TDR Targets

Basic information

Technical information

TDR Targets ID: 1447319
Name: N-(2-bromo-4-methylphenyl)-4-(2-methyl-9-oxoa cridin-10-yl)butanamide
MW: 463.366 | Formula: C25H23BrN2O2
H donors: 1 H acceptors: 2 LogP: 5.7 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(c(c1)Br)NC(=O)CCCn1c2ccccc2c(=O)c2c1ccc(c2)C
InChi: 1S/C25H23BrN2O2/c1-16-10-12-23-19(14-16)25(30)18-6-3-4-7-22(18)28(23)13-5-8-24(29)27-21-11-9-17(2)15-20(21)26/h3-4,6-7,9-12,14-15H,5,8,13H2,1-2H3,(H,27,29)
InChiKey: WJOTWHSLQXOGNX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2-bromo-4-methyl-phenyl)-4-(2-methyl-9-oxo-acridin-10-yl)butanamide
N-(2-bromo-4-methylphenyl)-4-(2-methyl-9-oxo-10-acridinyl)butanamide
N-(2-bromo-4-methyl-phenyl)-4-(9-keto-2-methyl-acridin-10-yl)butyramide
NCGC00098893-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bacillus subtilis (strain 168)	ATP-dependent Clp protease proteolytic subunit	Starlite/ChEMBL	No references
Homo sapiens	survival of motor neuron 2, centromeric	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Theileria parva	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	Get druggable targets OG5_127187	All targets in OG5_127187
Theileria parva	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Echinococcus multilocularis	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma mansoni	peptidase Clp (S14 family)	Get druggable targets OG5_127187	All targets in OG5_127187
Brugia malayi	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Brugia malayi	Probable ClpP-like protease	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium yoelii	ATP-dependent Clp protease, proteolytic subunit ClpP, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus multilocularis	peptidase Clp (S14 family)	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium knowlesi	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	Get druggable targets OG5_127187	All targets in OG5_127187
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Neospora caninum	ATP-dependent Clp protease proteolytic subunit, related	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma japonicum	ko:K06275 parvin, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium berghei	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Babesia bovis	ATP-dependent Clp protease proteolytic subunit 1, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	peptidase Clp S14 family	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma japonicum	ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative	Get druggable targets OG5_127187	All targets in OG5_127187
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Babesia bovis	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	188 aa	41.5 %
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	ATP-dependent Clp protease proteolytic subunit	197 aa	172 aa	57.0 %
Plasmodium knowlesi	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	189 aa	36.0 %
Babesia bovis	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	188 aa	41.5 %
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	189 aa	35.5 %
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	ATP-dependent Clp protease proteolytic subunit	197 aa	186 aa	40.3 %
Plasmodium yoelii	Clp protease	ATP-dependent Clp protease proteolytic subunit	197 aa	183 aa	36.6 %
Schistosoma mansoni	neuropeptide receptor	ATP-dependent Clp protease proteolytic subunit	197 aa	174 aa	20.1 %
Chlamydia trachomatis	hypothetical protein	ATP-dependent Clp protease proteolytic subunit	197 aa	171 aa	22.8 %
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	ATP-dependent Clp protease proteolytic subunit	197 aa	183 aa	36.1 %
Plasmodium berghei	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	180 aa	36.7 %
Onchocerca volvulus	Putative V-type proton ATPase subunit F	ATP-dependent Clp protease proteolytic subunit	197 aa	194 aa	54.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine peptidase, putative	0.0712	0.4392	0.4392
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0279	0.0051	0.0199
Loa Loa (eye worm)	ctsf protein	0.0456	0.1822	0.1728
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0576	0.3028	0.3028
Echinococcus granulosus	cathepsin l1	0.0456	0.1822	0.1822
Echinococcus multilocularis	cathepsin L cysteine protease	0.0456	0.1822	0.1822
Onchocerca volvulus	Cathepsin L homolog	0.0456	0.1822	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.1822	0.6016
Schistosoma mansoni	cathepsin F (C01 family)	0.0309	0.0346	0.0346
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0565	0.2916	0.2916
Trypanosoma cruzi	cysteine peptidase, putative	0.0712	0.4392	0.4392
Leishmania major	cathepsin L-like protease	0.0712	0.4392	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0456	0.1822	0.7151
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0376	0.1021	0.3372
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0712	0.4392	1
Loa Loa (eye worm)	hypothetical protein	0.0456	0.1822	0.1728
Echinococcus multilocularis	cathepsin b	0.1272	1	1
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0346	0.0236
Onchocerca volvulus		0.0456	0.1822	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0712	0.4392	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1272	1	1
Brugia malayi	Cathepsin L-like precursor	0.0309	0.0346	0.0346
Schistosoma mansoni	cathepsin F (C01 family)	0.0456	0.1822	0.1822
Giardia lamblia	Cathepsin B precursor	0.0576	0.3028	1
Echinococcus granulosus	cathepsin l1	0.0309	0.0346	0.0346
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0456	0.1822	0.6016
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0576	0.3028	0.4693
Onchocerca volvulus		0.0456	0.1822	1
Entamoeba histolytica	cysteine protease, putative	0.0456	0.1822	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1272	1	1
Toxoplasma gondii	cathepsin B	0.0576	0.3028	1
Onchocerca volvulus		0.0456	0.1822	1
Echinococcus granulosus	cathepsin b	0.1272	1	1
Brugia malayi	Cathepsin L-like precursor	0.0456	0.1822	0.1822
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.1822	0.6016
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0309	0.0346	0.0346
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.1822	0.6016
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.1822	0.6016
Leishmania major	cathepsin L-like protease	0.0712	0.4392	1
Onchocerca volvulus	Cathepsin L homolog	0.0456	0.1822	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0456	0.1822	0.6016
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0576	0.3028	0.6894
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0456	0.1822	0.6016
Brugia malayi	hypothetical protein	0.0286	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0346	0.0236
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0456	0.1822	0.6016
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.1822	0.6016
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0528	0.2548	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0712	0.4392	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0576	0.3028	0.3028
Brugia malayi	Cathepsin L-like precursor	0.0456	0.1822	0.1822
Echinococcus multilocularis	cathepsin b	0.1272	1	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0456	0.1822	0.1822
Trypanosoma cruzi	cysteine peptidase, putative	0.0456	0.1822	0.1822
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0528	0.2548	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0528	0.2548	0.8386
Plasmodium vivax	vivapain-2	0.0456	0.1822	0.7151
Onchocerca volvulus		0.0456	0.1822	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0712	0.4392	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0712	0.4392	0.4392
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0712	0.4392	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0712	0.4392	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0528	0.2548	1
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0528	0.2548	0.8386
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0456	0.1822	0.6016
Leishmania major	cathepsin L-like protease	0.0712	0.4392	1
Entamoeba histolytica	cysteine proteinase, putative	0.0309	0.0346	0.1899
Loa Loa (eye worm)	hypothetical protein	0.1272	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1272	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.1822	0.6016
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0456	0.1822	0.7151
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.1822	0.6016
Onchocerca volvulus	Cathepsin F homolog	0.0456	0.1822	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0712	0.4392	1
Toxoplasma gondii	cathepsin CPC1	0.0528	0.2548	0.8386
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0712	0.4392	1
Giardia lamblia	Cathepsin B precursor	0.0576	0.3028	1
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0528	0.2548	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0456	0.1822	0.6016
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0279	0.0051	0.0199
Loa Loa (eye worm)	cysteine protease	0.0456	0.1822	0.1728
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0456	0.1822	0.1728
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0712	0.4392	1
Brugia malayi	Cathepsin L-like precursor	0.0456	0.1822	0.1822
Loa Loa (eye worm)	hypothetical protein	0.0309	0.0346	0.0236
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0456	0.1822	0.1822
Giardia lamblia	Cathepsin B precursor	0.0576	0.3028	1
Echinococcus multilocularis	cysteine protease	0.0456	0.1822	0.1822
Plasmodium vivax	vivapain-2	0.0456	0.1822	0.7151
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.0113	0.0113
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1272	1	1
Brugia malayi	cathepsin L-like precursor	0.0309	0.0346	0.0346
Trypanosoma cruzi	cruzipain precursor, putative	0.0712	0.4392	0.4392
Onchocerca volvulus		0.0456	0.1822	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.1822	0.6016
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0456	0.1822	0.7151
Echinococcus granulosus	cathepsin b	0.1272	1	1
Echinococcus multilocularis	cysteine protease	0.0456	0.1822	0.1822
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0456	0.1822	0.6016
Brugia malayi	Cathepsin L-like precursor	0.0309	0.0346	0.0346
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1272	1	1
Brugia malayi	Cathepsin L-like precursor	0.0456	0.1822	0.1822
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0576	0.3028	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.1822	0.6016
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.1822	0.6016
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0712	0.4392	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0456	0.1822	0.6016
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0456	0.1822	0.1728
Onchocerca volvulus		0.0456	0.1822	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.1822	0.6016
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0456	0.1822	0.1822
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.1822	0.6016
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0528	0.2548	0.2548
Brugia malayi	Papain family cysteine protease containing protein	0.0456	0.1822	0.1822
Loa Loa (eye worm)	cathepsin B	0.0576	0.3028	0.2949
Toxoplasma gondii	cathepsin CPL	0.0456	0.1822	0.5948
Onchocerca volvulus		0.0456	0.1822	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.1822	0.6016
Echinococcus multilocularis	cathepsin L cysteine protease	0.0456	0.1822	0.1822
Brugia malayi	Cathepsin L-like precursor	0.0456	0.1822	0.1822
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0309	0.0346	0.1142
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0712	0.4392	1
Entamoeba histolytica	cysteine proteinase, putative	0.0456	0.1822	1
Loa Loa (eye worm)	fibroinase	0.0456	0.1822	0.1728
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0456	0.1822	0.1822
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0456	0.1822	0.6016
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.0113	0.0113
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0456	0.1822	0.6016
Brugia malayi	Cathepsin L-like precursor	0.0456	0.1822	0.1822
Trypanosoma cruzi	major cysteine proteinase, putative	0.0384	0.1095	0.1095
Entamoeba histolytica	cysteine proteinase, putative	0.0456	0.1822	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0456	0.1822	0.6016
Schistosoma mansoni	cathepsin F (C01 family)	0.0456	0.1822	0.1822
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0309	0.0346	0.1142
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0456	0.1822	0.6016

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.8184 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	4.4668 uM	PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 5.6234 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	32.6427 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1592272

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1447319