Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0173 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0173 | 0.0173 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.257 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0173 | 1 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.257 | 0.2439 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0173 | 0.0173 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.0173 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0669 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.257 | 0.2439 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0173 | 0.0173 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0669 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0.0173 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.257 | 0.257 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0669 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0669 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0173 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.0173 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0173 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.257 | 0.2439 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0173 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.257 | 0.257 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0173 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0173 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0669 | 1 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0173 | 0.5 |
Mycobacterium leprae | Possible lipase LipU | 0.0011 | 0 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0173 | 0.0673 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0173 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0173 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0173 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0173 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.5003 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | 14.1254 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.