Detailed information for compound 1457607

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 454.329 | Formula: C20H14F4N2O6
  • H donors: 1 H acceptors: 5 LogP: 4.15 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cc1nnc(c2c1cccc2)O)OCC(=O)c1ccc(cc1OC(F)F)OC(F)F
  • InChi: 1S/C20H14F4N2O6/c21-19(22)31-10-5-6-13(16(7-10)32-20(23)24)15(27)9-30-17(28)8-14-11-3-1-2-4-12(11)18(29)26-25-14/h1-7,19-20H,8-9H2,(H,26,29)
  • InChiKey: UPLGZXXPOBBLTO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major alpha glucosidase II subunit, putative 0.0959 0.2042 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.4621 1 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0185 0.8342
Schistosoma mansoni hypothetical protein 0.0326 0.0667 0.0732
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0097 0.0198
Loa Loa (eye worm) ceramide glucosyltransferase 0.1192 0.2549 0.2549
Brugia malayi hypothetical protein 0.0045 0.0057 0.0057
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0066 0.0066
Trichomonas vaginalis alpha-glucosidase, putative 0.0959 0.2042 0.5173
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0959 0.2042 0.2042
Echinococcus multilocularis glycogen debranching enzyme 0.0254 0.051 0.051
Echinococcus multilocularis lysosomal alpha glucosidase 0.4621 1 1
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0066 0.0066
Trichomonas vaginalis sucrase-isomaltase, putative 0.0929 0.1977 0.5004
Brugia malayi intermediate filament protein 0.0026 0.0016 0.0016
Loa Loa (eye worm) trehalase 0.013 0.0242 0.0242
Brugia malayi hypothetical protein 0.0045 0.0057 0.0057
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0097 0.0097
Brugia malayi Trehalase family protein 0.013 0.0242 0.0242
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0097 0.0097
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0185 0.8342
Entamoeba histolytica beta-galactosidase, putative 0.0107 0.0192 0.0487
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.021 1
Onchocerca volvulus 0.013 0.0242 0.0313
Trichomonas vaginalis maltase-glucoamylase, putative 0.0959 0.2042 0.5173
Loa Loa (eye worm) TRE-2 protein 0.013 0.0242 0.0242
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0016 0.0016
Schistosoma mansoni lamin 0.0026 0.0016 0.0017
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0066 0.0041
Brugia malayi Glycosyl hydrolases family 38 protein 0.0045 0.0056 0.0056
Trichomonas vaginalis alpha-glucosidase, putative 0.0959 0.2042 0.5173
Echinococcus granulosus intermediate filament protein 0.0026 0.0016 0.0016
Schistosoma mansoni beta-mannosidase 0.0052 0.0071 0.0078
Echinococcus multilocularis non lysosomal glucosylceramidase 0.1041 0.2221 0.2221
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0066 0.0026
Brugia malayi hypothetical protein 0.0045 0.0057 0.0057
Treponema pallidum hypothetical protein 0.0045 0.0057 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0959 0.2042 0.5173
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0016 0.0016
Schistosoma mansoni beta-galactosidase 0.0504 0.1054 0.1156
Mycobacterium ulcerans alpha-mannosidase 0.0045 0.0056 0.5
Echinococcus granulosus neutral alpha glucosidase AB 0.0959 0.2042 0.2042
Loa Loa (eye worm) hypothetical protein 0.013 0.0242 0.0242
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0097 0.0198
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0959 0.2042 1
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0058 0.0058
Loa Loa (eye worm) beta-glucuronidase 0.0052 0.0071 0.0071
Brugia malayi Beta-glucuronidase precursor 0.0052 0.0071 0.0071
Onchocerca volvulus Ceramide glucosyltransferase homolog 0.1192 0.2549 0.351
Onchocerca volvulus 0.0045 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0254 0.051 0.051
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0016 0.0016
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0066 0.0041
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0058 0.0058
Echinococcus multilocularis lamin dm0 0.0026 0.0016 0.0016
Schistosoma mansoni bile acid beta-glucosidase-related 0.1041 0.2221 0.2437
Trichomonas vaginalis glucosylceramidase, putative 0.1811 0.3895 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0093 0.0093
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0093 0.0102
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0039 0.0039
Echinococcus granulosus cpg binding protein 0.003 0.0023 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.1253 0.268 0.6836
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0066 0.0066
Loa Loa (eye worm) amylo-alpha-1,6-glucosidase 0.0123 0.0227 0.0227
Onchocerca volvulus 0.013 0.0242 0.0313
Loa Loa (eye worm) hypothetical protein 0.0026 0.0015 0.0015
Plasmodium vivax hypothetical protein, conserved 0.0154 0.0293 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0097 0.0097
Echinococcus multilocularis expressed protein 0.0361 0.0742 0.0742
Brugia malayi hypothetical protein 0.0057 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0045 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.0016
Loa Loa (eye worm) TRE-1 protein 0.013 0.0242 0.0242
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.021 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0959 0.2042 0.2042
Echinococcus multilocularis bile acid beta glucosidase 0.1041 0.2221 0.2221
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0088 0.0096
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0093 0.0093
Onchocerca volvulus 0.0045 0.0056 0.0056
Trichomonas vaginalis alpha-glucosidase, putative 0.0521 0.109 0.2693
Onchocerca volvulus Trehalase homolog 0.013 0.0242 0.0313
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0093 0.0102
Schistosoma mansoni lamin 0.0026 0.0016 0.0017
Schistosoma mansoni hypothetical protein 0.0183 0.0357 0.0391
Echinococcus granulosus lysosomal alpha mannosidase 0.0081 0.0136 0.0136
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0093 0.0102
Loa Loa (eye worm) hypothetical protein 0.0521 0.109 0.109
Brugia malayi RNA binding protein 0.0062 0.0093 0.0093
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0521 0.109 0.5104
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0029 0.0021 0.0023
Brugia malayi CXXC zinc finger family protein 0.0028 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0045 0.0057 0.0057
Echinococcus multilocularis alpha mannosidase 2 0.0045 0.0056 0.0056
Echinococcus multilocularis neutral alpha glucosidase AB 0.0959 0.2042 0.2042
Trichomonas vaginalis conserved hypothetical protein 0.013 0.0242 0.0483
Trichomonas vaginalis glucosylceramidase, putative 0.1811 0.3895 1
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0066 0.0026
Loa Loa (eye worm) hypothetical protein 0.0687 0.1451 0.1451
Brugia malayi manba-prov protein 0.0052 0.0071 0.0071
Trypanosoma brucei glycosyl hydrolase-like protein 0.0521 0.109 0.5201
Echinococcus multilocularis cpg binding protein 0.003 0.0023 0.0023
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0521 0.109 0.2693
Entamoeba histolytica glycogen debranching enzyme, putative 0.0254 0.051 0.2121
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.1811 0.3895 0.3895
Loa Loa (eye worm) hypothetical protein 0.0029 0.0021 0.0021
Brugia malayi Glycosyl hydrolases family 38 protein 0.0045 0.0056 0.0056
Giardia lamblia 4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase 0.0254 0.051 0.4157
Echinococcus multilocularis lamin 0.0026 0.0016 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.1189 0.2541 0.6474
Trichomonas vaginalis alpha-glucosidase, putative 0.0521 0.109 0.2693
Schistosoma mansoni intermediate filament proteins 0.0026 0.0016 0.0017
Echinococcus granulosus bile acid beta glucosidase 0.1041 0.2221 0.2221
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0097 0.0097
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0959 0.2042 1
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0066 0.0073
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0066 0.0041
Trypanosoma cruzi lysosomal alpha-mannosidase precursor, putative 0.0081 0.0136 0.0391
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0093 0.0102
Brugia malayi Trehalase protein 5 0.0045 0.0057 0.0057
Schistosoma mansoni alpha-glucosidase 0.4213 0.9113 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0521 0.109 0.5201
Trypanosoma brucei lysosomal alpha-mannosidase precursor, putative 0.0081 0.0136 0.0391
Brugia malayi trehalase 0.0045 0.0057 0.0057
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0521 0.109 0.1488
Onchocerca volvulus 0.0028 0.002 0.0006
Echinococcus granulosus non lysosomal glucosylceramidase 0.1041 0.2221 0.2221
Echinococcus multilocularis lysosomal alpha mannosidase 0.0081 0.0136 0.0136
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.4621 1 1
Brugia malayi Glycosyl hydrolases family 2, sugar binding domain containing protein 0.0056 0.008 0.008
Brugia malayi Glycosyl hydrolases family 38 protein 0.0045 0.0056 0.0056
Mycobacterium tuberculosis Probable reductase 0.0104 0.0185 0.8342
Trypanosoma cruzi hypothetical protein, conserved 0.0959 0.2042 1
Brugia malayi Trehalase family protein 0.0045 0.0057 0.0057
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0097 0.0198
Echinococcus multilocularis beta galactosidase 0.0504 0.1054 0.1054
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0521 0.109 0.5201
Echinococcus granulosus dnaJ subfamily B 0.0399 0.0826 0.0826
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0066 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.1189 0.2541 0.6474
Echinococcus multilocularis ceramide glucosyltransferase 0.1192 0.2549 0.2549
Loa Loa (eye worm) hypothetical protein 0.0703 0.1486 0.1486
Trichomonas vaginalis trehalase, putative 0.013 0.0242 0.0483
Echinococcus granulosus expressed protein 0.0361 0.0742 0.0742
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0097 0.0107
Loa Loa (eye worm) hypothetical protein 0.0065 0.0101 0.0101
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0066 0.0041
Loa Loa (eye worm) hypothetical protein 0.0045 0.0056 0.0056
Trichomonas vaginalis glucosylceramidase, putative 0.1189 0.2541 0.6474
Brugia malayi lysosomal alpha-mannosidase 0.0045 0.0056 0.0056
Trichomonas vaginalis glucosylceramidase, putative 0.1811 0.3895 1
Trypanosoma brucei glucosidase, putative 0.0959 0.2042 1
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0081 0.0136 0.0149
Echinococcus granulosus lysosomal alpha glucosidase 0.4621 1 1
Brugia malayi TAR-binding protein 0.0062 0.0093 0.0093
Loa Loa (eye worm) trehalase 0.0045 0.0057 0.0057
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0959 0.2042 0.5173
Loa Loa (eye worm) RNA binding protein 0.0062 0.0093 0.0093
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0254 0.051 0.1182
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0066 0.0041
Echinococcus granulosus lamin 0.0026 0.0016 0.0016
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0093 0.0093
Schistosoma mansoni cpg binding protein 0.0028 0.002 0.0022
Schistosoma mansoni alpha-glucosidase 0.4213 0.9113 1
Brugia malayi Trehalase family protein 0.013 0.0242 0.0242
Echinococcus granulosus lamin dm0 0.0026 0.0016 0.0016
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.0826 0.0826
Trichomonas vaginalis beta-galactosidase, putative 0.0159 0.0304 0.0646
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.021 1
Brugia malayi hypothetical protein 0.013 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0045 0.0057 0.0057
Schistosoma mansoni lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) 0.0045 0.0056 0.0062
Trichomonas vaginalis maltase-glucoamylase, putative 0.0521 0.109 0.2693
Loa Loa (eye worm) trehalase 0.013 0.0242 0.0242
Brugia malayi trehalase I 0.0045 0.0057 0.0057
Loa Loa (eye worm) trehalase 0.013 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0085 0.0144 0.0144
Loa Loa (eye worm) glycosyl hydrolase family 38 protein 0.0045 0.0056 0.0056
Loa Loa (eye worm) trehalase 0.0045 0.0057 0.0057
Brugia malayi Amylo-alpha-1,6-glucosidase family protein 0.0254 0.051 0.051
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.002 0.002
Schistosoma mansoni ceramide glucosyltransferase 0.1192 0.2549 0.2797
Loa Loa (eye worm) hypothetical protein 0.0504 0.1054 0.1054
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0066 0.0066
Schistosoma mansoni alpha glucosidase 0.0959 0.2042 0.2241
Trichomonas vaginalis alpha-glucosidase, putative 0.0521 0.109 0.2693
Trichomonas vaginalis glucosylceramidase, putative 0.1253 0.268 0.6836
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0185 0.8342
Trichomonas vaginalis glucosylceramidase, putative 0.1189 0.2541 0.6474
Trichomonas vaginalis glucosylceramidase, putative 0.1189 0.2541 0.6474
Schistosoma mansoni hypothetical protein 0.0151 0.0286 0.0314
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0929 0.1977 0.9666
Trichomonas vaginalis alpha-glucosidase, putative 0.0521 0.109 0.2693
Onchocerca volvulus 0.013 0.0242 0.0313
Trichomonas vaginalis glucosylceramidase, putative 0.1811 0.3895 1
Trichomonas vaginalis glucosylceramidase, putative 0.1811 0.3895 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0097 0.0198
Brugia malayi Trehalase family protein 0.013 0.0242 0.0242
Loa Loa (eye worm) glycosyl hydrolase family 2 0.0056 0.008 0.008
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0039 0.0039
Giardia lamblia Ceramide glucosyltransferase 0.054 0.1133 1
Loa Loa (eye worm) hypothetical protein 0.013 0.0242 0.0242
Onchocerca volvulus 0.013 0.0242 0.0313
Trichomonas vaginalis alpha-glucosidase, putative 0.0521 0.109 0.2693
Brugia malayi Trehalase family protein 0.0045 0.0057 0.0057
Echinococcus granulosus ceramide glucosyltransferase 0.1192 0.2549 0.2549
Echinococcus multilocularis musashi 0.0026 0.0016 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0959 0.2042 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0074 0.0081
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.1811 0.3895 0.3895
Loa Loa (eye worm) hypothetical protein 0.013 0.0242 0.0242
Onchocerca volvulus 0.013 0.0242 0.0313
Trichomonas vaginalis glycoside hydrolase, putative 0.0254 0.051 0.1183
Leishmania major glycosyl hydrolase-like protein 0.0521 0.109 0.5201
Echinococcus granulosus tar DNA binding protein 0.0062 0.0093 0.0093
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.021 1
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.0304 0.0646
Schistosoma mansoni cpg binding protein 0.003 0.0023 0.0025
Onchocerca volvulus 0.3348 0.7233 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0093 0.0102
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0254 0.051 0.1182
Onchocerca volvulus Glucosylceramidase homolog 0.1189 0.2541 0.3499
Brugia malayi Glycosyl hydrolases family 31 protein 0.0521 0.109 0.109
Loa Loa (eye worm) hypothetical protein 0.0045 0.0057 0.0057
Schistosoma mansoni ceramide glucosyltransferase 0.1192 0.2549 0.2797
Trichomonas vaginalis glycoside hydrolases, putative 0.0255 0.0512 0.1188
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0066 0.0066
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0066 0.0026
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0959 0.2042 0.5173
Trypanosoma brucei protein kinase, putative 0.0049 0.0066 0.0041
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0521 0.109 0.2693
Loa Loa (eye worm) hypothetical protein 0.013 0.0242 0.0242
Trichomonas vaginalis alpha-glucosidase, putative 0.0959 0.2042 0.5173
Trichomonas vaginalis beta-glucosidase, putative 0.0255 0.0512 0.1188
Brugia malayi Trehalase family protein 0.013 0.0242 0.0242
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0066 0.0026
Schistosoma mansoni bile acid beta-glucosidase-related 0.1041 0.2221 0.2437
Echinococcus granulosus beta galactosidase 0.0504 0.1054 0.1054
Trichomonas vaginalis glucosylceramidase, putative 0.1811 0.3895 1
Loa Loa (eye worm) hypothetical protein 0.013 0.0242 0.0242
Brugia malayi MAP kinase sur-1 0.0049 0.0066 0.0066
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0045 0.0057 0.0057
Schistosoma mansoni mannosidase alpha class 2a 0.0045 0.0056 0.0062
Trichomonas vaginalis glucosylceramidase, putative 0.1189 0.2541 0.6474
Echinococcus granulosus glycogen debranching enzyme 0.0254 0.051 0.051
Trichomonas vaginalis glucosylceramidase, putative 0.1189 0.2541 0.6474
Schistosoma mansoni hypothetical protein 0.0399 0.0826 0.0906
Brugia malayi glutathione reductase 0.0046 0.0058 0.0058
Schistosoma mansoni cpg binding protein 0.003 0.0023 0.0025
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0185 0.8342
Toxoplasma gondii Amylo-alpha-1,6-glucosidase 0.0254 0.051 0.2277
Trichomonas vaginalis beta-mannosidase, putative 0.0052 0.0071 0.0038
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0066 0.0041
Brugia malayi Thioredoxin reductase 0.0046 0.0058 0.0058
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0185 0.8342
Loa Loa (eye worm) glutathione reductase 0.0046 0.0058 0.0058
Trypanosoma brucei lysosomal alpha-mannosidase precursor, putative 0.0068 0.0106 0.0244
Brugia malayi Ceramide glucosyltransferase 0.1192 0.2549 0.2549
Trichomonas vaginalis alpha-glucosidase, putative 0.0959 0.2042 0.5173
Trichomonas vaginalis conserved hypothetical protein 0.013 0.0242 0.0483
Trypanosoma cruzi lysosomal alpha-mannosidase precursor, putative 0.0081 0.0136 0.0391
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0154 0.0293 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0066 0.0041
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0093 0.0093

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.