Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0071 | 0.335 | 0.335 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0014 | 0.0007 | 0.0007 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0106 | 0.535 | 0.5 |
Schistosoma mansoni | fructose 16-bisphosphate aldolase | 0.0106 | 0.535 | 0.535 |
Loa Loa (eye worm) | fructose-bisphosphate aldolase 1 | 0.0106 | 0.535 | 1 |
Trypanosoma brucei | fructose-bisphosphate aldolase, glycosomal, putative | 0.0106 | 0.535 | 0.5 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0106 | 0.535 | 0.5 |
Brugia malayi | fructose-bisphosphate aldolase 2 | 0.0106 | 0.535 | 1 |
Plasmodium falciparum | fructose-bisphosphate aldolase | 0.0106 | 0.535 | 0.5 |
Toxoplasma gondii | fructose-bisphosphate aldolase, putative | 0.0106 | 0.535 | 0.5 |
Plasmodium vivax | fructose 1,6-bisphosphate aldolase, putative | 0.0106 | 0.535 | 0.5 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0106 | 0.535 | 0.5 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0106 | 0.535 | 0.5 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0106 | 0.535 | 0.535 |
Echinococcus multilocularis | fructose bisphosphate aldolase class I | 0.0106 | 0.535 | 0.535 |
Brugia malayi | fructose-bisphosphate aldolase 1 | 0.0106 | 0.535 | 1 |
Echinococcus multilocularis | geminin | 0.0185 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0106 | 0.535 | 0.535 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0071 | 0.335 | 0.335 |
Echinococcus granulosus | Ankyrin | 0.0014 | 0.0007 | 0.0007 |
Schistosoma mansoni | fructose 16-bisphosphate aldolase | 0.0106 | 0.535 | 0.535 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0106 | 0.535 | 0.535 |
Loa Loa (eye worm) | fructose-bisphosphate aldolase 2 | 0.0106 | 0.535 | 1 |
Leishmania major | fructose-1,6-bisphosphate aldolase | 0.0106 | 0.535 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 1 | 1 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0106 | 0.535 | 0.5 |
Echinococcus multilocularis | Ankyrin | 0.0014 | 0.0007 | 0.0007 |
Echinococcus granulosus | fructose bisphosphate aldolase class I | 0.0106 | 0.535 | 0.535 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 1 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0106 | 0.535 | 0.535 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0106 | 0.535 | 0.535 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0106 | 0.535 | 0.5 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0106 | 0.535 | 0.535 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.