Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neuronal acetylcholine receptor subunit alpha-6 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hypothetical protein | 0.0224 | 0.34 | 1 |
Loa Loa (eye worm) | ILVBL protein | 0.0136 | 0.1418 | 0.0516 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0224 | 0.34 | 1 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0224 | 0.34 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0128 | 0.1251 | 0.368 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0073 | 0 | 0.5 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0128 | 0.1251 | 0.5 |
Mycobacterium ulcerans | acetolactate synthase | 0.0128 | 0.1251 | 0.368 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0224 | 0.34 | 1 |
Brugia malayi | Glycogen synthase | 0.0212 | 0.3128 | 0.2405 |
Echinococcus granulosus | glycogen synthase | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0519 | 1 | 1 |
Brugia malayi | Thiamine pyrophosphate enzyme, central domain containing protein | 0.0224 | 0.34 | 0.2706 |
Loa Loa (eye worm) | hypothetical protein | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0129 | 0.1256 | 0.0337 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0128 | 0.1251 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0519 | 1 | 1 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0224 | 0.34 | 1 |
Schistosoma mansoni | glycogen synthase | 0.0519 | 1 | 1 |
Onchocerca volvulus | Glycogen synthase homolog | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.3128 | 0.2405 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0073 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0519 | 1 | 1 |
Echinococcus multilocularis | glycogen synthase | 0.0519 | 1 | 1 |
Brugia malayi | Glycogen synthase | 0.0212 | 0.3128 | 0.2405 |
Loa Loa (eye worm) | hypothetical protein | 0.0519 | 1 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0128 | 0.1251 | 0.5 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0073 | 0 | 0.5 |
Giardia lamblia | Glycogen synthase, putative | 0.0519 | 1 | 0.5 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0128 | 0.1251 | 0.368 |
Loa Loa (eye worm) | hypothetical protein | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | glycogen synthase | 0.0212 | 0.3128 | 0.2405 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0224 | 0.34 | 0.5 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0224 | 0.34 | 1 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0073 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.95 nM | Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release | ChEMBL. | 21147530 |
Imax (functional) | = 60 % | Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release relative to nicotine | ChEMBL. | 21147530 |
Inhibition (functional) | = 50 % | Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine release at 100 nM relative to control | ChEMBL. | 21147530 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.