Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0095 | 0.3945 | 0.3945 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0126 | 0.6922 | 0.6922 |
Loa Loa (eye worm) | hydroxyacylglutathione hydrolase | 0.0138 | 0.8072 | 0.8072 |
Toxoplasma gondii | hydroxyacylglutathione hydrolase | 0.0138 | 0.8072 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0106 | 0.5047 | 0.5047 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0075 | 0.207 | 0.207 |
Mycobacterium ulcerans | hypothetical protein | 0.0138 | 0.8072 | 0.5 |
Onchocerca volvulus | 0.0138 | 0.8072 | 0.5 | |
Trypanosoma cruzi | metallo-beta-lactamase superfamily, putative | 0.0138 | 0.8072 | 0.8072 |
Mycobacterium leprae | conserved hypothetical protein | 0.0138 | 0.8072 | 0.5 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0158 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0085 | 0.3066 | 0.3066 |
Trichomonas vaginalis | apoptosis inducing factor, putative | 0.0138 | 0.8072 | 0.8072 |
Trichomonas vaginalis | beta lactamase domain, putative | 0.0138 | 0.8072 | 0.8072 |
Echinococcus multilocularis | ETHE1 protein | 0.0138 | 0.8072 | 0.8072 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0126 | 0.6934 | 0.6934 |
Plasmodium vivax | hydroxyacyl glutathione hydrolase, putative | 0.0138 | 0.8072 | 0.5 |
Echinococcus multilocularis | zinc phosphodiesterase | 0.0138 | 0.8072 | 0.8072 |
Leishmania major | hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative | 0.0138 | 0.8072 | 0.8072 |
Mycobacterium ulcerans | glyoxalase II, GloB | 0.0138 | 0.8072 | 0.5 |
Onchocerca volvulus | 0.0138 | 0.8072 | 0.5 | |
Mycobacterium tuberculosis | Conserved protein | 0.0138 | 0.8072 | 0.5 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.8072 | 0.8072 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0126 | 0.6934 | 0.6934 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0138 | 0.8072 | 0.5 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0158 | 1 | 1 |
Toxoplasma gondii | metallo-beta-lactamase domain-containing protein | 0.0138 | 0.8072 | 1 |
Mycobacterium tuberculosis | Possible hydrolase | 0.0138 | 0.8072 | 0.5 |
Plasmodium vivax | unspecified product | 0.0138 | 0.8072 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0138 | 0.8072 | 0.5 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0158 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0085 | 0.3066 | 0.3066 |
Trypanosoma brucei | hydroxyacylglutathione hydrolase, putative | 0.0138 | 0.8072 | 0.8072 |
Chlamydia trachomatis | ribonuclease Z | 0.0138 | 0.8072 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0126 | 0.6922 | 0.6922 |
Plasmodium falciparum | cytosolic glyoxalase II | 0.0138 | 0.8072 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0118 | 0.6145 | 0.6145 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0086 | 0.3078 | 0.3078 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0086 | 0.3078 | 0.3078 |
Mycobacterium ulcerans | hydrolase | 0.0138 | 0.8072 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0095 | 0.3945 | 0.3945 |
Brugia malayi | ethe1-prov protein | 0.0138 | 0.8072 | 0.8072 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0126 | 0.6922 | 0.6922 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0095 | 0.3945 | 0.3945 |
Mycobacterium ulcerans | hypothetical protein | 0.0138 | 0.8072 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0118 | 0.6145 | 0.6145 |
Wolbachia endosymbiont of Brugia malayi | metallo-beta-lactamase superfamily hydrolase | 0.0138 | 0.8072 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.8072 | 0.8072 |
Trichomonas vaginalis | beta lactamase domain, putative | 0.0138 | 0.8072 | 0.8072 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0094 | 0.3855 | 0.3855 |
Echinococcus granulosus | hydroxyacylglutathione hydrolase | 0.0138 | 0.8072 | 0.8072 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0118 | 0.6145 | 0.6145 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0158 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0118 | 0.6145 | 0.6145 |
Echinococcus granulosus | zinc phosphodiesterase | 0.0138 | 0.8072 | 0.8072 |
Leishmania major | metallo-beta-lactamase family-like protein | 0.0138 | 0.8072 | 0.8072 |
Brugia malayi | metallo-beta-lactamase superfamily protein | 0.0138 | 0.8072 | 0.8072 |
Echinococcus granulosus | ETHE1 protein | 0.0138 | 0.8072 | 0.8072 |
Trypanosoma brucei | metallo-beta-lactamase-like protein, putative | 0.0138 | 0.8072 | 0.8072 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0135 | 0.78 | 0.78 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0158 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0138 | 0.8072 | 0.5 |
Trypanosoma cruzi | hydroxyacylglutathione hydrolase, putative | 0.0138 | 0.8072 | 0.8072 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0138 | 0.8072 | 0.5 |
Echinococcus granulosus | metallo beta lactamase domain containing protein | 0.0138 | 0.8072 | 0.8072 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0138 | 0.8072 | 0.8072 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0158 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0158 | 1 | 1 |
Trichomonas vaginalis | beta lactamase domain, putative | 0.0138 | 0.8072 | 0.8072 |
Trypanosoma cruzi | metallo-beta-lactamase-like protein, putative | 0.0138 | 0.8072 | 0.8072 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0126 | 0.6922 | 0.6922 |
Treponema pallidum | ribonuclease Z | 0.0138 | 0.8072 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0138 | 0.8072 | 0.8072 |
Schistosoma mansoni | hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) | 0.0138 | 0.8072 | 0.8072 |
Mycobacterium ulcerans | hydrolase | 0.0138 | 0.8072 | 0.5 |
Trypanosoma brucei | cleavage and polyadenylation specificity factor subunit, putative | 0.0138 | 0.8072 | 0.8072 |
Mycobacterium leprae | conserved hypothetical protein | 0.0138 | 0.8072 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0138 | 0.8072 | 0.8072 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0118 | 0.6145 | 0.6145 |
Loa Loa (eye worm) | hydroxyacylglutathione hydrolase cytoplasmic | 0.0138 | 0.8072 | 0.8072 |
Onchocerca volvulus | Putative hydrolase PNKD | 0.0138 | 0.8072 | 0.5 |
Trypanosoma cruzi | hydroxyacylglutathione hydrolase, putative | 0.0138 | 0.8072 | 0.8072 |
Onchocerca volvulus | Hydroxyacylglutathione hydrolase, mitochondrial homolog | 0.0138 | 0.8072 | 0.5 |
Trypanosoma cruzi | glyoxalase II | 0.0138 | 0.8072 | 0.8072 |
Trypanosoma brucei | glyoxalase II | 0.0138 | 0.8072 | 0.8072 |
Brugia malayi | hypothetical protein | 0.0138 | 0.8072 | 0.8072 |
Schistosoma mansoni | zinc phosphodiesterase | 0.0138 | 0.8072 | 0.8072 |
Giardia lamblia | GTOR | 0.0158 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0118 | 0.6145 | 0.6145 |
Trypanosoma cruzi | glyoxalase II | 0.0138 | 0.8072 | 0.8072 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0158 | 1 | 1 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.0066 | 0.1204 | 0.1204 |
Trypanosoma cruzi | metallo-beta-lactamase-like protein, putative | 0.0138 | 0.8072 | 0.8072 |
Mycobacterium tuberculosis | Possible hydrolase | 0.0138 | 0.8072 | 0.5 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0158 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0138 | 0.8072 | 0.8072 |
Brugia malayi | metallo-beta-lactamase superfamily protein | 0.0138 | 0.8072 | 0.8072 |
Schistosoma mansoni | zinc phosphodiesterase | 0.0138 | 0.8072 | 0.8072 |
Mycobacterium leprae | POSSIBLE HYDROLASE | 0.0138 | 0.8072 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0138 | 0.8072 | 0.8072 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0126 | 0.6922 | 0.6922 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0094 | 0.3855 | 0.3855 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0138 | 0.8072 | 0.8072 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0158 | 1 | 1 |
Loa Loa (eye worm) | metallo-beta-lactamase superfamily protein | 0.0138 | 0.8072 | 0.8072 |
Brugia malayi | Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. | 0.0138 | 0.8072 | 0.8072 |
Echinococcus granulosus | metallo beta lactamase domain containing protein | 0.0138 | 0.8072 | 0.8072 |
Leishmania major | metallo-beta-lactamase family protein-like protein | 0.0138 | 0.8072 | 0.8072 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.8072 | 0.8072 |
Echinococcus multilocularis | metallo beta lactamase domain containing protein | 0.0138 | 0.8072 | 0.8072 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0103 | 0.4722 | 0.4722 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0158 | 1 | 1 |
Leishmania major | cleavage and polyadenylation specificity factor, putative | 0.0138 | 0.8072 | 0.8072 |
Trypanosoma cruzi | glyoxalase II | 0.0138 | 0.8072 | 0.8072 |
Trichomonas vaginalis | A-type flavoprotein | 0.0138 | 0.8072 | 0.8072 |
Mycobacterium tuberculosis | Beta lactamase like protein | 0.0138 | 0.8072 | 0.5 |
Trypanosoma cruzi | metallo-beta-lactamase superfamily, putative | 0.0138 | 0.8072 | 0.8072 |
Mycobacterium tuberculosis | Conserved protein | 0.0138 | 0.8072 | 0.5 |
Trichomonas vaginalis | beta lactamase domain, putative | 0.0138 | 0.8072 | 0.8072 |
Trichomonas vaginalis | disulfide oxidoreductase, putative | 0.0138 | 0.8072 | 0.8072 |
Mycobacterium ulcerans | hydrolase | 0.0138 | 0.8072 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0086 | 0.3078 | 0.3078 |
Mycobacterium tuberculosis | Conserved protein | 0.0138 | 0.8072 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0118 | 0.6145 | 0.6145 |
Echinococcus multilocularis | metallo beta lactamase domain containing protein | 0.0138 | 0.8072 | 0.8072 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0126 | 0.6934 | 0.6934 |
Mycobacterium ulcerans | Zn-dependent glyoxylase | 0.0138 | 0.8072 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0138 | 0.8072 | 0.8072 |
Mycobacterium leprae | Beta-lactamase-like protein | 0.0138 | 0.8072 | 0.5 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0158 | 1 | 1 |
Trichomonas vaginalis | beta lactamase domain, putative | 0.0138 | 0.8072 | 0.8072 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.8072 | 0.8072 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0158 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0138 | 0.8072 | 0.8072 |
Leishmania major | hypothetical protein, conserved | 0.0138 | 0.8072 | 0.8072 |
Trichomonas vaginalis | beta lactamase domain, putative | 0.0138 | 0.8072 | 0.8072 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0086 | 0.3078 | 0.3078 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0138 | 0.8072 | 0.5 |
Mycobacterium ulcerans | beta lactamase-like protein | 0.0138 | 0.8072 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0158 | 1 | 1 |
Echinococcus multilocularis | hydroxyacylglutathione hydrolase | 0.0138 | 0.8072 | 0.8072 |
Schistosoma mansoni | hypothetical protein | 0.0138 | 0.8072 | 0.8072 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0085 | 0.3066 | 0.3066 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 32 mm | Antifungal activity against Candida albicans at 1000 ug/mL after 72 hrs by agar diffusion assay | ChEMBL. | 21134751 |
IZ (functional) | = 42 mm | Antibacterial activity against Escherichia coli at 1000 ug/mL after 72 hrs by agar diffusion assay | ChEMBL. | 21134751 |
MIC (functional) | = 10 ug ml-1 | Antibacterial activity against Escherichia coli by liquid dilution method | ChEMBL. | 21134751 |
MIC (functional) | = 40 ug ml-1 | Antifungal activity against Candida albicans by liquid dilution method | ChEMBL. | 21134751 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.