Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | v-ets avian erythroblastosis virus E26 oncogene homolog | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Fli-1 protein | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Schistosoma mansoni | ets-related | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Loa Loa (eye worm) | fli-1 protein | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Schistosoma japonicum | ko:K09435 transcriptional regulator ERG, putative | Get druggable targets OG5_131947 | All targets in OG5_131947 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hypothetical protein | 0.0234 | 0.8344 | 1 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0087 | 0.0621 | 0.5 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0234 | 0.8344 | 1 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0234 | 0.8344 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0134 | 0.307 | 0.5 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0234 | 0.8344 | 0.5 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0087 | 0.0621 | 0.5 |
Loa Loa (eye worm) | ILVBL protein | 0.0142 | 0.3481 | 0.3049 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0134 | 0.307 | 0.368 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0234 | 0.8344 | 1 |
Mycobacterium ulcerans | acetolactate synthase | 0.0134 | 0.307 | 0.368 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0076 | 0 | 0.5 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0076 | 0 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.02 | 0.6551 | 0.6322 |
Loa Loa (eye worm) | fli-1 protein | 0.0265 | 1 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0134 | 0.307 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0234 | 0.8344 | 1 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0076 | 0 | 0.5 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0134 | 0.307 | 0.368 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0134 | 0.3082 | 0.2624 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0076 | 0 | 0.5 |
Schistosoma mansoni | ets-related | 0.0265 | 1 | 1 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0234 | 0.8344 | 0.5 |
Brugia malayi | Thiamine pyrophosphate enzyme, central domain containing protein | 0.0234 | 0.8344 | 0.8234 |
Schistosoma mansoni | acetolactate synthase | 0.02 | 0.6551 | 0.6322 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0134 | 0.307 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.