Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | Niemann-Pick disease, type C1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.0167 | 0.1415 | 0.1367 |
Brugia malayi | fatty acid elongation protein 3 | 0.0167 | 0.1415 | 0.0679 |
Plasmodium falciparum | long chain fatty acid elongation enzyme, putative | 0.0827 | 1 | 1 |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.0167 | 0.1415 | 0.9491 |
Brugia malayi | Hypothetical 34.1 kDa protein C40H1.4 in chromosome III | 0.0167 | 0.1415 | 0.0679 |
Brugia malayi | fatty acid elongation protein 3 | 0.0167 | 0.1415 | 0.0679 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0167 | 0.1415 | 0.1367 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0167 | 0.1415 | 0.1367 |
Leishmania major | fatty acid elongase, putative | 0.0827 | 1 | 1 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0167 | 0.1415 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0827 | 1 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0119 | 0.0789 | 0.5432 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.0789 | 0.0738 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0827 | 1 | 1 |
Brugia malayi | fatty acid elongation protein 3 | 0.0167 | 0.1415 | 0.0679 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.0167 | 0.1415 | 0.5 |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.0167 | 0.1415 | 0.9735 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0827 | 1 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0119 | 0.0789 | 0.1238 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0827 | 1 | 1 |
Schistosoma mansoni | fatty acid acyl transferase-related | 0.0167 | 0.1415 | 1 |
Trypanosoma brucei | Fatty acid elongase | 0.0827 | 1 | 1 |
Plasmodium vivax | GNS1/SUR4 domain containing protein | 0.0827 | 1 | 1 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0827 | 1 | 1 |
Brugia malayi | GNS1/SUR4 family protein | 0.0827 | 1 | 1 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.0167 | 0.1415 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.017 | 0.1453 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.017 | 0.1453 | 1 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0119 | 0.0789 | 0.5 |
Leishmania major | fatty acid elongase, putative | 0.0827 | 1 | 1 |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.0167 | 0.1415 | 0.9735 |
Loa Loa (eye worm) | ELO-9 protein | 0.0167 | 0.1415 | 0.1367 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0827 | 1 | 1 |
Brugia malayi | fatty acid elongation protein 3 | 0.0167 | 0.1415 | 0.0679 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.1415 | 0.1367 |
Echinococcus multilocularis | expressed conserved protein | 0.0112 | 0.0696 | 0.4786 |
Toxoplasma gondii | GNS1/SUR4 family protein | 0.0827 | 1 | 1 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0167 | 0.1415 | 0.1367 |
Toxoplasma gondii | integral membrane protein, GNS1/SUR4 family protein, putative | 0.0827 | 1 | 1 |
Onchocerca volvulus | 0.0167 | 0.1415 | 0.5 | |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0167 | 0.1415 | 1 |
Onchocerca volvulus | 0.0167 | 0.1415 | 0.5 | |
Plasmodium falciparum | fatty acid elongation protein, GNS1/SUR4 family, putative | 0.0827 | 1 | 1 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein 5 homolog | 0.0167 | 0.1415 | 0.5 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0167 | 0.1415 | 1 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0167 | 0.1415 | 1 |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.0167 | 0.1415 | 0.9491 |
Brugia malayi | GNS1/SUR4 family protein | 0.0167 | 0.1415 | 0.0679 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.0827 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.122 um | PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.