Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0998 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0377 | 0.359 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0708 | 0.7005 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0998 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0708 | 0.7005 | 0.6572 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0413 | 0.3965 | 0.1097 |
Entamoeba histolytica | cysteine protease, putative | 0.0708 | 0.7005 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0708 | 0.7005 | 0.7005 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0708 | 0.7005 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0708 | 0.7005 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Leishmania major | cathepsin L-like protease | 0.0708 | 0.7005 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0377 | 0.359 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1262 | 0.1262 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0377 | 0.359 | 0.2664 |
Plasmodium vivax | vivapain-1 | 0.0377 | 0.359 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1262 | 0.1262 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0377 | 0.359 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0377 | 0.359 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Leishmania major | cathepsin L-like protease | 0.0708 | 0.7005 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0225 | 0.2021 | 0.2021 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0377 | 0.359 | 0.359 |
Plasmodium vivax | vivapain-2 | 0.0708 | 0.7005 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0708 | 0.7005 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Echinococcus granulosus | cathepsin L | 0.0377 | 0.359 | 0.2664 |
Loa Loa (eye worm) | hypothetical protein | 0.0482 | 0.4677 | 0.4677 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0998 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0708 | 0.7005 | 0.6572 |
Echinococcus granulosus | cathepsin l1 | 0.0708 | 0.7005 | 0.6572 |
Brugia malayi | cathepsin L precursor | 0.0152 | 0.1262 | 0.1262 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0708 | 0.7005 | 0.6572 |
Brugia malayi | cahepsin L-like non-peptiedase homolog | 0.0152 | 0.1262 | 0.1262 |
Plasmodium vivax | unspecified product | 0.0377 | 0.359 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.0708 | 0.7005 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0152 | 0.1262 | 0.1262 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0708 | 0.7005 | 0.7005 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0377 | 0.359 | 0.2664 |
Loa Loa (eye worm) | cysteine protease | 0.0708 | 0.7005 | 0.7005 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0708 | 0.7005 | 0.7005 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0377 | 0.359 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0708 | 0.7005 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1262 | 0.1262 |
Schistosoma mansoni | cathepsin s | 0.0225 | 0.2021 | 0.0868 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0708 | 0.7005 | 0.6572 |
Onchocerca volvulus | Cathepsin F homolog | 0.0708 | 0.7005 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0708 | 0.7005 | 1 |
Leishmania major | cathepsin L-like protease | 0.0708 | 0.7005 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1262 | 0.1262 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0152 | 0.1262 | 0.1262 |
Loa Loa (eye worm) | hypothetical protein | 0.0708 | 0.7005 | 0.7005 |
Onchocerca volvulus | 0.0708 | 0.7005 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0708 | 0.7005 | 0.6572 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Toxoplasma gondii | cathepsin B | 0.0413 | 0.3965 | 0.4706 |
Plasmodium vivax | unspecified product | 0.0225 | 0.2021 | 0.132 |
Loa Loa (eye worm) | cathepsin B | 0.0413 | 0.3965 | 0.3965 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0152 | 0.1262 | 0.1262 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0377 | 0.359 | 0.2664 |
Entamoeba histolytica | cysteine protease, putative | 0.0377 | 0.359 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Echinococcus granulosus | cathepsin b | 0.0998 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0708 | 0.7005 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0413 | 0.3965 | 1 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0377 | 0.359 | 0.4054 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0708 | 0.7005 | 0.6572 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.2021 | 0.2021 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0998 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0708 | 0.7005 | 0.7005 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.0152 | 0.1262 | 0.1262 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0377 | 0.359 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0708 | 0.7005 | 0.7005 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0225 | 0.2021 | 0.0868 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0377 | 0.359 | 0.2664 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0377 | 0.359 | 0.4054 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0152 | 0.1262 | 0.1262 |
Onchocerca volvulus | Cathepsin L homolog | 0.0708 | 0.7005 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0708 | 0.7005 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0482 | 0.4677 | 0.3907 |
Entamoeba histolytica | cysteine protease, putative | 0.0377 | 0.359 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0413 | 0.3965 | 0.3093 |
Leishmania major | cathepsin L-like protease | 0.0708 | 0.7005 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0998 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0377 | 0.359 | 0.4054 |
Loa Loa (eye worm) | fibroinase | 0.0708 | 0.7005 | 0.7005 |
Onchocerca volvulus | 0.0708 | 0.7005 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0377 | 0.359 | 0.4054 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0377 | 0.359 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0482 | 0.4677 | 0.4677 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0708 | 0.7005 | 0.7005 |
Brugia malayi | fibroinase precursor | 0.0152 | 0.1262 | 0.1262 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.2021 | 0.2021 |
Onchocerca volvulus | 0.0708 | 0.7005 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0708 | 0.7005 | 1 |
Onchocerca volvulus | 0.0482 | 0.4677 | 0.5946 | |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0708 | 0.7005 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0482 | 0.4677 | 0.4677 |
Entamoeba histolytica | cysteine protease, putative | 0.0377 | 0.359 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Onchocerca volvulus | 0.0708 | 0.7005 | 1 | |
Entamoeba histolytica | cysteine protease, putative | 0.0377 | 0.359 | 0.4054 |
Onchocerca volvulus | 0.0708 | 0.7005 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0708 | 0.7005 | 0.6572 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0708 | 0.7005 | 0.6572 |
Onchocerca volvulus | 0.0708 | 0.7005 | 1 | |
Brugia malayi | cathepsin L-like cysteine proteinase | 0.0152 | 0.1262 | 0.1262 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0225 | 0.2021 | 0.2021 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0482 | 0.4677 | 0.5946 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0708 | 0.7005 | 0.6572 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0377 | 0.359 | 0.2664 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0482 | 0.4677 | 0.5946 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0377 | 0.359 | 0.2664 |
Entamoeba histolytica | cysteine protease, putative | 0.0377 | 0.359 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0708 | 0.7005 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0482 | 0.4677 | 0.4677 |
Entamoeba histolytica | cysteine protease, putative | 0.0377 | 0.359 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0708 | 0.7005 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0377 | 0.359 | 0.2664 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0377 | 0.359 | 0.359 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0708 | 0.7005 | 0.6572 |
Leishmania major | cysteine peptidase A (CPA) | 0.0708 | 0.7005 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0482 | 0.4677 | 0.4677 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0482 | 0.4677 | 0.3907 |
Echinococcus multilocularis | cysteine protease | 0.0708 | 0.7005 | 0.6572 |
Loa Loa (eye worm) | cysteine proteinase cathepsin Z | 0.0152 | 0.1262 | 0.1262 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0708 | 0.7005 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0225 | 0.2021 | 0.0868 |
Echinococcus granulosus | cathepsin l1 | 0.0482 | 0.4677 | 0.3907 |
Giardia lamblia | Cathepsin B precursor | 0.0413 | 0.3965 | 1 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.0152 | 0.1262 | 0.1262 |
Echinococcus multilocularis | cathepsin L | 0.0377 | 0.359 | 0.2664 |
Brugia malayi | cathepsin L-like precursor | 0.0482 | 0.4677 | 0.4677 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0708 | 0.7005 | 0.6572 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0225 | 0.2021 | 0.2021 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0152 | 0.1262 | 0.1262 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0413 | 0.3965 | 0.4706 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0152 | 0.1262 | 0.1262 |
Echinococcus granulosus | cathepsin b | 0.0998 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0998 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0708 | 0.7005 | 0.7005 |
Leishmania major | cathepsin L-like protease | 0.0708 | 0.7005 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0482 | 0.4677 | 0.4677 |
Leishmania major | cathepsin L-like protease | 0.0708 | 0.7005 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1262 | 0.1262 |
Brugia malayi | Cathepsin L-like precursor | 0.0708 | 0.7005 | 0.7005 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0225 | 0.2021 | 0.2021 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0708 | 0.7005 | 0.6572 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0708 | 0.7005 | 0.7005 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0377 | 0.359 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Plasmodium vivax | vivapain-2 | 0.0708 | 0.7005 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0377 | 0.359 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0708 | 0.7005 | 1 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0377 | 0.359 | 0.2664 |
Entamoeba histolytica | cysteine protease, putative | 0.0377 | 0.359 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.0708 | 0.7005 | 0.7005 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0708 | 0.7005 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0482 | 0.4677 | 0.5946 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0708 | 0.7005 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0413 | 0.3965 | 1 |
Echinococcus granulosus | cysteine protease | 0.0377 | 0.359 | 0.2664 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0708 | 0.7005 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0708 | 0.7005 | 0.6572 |
Trypanosoma cruzi | cysteine protease, putative | 0.0377 | 0.359 | 0.2664 |
Plasmodium vivax | vivapain-3 | 0.0377 | 0.359 | 0.4054 |
Echinococcus multilocularis | cathepsin b | 0.0998 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0413 | 0.3965 | 0.3093 |
Onchocerca volvulus | Cathepsin L homolog | 0.0708 | 0.7005 | 1 |
Onchocerca volvulus | 0.0708 | 0.7005 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1262 | 0.1262 |
Leishmania major | cathepsin L-like protease | 0.0708 | 0.7005 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.2021 | 0.2021 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0998 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0708 | 0.7005 | 0.6572 |
Entamoeba histolytica | cysteine protease, putative | 0.0377 | 0.359 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0708 | 0.7005 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0377 | 0.359 | 0.4054 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 21 % | Antiinflammatory activity against histamine-induced mouse edema model assessed as antiinflammatory effect 20 mg/kg, po (untreated control = 0%) | ChEMBL. | 21159508 |
Activity (functional) | = 22 % | Antiinflammatory activity against histamine-induced mouse edema model assessed as antiinflammatory effect 50 mg/kg, po (untreated control = 0%) | ChEMBL. | 21159508 |
Activity (functional) | = 25.4 % | Antiinflammatory activity against histamine-induced mouse edema model assessed as inflammation index 50 mg/kg, po (untreated control = 32.6+/-3.1%) | ChEMBL. | 21159508 |
Activity (functional) | = 25.6 % | Antiinflammatory activity against histamine-induced mouse edema model assessed as inflammation index 20 mg/kg, po (untreated control = 32.6+/-3.1%) | ChEMBL. | 21159508 |
Activity (functional) | = 41 % | Antioxidant activity agains CCl4-induced hepatitis mouse model assessed as TBARS level in serum at 20 mg/kg, po (untreated control = 100%) | ChEMBL. | 21159508 |
Activity (functional) | = 59 % | Antioxidant activity agains CCl4-induced hepatitis mouse model at 20 mg/kg, po (untreated control = 0%) | ChEMBL. | 21159508 |
Inhibition (functional) | = 77.9 % | Antiinflammatory activity against histamine-induced mouse edema model assessed as edema size 50 mg/kg, po (untreated control = 100%) | ChEMBL. | 21159508 |
Inhibition (functional) | = 78.5 % | Antiinflammatory activity against histamine-induced mouse edema model assessed as edema size 20 mg/kg, po (untreated control = 100%) | ChEMBL. | 21159508 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.