Detailed information for compound 1444749

Basic information

Technical information
  • TDR Targets ID: 1444749
  • Name: (2S)-2-[[2-[(4-oxo-2,3-dihydro-1H-cyclopenta[ c]chromen-7-yl)oxy]acetyl]amino]-3-phenylprop anoic acid
  • MW: 407.416 | Formula: C23H21NO6
  • H donors: 2 H acceptors: 4 LogP: 3.21 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N[C@H](C(=O)O)Cc1ccccc1)COc1ccc2c(c1)oc(=O)c1c2CCC1
  • InChi: 1S/C23H21NO6/c25-21(24-19(22(26)27)11-14-5-2-1-3-6-14)13-29-15-9-10-17-16-7-4-8-18(16)23(28)30-20(17)12-15/h1-3,5-6,9-10,12,19H,4,7-8,11,13H2,(H,24,25)(H,26,27)/t19-/m0/s1
  • InChiKey: OWFZDADMSQYQET-IBGZPJMESA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-[[2-[(4-oxo-2,3-dihydro-1H-cyclopenta[c]chromen-7-yl)oxy]acetyl]amino]-3-phenyl-propanoic acid
  • (2S)-2-[[1-oxo-2-[(4-oxo-2,3-dihydro-1H-cyclopenta[c]chromen-7-yl)oxy]ethyl]amino]-3-phenylpropanoic acid
  • (2S)-2-[[2-[(4-keto-2,3-dihydro-1H-cyclopenta[c]chromen-7-yl)oxy]acetyl]amino]-3-phenyl-propionic acid
  • (2S)-2-[2-[(4-oxo-2,3-dihydro-1H-cyclopenta[c]chromen-7-yl)oxy]ethanoylamino]-3-phenyl-propanoic acid
  • STOCK1N-40538

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.1757 0.3326
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0162 0.2447 0.3558
Plasmodium falciparum long chain fatty acid elongation enzyme, putative 0.0604 1 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.0721 0.1364
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.004
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0414 0.0547
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0429 0.0429
Mycobacterium ulcerans phosphoglycerate kinase 0.0095 0.1307 0.2552
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0051 0.0097
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0059 0.0697 0.0967
Leishmania major fatty acid elongase, putative 0.0604 1 1
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0021 0.0051 0.004
Leishmania major fatty acid elongase, putative 0.0122 0.1769 0.1769
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0051 0.0007
Mycobacterium tuberculosis Conserved protein 0.0043 0.0429 0.0758
Loa Loa (eye worm) hypothetical protein 0.0122 0.1769 0.1733
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0044 0.0044
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0044 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.1204 0.1204
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0007
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0595 0.1126
Brugia malayi MH2 domain containing protein 0.0144 0.215 0.2114
Echinococcus multilocularis elongation of very long chain fatty acids 0.0122 0.1769 0.2555
Trypanosoma cruzi DNA polymerase kappa, putative 0.0089 0.1204 0.1204
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0429 0.2247
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0166 0.0166
Loa Loa (eye worm) pip kinase 2 0.0181 0.2782 0.275
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0095 0.1307 1
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0051 0.0097
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0051 0.0097
Mycobacterium ulcerans DNA polymerase IV 0.0089 0.1204 0.235
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0318 0.5121 1
Leishmania major fatty acid elongase, putative 0.0122 0.1769 0.1769
Leishmania major fatty acid elongase, putative 0.0122 0.1769 0.1769
Onchocerca volvulus 0.0181 0.2782 1
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.1757 1
Loa Loa (eye worm) phosphofructokinase 0.0121 0.1757 0.172
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0391 0.0513
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0595 0.0815
Brugia malayi Phosphoglycerate kinase 0.0095 0.1307 0.1268
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0035 0.0281 0.0281
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0035 0.0281 0.0281
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0051 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0506 0.0506
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.043 0.3293
Chlamydia trachomatis phosphoglycerate kinase 0.0095 0.1307 1
Leishmania major fatty acid elongase, putative 0.0604 1 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0721 0.0679
Loa Loa (eye worm) fatty acid elongation protein 3 0.0604 1 1
Echinococcus granulosus elongation of very long chain fatty acids 0.0122 0.1769 0.2555
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0074 0.0944 0.0944
Echinococcus granulosus chromobox protein 1 0.0078 0.1013 0.1435
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.1757 1
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0095 0.1307 0.7375
Brugia malayi mbt repeat family protein 0.0053 0.0595 0.0553
Brugia malayi fatty acid elongation protein 3 0.0122 0.1769 0.1733
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0094 0.1298 0.1298
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0429 0.2247
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.0721 0.1001
Brugia malayi CXXC zinc finger family protein 0.0037 0.0324 0.0281
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.1204 0.1204
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.1757 0.1757
Toxoplasma gondii integral membrane protein, GNS1/SUR4 family protein, putative 0.0604 1 1
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0429 0.0758
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0246 0.1175
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0246 0.1175
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0487 0.2582
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.0721 0.1001
Trypanosoma cruzi fatty acid elongase, putative 0.0122 0.1769 0.1769
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0051 0.0007
Toxoplasma gondii hypothetical protein 0.0094 0.1298 0.1298
Trypanosoma cruzi fatty acid elongase, putative 0.0122 0.1769 0.1769
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0044 0.0044
Trypanosoma brucei phosphoglycerate kinase, putative 0.0035 0.0281 0.0281
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0391 0.2022
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0391 0.0513
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0214 0.3339 0.488
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0074 0.0944 0.0903
Echinococcus multilocularis dna polymerase eta 0.0088 0.1182 0.1685
Brugia malayi hypothetical protein 0.0028 0.0166 0.0122
Leishmania major fatty acid elongase, putative 0.0122 0.1769 0.1769
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0498 0.0498
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0506 0.0506
Toxoplasma gondii fatty acid elongase 0.0122 0.1769 0.1769
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0044 0.0044
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0044 0.034
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0051 0.0007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0044 0.0044
Mycobacterium ulcerans hypothetical protein 0.0043 0.0429 0.0838
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0051 0.0097
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0372 0.0484
Brugia malayi Pip kinase protein 2 0.0181 0.2782 0.275
Treponema pallidum phosphoglycerate kinase 0.0095 0.1307 0.2487
Loa Loa (eye worm) hypothetical protein 0.0028 0.0166 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.004
Leishmania major fatty acid elongase, putative 0.0122 0.1769 0.1769
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0051 0.0097
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0022 0.0062 0.0027
Brugia malayi hypothetical protein 0.0021 0.0051 0.0007
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0051 0.0097
Leishmania major hypothetical protein, conserved 0.0043 0.0429 0.0429
Brugia malayi beta-lactamase 0.0043 0.0429 0.0386
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0051 0.0007
Leishmania major phosphoglycerate kinase B, cytosolic 0.0095 0.1307 0.1307
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0121 0.1757 0.2829
Loa Loa (eye worm) beta-lactamase 0.0043 0.0429 0.0386
Leishmania major hypothetical protein, conserved 0.0028 0.0166 0.0166
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0166 0.0166
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0047 0.0485 0.0485
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0414 0.0547
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0044 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0509 0.0509
Mycobacterium ulcerans 6-phosphofructokinase 0.0121 0.1757 0.343
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.1204 0.1204
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0095 0.1307 0.7375
Toxoplasma gondii ABC1 family protein 0.0043 0.0429 0.0429
Leishmania major long chain polyunsaturated fatty acid elongation enzyme-like protein 0.0122 0.1769 0.1769
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0051 0.0007
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0246 0.0246
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0043 0.0429 0.0386
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.1757 0.172
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0051 0.001
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.1078 0.1078
Brugia malayi 6-phosphofructokinase 0.0121 0.1757 0.172
Loa Loa (eye worm) hypothetical protein 0.0053 0.0595 0.0553
Trypanosoma brucei DNA polymerase eta, putative 0.0088 0.1182 0.1182
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0051 0.001
Plasmodium vivax phosphoglycerate kinase, putative 0.0095 0.1307 0.1307
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0067 0.0823 0.1533
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0007
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0059 0.0697 0.0656
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0051 0.0097
Entamoeba histolytica deoxycytidyl transferase, putative 0.0059 0.0697 0.3812
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0498 0.2649
Echinococcus multilocularis geminin 0.0205 0.3183 0.4648
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0391 0.2022
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0595 0.0815
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0246 0.1175
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0035 0.0281 0.0281
Schistosoma mansoni cpg binding protein 0.0037 0.0324 0.0614
Trypanosoma cruzi fatty acid elongase, putative 0.0122 0.1769 0.1769
Trypanosoma brucei Long chain fatty acyl elongase 0.0122 0.1769 0.1769
Echinococcus granulosus chromobox protein 1 0.0078 0.1013 0.1435
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.043 0.043
Brugia malayi Heterochromatin protein 1 0.0078 0.1013 0.0973
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0391 0.0513
Giardia lamblia DINP protein human, muc B family 0.0067 0.0823 0.6295
Loa Loa (eye worm) GNS1/SUR4 family protein 0.0604 1 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0051 0.001
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.1757 0.172
Onchocerca volvulus 0.0037 0.0324 0.0219
Leishmania major DNA polymerase eta, putative 0.0088 0.1182 0.1182
Mycobacterium tuberculosis Conserved protein 0.0043 0.0429 0.0758
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0095 0.1307 0.2487
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0095 0.1307 0.1307
Mycobacterium tuberculosis Conserved protein 0.0043 0.0429 0.0758
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.0721 0.1001
Toxoplasma gondii GNS1/SUR4 family protein 0.0604 1 1
Plasmodium vivax elongation of very long chain fatty acids protein 3, putative 0.0122 0.1769 0.1769
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.1757 1
Brugia malayi chromobox protein homolog 3 0.0044 0.043 0.0387
Loa Loa (eye worm) hypothetical protein 0.0044 0.043 0.0387
Leishmania major fatty acid elongase, putative 0.0122 0.1769 0.1769
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0595 0.0815
Loa Loa (eye worm) hypothetical protein 0.0088 0.1182 0.1143
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0051 0.0007
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.043 0.2254
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.004
Brugia malayi PXA domain containing protein 0.0021 0.0051 0.0007
Brugia malayi hypothetical protein 0.004 0.0372 0.0329
Loa Loa (eye worm) hypothetical protein 0.0043 0.0429 0.0386
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0391 0.2988
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0022 0.0062 0.0118
Brugia malayi ImpB/MucB/SamB family protein 0.0059 0.0697 0.0656
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0487 0.0864
Loa Loa (eye worm) hypothetical protein 0.0095 0.1307 0.1268
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0246 0.0246
Schistosoma mansoni DNA polymerase eta 0.0088 0.1182 0.2239
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.0721 0.0679
Echinococcus granulosus dna polymerase eta 0.0088 0.1182 0.1685
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0022 0.0062 0.0105
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0051 0.001
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0051 0.001
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0429 0.0429
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0429 0.0758
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0246 0.1175
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0051 0.0097
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0022 0.0062 0.0062
Leishmania major fatty acid elongase, putative 0.0604 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0823 0.0823
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.043 0.2252
Echinococcus multilocularis cpg binding protein 0.0037 0.0324 0.0415
Mycobacterium ulcerans beta-lactamase 0.0043 0.0429 0.0838
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0391 0.0391
Schistosoma mansoni hypothetical protein 0.0205 0.3183 0.6026
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.043 0.2252
Loa Loa (eye worm) hypothetical protein 0.0043 0.0429 0.0386
Echinococcus granulosus cpg binding protein 0.0037 0.0324 0.0415
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0074 0.0944 0.1332
Plasmodium vivax GNS1/SUR4 domain containing protein 0.0604 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0059 0.0697 0.1285
Onchocerca volvulus 0.0053 0.0595 0.1295
Trypanosoma cruzi fatty acid elongase, putative 0.0604 1 1
Schistosoma mansoni cpg binding protein 0.0037 0.0324 0.0614
Trypanosoma cruzi fatty acid elongase, putative 0.0122 0.1769 0.1769
Brugia malayi fatty acid elongation protein 3 0.0122 0.1769 0.1733
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0429 0.0758
Entamoeba histolytica hypothetical protein 0.004 0.0372 0.191
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0181 0.2782 0.4055
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0022 0.0062 0.0062
Toxoplasma gondii DNA methyltransferase 2, putative 0.0022 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0043 0.0429 0.0386
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0429 0.2247
Echinococcus multilocularis disco interacting protein 2 0.0043 0.042 0.0556
Mycobacterium ulcerans lipase LipD 0.0043 0.0429 0.0838
Trypanosoma cruzi fatty acid elongase, putative 0.0122 0.1769 0.1769
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.1204 0.1204
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0051 0.001
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0051 0.001
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0429 0.0838
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0318 0.5121 0.5121
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0246 0.1175
Onchocerca volvulus 0.0043 0.042 0.0599
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0007
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0246 0.0246
Leishmania major fatty acid elongase, putative 0.0122 0.1769 0.1769
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0498 0.0498
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0181 0.2782 0.5268
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0051 0.001
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.1757 1
Trypanosoma cruzi fatty acid elongase, putative 0.0604 1 1
Brugia malayi beta-lactamase family protein 0.0043 0.0429 0.0386
Leishmania major ATP-dependent phosphofructokinase 0.0121 0.1757 0.1757
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0007
Loa Loa (eye worm) acetyltransferase 0.0162 0.2447 0.2413
Schistosoma mansoni hypothetical protein 0.004 0.0372 0.0703
Loa Loa (eye worm) hypothetical protein 0.0043 0.042 0.0377
Trypanosoma brucei phosphoglycerate kinase 0.0095 0.1307 0.1307
Echinococcus granulosus disco interacting protein 2 0.0043 0.042 0.0556
Schistosoma mansoni elongation of fatty acids protein 1 0.0122 0.1769 0.335
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.4432 0.8643
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0595 0.1126
Treponema pallidum hypothetical protein 0.0318 0.5121 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0429 0.0386
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.215 0.2114
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0089 0.1204 0.677
Brugia malayi mbt repeat family protein 0.0053 0.0595 0.0553
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0429 0.0758
Echinococcus multilocularis chromobox protein 1 0.0078 0.1013 0.1435
Loa Loa (eye worm) hypothetical protein 0.0043 0.0429 0.0386
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0595 0.1126
Trypanosoma brucei unspecified product 0.0081 0.1078 0.1078
Schistosoma mansoni terminal deoxycytidyl transferase 0.0059 0.0697 0.132
Trypanosoma cruzi fatty acid elongase, putative 0.0604 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0051 0.0097
Brugia malayi hypothetical protein 0.0021 0.0051 0.0007
Trichomonas vaginalis esterase, putative 0.0043 0.0429 0.2247
Leishmania major DNA polymerase eta, putative 0.0047 0.0485 0.0485
Loa Loa (eye worm) fatty acid elongation protein 3 0.0122 0.1769 0.1733
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0051 0.001
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0121 0.1757 0.3372
Brugia malayi PXA domain containing protein 0.0021 0.0051 0.0007
Loa Loa (eye worm) heterochromatin protein 1 0.0078 0.1013 0.0973
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0007
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0318 0.5121 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0051 0.001
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0022 0.0062 0.0062
Brugia malayi acetyltransferase, GNAT family protein 0.0162 0.2447 0.2413
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0318 0.5121 0.5121
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0391 0.0513
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0051 0.0007
Trypanosoma brucei elongation of very long chain fatty acids protein, putative 0.0122 0.1769 0.1769
Entamoeba histolytica hypothetical protein 0.004 0.0372 0.191
Schistosoma mansoni cpg binding protein 0.0037 0.0324 0.0614
Trypanosoma brucei DNA polymerase IV, putative 0.0089 0.1204 0.1204
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0429 0.2247
Onchocerca volvulus 0.0043 0.0429 0.0636
Loa Loa (eye worm) GNS1/SUR4 family protein 0.0122 0.1769 0.1733
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0429 0.057
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0429 0.0838
Brugia malayi polk-prov protein 0.0048 0.0506 0.0464
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0595 0.1295
Leishmania major fatty acid elongase, putative 0.0122 0.1769 0.1769
Brugia malayi beta-lactamase family protein 0.0043 0.0429 0.0386
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0035 0.0281 0.0281
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0429 0.0758
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0509 0.0509
Echinococcus multilocularis phosphoglycerate kinase 1 0.0095 0.1307 0.187
Entamoeba histolytica hypothetical protein 0.004 0.0372 0.191
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0059 0.0697 0.132
Echinococcus granulosus 6 phosphofructokinase 0.0121 0.1757 0.2536
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0051 0.001
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0246 0.1879
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0035 0.0281 0.0281
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0051 0.001
Trypanosoma brucei Fatty acid elongase 0.0122 0.1769 0.1769
Schistosoma mansoni ap endonuclease 0.0021 0.0044 0.0084
Trypanosoma cruzi DNA polymerase kappa, putative 0.0089 0.1204 0.1204
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0246 0.0246
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0498 0.2649
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0051 0.0097
Trypanosoma brucei Fatty acid elongase 0.0604 1 1
Entamoeba histolytica hypothetical protein 0.0021 0.0051 0.004
Entamoeba histolytica hypothetical protein 0.0021 0.0051 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0213 0.0984
Trypanosoma brucei DNA polymerase kappa, putative 0.0048 0.0509 0.0509
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0391 0.0391
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0498 0.0498
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0051 0.001
Schistosoma mansoni fatty acid acyl transferase-related 0.0122 0.1769 0.335
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0166 0.0166
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.1204 0.1204
Schistosoma mansoni hypothetical protein 0.0205 0.3183 0.6026
Onchocerca volvulus Elongation of very long chain fatty acids protein 5 homolog 0.0122 0.1769 0.5969
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.1204 0.1204
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0429 0.0386
Brugia malayi phosphofructokinase 0.0121 0.1757 0.172
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0246 0.1175
Trypanosoma cruzi DNA polymerase eta, putative 0.0088 0.1182 0.1182
Leishmania major fatty acid elongase, putative 0.0122 0.1769 0.1769
Brugia malayi 6-phosphofructokinase 0.0121 0.1757 0.172
Brugia malayi Phosphoglycerate kinase 0.0035 0.0281 0.0238
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.1757 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0498 0.0672
Schistosoma mansoni phosphoglycerate kinase 0.0095 0.1307 0.2475
Echinococcus granulosus histone acetyltransferase KAT2B 0.0157 0.237 0.3444
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0429 0.0758
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0051 0.0007
Leishmania major fatty acid elongase, putative 0.0122 0.1769 0.1769
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.004
Schistosoma mansoni elongation of fatty acids protein 1 0.0122 0.1769 0.335
Brugia malayi Disco-interacting protein 2 homolog 0.0043 0.042 0.0377
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.1757 1
Loa Loa (eye worm) ELO-9 protein 0.0122 0.1769 0.1733
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0074 0.0944 0.0903
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.1757 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.1204 0.1204
Schistosoma mansoni hypothetical protein 0.0327 0.5282 1
Entamoeba histolytica phosphoglycerate kinase, putative 0.0095 0.1307 0.7375
Entamoeba histolytica hypothetical protein 0.004 0.0372 0.191
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0246 0.1175
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.0721 0.1001
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0043 0.042 0.0795
Entamoeba histolytica hypothetical protein 0.0021 0.0051 0.004
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0051 0.0007
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0595 0.0553
Trypanosoma cruzi DNA polymerase kappa, putative 0.0089 0.1204 0.1204
Plasmodium vivax long chain polyunsaturated fatty acid elongation enzyme, putative 0.0122 0.1769 0.1769
Brugia malayi fatty acid elongation protein 3 0.0122 0.1769 0.1733
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0391 0.0391
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0095 0.1307 0.1307
Trypanosoma brucei unspecified product 0.0041 0.0383 0.0383
Loa Loa (eye worm) fatty acid elongation protein 3 0.0122 0.1769 0.1733
Loa Loa (eye worm) hypothetical protein 0.0048 0.0506 0.0464
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.043 0.064
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0051 0.001
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0121 0.1757 0.3372
Onchocerca volvulus Elongation of very long chain fatty acids protein homolog 0.0122 0.1769 0.5969
Trypanosoma cruzi fatty acid elongase, putative 0.0122 0.1769 0.1769
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.1757 0.1757
Schistosoma mansoni chromobox protein 0.0078 0.1013 0.1919
Onchocerca volvulus 0.0043 0.0429 0.0636
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0246 0.0246
Loa Loa (eye worm) MBCTL1 0.0061 0.0721 0.0679
Giardia lamblia Phosphoglycerate kinase 0.0095 0.1307 1
Plasmodium falciparum fatty acid elongation protein, GNS1/SUR4 family, putative 0.0604 1 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0944 0.0944
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0944 0.0944
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0051 0.001
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0051 0.0007
Echinococcus multilocularis chromobox protein 1 0.0078 0.1013 0.1435
Echinococcus multilocularis elongation of very long chain fatty acids 0.0122 0.1769 0.2555
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0166 0.0166
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.1204 0.1204
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0074 0.0944 0.1332
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0391 0.0513
Onchocerca volvulus 0.0122 0.1769 0.5969
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0074 0.0944 0.1787
Schistosoma mansoni elongation of fatty acids protein 1 0.0122 0.1769 0.335
Toxoplasma gondii exonuclease III APE 0.0021 0.0044 0.0044
Trypanosoma brucei unspecified product 0.0041 0.0383 0.0383
Brugia malayi GNS1/SUR4 family protein 0.0604 1 1
Echinococcus multilocularis 6 phosphofructokinase 0.0121 0.1757 0.2536
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0181 0.2782 0.4055
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0166 0.0166
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0095 0.1307 0.1307
Trypanosoma cruzi DNA polymerase kappa, putative 0.0089 0.1204 0.1204
Leishmania major DNA polymerase kappa, putative 0.0067 0.0823 0.0823
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0246 0.0246
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0318 0.5121 1
Onchocerca volvulus 0.0043 0.0429 0.0636
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0487 0.2582
Echinococcus granulosus dna polymerase kappa 0.0089 0.1204 0.1717
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0372 0.0484
Trypanosoma brucei phosphoglycerate kinase 0.0035 0.0281 0.0281
Trypanosoma cruzi fatty acid elongase, putative 0.0604 1 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0214 0.3339 0.488
Schistosoma mansoni chromobox protein 0.0078 0.1013 0.1919
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.004
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0051 0.0097
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0391 0.074
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0044 0.0044
Echinococcus granulosus geminin 0.0205 0.3183 0.4648
Plasmodium falciparum long chain polyunsaturated fatty acid elongation enzyme, putative 0.0122 0.1769 0.1769
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0022 0.0062 0.0062
Trypanosoma brucei phosphoglycerate kinase 0.0095 0.1307 0.1307
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0595 0.0815
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.215 0.2114
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0429 0.0429
Trypanosoma brucei DNA polymerase IV, putative 0.0089 0.1204 0.1204
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0391 0.0348
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0181 0.2782 0.5268
Schistosoma mansoni elongation of fatty acids protein 1 0.0122 0.1769 0.335
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0033 0.0246 0.0396
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0026 0.0126 0.0126
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0429 0.0758
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0391 0.2022
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.1757 0.3326
Leishmania major modification methylase-like protein 0.0022 0.0062 0.0062
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0391 0.074
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0051 0.004
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0429 0.0386
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0166 0.0166
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0391 0.2022
Mycobacterium ulcerans DNA polymerase IV 0.0089 0.1204 0.235
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0429 0.0429
Echinococcus granulosus elongation of very long chain fatty acids 0.0122 0.1769 0.2555
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0429 0.0813
Loa Loa (eye worm) hypothetical protein 0.0041 0.0391 0.0348
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0007
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0391 0.0391
Brugia malayi fatty acid elongation protein 3 0.0122 0.1769 0.1733
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0429 0.057
Trypanosoma brucei Fatty acid elongase 0.0122 0.1769 0.1769
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0067 0.0823 0.0823
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0051 0.0097
Leishmania major phosphoglycerate kinase C, glycosomal 0.0095 0.1307 0.1307
Brugia malayi GNS1/SUR4 family protein 0.0122 0.1769 0.1733
Onchocerca volvulus 0.0122 0.1769 0.5969
Loa Loa (eye worm) fatty acid elongation protein 3 0.0122 0.1769 0.1733
Trichomonas vaginalis chromobox protein, putative 0.0078 0.1013 0.5659
Trypanosoma brucei DNA polymerase kappa, putative 0.0089 0.1204 0.1204
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0051 0.001
Echinococcus granulosus phosphoglycerate kinase 1 0.0095 0.1307 0.187
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0051 0.001
Echinococcus granulosus DNA methyltransferase 2, putative 0.0022 0.0062 0.0027
Plasmodium falciparum phosphoglycerate kinase 0.0095 0.1307 0.1307
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0051 0.0097
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0074 0.0944 0.5251
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0391 0.0513
Echinococcus multilocularis dna polymerase kappa 0.0089 0.1204 0.1717
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0429 0.2247
Brugia malayi Hypothetical 34.1 kDa protein C40H1.4 in chromosome III 0.0122 0.1769 0.1733
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0213 0.0984
Trichomonas vaginalis DNA polymerase eta, putative 0.0089 0.1204 0.677
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0095 0.1307 0.1871
Loa Loa (eye worm) hypothetical protein 0.0181 0.2782 0.275
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0372 0.0703
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0051 0.0007
Schistosoma mansoni phosphoglycerate kinase 0.0095 0.1307 0.2475
Schistosoma mansoni ap endonuclease 0.0021 0.0044 0.0084
Loa Loa (eye worm) CXXC zinc finger family protein 0.0037 0.0324 0.0281
Trichomonas vaginalis chromobox protein, putative 0.0078 0.1013 0.5659
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0485 0.0485
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0162 0.2447 0.4633
Onchocerca volvulus Elongation of very long chain fatty acids protein homolog 0.0122 0.1769 0.5969
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.0944 0.0944
Brugia malayi ImpB/MucB/SamB family protein 0.0088 0.1182 0.1143
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0059 0.0697 0.0967
Echinococcus granulosus expressed protein 0.0416 0.6796 1
Echinococcus multilocularis expressed protein 0.0416 0.6796 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0095 0.1307 0.1307
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0051 0.0097
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0429 0.0813
Loa Loa (eye worm) hypothetical protein 0.0034 0.0269 0.0226
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0035 0.0281 0.0281
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0246 0.1175
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0051 0.001
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0166 0.0166

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 0.7308 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.9185 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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