Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0177 | 0.0177 |
Plasmodium falciparum | fatty acid elongation protein, GNS1/SUR4 family, putative | 0.0336 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0758 | 1 |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.0068 | 0.0448 | 0.5915 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.0758 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0758 | 1 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.0336 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.0758 | 0.0758 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.0068 | 0.0448 | 0.5 |
Brugia malayi | GNS1/SUR4 family protein | 0.0068 | 0.0448 | 0.0448 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0336 | 1 | 1 |
Brugia malayi | Hypothetical 34.1 kDa protein C40H1.4 in chromosome III | 0.0068 | 0.0448 | 0.0448 |
Brugia malayi | fatty acid elongation protein 3 | 0.0068 | 0.0448 | 0.0448 |
Onchocerca volvulus | 0.0068 | 0.0448 | 0.5 | |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0336 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.0758 | 0.0758 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.0758 | 1 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0068 | 0.0448 | 0.5915 |
Leishmania major | fatty acid elongase, putative | 0.0336 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0758 | 1 |
Schistosoma mansoni | fatty acid acyl transferase-related | 0.0068 | 0.0448 | 0.5915 |
Brugia malayi | GNS1/SUR4 family protein | 0.0336 | 1 | 1 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.0068 | 0.0448 | 0.0448 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.0758 | 0.0758 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0068 | 0.0448 | 0.5915 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0336 | 1 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0336 | 1 | 1 |
Brugia malayi | fatty acid elongation protein 3 | 0.0068 | 0.0448 | 0.0448 |
Leishmania major | fatty acid elongase, putative | 0.0336 | 1 | 1 |
Plasmodium falciparum | long chain fatty acid elongation enzyme, putative | 0.0336 | 1 | 1 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0068 | 0.0448 | 0.0448 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.0758 | 0.0758 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.0068 | 0.0448 | 0.5 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0068 | 0.0448 | 0.5915 |
Toxoplasma gondii | integral membrane protein, GNS1/SUR4 family protein, putative | 0.0336 | 1 | 1 |
Brugia malayi | fatty acid elongation protein 3 | 0.0068 | 0.0448 | 0.0448 |
Toxoplasma gondii | GNS1/SUR4 family protein | 0.0336 | 1 | 1 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0336 | 1 | 1 |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.0068 | 0.0448 | 0.5915 |
Brugia malayi | RNA binding protein | 0.0076 | 0.0758 | 0.0758 |
Loa Loa (eye worm) | ELO-9 protein | 0.0068 | 0.0448 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0177 | 0.0177 |
Trypanosoma brucei | Fatty acid elongase | 0.0336 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0758 | 1 |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.0068 | 0.0448 | 0.5915 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0068 | 0.0448 | 0.0448 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0177 | 0.0177 |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.0068 | 0.0448 | 0.5915 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0336 | 1 | 1 |
Plasmodium vivax | GNS1/SUR4 domain containing protein | 0.0336 | 1 | 1 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0068 | 0.0448 | 0.5915 |
Brugia malayi | fatty acid elongation protein 3 | 0.0068 | 0.0448 | 0.0448 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0177 | 0.0177 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein 5 homolog | 0.0068 | 0.0448 | 0.5 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0068 | 0.0448 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0448 | 0.0448 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0758 | 1 |
Onchocerca volvulus | 0.0068 | 0.0448 | 0.5 | |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.0758 | 0.0758 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.