Detailed information for compound 1444743

Basic information

Technical information
  • TDR Targets ID: 1444743
  • Name: N-([1,3]dioxolo[4,5-f][1,3]benzothiazol-6-yl) -5,6-dihydro-1,4-dioxine-2-carboxamide
  • MW: 306.294 | Formula: C13H10N2O5S
  • H donors: 1 H acceptors: 2 LogP: 1.87 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1=COCCO1)Nc1sc2c(n1)cc1c(c2)OCO1
  • InChi: 1S/C13H10N2O5S/c16-12(10-5-17-1-2-18-10)15-13-14-7-3-8-9(20-6-19-8)4-11(7)21-13/h3-5H,1-2,6H2,(H,14,15,16)
  • InChiKey: ZLBALECABDZFAP-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • SMR000017707
  • ZINC04325851
  • MLS000103798

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens microphthalmia-associated transcription factor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Leishmania mexicana pyruvate kinase, putative Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens pyruvate kinase, muscle Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Photuris pennsylvanica Luciferase Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Helix-loop-helix DNA-binding domain containing protein Get druggable targets OG5_133408 All targets in OG5_133408
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein Get druggable targets OG5_133408 All targets in OG5_133408
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus transcription factor eb Get druggable targets OG5_133408 All targets in OG5_133408
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133408 All targets in OG5_133408
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis transcription factor eb Get druggable targets OG5_133408 All targets in OG5_133408
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferase   552 aa 491 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferase   552 aa 481 aa 23.7 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative Luciferase   552 aa 544 aa 21.7 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferase   552 aa 451 aa 22.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Brugia malayi AMP-binding enzyme family protein Luciferase   552 aa 492 aa 24.8 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferase   552 aa 468 aa 20.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, muscle 605 aa 521 aa 34.9 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Schistosoma mansoni long-chain-fatty-acid--CoA ligase Luciferase   552 aa 526 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferase   552 aa 470 aa 25.1 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Plasmodium vivax long-chain fatty acid CoA ligase, putative Luciferase   552 aa 453 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Leishmania mexicana long-chain-fatty-acid-CoA ligase, putative,acyl-CoA synthetase, putative,fatty acid thiokinase (long chain), putative Luciferase   552 aa 472 aa 21.6 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferase   552 aa 481 aa 20.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium tuberculosis Long-chain-fatty-acid-CoA ligase FadD15 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferase   552 aa 483 aa 23.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Neospora caninum hypothetical protein Luciferase   552 aa 529 aa 22.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Theileria parva acetyl-coenzyme A synthetase, putative Luciferase   552 aa 580 aa 22.4 %
Giardia lamblia Long chain fatty acid CoA ligase 5 Luciferase   552 aa 491 aa 21.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferase   552 aa 481 aa 25.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferase   552 aa 510 aa 23.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) Luciferase   552 aa 512 aa 22.7 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferase   552 aa 476 aa 25.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Babesia bovis acetyl-CoA synthetase, putative Luciferase   552 aa 545 aa 21.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Onchocerca volvulus Luciferase   552 aa 553 aa 24.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, putative 498 aa 515 aa 27.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0043 0.0366 0.2949
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0045 0.0044
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0057 0.0509 0.6606
Giardia lamblia Pyruvate kinase 0.0081 0.0749 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0017 0.0092 0.0108
Brugia malayi GNS1/SUR4 family protein 0.047 0.4756 1
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0045 0.0044
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0045 0.0037
Entamoeba histolytica hypothetical protein 0.0043 0.0366 0.2949
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0024 0.017 0.03
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1143 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0045 0.0035
Onchocerca volvulus 0.0057 0.0509 0.5467
Brugia malayi fatty acid elongation protein 3 0.0095 0.0896 0.1836
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0017 0.0092 0.0717
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0045 0.0044
Brugia malayi pyruvate kinase, muscle isozyme 0.0017 0.0094 0.0139
Loa Loa (eye worm) hypothetical protein 0.0043 0.036 0.0698
Schistosoma mansoni hypothetical protein 0.0205 0.2026 0.2377
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0488 0.0565
Echinococcus multilocularis elongation of very long chain fatty acids 0.0095 0.0896 0.0889
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.0311 0.0596
Echinococcus multilocularis cpg binding protein 0.0037 0.0296 0.0289
Leishmania major fatty acid elongase, putative 0.0095 0.0896 0.1723
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0045 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0045 0.0032
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0032
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0092 0.0717
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1668 0.1662
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0025
Leishmania major 4-coumarate:coa ligase-like protein 0.0057 0.0509 0.0893
Schistosoma mansoni DNA ligase IV 0.0012 0.0041 0.004
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.003 0.0022
Loa Loa (eye worm) fatty acid elongation protein 3 0.0095 0.0896 0.1833
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0045 0.0035
Brugia malayi nuclear receptor NHR-88 0.0012 0.0045 0.0035
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0092 0.0354
Trichomonas vaginalis antibiotic synthetase, putative 0.0017 0.0092 0.1232
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0045 0.0044
Echinococcus granulosus pyruvate kinase 0.0081 0.0749 0.0872
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0116 0.0157
Mycobacterium leprae Probable pyruvate kinase PykA 0.0081 0.0749 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0045 0.0032
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0025
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0116 0.0108
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0092 0.0717
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.0311 0.0304
Echinococcus multilocularis pyruvate kinase 0.0081 0.0749 0.0741
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0057 0.0509 0.6474
Trypanosoma cruzi pyruvate kinase 2, putative 0.0081 0.0749 0.15
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0017 0.0092 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0041 0.0554
Trypanosoma cruzi fatty acid elongase, putative 0.0095 0.0896 0.1812
Schistosoma mansoni topbp1 0.0012 0.0041 0.004
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0045 0.0037
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0092 0.0717
Schistosoma mansoni pyruvate kinase 0.0081 0.0749 0.0872
Brugia malayi ecdysteroid receptor 0.0012 0.0045 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0488 0.0565
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0081 0.0749 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0488 0.0565
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.004 0.0336 0.393
Loa Loa (eye worm) hypothetical protein 0.0062 0.0563 0.1128
Schistosoma mansoni hypothetical protein 0.0082 0.0766 0.0894
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.1159 0.2389
Trypanosoma brucei Fatty acid elongase 0.047 0.4756 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0043 0.036 0.4499
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0116 0.0108
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0116 0.0108
Trypanosoma brucei pyruvate kinase 1, putative 0.0081 0.0749 0.15
Echinococcus granulosus pyruvate kinase 0.0041 0.0345 0.0397
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8498 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0045 0.0044
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0042 0.0034
Trypanosoma brucei Fatty acid elongase 0.0095 0.0896 0.1812
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0017 0.0092 0.0717
Brugia malayi fatty acid elongation protein 3 0.0095 0.0896 0.1836
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0045 0.0032
Brugia malayi hypothetical protein 0.0012 0.0041 0.0028
Loa Loa (eye worm) hypothetical protein 0.0057 0.0509 0.1014
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0042 0.0000031374
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.0311 0.0357
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.1159 0.2391
Plasmodium vivax long chain polyunsaturated fatty acid elongation enzyme, putative 0.0095 0.0896 0.1812
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.0509 0.6606
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0092 0.0354
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0045 0.0044
Echinococcus multilocularis muscleblind protein 1 0.018 0.1776 0.177
Leishmania major pyruvate kinase 0.0081 0.0749 0.1407
Entamoeba histolytica acyl-coA synthetase, putative 0.0057 0.0509 0.424
Trypanosoma cruzi fatty acid elongase, putative 0.0095 0.0896 0.1812
Trypanosoma cruzi fatty acid elongase, putative 0.047 0.4756 1
Leishmania major fatty acid elongase, putative 0.0095 0.0896 0.1723
Loa Loa (eye worm) hypothetical protein 0.0082 0.0766 0.1559
Echinococcus multilocularis muscleblind protein 0.018 0.1776 0.177
Trichomonas vaginalis pyruvate kinase, putative 0.0081 0.0749 1
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0092 0.0135
Toxoplasma gondii pyruvate kinase PyKII 0.0041 0.0345 0.0643
Echinococcus multilocularis protein dispatched 1 0.0058 0.0519 0.0511
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0045 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0045 0.0035
Schistosoma mansoni topbp1 0.0012 0.0041 0.004
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0116 0.0157
Schistosoma mansoni cpg binding protein 0.0037 0.0296 0.034
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0596 0.1175
Brugia malayi Fatty acid elongation protein 3 0.047 0.4756 1
Schistosoma mansoni hypothetical protein 0.0043 0.0366 0.0422
Toxoplasma gondii integral membrane protein, GNS1/SUR4 family protein, putative 0.047 0.4756 1
Schistosoma mansoni patched 1 0.0051 0.0444 0.0514
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0366 0.0422
Brugia malayi fatty acid elongation protein 3 0.0095 0.0896 0.1836
Onchocerca volvulus Elongation of very long chain fatty acids protein homolog 0.0095 0.0896 1
Brugia malayi AMP-binding enzyme family protein 0.0057 0.0509 0.1016
Plasmodium falciparum pyruvate kinase 2 0.0041 0.0345 0.0643
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0116 0.0157
Leishmania major fatty acid elongase, putative 0.0095 0.0896 0.1723
Entamoeba histolytica acyl-CoA synthetase, putative 0.0057 0.0509 0.424
Entamoeba histolytica hypothetical protein 0.0043 0.0366 0.2949
Trypanosoma cruzi fatty acid elongase, putative 0.047 0.4756 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0032
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0116 0.0157
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0092 0.0717
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0045 0.0044
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0017 0.0092 0.0108
Brugia malayi Muscleblind-like protein 0.018 0.1776 0.3698
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0116 0.0182
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0116 0.0127
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0042 0.004
Schistosoma mansoni hypothetical protein 0.0049 0.0425 0.0492
Trypanosoma cruzi fatty acid elongase, putative 0.047 0.4756 1
Echinococcus granulosus pyruvate kinase 0.0041 0.0345 0.0397
Echinococcus multilocularis GPCR, family 2 0.0038 0.0311 0.0304
Toxoplasma gondii fatty acid elongase 0.0095 0.0896 0.1812
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0041 0.0028
Toxoplasma gondii GNS1/SUR4 family protein 0.047 0.4756 1
Echinococcus granulosus expressed conserved protein 0.0112 0.1069 0.125
Onchocerca volvulus 0.0017 0.0092 0.0593
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0045 0.0044
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1668 0.1956
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0041 0.0554
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0045 0.0035
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0017 0.0092 0.0354
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0116 0.0185
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0092 0.0354
Onchocerca volvulus 0.0017 0.0092 0.0593
Schistosoma mansoni elongation of fatty acids protein 1 0.0095 0.0896 0.1046
Loa Loa (eye worm) hypothetical protein 0.0057 0.0509 0.1014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0045 0.0032
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0041 0.0554
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0017 0.0092 0.0717
Loa Loa (eye worm) hypothetical protein 0.0286 0.2859 0.5987
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0045 0.0038
Trypanosoma cruzi fatty acid elongase, putative 0.0095 0.0896 0.1812
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0116 0.0157
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.0311 0.0357
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0041 0.0028
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.013 0.1254 0.2592
Trypanosoma cruzi fatty acid elongase, putative 0.0095 0.0896 0.1812
Leishmania major fatty acid elongase, putative 0.047 0.4756 1
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0017 0.0092 0.0108
Plasmodium falciparum long chain polyunsaturated fatty acid elongation enzyme, putative 0.0095 0.0896 0.1812
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0017 0.0092 0.0108
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.1159 0.2391
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0017 0.0092 0.0717
Schistosoma mansoni survival motor neuron protein 0.0058 0.0519 0.0602
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0017 0.0092 0.0354
Echinococcus granulosus elongation of very long chain fatty acids 0.0095 0.0896 0.1046
Echinococcus multilocularis geminin 0.0205 0.2026 0.2019
Echinococcus granulosus GPCR family 2 0.0038 0.0311 0.0357
Brugia malayi hypothetical protein 0.0286 0.2859 0.5988
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0092 0.0717
Plasmodium falciparum acyl-CoA synthetase 0.0043 0.036 0.0675
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0045 0.0044
Echinococcus multilocularis pyruvate kinase 0.0041 0.0345 0.0337
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0043 0.036 0.4283
Schistosoma mansoni hypothetical protein 0.0038 0.0311 0.0357
Loa Loa (eye worm) hypothetical protein 0.018 0.1776 0.3696
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0017 0.0092 0.0084
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.004 0.0336 0.393
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0045 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0045 0.0035
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0045 0.0037
Onchocerca volvulus 0.0095 0.0896 1
Leishmania major fatty acid elongase, putative 0.0095 0.0896 0.1723
Brugia malayi CHE-14 protein 0.0051 0.0444 0.088
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0444 0.0878
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0092 0.0135
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0043 0.036 0.4499
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0116 0.0157
Plasmodium falciparum fatty acid elongation protein, GNS1/SUR4 family, putative 0.047 0.4756 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0045 0.0035
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0045 0.0037
Loa Loa (eye worm) pyruvate kinase 0.0081 0.0749 0.1521
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0676 0.0788
Trichomonas vaginalis antibiotic synthetase, putative 0.0017 0.0092 0.1232
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0488 0.048
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0519 0.1038
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0092 0.0354
Loa Loa (eye worm) hypothetical protein 0.0043 0.036 0.0698
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8498 1
Onchocerca volvulus Elongation of very long chain fatty acids protein 5 homolog 0.0095 0.0896 1
Chlamydia trachomatis pyruvate kinase 0.0081 0.0749 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0116 0.0157
Trypanosoma brucei elongation of very long chain fatty acids protein, putative 0.0095 0.0896 0.1812
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0116 0.005
Schistosoma mansoni hypothetical protein 0.0038 0.0311 0.0357
Loa Loa (eye worm) hypothetical protein 0.0056 0.0498 0.099
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0042 0.0554
Brugia malayi isocitrate dehydrogenase 0.0019 0.0116 0.0185
Echinococcus granulosus nibrin 0.0012 0.0041 0.004
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0045 0.0035
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0017 0.0092 0.0717
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0017 0.0092 0.0717
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0032
Echinococcus multilocularis pyruvate kinase 0.0041 0.0345 0.0337
Onchocerca volvulus 0.0012 0.0045 0.0038
Mycobacterium ulcerans pyruvate kinase 0.0081 0.0749 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0276 0.0522
Loa Loa (eye worm) pyruvate kinase-PB 0.0056 0.0498 0.099
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0366 0.0422
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0488 0.097
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0025
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0045 0.0035
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0017 0.0092 0.0108
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0116 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0045 0.0035
Echinococcus granulosus elongation of very long chain fatty acids 0.0095 0.0896 0.1046
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0041 0.0554
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0032
Leishmania major 4-coumarate:coa ligase-like protein 0.0057 0.0509 0.0893
Echinococcus granulosus muscleblind protein 0.018 0.1776 0.2083
Leishmania major fatty acid elongase, putative 0.0095 0.0896 0.1723
Brugia malayi AMP-binding enzyme family protein 0.0057 0.0509 0.1016
Loa Loa (eye worm) hypothetical protein 0.0017 0.0092 0.0132
Toxoplasma gondii pyruvate kinase PyK1 0.0081 0.0749 0.15
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0045 0.0044
Entamoeba histolytica pyruvate kinase, putative 0.0056 0.0498 0.414
Trypanosoma cruzi fatty acid elongase, putative 0.0095 0.0896 0.1812
Schistosoma mansoni pyruvate kinase 0.0081 0.0749 0.0872
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0045 0.0044
Onchocerca volvulus Pyruvate kinase homolog 0.0081 0.0749 0.8275
Onchocerca volvulus 0.0058 0.0519 0.5585
Echinococcus granulosus cpg binding protein 0.0037 0.0296 0.034
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0017 0.0092 0.0354
Loa Loa (eye worm) hypothetical protein 0.012 0.1159 0.2389
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0041 0.0554
Loa Loa (eye worm) fatty acid elongation protein 3 0.0095 0.0896 0.1833
Schistosoma mansoni elongation of fatty acids protein 1 0.0095 0.0896 0.1046
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0017 0.0092 0.0354
Loa Loa (eye worm) fatty acid elongation protein 3 0.0095 0.0896 0.1833
Brugia malayi GNS1/SUR4 family protein 0.0095 0.0896 0.1836
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0444 0.5936
Onchocerca volvulus Pyruvate kinase homolog 0.0081 0.0749 0.8275
Loa Loa (eye worm) hypothetical protein 0.0057 0.0509 0.1014
Leishmania major fatty acid elongase, putative 0.047 0.4756 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0045 0.0044
Plasmodium falciparum pyruvate kinase 0.0081 0.0749 0.15
Plasmodium vivax acyl-CoA synthetase, putative 0.0043 0.036 0.0675
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0045 0.0044
Onchocerca volvulus 0.0017 0.0092 0.0593
Treponema pallidum DNA ligase (lig) 0.0012 0.0041 0.5
Echinococcus multilocularis nibrin 0.0012 0.0041 0.0034
Brugia malayi Latrophilin receptor protein 2 0.0038 0.0311 0.0599
Leishmania major 4-coumarate:coa ligase-like protein 0.0057 0.0509 0.0893
Loa Loa (eye worm) GNS1/SUR4 family protein 0.0095 0.0896 0.1833
Schistosoma mansoni elongation of fatty acids protein 1 0.0095 0.0896 0.1046
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0017 0.0092 0.0135
Loa Loa (eye worm) pyruvate kinase 0.0081 0.0749 0.1521
Loa Loa (eye worm) ELO-9 protein 0.0095 0.0896 0.1833
Schistosoma mansoni acetyl-CoA synthetase 0.0017 0.0092 0.0099
Schistosoma mansoni hypothetical protein 0.0038 0.0311 0.0357
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0042 0.0554
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0116 0.0157
Plasmodium vivax pyruvate kinase, putative 0.0081 0.0749 0.15
Leishmania major long chain polyunsaturated fatty acid elongation enzyme-like protein 0.0095 0.0896 0.1723
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1143 0.1337
Trichomonas vaginalis pyruvate kinase, putative 0.0081 0.0749 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0488 0.0565
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0116 0.0108
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1143 0.1136
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0057 0.0509 0.6606
Schistosoma mansoni pyruvate kinase 0.0041 0.0345 0.0397
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0092 0.0717
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0444 0.0437
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0017 0.0092 0.0717
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0488 0.0565
Giardia lamblia Pyruvate kinase 0.0041 0.0345 0.429
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.004 0.0336 0.393
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8498 0.8497
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0042 0.0554
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0116 0.0127
Schistosoma mansoni cpg binding protein 0.0035 0.0276 0.0316
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0025
Brugia malayi fatty acid elongation protein 3 0.0095 0.0896 0.1836
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0045 0.0035
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.0766 0.1562
Echinococcus granulosus geminin 0.0205 0.2026 0.2377
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0488 0.0972
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0041 0.0554
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0045 0.0035
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0032
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1162 0.1359
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2859 0.2853
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0017 0.0092 0.0717
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0045 0.0044
Leishmania major fatty acid elongase, putative 0.0095 0.0896 0.1723
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0042 0.004
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0045 0.0044
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0057 0.0509 0.6606
Onchocerca volvulus 0.0017 0.0092 0.0593
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0017 0.0092 0.0108
Echinococcus multilocularis elongation of very long chain fatty acids 0.0095 0.0896 0.0889
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0017 0.0092 0.0717
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0017 0.0092 0.0108
Schistosoma mansoni cpg binding protein 0.0037 0.0296 0.034
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.004 0.0336 0.393
Onchocerca volvulus 0.0095 0.0896 1
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0017 0.0092 0.0717
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0045 0.0037
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0092 0.0717
Trypanosoma cruzi pyruvate kinase 2, putative 0.0081 0.0749 0.15
Loa Loa (eye worm) hypothetical protein 0.0038 0.0311 0.0596
Loa Loa (eye worm) pyruvate kinase 0.0081 0.0749 0.1521
Echinococcus granulosus pyruvate kinase 0.0041 0.0345 0.0397
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0045 0.0037
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0045 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0045 0.0035
Brugia malayi DKFZp564C0469 protein 0.0012 0.0041 0.0028
Leishmania major fatty acid elongase, putative 0.0095 0.0896 0.1723
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.0509 0.6474
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0042 0.00000073313
Leishmania major fatty acid elongase, putative 0.047 0.4756 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.0311 0.0599
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0045 0.0035
Schistosoma mansoni hypothetical protein 0.0038 0.0311 0.0357
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0092 0.0135
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.0311 0.0304
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0017 0.0092 0.0132
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.003 0.0026
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0045 0.0038
Mycobacterium ulcerans acetyl-CoA synthetase 0.0017 0.0092 0.0717
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0017 0.0092 0.0108
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0057 0.0509 0.6606
Loa Loa (eye worm) oxidoreductase 0.0017 0.0092 0.0132
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0017 0.0092 0.0354
Leishmania major fatty acid elongase, putative 0.0095 0.0896 0.1723
Brugia malayi pyruvate kinase 0.0017 0.0094 0.0139
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0045 0.0044
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0017 0.0092 0.046
Onchocerca volvulus Elongation of very long chain fatty acids protein homolog 0.0095 0.0896 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0116 0.0697
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1143 0.2358
Loa Loa (eye worm) hypothetical protein 0.0081 0.0749 0.1521
Entamoeba histolytica hypothetical protein 0.0043 0.0366 0.2949
Echinococcus multilocularis expressed conserved protein 0.0112 0.1069 0.1062
Trypanosoma brucei Fatty acid elongase 0.0095 0.0896 0.1812
Schistosoma mansoni elongation of fatty acids protein 1 0.0095 0.0896 0.1046
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0444 0.0514
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0045 0.0035
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.0509 0.6606
Trypanosoma brucei pyruvate kinase 1 0.0081 0.0749 0.15
Brugia malayi topoisomerase 0.0012 0.0041 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0045 0.0032
Brugia malayi Pyruvate kinase, M2 isozyme 0.0081 0.0749 0.1524
Schistosoma mansoni hypothetical protein 0.0049 0.0425 0.0492
Toxoplasma gondii propionate-CoA ligase 0.0017 0.0092 0.0108
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0057 0.0509 0.6606
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0017 0.0092 0.0132
Plasmodium vivax elongation of very long chain fatty acids protein 3, putative 0.0095 0.0896 0.1812
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.0509 0.6606
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0045 0.0044
Echinococcus multilocularis pyruvate kinase 0.0064 0.0574 0.0566
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.013 0.1261 0.2608
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0045 0.0044
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0045 0.0037
Schistosoma mansoni hypothetical protein 0.0058 0.0519 0.0602
Schistosoma mansoni coup transcription factor 0.0012 0.0045 0.0044
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0444 0.0514
Brugia malayi CXXC zinc finger family protein 0.0035 0.0276 0.0525
Loa Loa (eye worm) hypothetical protein 0.013 0.1254 0.2592
Loa Loa (eye worm) hypothetical protein 0.0095 0.0896 0.1833
Schistosoma mansoni hypothetical protein 0.0049 0.0425 0.0492
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0488 0.048
Trypanosoma cruzi fatty acid elongase, putative 0.047 0.4756 1
Plasmodium vivax pyruvate kinase 2, putative 0.0041 0.0345 0.0643
Loa Loa (eye worm) fatty acid elongation protein 3 0.047 0.4756 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0081 0.0749 0.1524
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0017 0.0092 0.0354
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0045 0.0037
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0045 0.0044
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0045 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0041 0.0554
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0032
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0045 0.0044
Plasmodium falciparum long chain fatty acid elongation enzyme, putative 0.047 0.4756 1
Leishmania major pyruvate kinase 0.0081 0.0749 0.1407
Brugia malayi hypothetical protein 0.0043 0.0366 0.0715
Loa Loa (eye worm) hypothetical protein 0.0043 0.036 0.0698
Loa Loa (eye worm) hypothetical protein 0.0043 0.036 0.0698
Leishmania major fatty acid elongase, putative 0.0095 0.0896 0.1723
Loa Loa (eye worm) hypothetical protein 0.0051 0.0444 0.0878
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0045 0.0035
Mycobacterium ulcerans hypothetical protein 0.0057 0.0509 0.6606
Loa Loa (eye worm) hypothetical protein 0.0017 0.0092 0.0132
Schistosoma mansoni hypothetical protein 0.0049 0.0425 0.0492
Trypanosoma brucei Long chain fatty acyl elongase 0.0095 0.0896 0.1812
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0366 0.0359
Brugia malayi Hypothetical 34.1 kDa protein C40H1.4 in chromosome III 0.0095 0.0896 0.1836
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0092 0.0135
Trypanosoma cruzi fatty acid elongase, putative 0.0095 0.0896 0.1812
Plasmodium vivax GNS1/SUR4 domain containing protein 0.047 0.4756 1
Echinococcus multilocularis transcription factor eb 0.013 0.1261 0.1254
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0032
Echinococcus granulosus pyruvate kinase 0.0081 0.0749 0.0872
Brugia malayi AMP-binding enzyme family protein 0.0057 0.0509 0.1016
Loa Loa (eye worm) hypothetical protein 0.0043 0.036 0.0698
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0045 0.0037
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0017 0.0092 0.0717
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2859 0.3358
Onchocerca volvulus 0.0035 0.0276 0.2746
Loa Loa (eye worm) pyruvate kinase 0.0017 0.0094 0.0136
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0057 0.0509 0.6606
Brugia malayi steroid hormone receptor 0.0012 0.0045 0.0035
Loa Loa (eye worm) GNS1/SUR4 family protein 0.047 0.4756 1
Schistosoma mansoni hypothetical protein 0.0205 0.2026 0.2377
Echinococcus multilocularis protein patched 0.0051 0.0444 0.0437
Brugia malayi nuclear hormone receptor 0.0012 0.0045 0.0035
Loa Loa (eye worm) hypothetical protein 0.0012 0.0045 0.0032
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0092 0.0135
Loa Loa (eye worm) hypothetical protein 0.018 0.1776 0.3696
Loa Loa (eye worm) hypothetical protein 0.0012 0.0041 0.0025
Leishmania major fatty acid elongase, putative 0.0095 0.0896 0.1723
Echinococcus multilocularis pyruvate kinase 0.0081 0.0749 0.0741
Loa Loa (eye worm) hypothetical protein 0.0119 0.1143 0.2356
Echinococcus multilocularis pyruvate kinase 0.0041 0.0345 0.0337
Entamoeba histolytica acyl-CoA synthetase, putative 0.0057 0.0509 0.424
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0017 0.0092 0.0354
Plasmodium vivax acetyl-CoA synthetase, putative 0.0017 0.0092 0.0108
Schistosoma mansoni fatty acid acyl transferase-related 0.0095 0.0896 0.1046
Echinococcus granulosus transcription factor eb 0.013 0.1261 0.1476
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0045 0.0032
Onchocerca volvulus Pyruvate kinase homolog 0.0081 0.0749 0.8275
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0092 0.0717
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0017 0.0092 0.0099
Brugia malayi hypothetical protein 0.0012 0.0041 0.0028
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0012 0.0041 0.5

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 3.769 uM PUBCHEM_BIOASSAY: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
AC50 (functional) = 3.769 uM PUBCHEM_BIOASSAY: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set4. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
AC50 (functional) = 3.769 uM PUBCHEM_BIOASSAY: MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
Potency (functional) 0.1472 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.1901 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 0.2079 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.2311 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 0.2512 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.4109 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 0.5012 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.92 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 1.2151 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 2.8184 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: Counterscreen for Luciferase (Kinase-Glo TM) Inhibition. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (binding) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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