Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0069 | 0.1732 | 0.5 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0213 | 1 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0069 | 0.1732 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0123 | 0.4875 | 0.5929 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0959 | 0.1166 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0213 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0855 | 0.0855 |
Echinococcus granulosus | geminin | 0.0182 | 0.8221 | 1 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0213 | 1 | 1 |
Mycobacterium ulcerans | acetolactate synthase | 0.0122 | 0.4774 | 0.368 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0959 | 0.1166 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0133 | 0.5444 | 0.6622 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0855 | 0.0855 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0959 | 0.1166 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0959 | 0.0959 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0069 | 0.1732 | 0.5 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0122 | 0.4774 | 0.5 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0213 | 1 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.0182 | 0.8223 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0122 | 0.4774 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.8221 | 0.9998 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0213 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0959 | 0.1166 |
Mycobacterium ulcerans | hypothetical protein | 0.0213 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.4875 | 0.5928 |
Schistosoma mansoni | thyroid hormone receptor | 0.0133 | 0.5444 | 0.662 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0122 | 0.4774 | 0.368 |
Schistosoma mansoni | thyroid hormone receptor | 0.0133 | 0.5444 | 0.662 |
Echinococcus multilocularis | geminin | 0.0182 | 0.8221 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0959 | 0.1166 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0122 | 0.4774 | 0.368 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0959 | 0.1166 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0122 | 0.4786 | 0.9088 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0959 | 0.1166 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0122 | 0.4774 | 1 |
Loa Loa (eye worm) | ILVBL protein | 0.0129 | 0.5181 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0959 | 0.0241 |
Schistosoma mansoni | acetolactate synthase | 0.0182 | 0.8223 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.8221 | 0.9998 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0123 | 0.4875 | 0.5929 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0069 | 0.1732 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0213 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5221 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 1.9953 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.