Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Bacillus subtilis (strain 168) | ATP-dependent Clp protease proteolytic subunit | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific demethylase 4E | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lysine specific demethylase 5A | 0.0071 | 0.0208 | 0.0208 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0071 | 0.0208 | 0.0208 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.0261 | 0.0261 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.0742 | 0.5 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0094 | 0.0742 | 0.0742 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0293 | 0.528 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0071 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0742 | 0.1053 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0474 | 0.9412 | 0.5 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.0742 | 0.0934 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.0474 | 0.9412 | 0.5 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0474 | 0.9412 | 1 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.05 | 1 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.0261 | 0.0261 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.05 | 1 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.0094 | 0.0742 | 0.1053 |
Trypanosoma brucei | Valosin-containing protein | 0.0474 | 0.9412 | 0.5 |
Plasmodium vivax | cell division cycle ATPase, putative | 0.0181 | 0.2719 | 0.228 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.0742 | 0.5 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.0742 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0071 | 0.0208 | 0.0208 |
Brugia malayi | valosin containing protein | 0.0293 | 0.528 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 0.0742 | 0.0495 |
Brugia malayi | transitional endoplasmic reticulum ATPase TER94, putative | 0.0207 | 0.3307 | 0.6109 |
Toxoplasma gondii | cell division protein CDC48CY | 0.05 | 1 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.0742 | 0.0934 |
Mycobacterium ulcerans | ATPase | 0.0299 | 0.5418 | 1 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.0742 | 0.5 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0474 | 0.9412 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0261 | 0.0054 |
Giardia lamblia | AAA family ATPase | 0.0299 | 0.5418 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.0261 | 0.0481 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0474 | 0.9412 | 0.94 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0299 | 0.5418 | 0.5295 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0207 | 0.3307 | 0.3165 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0299 | 0.5418 | 1 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0474 | 0.9412 | 1 |
Brugia malayi | vesicle-fusing ATPase | 0.0293 | 0.528 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 0.0742 | 0.0495 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0094 | 0.0742 | 0.0546 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0094 | 0.0742 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.05 | 1 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0207 | 0.3307 | 0.3307 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0094 | 0.0742 | 0.0742 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.528 | 1 |
Loa Loa (eye worm) | VCP protein | 0.0207 | 0.3307 | 0.6109 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0261 | 0.0054 |
Toxoplasma gondii | transitional endoplasmic reticulum ATPase, putative | 0.0299 | 0.5417 | 0.5295 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.05 | 1 | 1 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0474 | 0.9412 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0033 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 5.0119 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.