Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | geminin | 0.0205 | 0.539 | 0.5155 |
Echinococcus granulosus | alpha glucosidase | 0.0158 | 0.3656 | 0.3332 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0073 | 0.0485 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0073 | 0.0485 | 0.0485 |
Onchocerca volvulus | 0.0297 | 0.8855 | 0.5 | |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0073 | 0.0485 | 0.5 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0073 | 0.0485 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0328 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0328 | 1 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0328 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0073 | 0.0485 | 0.5 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0073 | 0.0485 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0297 | 0.8855 | 1 |
Brugia malayi | Alpha amylase, catalytic domain containing protein | 0.0158 | 0.3656 | 0.3656 |
Loa Loa (eye worm) | alpha amylase | 0.0158 | 0.3656 | 0.3656 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0073 | 0.0485 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0073 | 0.0485 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0073 | 0.0485 | 0.0485 |
Mycobacterium leprae | Putative uncharacterized protein ML2045 | 0.0158 | 0.3656 | 0.5 |
Brugia malayi | Alpha amylase, catalytic domain containing protein | 0.0158 | 0.3656 | 0.3656 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.539 | 0.586 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0073 | 0.0485 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0073 | 0.0485 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0073 | 0.0485 | 0.5 |
Trypanosoma brucei | glucosidase, putative | 0.0073 | 0.0485 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0158 | 0.3656 | 0.3788 |
Schistosoma mansoni | alpha-amylase | 0.0158 | 0.3656 | 0.3788 |
Mycobacterium tuberculosis | Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas | 0.0158 | 0.3656 | 0.5 |
Loa Loa (eye worm) | alpha amylase | 0.0158 | 0.3656 | 0.3656 |
Schistosoma mansoni | alpha-amylase | 0.0158 | 0.3656 | 0.3788 |
Mycobacterium tuberculosis | Trehalose synthase TreS | 0.0158 | 0.3656 | 0.5 |
Schistosoma mansoni | alpha-amylase | 0.0158 | 0.3656 | 0.3788 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0073 | 0.0485 | 0.5 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0073 | 0.0485 | 0.5 |
Mycobacterium ulcerans | trehalose synthase TreS | 0.0158 | 0.3656 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0297 | 0.8855 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0328 | 1 | 1 |
Entamoeba histolytica | oligo-1,6-glucosidase, putative | 0.0158 | 0.3656 | 1 |
Schistosoma mansoni | alpha-amylase | 0.0158 | 0.3656 | 0.3788 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0073 | 0.0485 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.539 | 0.586 |
Echinococcus granulosus | geminin | 0.0205 | 0.539 | 0.5155 |
Echinococcus multilocularis | alpha glucosidase | 0.0158 | 0.3656 | 0.3332 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.8356 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.5131 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.