Detailed information for compound 1463098

Basic information

Technical information
  • TDR Targets ID: 1463098
  • Name: 2-[(5Z)-5-[(3-methoxyphenyl)methylidene]-2,4- dioxo-1,3-thiazolidin-3-yl]acetic acid
  • MW: 293.295 | Formula: C13H11NO5S
  • H donors: 1 H acceptors: 4 LogP: 1.94 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)/C=C/1\SC(=O)N(C1=O)CC(=O)O
  • InChi: 1S/C13H11NO5S/c1-19-9-4-2-3-8(5-9)6-10-12(17)14(7-11(15)16)13(18)20-10/h2-6H,7H2,1H3,(H,15,16)/b10-6-
  • InChiKey: MYISOQXSDQHERI-POHAHGRESA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[5-[(3-methoxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid
  • 2-[5-[(3-methoxyphenyl)methylene]-2,4-dioxo-thiazolidin-3-yl]acetic acid
  • 2-[(5Z)-5-[(3-methoxyphenyl)methylene]-2,4-dioxo-thiazolidin-3-yl]acetic acid
  • 2-[5-[(3-methoxyphenyl)methylene]-2,4-dioxo-3-thiazolidinyl]acetic acid
  • 2-[(5Z)-5-[(3-methoxyphenyl)methylene]-2,4-dioxo-3-thiazolidinyl]acetic acid
  • 2-[2,4-diketo-5-(3-methoxybenzylidene)thiazolidin-3-yl]acetic acid
  • 2-[(5Z)-2,4-diketo-5-(3-methoxybenzylidene)thiazolidin-3-yl]acetic acid
  • 2-[5-[(3-methoxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethanoic acid
  • 2-[(5Z)-5-[(3-methoxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethanoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldo-keto reductase family 1, member B1 (aldose reductase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum IPR001395,Aldo/keto reductase,domain-containing Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium ulcerans oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni pol-related Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae PROBABLE OXIDOREDUCTASE Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae Conserved hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense prostaglandin f synthase. putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Toxoplasma gondii aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Neospora caninum Oxidoreductase, aldo/keto reductase family, related Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldehyde reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei prostaglandin f synthase Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum ko:K00011 aldehyde reductase [EC1.1.1.21], putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Conserved protein aldo-keto reductase family 1, member B1 (aldose reductase) 316 aa 325 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.005 0.2945 1
Echinococcus granulosus cathepsin l1 0.0019 0.0616 0.0616
Loa Loa (eye worm) hypothetical protein 0.0019 0.0616 0.0616
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.1182 0.1182
Brugia malayi Cathepsin L-like cysteine proteinase 0.0019 0.0616 0.0616
Plasmodium falciparum cysteine proteinase falcipain 1 0.0016 0.0352 0.2975
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0016 0.0352 0.0352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0616 0.2091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0352 0.1194
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1182 0.4013
Leishmania major prostaglandin f synthase, putative 0.0038 0.2075 0.7047
Loa Loa (eye worm) oxidoreductase 0.0038 0.2075 0.2075
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0352 0.1694
Plasmodium vivax vivapain-2 0.0027 0.1182 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0616 0.0616
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.2075 0.2075
Echinococcus multilocularis aldo keto reductase 0.0038 0.2075 0.2075
Mycobacterium tuberculosis Probable oxidoreductase 0.0038 0.2075 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.0616 0.0616
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1182 0.4013
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.2075 0.2075
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0616 0.2967
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1182 0.4013
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.1182 0.1182
Onchocerca volvulus Cathepsin L homolog 0.0027 0.1182 0.5694
Toxoplasma gondii cathepsin B 0.005 0.2945 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.005 0.2945 0.2945
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2075 0.7047
Brugia malayi Cathepsin L-like precursor 0.0027 0.1182 0.1182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1182 0.4013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0616 0.0616
Schistosoma mansoni aldo-keto reductase 0.0038 0.2075 0.2075
Echinococcus granulosus cathepsin l1 0.0027 0.1182 0.1182
Leishmania major cathepsin L-like protease 0.0027 0.1182 0.4013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1182 0.4013
Entamoeba histolytica cysteine protease, putative 0.0016 0.0352 0.1694
Trypanosoma brucei prostaglandin f synthase 0.0038 0.2075 0.7047
Trypanosoma cruzi cysteine proteinase, putative 0.0016 0.0352 0.0352
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0142 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.1182 0.1182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1182 0.4013
Entamoeba histolytica cysteine protease, putative 0.0016 0.0352 0.1694
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.2075 0.2075
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.1182 0.5694
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0038 0.2075 1
Echinococcus multilocularis cathepsin b 0.0142 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1182 0.4013
Loa Loa (eye worm) hypothetical protein 0.0027 0.1182 0.1182
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0352 0.1694
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0352 0.1694
Mycobacterium ulcerans oxidoreductase 0.0038 0.2075 1
Schistosoma mansoni aldo-keto reductase 0.0038 0.2075 0.2075
Plasmodium vivax vivapain-2 0.0027 0.1182 1
Loa Loa (eye worm) fibroinase 0.0027 0.1182 0.1182
Entamoeba histolytica cysteine protease, putative 0.0016 0.0352 0.1694
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2075 0.7047
Leishmania major cathepsin L-like protease 0.0027 0.1182 0.4013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1182 0.4013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0016 0.0352 0.1194
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.2075 0.2075
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.2075 0.7047
Onchocerca volvulus Cathepsin F homolog 0.0027 0.1182 0.5694
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0142 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0616 0.0616
Echinococcus granulosus cathepsin L cysteine proteinase 0.0027 0.1182 0.1182
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.2075 0.2075
Onchocerca volvulus 0.0038 0.2075 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0142 1 1
Entamoeba histolytica cysteine protease, putative 0.0027 0.1182 0.5694
Trypanosoma cruzi cysteine protease, putative 0.0016 0.0352 0.0352
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2075 0.7047
Onchocerca volvulus 0.0038 0.2075 1
Entamoeba histolytica aldose reductase, putative 0.0038 0.2075 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0616 0.2091
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0027 0.1182 0.1182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0352 0.1194
Loa Loa (eye worm) cathepsin B 0.005 0.2945 0.2945
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.2075 0.2075
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.2075 0.2075
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.2075 0.7047
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.2075 0.2075
Leishmania major cathepsin L-like protease 0.0027 0.1182 0.4013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1182 0.4013
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2075 0.7047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1182 0.4013
Loa Loa (eye worm) ctsf protein 0.0027 0.1182 0.1182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1182 0.4013
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.2075 0.2075
Echinococcus granulosus cathepsin l cysteine peptidase 0.0027 0.1182 0.1182
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0027 0.1182 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.2075 0.2075
Mycobacterium leprae Conserved hypothetical protein 0.0027 0.1229 0.5922
Entamoeba histolytica aldose reductase, putative 0.0038 0.2075 1
Brugia malayi Cathepsin L-like precursor 0.0027 0.1182 0.1182
Echinococcus granulosus hypothetical protein 0.0038 0.2075 0.2075
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.2075 0.2075
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.2075 0.2075
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0352 0.0352
Echinococcus granulosus cathepsin b 0.0142 1 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0027 0.1182 0.1182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1182 0.4013
Trypanosoma brucei aldo-keto reductase, putative 0.0038 0.2075 0.7047
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2075 0.7047
Entamoeba histolytica aldose reductase, putative 0.0038 0.2075 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1182 0.4013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1182 0.4013
Loa Loa (eye worm) oxidoreductase 0.0038 0.2075 0.2075
Echinococcus multilocularis cathepsin L cysteine protease 0.0027 0.1182 0.1182
Toxoplasma gondii cathepsin CPL 0.0027 0.1182 0.4013
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2075 0.7047
Onchocerca volvulus 0.0027 0.1182 0.5694
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2075 0.7047
Giardia lamblia Cathepsin B precursor 0.005 0.2945 1
Entamoeba histolytica cysteine protease, putative 0.0016 0.0352 0.1694
Giardia lamblia Cathepsin B precursor 0.005 0.2945 1
Entamoeba histolytica cysteine proteinase 2 0.0016 0.0352 0.1694
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2075 0.7047
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2075 0.7047
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.2075 0.7047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1182 0.4013
Entamoeba histolytica cysteine protease, putative 0.0016 0.0352 0.1694
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.005 0.2945 1
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0352 0.0352
Brugia malayi Cathepsin L-like precursor 0.0027 0.1182 0.1182
Echinococcus multilocularis cysteine protease 0.0027 0.1182 0.1182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1182 0.4013
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0027 0.1182 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0016 0.0352 0.1694
Entamoeba histolytica cysteine protease, putative 0.0016 0.0352 0.1694
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0352 0.0352
Loa Loa (eye worm) hypothetical protein 0.0142 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0142 1 1
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0038 0.2075 0.7047
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.2075 0.2075
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1182 0.4013
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.2075 0.7047
Brugia malayi Cathepsin L-like precursor 0.0027 0.1182 0.1182
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.1182 0.5694
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.2075 0.2075
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.2075 0.7047
Entamoeba histolytica cysteine protease, putative 0.0016 0.0352 0.1694
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.2075 0.7047
Loa Loa (eye worm) oxidoreductase 0.0038 0.2075 0.2075
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2075 0.7047
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.1182 0.1182
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.2075 0.2075
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1182 0.4013
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.2075 0.2075
Leishmania major cathepsin L-like protease 0.0027 0.1182 0.4013
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.1182 0.1182
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0038 0.2075 0.7047
Trypanosoma brucei cysteine peptidase C (CPC) 0.005 0.2945 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.2075 0.2075
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1182 0.4013
Entamoeba histolytica cysteine protease, putative 0.0016 0.0352 0.1694
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1182 0.4013
Schistosoma mansoni pol-related 0.0038 0.2075 0.2075
Echinococcus multilocularis aldo keto reductase 0.0038 0.2075 0.2075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1182 0.4013
Echinococcus granulosus cysteine protease 0.0016 0.0352 0.0352
Entamoeba histolytica cysteine protease, putative 0.0016 0.0352 0.1694
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.2075 0.2075
Echinococcus granulosus cathepsin L 0.0016 0.0352 0.0352
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0016 0.0352 0.0352
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0142 1 1
Loa Loa (eye worm) cysteine protease 0.0027 0.1182 0.1182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1182 0.4013
Onchocerca volvulus 0.0019 0.0616 0.2967
Echinococcus multilocularis cysteine protease 0.0027 0.1182 0.1182
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0352 0.1694
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.005 0.2945 0.2945
Onchocerca volvulus 0.0038 0.2075 1
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.1182 0.1182
Onchocerca volvulus 0.0038 0.2075 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1182 0.4013
Brugia malayi cathepsin L-like precursor 0.0019 0.0616 0.0616
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.1182 0.4013
Echinococcus multilocularis cathepsin b 0.0142 1 1
Entamoeba histolytica cysteine protease, putative 0.0016 0.0352 0.1694
Entamoeba histolytica cysteine protease, putative 0.0016 0.0352 0.1694
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.1182 0.1182
Plasmodium vivax unspecified product 0.0016 0.0352 0.2975
Plasmodium vivax vivapain-1 0.0016 0.0352 0.2975
Trypanosoma cruzi aldo/keto reductase, putative 0.0038 0.2075 0.2075
Leishmania major cathepsin L-like protease 0.0027 0.1182 0.4013
Leishmania major cysteine peptidase A (CPA) 0.0027 0.1182 0.4013
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0019 0.0616 0.0616
Echinococcus granulosus aldo keto reductase 0.0038 0.2075 0.2075
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0027 0.1182 0.4013
Leishmania major cathepsin L-like protease 0.0027 0.1182 0.4013
Echinococcus granulosus cathepsin b 0.0142 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.2075 0.2075
Loa Loa (eye worm) oxidoreductase 0.0038 0.2075 0.2075
Echinococcus multilocularis cathepsin L 0.0016 0.0352 0.0352
Echinococcus granulosus aldehyde reductase 0.0027 0.1229 0.1229
Echinococcus granulosus aldo keto reductase 0.0038 0.2075 0.2075
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1182 0.4013
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.2075 0.2075
Brugia malayi Cathepsin L-like precursor 0.0019 0.0616 0.0616
Toxoplasma gondii aldose reductase, putative 0.0038 0.2075 0.7047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1182 0.4013
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.2075 0.2075
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.2075 0.2075
Leishmania major cathepsin L-like protease 0.0027 0.1182 0.4013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1182 0.4013
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0016 0.0352 0.0352
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1182 0.4013
Echinococcus multilocularis aldo keto reductase 0.0038 0.2075 0.2075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0352 0.1194
Echinococcus granulosus cathepsin L cysteine protease 0.0016 0.0352 0.0352
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.1182 0.1182
Onchocerca volvulus 0.0027 0.1182 0.5694
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2075 0.7047
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.2075 0.2075
Onchocerca volvulus 0.0038 0.2075 1
Brugia malayi Cathepsin L-like precursor 0.0027 0.1182 0.1182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1182 0.4013
Trypanosoma cruzi aldo-keto reductase 0.0038 0.2075 0.2075
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.1182 0.1182
Onchocerca volvulus 0.0027 0.1182 0.5694
Leishmania major cathepsin L-like protease 0.0027 0.1182 0.4013
Loa Loa (eye worm) oxidoreductase 0.0038 0.2075 0.2075
Echinococcus multilocularis aldo keto reductase 0.0038 0.2075 0.2075
Echinococcus multilocularis aldehyde reductase 0.0027 0.1229 0.1229
Giardia lamblia Cathepsin B precursor 0.005 0.2945 1
Onchocerca volvulus 0.0027 0.1182 0.5694
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1182 0.4013
Trypanosoma cruzi cysteine proteinase, putative 0.0016 0.0352 0.0352
Entamoeba histolytica cysteine protease, putative 0.0016 0.0352 0.1694
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.2075 0.2075
Brugia malayi Cathepsin L-like precursor 0.0027 0.1182 0.1182
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0016 0.0352 0.0352
Trypanosoma cruzi cruzipain precursor, putative 0.0027 0.1182 0.1182
Leishmania major aldo-keto reductase-like protein 0.0038 0.2075 0.7047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1182 0.4013
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.1182 0.1182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0027 0.1182 0.4013
Echinococcus granulosus aldo keto reductase 0.0038 0.2075 0.2075
Plasmodium vivax vivapain-3 0.0016 0.0352 0.2975
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.2075 0.2075
Onchocerca volvulus 0.0027 0.1182 0.5694
Onchocerca volvulus 0.0027 0.1182 0.5694
Plasmodium falciparum cysteine proteinase falcipain 3 0.0027 0.1182 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.2075 0.7047
Onchocerca volvulus 0.0038 0.2075 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1182 0.4013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.1182 0.4013
Entamoeba histolytica cysteine protease, putative 0.0016 0.0352 0.1694
Onchocerca volvulus 0.0027 0.1182 0.5694
Onchocerca volvulus Cathepsin L homolog 0.0027 0.1182 0.5694
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.1182 0.4013

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.48 uM Inhibition of aldose reductase ChEMBL. 21129963

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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