Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0631 | 0.0743 |
Wolbachia endosymbiont of Brugia malayi | threonyl-tRNA synthetase | 0.0076 | 0.8494 | 1 |
Plasmodium vivax | threonine--tRNA ligase, putative | 0.0076 | 0.8494 | 1 |
Mycobacterium leprae | Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) | 0.0076 | 0.8494 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0631 | 0.0631 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0631 | 0.0631 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0631 | 0.0743 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0631 | 0.0631 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0631 | 0.0743 |
Entamoeba histolytica | threonyl-tRNA synthetase, putative | 0.0076 | 0.8494 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.0631 | 0.0631 |
Mycobacterium tuberculosis | Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) | 0.0076 | 0.8494 | 1 |
Giardia lamblia | Threonyl-tRNA synthetase | 0.0076 | 0.8494 | 1 |
Mycobacterium ulcerans | threonyl-tRNA synthetase | 0.0076 | 0.8494 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0631 | 0.0743 |
Trypanosoma cruzi | threonyl-tRNA synthetase, putative | 0.0087 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.0631 | 0.0743 |
Toxoplasma gondii | threonyl-tRNA synthetase family protein | 0.0076 | 0.8494 | 1 |
Leishmania major | threonyl-tRNA synthetase, putative | 0.0087 | 1 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0631 | 0.0743 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0631 | 0.0631 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0631 | 0.0743 |
Echinococcus multilocularis | Threonyl tRNA synthetase, C | 0.0087 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0.0631 | 0.0631 |
Loa Loa (eye worm) | threonyl-tRNA synthetase | 0.0087 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0631 | 0.0631 |
Echinococcus granulosus | Threonyl tRNA synthetase C | 0.0087 | 1 | 1 |
Trypanosoma brucei | threonyl-tRNA synthetase, putative | 0.0087 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0631 | 0.0851 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0631 | 0.0743 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.0631 | 0.0631 |
Trypanosoma cruzi | threonyl-tRNA synthetase, putative | 0.0087 | 1 | 1 |
Trichomonas vaginalis | threonyl-tRNA synthetase, putative | 0.0076 | 0.8494 | 1 |
Schistosoma mansoni | threonyl-tRNA synthetase | 0.0069 | 0.7416 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0631 | 0.0743 |
Chlamydia trachomatis | threonine--tRNA ligase | 0.0087 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0631 | 0.0743 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0631 | 0.0851 |
Plasmodium falciparum | threonine--tRNA ligase | 0.0076 | 0.8494 | 1 |
Treponema pallidum | threonyl-tRNA synthetase | 0.0076 | 0.8494 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.2818 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.3981 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 1 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.