Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cathepsin L-like protease | 0.0606 | 0.6391 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0132 | 0.1154 | 0.1154 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0606 | 0.6391 | 0.6391 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0324 | 0.3277 | 0.24 |
Loa Loa (eye worm) | cysteine protease | 0.0606 | 0.6391 | 0.6391 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0606 | 0.6391 | 0.592 |
Brugia malayi | cahepsin L-like non-peptiedase homolog | 0.0132 | 0.1154 | 0.1154 |
Plasmodium vivax | unspecified product | 0.0324 | 0.3277 | 0.4054 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0606 | 0.6391 | 0.6391 |
Plasmodium vivax | vivapain-2 | 0.0606 | 0.6391 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0606 | 0.6391 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Leishmania major | cathepsin L-like protease | 0.0606 | 0.6391 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0192 | 0.1818 | 0.1818 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0324 | 0.3277 | 0.3277 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0606 | 0.6391 | 0.592 |
Brugia malayi | cathepsin L precursor | 0.0132 | 0.1154 | 0.1154 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Echinococcus granulosus | cathepsin L | 0.0324 | 0.3277 | 0.24 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.4268 | 0.4268 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0932 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0606 | 0.6391 | 0.592 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0379 | 0.389 | 0.1968 |
Entamoeba histolytica | cysteine protease, putative | 0.0606 | 0.6391 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0606 | 0.6391 | 0.6391 |
Toxoplasma gondii | cathepsin CPL | 0.0606 | 0.6391 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0606 | 0.6391 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1154 | 0.1154 |
Entamoeba histolytica | cysteine protease, putative | 0.0324 | 0.3277 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0324 | 0.3277 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.0606 | 0.6391 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1154 | 0.1154 |
Entamoeba histolytica | cysteine protease, putative | 0.0324 | 0.3277 | 0.4054 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0324 | 0.3277 | 0.24 |
Plasmodium vivax | vivapain-1 | 0.0324 | 0.3277 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0324 | 0.3277 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0606 | 0.6391 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0932 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0932 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0606 | 0.6391 | 0.592 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0324 | 0.3277 | 0.24 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0192 | 0.1818 | 0.0751 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0324 | 0.3277 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0606 | 0.6391 | 0.6391 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0606 | 0.6391 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0606 | 0.6391 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0414 | 0.4268 | 0.352 |
Entamoeba histolytica | cysteine protease, putative | 0.0324 | 0.3277 | 0.4054 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0132 | 0.1154 | 0.1154 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.1818 | 0.1818 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0606 | 0.6391 | 0.592 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0932 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0606 | 0.6391 | 0.6391 |
Echinococcus granulosus | cathepsin b | 0.0932 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0606 | 0.6391 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0379 | 0.389 | 1 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0324 | 0.3277 | 0.4054 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.0132 | 0.1154 | 0.1154 |
Leishmania major | cathepsin L-like protease | 0.0606 | 0.6391 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1154 | 0.1154 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0132 | 0.1154 | 0.1154 |
Onchocerca volvulus | Cathepsin F homolog | 0.0606 | 0.6391 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0606 | 0.6391 | 0.592 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0606 | 0.6391 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0379 | 0.389 | 0.389 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0324 | 0.3277 | 0.24 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0132 | 0.1154 | 0.1154 |
Entamoeba histolytica | cysteine protease, putative | 0.0324 | 0.3277 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0606 | 0.6391 | 0.6391 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0606 | 0.6391 | 0.592 |
Onchocerca volvulus | 0.0606 | 0.6391 | 1 | |
Toxoplasma gondii | cathepsin B | 0.0379 | 0.389 | 0.5224 |
Plasmodium vivax | unspecified product | 0.0192 | 0.1818 | 0.1269 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0606 | 0.6391 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1154 | 0.1154 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0324 | 0.3277 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Schistosoma mansoni | cathepsin s | 0.0192 | 0.1818 | 0.0751 |
Brugia malayi | Cathepsin L-like precursor | 0.0414 | 0.4268 | 0.4268 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0414 | 0.4268 | 0.352 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0606 | 0.6391 | 0.592 |
Leishmania major | cysteine peptidase A (CPA) | 0.0606 | 0.6391 | 1 |
Echinococcus multilocularis | cathepsin L | 0.0324 | 0.3277 | 0.24 |
Echinococcus multilocularis | cysteine protease | 0.0606 | 0.6391 | 0.592 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0606 | 0.6391 | 1 |
Loa Loa (eye worm) | cysteine proteinase cathepsin Z | 0.0132 | 0.1154 | 0.1154 |
Giardia lamblia | Cathepsin B precursor | 0.0379 | 0.389 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0192 | 0.1818 | 0.0751 |
Echinococcus granulosus | cathepsin l1 | 0.0414 | 0.4268 | 0.352 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.0132 | 0.1154 | 0.1154 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0414 | 0.4268 | 0.5946 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0324 | 0.3277 | 0.24 |
Onchocerca volvulus | 0.0606 | 0.6391 | 1 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0606 | 0.6391 | 0.592 |
Brugia malayi | cathepsin L-like cysteine proteinase | 0.0132 | 0.1154 | 0.1154 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0192 | 0.1818 | 0.1818 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0414 | 0.4268 | 0.5946 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0606 | 0.6391 | 0.592 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0324 | 0.3277 | 0.24 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0414 | 0.4268 | 0.4268 |
Entamoeba histolytica | cysteine protease, putative | 0.0324 | 0.3277 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0606 | 0.6391 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0324 | 0.3277 | 0.3277 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0324 | 0.3277 | 0.24 |
Entamoeba histolytica | cysteine protease, putative | 0.0324 | 0.3277 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0606 | 0.6391 | 1 |
Onchocerca volvulus | 0.0414 | 0.4268 | 0.5946 | |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0606 | 0.6391 | 1 |
Brugia malayi | fibroinase precursor | 0.0132 | 0.1154 | 0.1154 |
Onchocerca volvulus | 0.0606 | 0.6391 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.1818 | 0.1818 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0606 | 0.6391 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0324 | 0.3277 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Onchocerca volvulus | 0.0606 | 0.6391 | 1 | |
Onchocerca volvulus | 0.0606 | 0.6391 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0606 | 0.6391 | 0.592 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.4268 | 0.4268 |
Entamoeba histolytica | cysteine protease, putative | 0.0324 | 0.3277 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0932 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0324 | 0.3277 | 0.4054 |
Loa Loa (eye worm) | fibroinase | 0.0606 | 0.6391 | 0.6391 |
Onchocerca volvulus | 0.0606 | 0.6391 | 1 | |
Entamoeba histolytica | cysteine protease, putative | 0.0324 | 0.3277 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0379 | 0.389 | 0.3093 |
Leishmania major | cathepsin L-like protease | 0.0606 | 0.6391 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0414 | 0.4268 | 0.4268 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0606 | 0.6391 | 0.6391 |
Entamoeba histolytica | cysteine protease, putative | 0.0324 | 0.3277 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0324 | 0.3277 | 0.4054 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0379 | 0.389 | 0.3093 |
Onchocerca volvulus | Cathepsin L homolog | 0.0606 | 0.6391 | 1 |
Onchocerca volvulus | 0.0606 | 0.6391 | 1 | |
Trypanosoma cruzi | cysteine protease, putative | 0.0324 | 0.3277 | 0.24 |
Plasmodium vivax | vivapain-3 | 0.0324 | 0.3277 | 0.4054 |
Echinococcus multilocularis | cathepsin b | 0.0932 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0324 | 0.3277 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.0324 | 0.3277 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0606 | 0.6391 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1154 | 0.1154 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.1818 | 0.1818 |
Leishmania major | cathepsin L-like protease | 0.0606 | 0.6391 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0932 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0606 | 0.6391 | 0.592 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0324 | 0.3277 | 0.24 |
Entamoeba histolytica | cysteine protease, putative | 0.0324 | 0.3277 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0606 | 0.6391 | 0.6391 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0606 | 0.6391 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0606 | 0.6391 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0606 | 0.6391 | 0.592 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0414 | 0.4268 | 0.5946 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0379 | 0.389 | 1 |
Echinococcus granulosus | cysteine protease | 0.0324 | 0.3277 | 0.24 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0606 | 0.6391 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0606 | 0.6391 | 0.6391 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1154 | 0.1154 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0192 | 0.1818 | 0.1818 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.4268 | 0.4268 |
Leishmania major | cathepsin L-like protease | 0.0606 | 0.6391 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0606 | 0.6391 | 0.6391 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0324 | 0.3277 | 0.4054 |
Plasmodium vivax | vivapain-2 | 0.0606 | 0.6391 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0324 | 0.3277 | 0.4054 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0606 | 0.6391 | 0.592 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0132 | 0.1154 | 0.1154 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0379 | 0.389 | 0.5224 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0606 | 0.6391 | 0.592 |
Brugia malayi | cathepsin L-like precursor | 0.0414 | 0.4268 | 0.4268 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0606 | 0.6391 | 1 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0192 | 0.1818 | 0.1818 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0932 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0932 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0606 | 0.6391 | 0.6391 |
Leishmania major | cathepsin L-like protease | 0.0606 | 0.6391 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0132 | 0.1154 | 0.1154 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 0.1 % | Reactivation of DEP-mediated inactive human recombinant AChE at 10 uM after 15 mins by Ellman's method | ChEMBL. | 21215642 |
Activity (binding) | = 0.6 % | Reactivation of POX-mediated inactive human recombinant AChE at 10 uM after 15 mins by Ellman's method | ChEMBL. | 21215642 |
Activity (binding) | = 1.1 % | Reactivation of DEP-mediated inactive human recombinant AChE at 100 uM after 15 mins by Ellman's method | ChEMBL. | 21215642 |
Activity (binding) | = 3.4 % | Reactivation of GA-mediated inactive human recombinant AChE at 100 uM after 15 mins by Ellman's method | ChEMBL. | 21215642 |
Activity (binding) | = 4.9 % | Reactivation of MePOX-mediated inactive human recombinant AChE at 10 uM after 15 mins by Ellman's method | ChEMBL. | 21215642 |
Activity (binding) | = 5.3 % | Reactivation of GA-mediated inactive human recombinant AChE at 10 uM after 15 mins by Ellman's method | ChEMBL. | 21215642 |
Activity (binding) | = 6.8 % | Reactivation of MePOX-mediated inactive human recombinant AChE at 100 uM after 15 mins by Ellman's method | ChEMBL. | 21215642 |
Activity (binding) | = 16.7 % | Reactivation of POX-mediated inactive human recombinant AChE at 100 uM after 15 mins by Ellman's method | ChEMBL. | 21215642 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.