.1173 0.2044
Brugia malayi Cathepsin L-like precursor 0.0948 0.5614 0.5614
Brugia malayi Probable ClpP-like protease 0.0094 0.0465 0.0465
Leishmania major cathepsin L-like protease 0.0948 0.5614 1
Toxoplasma gondii cathepsin CPC1 0.0212 0.1173 0.2044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.5614 1
Entamoeba histolytica hypothetical protein 0.0043 0.0157 0.0224
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0212 0.1173 0.2044
Giardia lamblia Cathepsin L precursor 0.0212 0.1173 0.2948
Echinococcus granulosus cysteine protease 0.051 0.2973 0.2951
Echinococcus granulosus lamin 0.0033 0.0091 0.006
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0948 0.5614 0.5614
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1674 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.051 0.2973 0.2951
Entamoeba histolytica cysteine protease, putative 0.0212 0.1173 0.2044
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0268 1
Leishmania major cathepsin L-like protease 0.0948 0.5614 1
Entamoeba histolytica cysteine protease, putative 0.0948 0.5614 1
Entamoeba histolytica cysteine proteinase, putative 0.0649 0.3814 0.6775
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0157 0.0126
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0465 1
Brugia malayi hypothetical protein 0.0043 0.0157 0.0157
Leishmania major cathepsin L-like protease 0.0948 0.5614 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0948 0.5614 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.051 0.2973 0.5269
Loa Loa (eye worm) hypothetical protein 0.0212 0.1173 0.1173
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0948 0.5614 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0268 0.0237
Echinococcus multilocularis cysteine protease 0.0948 0.5614 0.56
Plasmodium vivax vivapain-2 0.0948 0.5614 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0212 0.1173 0.2044
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0268 0.4744
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0465 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0212 0.1173 0.1145
Trypanosoma cruzi cysteine proteinase, putative 0.051 0.2973 0.2951
Echinococcus granulosus cathepsin L 0.0212 0.1173 0.1145
Loa Loa (eye worm) hypothetical protein 0.0094 0.0465 0.0465
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.1173 0.2044
Onchocerca volvulus Cathepsin F homolog 0.0948 0.5614 1
Trypanosoma cruzi cysteine proteinase, putative 0.051 0.2973 0.2951
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.1173 0.2044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.5614 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.051 0.2973 0.5269
Entamoeba histolytica cysteine proteinase 2 0.051 0.2973 0.5269
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0212 0.1173 0.2044
Trypanosoma cruzi cysteine protease, putative 0.051 0.2973 0.2951
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0157 0.0126
Loa Loa (eye worm) hypothetical protein 0.0649 0.3814 0.3814
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0212 0.1173 0.2044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0948 0.5614 1
Onchocerca volvulus 0.0948 0.5614 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0091 0.0091
Entamoeba histolytica cysteine protease, putative 0.051 0.2973 0.5269
Schistosoma mansoni cathepsin F (C01 family) 0.0948 0.5614 0.56
Giardia lamblia Cathepsin L precursor 0.0212 0.1173 0.2948
Trichomonas vaginalis conserved hypothetical protein 0.0212 0.1173 0.2044
Plasmodium falciparum serine repeat antigen 8 0.0212 0.1173 0.2044
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0948 0.5614 1
Entamoeba histolytica cysteine protease, putative 0.051 0.2973 0.5269
Schistosoma mansoni cathepsin F (C01 family) 0.0948 0.5614 0.56
Schistosoma mansoni cathepsin s 0.0298 0.1695 0.1669
Toxoplasma gondii hypothetical protein 0.0033 0.0091 0.0106
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0212 0.1173 0.2044
Trypanosoma cruzi cysteine peptidase, putative 0.0948 0.5614 0.56
Trypanosoma cruzi cruzipain precursor, putative 0.0298 0.1695 0.1669
Entamoeba histolytica cysteine protease, putative 0.051 0.2973 0.5269
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0212 0.1173 0.1145
Plasmodium falciparum serine repeat antigen 6 0.0212 0.1173 0.2044
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0948 0.5614 1
Brugia malayi Cathepsin L-like precursor 0.0948 0.5614 0.5614
Plasmodium falciparum serine repeat antigen 4 0.0212 0.1173 0.2044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.1173 0.2044
Brugia malayi Papain family cysteine protease containing protein 0.0212 0.1173 0.1173
Giardia lamblia Cathepsin B precursor 0.0212 0.1173 0.2948
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0212 0.1173 0.2948
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1674 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.5614 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0948 0.5614 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0212 0.1173 0.2044
Brugia malayi Papain family cysteine protease containing protein 0.051 0.2973 0.2973
Loa Loa (eye worm) hypothetical protein 0.018 0.0984 0.0984
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0465 0.0776
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0212 0.1173 0.2044
Brugia malayi Cathepsin L-like precursor 0.0948 0.5614 0.5614
Entamoeba histolytica cysteine proteinase, putative 0.0948 0.5614 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0157 0.0126
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0664 0.3903 0.3883
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0948 0.5614 0.5614
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.1173 0.2044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.5614 1
Giardia lamblia Cathepsin L precursor 0.0212 0.1173 0.2948
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0212 0.1173 0.2044
Echinococcus multilocularis muscleblind protein 1 0.018 0.0984 0.0955
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0212 0.1173 0.2044
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0948 0.5614 0.56
Loa Loa (eye worm) hypothetical protein 0.0212 0.1173 0.1173
Giardia lamblia Cathepsin B precursor 0.0212 0.1173 0.2948
Onchocerca volvulus 0.0948 0.5614 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.051 0.2973 0.5269
Echinococcus multilocularis lamin dm0 0.0033 0.0091 0.006
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0091 0.0106
Trypanosoma cruzi cysteine peptidase, putative 0.0298 0.1695 0.1669
Loa Loa (eye worm) hypothetical protein 0.1674 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0212 0.1173 0.1173
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0268 1
Giardia lamblia Hypothetical protein 0.0212 0.1173 0.2948
Loa Loa (eye worm) hypothetical protein 0.0212 0.1173 0.1173
Loa Loa (eye worm) hypothetical protein 0.0032 0.0088 0.0088
Schistosoma mansoni thyroid hormone receptor 0.0164 0.0886 0.0857
Entamoeba histolytica cysteine protease, putative 0.051 0.2973 0.5269
Loa Loa (eye worm) hypothetical protein 0.0212 0.1173 0.1173
Echinococcus granulosus muscleblind protein 0.018 0.0984 0.0955
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0091 0.0091
Schistosoma mansoni lamin 0.0033 0.0091 0.006
Plasmodium falciparum serine repeat antigen 5 0.0212 0.1173 0.2044
Brugia malayi Cathepsin L-like precursor 0.0649 0.3814 0.3814
Onchocerca volvulus 0.0948 0.5614 1
Trypanosoma cruzi cysteine peptidase, putative 0.051 0.2973 0.2951
Giardia lamblia Cysteine protease 0.0212 0.1173 0.2948
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0664 0.3903 0.6934
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.5614 1
Entamoeba histolytica cysteine protease, putative 0.051 0.2973 0.5269
Echinococcus multilocularis cathepsin L cysteine protease 0.0948 0.5614 0.56
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0948 0.5614 1
Giardia lamblia Hypothetical protein 0.0212 0.1173 0.2948
Entamoeba histolytica cysteine protease, putative 0.051 0.2973 0.5269
Onchocerca volvulus 0.0649 0.3814 0.674
Loa Loa (eye worm) hypothetical protein 0.018 0.0984 0.0984
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0948 0.5614 1
Trypanosoma cruzi cruzipain precursor, putative 0.0948 0.5614 0.56
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0948 0.5614 0.56
Schistosoma mansoni hypothetical protein 0.0152 0.0812 0.0783
Leishmania major cathepsin L-like protease 0.0948 0.5614 1
Onchocerca volvulus Cathepsin L homolog 0.0948 0.5614 1
Brugia malayi Cathepsin L-like precursor 0.0298 0.1695 0.1695
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0032 0.0032
Toxoplasma gondii cathepsin B 0.0664 0.3903 0.6934
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0212 0.1173 0.1173
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0465 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0948 0.5614 1
Plasmodium vivax vivapain-3 0.051 0.2973 0.5269
Leishmania major cysteine peptidase A (CPA) 0.0948 0.5614 1
Entamoeba histolytica cysteine proteinase 1, putative 0.051 0.2973 0.5269
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0465 0.0434
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.1173 0.2044
Brugia malayi cathepsin F-like cysteine proteinase 0.0298 0.1695 0.1695
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0664 0.3903 0.6934
Leishmania major cathepsin L-like protease 0.0948 0.5614 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0948 0.5614 1
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0091 0.0091
Echinococcus granulosus cathepsin L 0.051 0.2973 0.2951
Plasmodium falciparum serine repeat antigen 9 0.0212 0.1173 0.2044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0948 0.5614 1
Loa Loa (eye worm) fibroinase 0.0948 0.5614 0.5614
Brugia malayi Papain family cysteine protease containing protein 0.0212 0.1173 0.1173
Schistosoma mansoni cathepsin F (C01 family) 0.0649 0.3814 0.3794
Toxoplasma gondii preprocathepsin c precursor, putative 0.0212 0.1173 0.2044
Entamoeba histolytica hypothetical protein 0.0043 0.0157 0.0224
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0212 0.1173 0.2044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.5614 1
Entamoeba histolytica cysteine protease, putative 0.0212 0.1173 0.2044
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0664 0.3903 0.3883
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0212 0.1173 0.2044
Schistosoma mansoni lamin 0.0033 0.0091 0.006
Brugia malayi cathepsin Z-like cysteine proteinase 0.0212 0.1173 0.1173
Onchocerca volvulus 0.0212 0.1173 0.1958
Plasmodium falciparum serine repeat antigen 1 0.0212 0.1173 0.2044
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0212 0.1173 0.2948
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0948 0.5614 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0465 0.0776
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0948 0.5614 1
Brugia malayi intermediate filament protein 0.0033 0.0091 0.0091
Brugia malayi cathepsin L-like precursor 0.0649 0.3814 0.3814
Giardia lamblia Encystation-specific protease 0.0212 0.1173 0.2948
Plasmodium vivax unspecified product 0.0298 0.1695 0.298
Entamoeba histolytica cysteine proteinase, putative 0.051 0.2973 0.5269
Entamoeba histolytica cysteine protease, putative 0.051 0.2973 0.5269
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0465 0.0776
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.5614 1
Onchocerca volvulus 0.0948 0.5614 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0212 0.1173 0.2044
Brugia malayi cathepsin L precursor 0.0212 0.1173 0.1173
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0212 0.1173 0.1145
Brugia malayi cathepsin Z-like cysteine proteinase 0.0212 0.1173 0.1173
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0465 0.5
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0091 0.0106
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.0812 0.0783
Schistosoma mansoni hypothetical protein 0.0043 0.0157 0.0126
Onchocerca volvulus 0.0948 0.5614 1
Echinococcus granulosus cathepsin b 0.1674 1 1
Onchocerca volvulus Cathepsin L homolog 0.0212 0.1173 0.1958
Echinococcus granulosus cathepsin l1 0.0649 0.3814 0.3794
Loa Loa (eye worm) hypothetical protein 0.0298 0.1695 0.1695
Onchocerca volvulus 0.0948 0.5614 1
Loa Loa (eye worm) hypothetical protein 0.0212 0.1173 0.1173
Entamoeba histolytica cysteine protease, putative 0.0212 0.1173 0.2044
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0212 0.1173 0.1145
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0212 0.1173 0.1145
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0212 0.1173 0.2044
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0212 0.1173 0.2044
Giardia lamblia Cathepsin L precursor 0.0212 0.1173 0.2948
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0212 0.1173 0.1145
Schistosoma mansoni cathepsin B (C01 family) 0.0212 0.1173 0.1145
Entamoeba histolytica cysteine protease, putative 0.051 0.2973 0.5269
Plasmodium falciparum serine repeat antigen 7 0.0212 0.1173 0.2044
Loa Loa (eye worm) hypothetical protein 0.0298 0.1695 0.1695
Giardia lamblia Cysteine protease 0.0212 0.1173 0.2948
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1674 1 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0212 0.1173 0.2044
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0091 0.137
Plasmodium falciparum serine repeat antigen 2 0.0212 0.1173 0.2044
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1674 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0212 0.1173 0.2044
Echinococcus multilocularis musashi 0.0033 0.0091 0.006
Schistosoma mansoni thyroid hormone receptor 0.0164 0.0886 0.0857
Schistosoma mansoni cathepsin C 0.0212 0.1173 0.1145
Entamoeba histolytica cysteine protease, putative 0.0212 0.1173 0.2044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0948 0.5614 1
Entamoeba histolytica hypothetical protein 0.0043 0.0157 0.0224
Giardia lamblia Cathepsin L-like protease 0.0212 0.1173 0.2948
Giardia lamblia Cathepsin L precursor 0.0212 0.1173 0.2948
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0948 0.5614 1
Brugia malayi Papain family cysteine protease containing protein 0.051 0.2973 0.2973
Giardia lamblia Cysteine protease 0.0212 0.1173 0.2948
Entamoeba histolytica cysteine protease, putative 0.0212 0.1173 0.2044
Brugia malayi cathepsin F-like cysteine proteinase 0.0212 0.1173 0.1173
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0948 0.5614 1
Loa Loa (eye worm) hypothetical protein 0.0948 0.5614 0.5614
Echinococcus granulosus intermediate filament protein 0.0033 0.0091 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0948 0.5614 1
Schistosoma mansoni intermediate filament proteins 0.0033 0.0091 0.006
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0212 0.1173 0.2948
Plasmodium vivax vivapain-2 0.0948 0.5614 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1674 1 1
Giardia lamblia Cathepsin B precursor 0.0664 0.3903 1
Loa Loa (eye worm) ctsf protein 0.0948 0.5614 0.5614
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0465 0.0776
Echinococcus granulosus lamin dm0 0.0033 0.0091 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0948 0.5614 1
Plasmodium vivax unspecified product 0.0212 0.1173 0.2044
Giardia lamblia Cathepsin B precursor 0.0212 0.1173 0.2948
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0948 0.5614 1
Echinococcus granulosus cathepsin l1 0.0948 0.5614 0.56
Trypanosoma cruzi cysteine peptidase, putative 0.0948 0.5614 0.56
Brugia malayi fibroinase precursor 0.0212 0.1173 0.1173
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0212 0.1173 0.1145
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0212 0.1173 0.1173
Echinococcus multilocularis muscleblind protein 0.018 0.0984 0.0955
Brugia malayi Cathepsin L-like precursor 0.0948 0.5614 0.5614
Brugia malayi Muscleblind-like protein 0.018 0.0984 0.0984
Entamoeba histolytica cysteine protease, putative 0.051 0.2973 0.5269
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.5614 1
Loa Loa (eye worm) cysteine protease 0.0948 0.5614 0.5614
Plasmodium falciparum serine repeat antigen 3 0.0212 0.1173 0.2044
Echinococcus multilocularis cathepsin b 0.1674 1 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.0812 0.0783
Echinococcus multilocularis cathepsin L cysteine protease 0.0948 0.5614 0.56
Echinococcus granulosus cathepsin L cysteine proteinase 0.0948 0.5614 0.56
Giardia lamblia Cathepsin B precursor 0.0664 0.3903 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0212 0.1173 0.1145
Trypanosoma cruzi major cysteine proteinase, putative 0.0212 0.1173 0.1145
Brugia malayi Papain family cysteine protease containing protein 0.0948 0.5614 0.5614
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0212 0.1173 0.2044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0649 0.3814 0.6775
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0948 0.5614 1
Loa Loa (eye worm) hypothetical protein 0.0212 0.1173 0.1173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0948 0.5614 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0948 0.5614 0.56
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0212 0.1173 0.2044
Plasmodium vivax vivapain-1 0.051 0.2973 0.5269
Echinococcus multilocularis cathepsin L 0.051 0.2973 0.2951
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.5614 1
Plasmodium vivax unspecified product 0.051 0.2973 0.5269
Loa Loa (eye worm) hypothetical protein 0.0649 0.3814 0.3814
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0268 0.0237
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0212 0.1173 0.1173
Giardia lamblia Cathepsin B precursor 0.0664 0.3903 1
Toxoplasma gondii cathepsin CPL 0.0948 0.5614 1
Entamoeba histolytica cysteine protease, putative 0.051 0.2973 0.5269
Schistosoma mansoni cathepsin S (C01 family) 0.0212 0.1173 0.1145
Giardia lamblia Cysteine protease 0.0212 0.1173 0.2948
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.051 0.2973 0.2951
Onchocerca volvulus Cathepsin L homolog 0.0948 0.5614 1
Echinococcus multilocularis cysteine protease 0.0948 0.5614 0.56
Brugia malayi Cathepsin L-like precursor 0.0948 0.5614 0.5614
Trichomonas vaginalis conserved hypothetical protein 0.0212 0.1173 0.2044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.5614 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0212 0.1173 0.2044
Leishmania major cathepsin L-like protease 0.0948 0.5614 1
Entamoeba histolytica cysteine protease, putative 0.051 0.2973 0.5269
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0212 0.1173 0.2044
Entamoeba histolytica hypothetical protein 0.0212 0.1173 0.2044
Entamoeba histolytica cysteine protease, putative 0.051 0.2973 0.5269
Leishmania major cathepsin L-like protease 0.0948 0.5614 1
Echinococcus multilocularis cathepsin b 0.1674 1 1
Entamoeba histolytica cysteine protease, putative 0.051 0.2973 0.5269
Brugia malayi cathepsin L-like cysteine proteinase 0.0212 0.1173 0.1173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0948 0.5614 1
Giardia lamblia Cathepsin B precursor 0.0212 0.1173 0.2948
Trypanosoma cruzi major cysteine proteinase, putative 0.0212 0.1173 0.1145
Entamoeba histolytica cysteine proteinase, putative 0.051 0.2973 0.5269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0948 0.5614 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0948 0.5614 1
Brugia malayi Cathepsin L-like precursor 0.0948 0.5614 0.5614
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.1173 0.2044
Entamoeba histolytica hypothetical protein 0.0043 0.0157 0.0224
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0465 0.0434
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.051 0.2973 0.2951
Echinococcus multilocularis lamin 0.0033 0.0091 0.006
Echinococcus multilocularis cathepsin L 0.0212 0.1173 0.1145
Brugia malayi Cathepsin L-like cysteine proteinase 0.0649 0.3814 0.3814
Giardia lamblia Cathepsin L-like protease 0.0212 0.1173 0.2948
Echinococcus granulosus cathepsin b 0.1674 1 1
Entamoeba histolytica cysteine proteinase, putative 0.051 0.2973 0.5269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0948 0.5614 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0091 0.0091
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0465 0.0434
Onchocerca volvulus 0.0948 0.5614 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0298 0.1695 0.1695
Entamoeba histolytica cysteine protease, putative 0.0212 0.1173 0.2044
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0948 0.5614 1
Giardia lamblia Cathepsin L precursor 0.0212 0.1173 0.2948
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0465 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0212 0.1173 0.1145
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0212 0.1173 0.2044
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.051 0.2973 0.2951
Loa Loa (eye worm) cathepsin B 0.0664 0.3903 0.3903
Plasmodium vivax serine-repeat antigen (SERA) 0.0212 0.1173 0.2044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.051 0.2973 0.5269
Trypanosoma cruzi cysteine peptidase, putative 0.0948 0.5614 0.56
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0649 0.3814 0.6775
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.0886 0.0857
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0465 1
Loa Loa (eye worm) hypothetical protein 0.0649 0.3814 0.3814
Giardia lamblia Cathepsin B precursor 0.0212 0.1173 0.2948
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0212 0.1173 0.2044
Trypanosoma brucei cysteine peptidase C (CPC) 0.0664 0.3903 0.6934
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0212 0.1173 0.1173
Loa Loa (eye worm) hypothetical protein 0.0298 0.1695 0.1695
Entamoeba histolytica cysteine proteinase, putative 0.051 0.2973 0.5269
Trypanosoma cruzi cysteine peptidase, putative 0.0948 0.5614 0.56
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0212 0.1173 0.2948
Brugia malayi Cathepsin L-like precursor 0.0649 0.3814 0.3814

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0014 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0126 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.1122 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 19.9526 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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