Detailed information for compound 1455269

Basic information

Technical information
  • TDR Targets ID: 1455269
  • Name: 2-[2-ethoxy-4-[[4-ethoxycarbonyl-5-[(4-methox yphenyl)amino]-3-oxothiophen-2-ylidene]methyl ]phenoxy]acetic acid
  • MW: 499.533 | Formula: C25H25NO8S
  • H donors: 2 H acceptors: 4 LogP: 5.33 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1=C(Nc2ccc(cc2)OC)S/C(=C\c2ccc(c(c2)OCC)OCC(=O)O)/C1=O
  • InChi: 1S/C25H25NO8S/c1-4-32-19-12-15(6-11-18(19)34-14-21(27)28)13-20-23(29)22(25(30)33-5-2)24(35-20)26-16-7-9-17(31-3)10-8-16/h6-13,26H,4-5,14H2,1-3H3,(H,27,28)/b20-13-
  • InChiKey: MYWMFDPIJHIZIY-MOSHPQCFSA-N  


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Synonyms

  • 2-[2-ethoxy-4-[(Z)-[4-ethoxycarbonyl-5-[(4-methoxyphenyl)amino]-3-oxothiophen-2-ylidene]methyl]phenoxy]acetic acid
  • 2-[2-ethoxy-4-[[4-ethoxycarbonyl-5-[(4-methoxyphenyl)amino]-3-oxo-2-thienylidene]methyl]phenoxy]acetic acid
  • 2-[2-ethoxy-4-[(Z)-[4-ethoxycarbonyl-5-[(4-methoxyphenyl)amino]-3-oxo-2-thienylidene]methyl]phenoxy]acetic acid
  • 2-[4-[[4-carbethoxy-3-keto-5-[(4-methoxyphenyl)amino]-2-thienylidene]methyl]-2-ethoxy-phenoxy]acetic acid
  • 2-[4-[(Z)-[4-carbethoxy-3-keto-5-[(4-methoxyphenyl)amino]-2-thienylidene]methyl]-2-ethoxy-phenoxy]acetic acid
  • 2-[2-ethoxy-4-[[4-ethoxycarbonyl-5-[(4-methoxyphenyl)amino]-3-oxo-thiophen-2-ylidene]methyl]phenoxy]ethanoic acid
  • 2-[2-ethoxy-4-[(Z)-[4-ethoxycarbonyl-5-[(4-methoxyphenyl)amino]-3-oxo-thiophen-2-ylidene]methyl]phenoxy]ethanoic acid
  • MLS000704394
  • SMR000231706
  • {2-ethoxy-4-[(4-(ethoxycarbonyl)-5-(4-methoxyanilino)-3-oxo-2(3H)-thienylidene)methyl]phenoxy}acetic acid
  • AN-989/14669143

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0318 0.1639 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0228 0.135
Trichomonas vaginalis glucosylceramidase, putative 0.093 0.5212 0.6821
Trichomonas vaginalis glucosylceramidase, putative 0.0882 0.4935 0.6458
Trichomonas vaginalis rotamase, putative 0.004 0.0014 0.0007
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.008 0.0246 0.025
Brugia malayi lysosomal alpha-mannosidase 0.0044 0.0036 0.0022
Loa Loa (eye worm) hypothetical protein 0.0266 0.1335 0.1323
Loa Loa (eye worm) hypothetical protein 0.0054 0.0094 0.008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0228 0.135
Brugia malayi Trehalase family protein 0.0044 0.0036 0.0023
Loa Loa (eye worm) TRE-2 protein 0.0128 0.0524 0.0511
Brugia malayi Trehalase family protein 0.0128 0.0524 0.0511
Echinococcus multilocularis beta galactosidase 0.0155 0.0686 0.0673
Trichomonas vaginalis conserved hypothetical protein 0.0128 0.0524 0.0676
Trichomonas vaginalis alpha-glucosidase, putative 0.0197 0.0931 0.121
Echinococcus granulosus dna polymerase eta 0.0054 0.0094 0.008
Schistosoma mansoni hypothetical protein 0.0058 0.0118 0.0113
Schistosoma mansoni hypothetical protein 0.0162 0.0723 0.0765
Echinococcus multilocularis lysosomal alpha mannosidase 0.008 0.0246 0.0233
Brugia malayi Glycosyl hydrolases family 38 protein 0.0044 0.0036 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.1344 0.7637 1
Trypanosoma cruzi lysosomal alpha-mannosidase precursor, putative 0.008 0.0246 0.1501
Trichomonas vaginalis glucosylceramidase, putative 0.1344 0.7637 1
Brugia malayi hypothetical protein 0.0044 0.0036 0.0023
Brugia malayi Trehalase family protein 0.0044 0.0036 0.0023
Onchocerca volvulus 0.0128 0.0524 0.0652
Giardia lamblia Ceramide glucosyltransferase 0.0333 0.1726 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0318 0.1639 0.2138
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0132 0.0804
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1447 0.1435
Trichomonas vaginalis glucosylceramidase, putative 0.1344 0.7637 1
Brugia malayi Trehalase family protein 0.0128 0.0524 0.0511
Loa Loa (eye worm) hypothetical protein 0.0044 0.0036 0.0023
Echinococcus granulosus microtubule associated protein 2 0.0833 0.4649 0.4642
Brugia malayi trehalase I 0.0044 0.0036 0.0023
Leishmania major alpha glucosidase II subunit, putative 0.0318 0.1639 1
Trichomonas vaginalis glucosylceramidase, putative 0.0882 0.4935 0.6458
Trichomonas vaginalis glucosylceramidase, putative 0.1344 0.7637 1
Trichomonas vaginalis trehalase, putative 0.0128 0.0524 0.0676
Schistosoma mansoni survival motor neuron protein 0.0058 0.0118 0.0113
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0126 0.0513 0.0662
Trypanosoma brucei lysosomal alpha-mannosidase precursor, putative 0.008 0.0246 0.1459
Mycobacterium ulcerans alpha-mannosidase 0.0044 0.0036 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0228 0.1392
Trichomonas vaginalis alpha-glucosidase, putative 0.0318 0.1639 0.2138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0228 0.135
Echinococcus multilocularis glycogen debranching enzyme 0.0126 0.0513 0.05
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0318 0.1639 0.1628
Brugia malayi Trehalase family protein 0.0128 0.0524 0.0511
Trichomonas vaginalis glucosylceramidase, putative 0.0882 0.4935 0.6458
Trichomonas vaginalis glucosylceramidase, putative 0.0882 0.4935 0.6458
Brugia malayi Trehalase family protein 0.0128 0.0524 0.0511
Schistosoma mansoni ceramide glucosyltransferase 0.0735 0.4076 0.4378
Loa Loa (eye worm) trehalase 0.0128 0.0524 0.0511
Echinococcus granulosus neutral alpha glucosidase AB 0.0318 0.1639 0.1628
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0014 0.0007
Trichomonas vaginalis alpha-glucosidase, putative 0.0197 0.0931 0.121
Trichomonas vaginalis maltase-glucoamylase, putative 0.0197 0.0931 0.121
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.5502 0.5496
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0228 0.135
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0197 0.0931 0.121
Trichomonas vaginalis glucosylceramidase, putative 0.0882 0.4935 0.6458
Brugia malayi Glycosyl hydrolases family 38 protein 0.0044 0.0036 0.0022
Echinococcus multilocularis ceramide glucosyltransferase 0.0735 0.4076 0.4068
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0008 0.005
Loa Loa (eye worm) hypothetical protein 0.0128 0.0524 0.0511
Trichomonas vaginalis alpha-glucosidase, putative 0.0318 0.1639 0.2138
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0197 0.0931 0.1195
Loa Loa (eye worm) hypothetical protein 0.0044 0.0036 0.0023
Loa Loa (eye worm) TRE-1 protein 0.0128 0.0524 0.0511
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0008 0.005
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0318 0.1639 1
Schistosoma mansoni alpha-glucosidase 0.1628 0.9292 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.0513 0.05
Loa Loa (eye worm) hypothetical protein 0.057 0.311 0.3101
Onchocerca volvulus 0.0128 0.0524 0.0652
Echinococcus granulosus lysosomal alpha glucosidase 0.1749 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0094 0.008
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.1749 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0318 0.1639 0.2138
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0228 0.1392
Schistosoma mansoni beta-galactosidase 0.0155 0.0686 0.0725
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0118 0.0105
Loa Loa (eye worm) trehalase 0.0044 0.0036 0.0023
Onchocerca volvulus Glucosylceramidase homolog 0.0882 0.4935 0.6537
Onchocerca volvulus 0.0058 0.0118 0.011
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0228 0.1392
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0228 0.135
Echinococcus granulosus glycogen debranching enzyme 0.0126 0.0513 0.05
Trypanosoma cruzi hypothetical protein, conserved 0.0318 0.1639 1
Entamoeba histolytica glycogen debranching enzyme, putative 0.0126 0.0513 0.3098
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0126 0.0513 0.0662
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0124 0.5
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0318 0.1639 0.2138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0228 0.135
Brugia malayi hypothetical protein 0.0128 0.0524 0.0511
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0155 0.0193
Trypanosoma brucei lysosomal alpha-mannosidase precursor, putative 0.0067 0.0169 0.0984
Trichomonas vaginalis alpha-mannosidase 2c1, putative 0.0044 0.0036 0.0036
Echinococcus granulosus bile acid beta glucosidase 0.0845 0.4715 0.4707
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0228 0.1392
Trypanosoma brucei glycosyl hydrolase-like protein 0.0197 0.0931 0.5658
Trypanosoma cruzi lysosomal alpha-mannosidase precursor, putative 0.008 0.0246 0.1501
Loa Loa (eye worm) hypothetical protein 0.0064 0.0153 0.014
Trichomonas vaginalis alpha-glucosidase, putative 0.0197 0.0931 0.121
Trypanosoma brucei glucosidase, putative 0.0318 0.1639 1
Loa Loa (eye worm) hypothetical protein 0.0197 0.0931 0.0919
Brugia malayi hypothetical protein 0.0044 0.0036 0.0023
Schistosoma mansoni bile acid beta-glucosidase-related 0.0845 0.4715 0.5067
Trichomonas vaginalis glucosylceramidase, putative 0.0882 0.4935 0.6458
Loa Loa (eye worm) hypothetical protein 0.0044 0.0036 0.0022
Loa Loa (eye worm) glycosyl hydrolase family 38 protein 0.0044 0.0036 0.0022
Schistosoma mansoni alpha glucosidase 0.0318 0.1639 0.1752
Loa Loa (eye worm) trehalase 0.0128 0.0524 0.0511
Trichomonas vaginalis alpha-glucosidase, putative 0.0318 0.1639 0.2138
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0094 0.0573
Treponema pallidum hypothetical protein 0.0044 0.0036 0.5
Loa Loa (eye worm) trehalase 0.0128 0.0524 0.0511
Brugia malayi Glycosyl hydrolases family 38 protein 0.0044 0.0036 0.0022
Onchocerca volvulus Ceramide glucosyltransferase homolog 0.0735 0.4076 0.5391
Toxoplasma gondii Amylo-alpha-1,6-glucosidase 0.0126 0.0513 0.3132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0228 0.135
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0318 0.1639 0.2138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0228 0.135
Echinococcus multilocularis alpha mannosidase 2 0.0044 0.0036 0.0022
Echinococcus multilocularis lysosomal alpha glucosidase 0.1749 1 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.1344 0.7637 0.7634
Trichomonas vaginalis glucosylceramidase, putative 0.093 0.5212 0.6821
Leishmania major cathepsin L-like protease 0.0077 0.0228 0.1392
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.0931 0.0919
Echinococcus multilocularis non lysosomal glucosylceramidase 0.0845 0.4715 0.4707
Onchocerca volvulus 0.0128 0.0524 0.0652
Echinococcus granulosus non lysosomal glucosylceramidase 0.0845 0.4715 0.4707
Leishmania major cathepsin L-like protease 0.0077 0.0228 0.1392
Brugia malayi hypothetical protein 0.0044 0.0036 0.0023
Echinococcus multilocularis lysosomal alpha glucosidase 0.1749 1 1
Echinococcus granulosus ceramide glucosyltransferase 0.0735 0.4076 0.4068
Loa Loa (eye worm) amylo-alpha-1,6-glucosidase 0.0061 0.0136 0.0122
Loa Loa (eye worm) hypothetical protein 0.0128 0.0524 0.0511
Loa Loa (eye worm) ceramide glucosyltransferase 0.0735 0.4076 0.4068
Leishmania major cathepsin L-like protease 0.0077 0.0228 0.1392
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.4649 0.4642
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0008 0.005
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0197 0.0931 0.5658
Brugia malayi Ceramide glucosyltransferase 0.0735 0.4076 0.4068
Onchocerca volvulus 0.0128 0.0524 0.0652
Loa Loa (eye worm) hypothetical protein 0.0128 0.0524 0.0511
Echinococcus multilocularis neutral alpha glucosidase AB 0.0318 0.1639 0.1628
Echinococcus granulosus beta galactosidase 0.0155 0.0686 0.0673
Echinococcus multilocularis bile acid beta glucosidase 0.0845 0.4715 0.4707
Trichomonas vaginalis alpha-glucosidase, putative 0.0197 0.0931 0.121
Loa Loa (eye worm) hypothetical protein 0.0083 0.0266 0.0252
Onchocerca volvulus 0.0128 0.0524 0.0652
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0197 0.0931 0.568
Onchocerca volvulus 0.1326 0.753 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0318 0.1639 0.1628
Trypanosoma cruzi hypothetical protein, conserved 0.0318 0.1639 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0197 0.0931 0.121
Loa Loa (eye worm) trehalase 0.0044 0.0036 0.0023
Trichomonas vaginalis alpha-mannosidase, putative 0.0044 0.0036 0.0036
Brugia malayi hypothetical protein 0.0286 0.1447 0.1435
Schistosoma mansoni hypothetical protein 0.0091 0.0309 0.0318
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1447 0.1435
Schistosoma mansoni alpha-glucosidase 0.1628 0.9292 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0228 0.135
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.1344 0.7637 0.7634
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0228 0.135
Brugia malayi trehalase 0.0044 0.0036 0.0023
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0059 0.0124 0.5
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0318 0.1639 1
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0044 0.0036 0.0024
Loa Loa (eye worm) hypothetical protein 0.0044 0.0036 0.0022
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0197 0.0931 0.568
Trichomonas vaginalis glucosylceramidase, putative 0.0882 0.4935 0.6458
Leishmania major DNA polymerase eta, putative 0.0054 0.0094 0.0573
Schistosoma mansoni bile acid beta-glucosidase-related 0.0845 0.4715 0.5067
Leishmania major glycosyl hydrolase-like protein 0.0197 0.0931 0.568
Loa Loa (eye worm) hypothetical protein 0.0128 0.0524 0.0511
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0189 0.1154
Schistosoma mansoni DNA polymerase eta 0.0054 0.0094 0.0087
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0197 0.0931 0.121
Onchocerca volvulus Trehalase homolog 0.0128 0.0524 0.0652
Loa Loa (eye worm) hypothetical protein 0.0128 0.0524 0.0511
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0094 0.0526
Brugia malayi Amylo-alpha-1,6-glucosidase family protein 0.0126 0.0513 0.05
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0228 0.135
Brugia malayi Trehalase protein 5 0.0044 0.0036 0.0023
Echinococcus multilocularis dna polymerase eta 0.0054 0.0094 0.008
Loa Loa (eye worm) hypothetical protein 0.0044 0.0036 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.1344 0.7637 1
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.4649 0.4996
Trichomonas vaginalis maltase-glucoamylase, putative 0.0318 0.1639 0.2138
Schistosoma mansoni mannosidase alpha class 2a 0.0044 0.0036 0.0024
Trichomonas vaginalis alpha-glucosidase, putative 0.0318 0.1639 0.2138
Echinococcus granulosus lysosomal alpha mannosidase 0.008 0.0246 0.0233
Schistosoma mansoni ceramide glucosyltransferase 0.0735 0.4076 0.4378
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0008 0.005
Trichomonas vaginalis glucosylceramidase, putative 0.1344 0.7637 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0036 0.0023
Loa Loa (eye worm) hypothetical protein 0.0286 0.1447 0.1435
Loa Loa (eye worm) hypothetical protein 0.0155 0.0686 0.0673

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 21.29 um PUBCHEM_BIOASSAY: Inhibitors of Plasmodium falciparum M17- Family Leucine Aminopeptidase (M17LAP). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 36.3 um PUBCHEM_BIOASSAY: Inhibitors of Plasmodium falciparum M1- Family Alanyl Aminopeptidase (M1AAP). Inhibition of the rate of hydrolysis of fluorogenic peptide substrate (H-Leu-NHMec). Secondary screen (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 7.3078 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 15.1014 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): Confirmation of Cherrypicks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 46.4515 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): Cherrypicks in WT IDH1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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