Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable transketolase Tkt (TK) | 0.0194 | 0.4072 | 1 |
Entamoeba histolytica | transketolase, putative | 0.0194 | 0.4072 | 1 |
Chlamydia trachomatis | transketolase | 0.0194 | 0.4072 | 1 |
Onchocerca volvulus | 0.0071 | 0 | 0.5 | |
Mycobacterium ulcerans | transketolase | 0.0194 | 0.4072 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0373 | 1 | 1 |
Toxoplasma gondii | transketolase | 0.0194 | 0.4072 | 1 |
Entamoeba histolytica | transketolase, putative | 0.0194 | 0.4072 | 1 |
Plasmodium vivax | transketolase, putative | 0.0123 | 0.173 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0373 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | transketolase | 0.0194 | 0.4072 | 1 |
Trichomonas vaginalis | transketolase, putative | 0.0194 | 0.4072 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0143 | 0.2401 | 0.4126 |
Echinococcus granulosus | transketolase | 0.0194 | 0.4072 | 0.3243 |
Echinococcus multilocularis | transketolase | 0.0194 | 0.4072 | 0.3243 |
Treponema pallidum | transketolase | 0.0123 | 0.173 | 1 |
Giardia lamblia | Transketolase | 0.0123 | 0.173 | 0.5 |
Brugia malayi | transketolase | 0.0194 | 0.4072 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.4072 | 1 |
Echinococcus multilocularis | geminin | 0.0373 | 1 | 1 |
Trypanosoma cruzi | transketolase, putative | 0.0194 | 0.4072 | 1 |
Entamoeba histolytica | transketolase, putative | 0.0194 | 0.4072 | 1 |
Echinococcus multilocularis | transketolase | 0.0194 | 0.4072 | 0.3243 |
Brugia malayi | MH2 domain containing protein | 0.0143 | 0.2401 | 0.4126 |
Schistosoma mansoni | transketolase | 0.0194 | 0.4072 | 0.3243 |
Echinococcus granulosus | transketolase | 0.0194 | 0.4072 | 0.3243 |
Trypanosoma brucei | transketolase, putative | 0.0194 | 0.4072 | 1 |
Mycobacterium tuberculosis | Transketolase Tkt (TK) | 0.0194 | 0.4072 | 1 |
Leishmania major | transketolase | 0.0194 | 0.4072 | 1 |
Schistosoma mansoni | transketolase | 0.0194 | 0.4072 | 0.3243 |
Trypanosoma cruzi | transketolase, putative | 0.0194 | 0.4072 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0143 | 0.2401 | 0.4126 |
Entamoeba histolytica | transketolase, putative | 0.0123 | 0.173 | 0.1768 |
Plasmodium falciparum | transketolase | 0.0123 | 0.173 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.07 uM kg-1 | In vivo antinociceptive activity using mouse tail flick test, subcutaneous administration | ChEMBL. | 1652025 |
ED50 (functional) | = 0.07 uM kg-1 | In vivo antinociceptive activity using mouse tail flick test, subcutaneous administration | ChEMBL. | 1652025 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.