Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Rattus norvegicus | Inositol monophosphatase 1 | Starlite/ChEMBL | No references |
Homo sapiens | estrogen receptor 1 | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), beta | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0025 | 0.0056 | 0.0056 |
Toxoplasma gondii | hypothetical protein | 0.0059 | 0.0375 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 0.3281 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.176 | 0.176 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0.0239 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0051 | 0.0303 | 0.0923 |
Loa Loa (eye worm) | hyaluronidase | 0.1072 | 1 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.0239 | 0.073 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0045 | 0.0239 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0056 | 0.5 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0365 | 0.3281 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.0303 | 0.0923 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0341 | 0.0341 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 0.0239 | 0.0239 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.1072 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 0.3281 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0173 | 0.1456 | 0.4437 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0365 | 0.3281 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0045 | 0.0239 | 0.5 |
Loa Loa (eye worm) | inositol-1 | 0.0045 | 0.0239 | 0.0239 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0341 | 0.0341 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0192 | 0.1641 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0056 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0173 | 0.1456 | 0.4437 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0341 | 0.0341 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0045 | 0.0239 | 0.5753 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0341 | 0.0341 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0056 | 0.0172 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0056 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.176 | 0.176 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0045 | 0.0239 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 0.0239 | 0.0239 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.1072 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0056 | 0.0172 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0341 | 0.0341 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.004 | 0.0195 | 0.1189 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0051 | 0.0303 | 0.0923 |
Loa Loa (eye worm) | hypothetical protein | 0.0455 | 0.4142 | 0.4142 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0173 | 0.1456 | 0.4437 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.9121 | 0.9121 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0045 | 0.0239 | 0.0239 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0341 | 0.0341 |
Schistosoma mansoni | Hyaluronidase | 0.1072 | 1 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.0239 | 0.073 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.176 | 0.176 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0062 | 0.041 | 0.1248 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0.0239 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0056 | 0.0172 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.0239 | 0.073 |
Brugia malayi | Inositol-1 | 0.0045 | 0.0239 | 0.0239 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0341 | 0.0341 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0341 | 0.0341 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.0239 | 0.073 |
Mycobacterium ulcerans | hypothetical protein | 0.0192 | 0.1641 | 1 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.1072 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.176 | 0.176 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0056 | 0.0172 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.004 | 0.0195 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0056 | 0.0056 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0045 | 0.0239 | 0.0239 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0051 | 0.0303 | 0.0923 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0045 | 0.0239 | 0.1459 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0341 | 0.0341 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 12.75666 um | PUBCHEM_BIOASSAY: Estrogen Receptor-alpha Coactivator Binding Potentiators Dose Response Confirmation. (Class of assay: confirmatory) [Related pubchem assays: 639 (Primary screen preceding this dose response confirmation assay.)] | ChEMBL. | No reference |
IC50 (functional) | 43.962 uM | PubChem BioAssay. Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 1.122 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.2753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10.3225 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.