Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0324 | 0.1811 | 0.1743 |
Schistosoma mansoni | amine GPCR | 0.0376 | 0.227 | 0.2206 |
Loa Loa (eye worm) | hypothetical protein | 0.0457 | 0.2992 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0298 | 0.1581 | 0.1511 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0667 | 0.486 | 0.4818 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.013 | 0.0082 | 0.0273 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0457 | 0.2992 | 0.2935 |
Brugia malayi | RNA recognition motif domain containing protein | 0.013 | 0.0082 | 0.0253 |
Loa Loa (eye worm) | TAR-binding protein | 0.013 | 0.0082 | 0.0273 |
Echinococcus multilocularis | serotonin receptor | 0.0298 | 0.1581 | 0.1511 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0457 | 0.2992 | 0.2935 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.1493 | 0.4989 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0457 | 0.2992 | 0.2935 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.1244 | 1 | 1 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.1244 | 1 | 1 |
Brugia malayi | Serotonin receptor | 0.0483 | 0.3223 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.1811 | 0.6051 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.02 | 0.0707 | 0.2362 |
Schistosoma mansoni | serine/threonine protein kinase | 0.02 | 0.0707 | 0.063 |
Echinococcus multilocularis | serotonin receptor | 0.0298 | 0.1581 | 0.1511 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0457 | 0.2992 | 0.2935 |
Echinococcus granulosus | hormone sensitive lipase | 0.0457 | 0.2992 | 0.2935 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0298 | 0.1581 | 0.1511 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.1811 | 0.6051 |
Echinococcus granulosus | hypothetical protein | 0.0705 | 0.52 | 0.516 |
Brugia malayi | TAR-binding protein | 0.013 | 0.0082 | 0.0253 |
Brugia malayi | RNA binding protein | 0.013 | 0.0082 | 0.0253 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.1581 | 0.5282 |
Loa Loa (eye worm) | RNA binding protein | 0.013 | 0.0082 | 0.0273 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.1581 | 0.5282 |
Brugia malayi | Protein kinase domain containing protein | 0.02 | 0.0707 | 0.2193 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0324 | 0.1811 | 0.5618 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = -5 % | Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cells relative to DAMGO | ChEMBL. | 21115248 |
Activity (binding) | = 0 % | Displacement of [3H]diprenorphine from kappa opioid receptor expressed in HEK293 cells relative to salvinorin A | ChEMBL. | 21115248 |
Activity (binding) | = 17 % | Displacement of [3H]DADLE from delta opioid receptor expressed in HEK293 cells relative to DADLE | ChEMBL. | 21115248 |
Activity (binding) | = 41 % | Displacement of [3H]U69593 from kappa opioid receptor expressed in HEK293 cells relative to salvinorin A | ChEMBL. | 21115248 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.