Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | transglycolase/transpeptidase | 0.0379 | 0.8153 | 1 |
Onchocerca volvulus | 0.037 | 0.7931 | 0.783 | |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0075 | 0.0464 | 0.1406 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0075 | 0.0464 | 0.0584 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0187 | 0.3297 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Echinococcus granulosus | hypoxanthine guanine phosphoribosyltransferase | 0.0187 | 0.3297 | 1 |
Onchocerca volvulus | 0.0187 | 0.3297 | 0.2971 | |
Brugia malayi | Phosphoribosyl transferase domain containing protein | 0.0187 | 0.3297 | 0.2971 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0075 | 0.0464 | 0.1406 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.0187 | 0.3297 | 0.5 |
Onchocerca volvulus | Putative nachr subunit | 0.014 | 0.2117 | 0.1734 |
Toxoplasma gondii | hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT | 0.0187 | 0.3297 | 0.5 |
Brugia malayi | Cation transporter family protein | 0.037 | 0.7931 | 0.783 |
Schistosoma mansoni | nAChR subunit | 0.0075 | 0.0464 | 0.0584 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0277 | 0.5582 | 0.6348 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0075 | 0.0464 | 0.0584 |
Echinococcus multilocularis | hypoxanthine guanine phosphoribosyltransferase | 0.0187 | 0.3297 | 1 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0075 | 0.0464 | 0.0464 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.014 | 0.2117 | 0.1734 |
Plasmodium falciparum | hypoxanthine-guanine phosphoribosyltransferase | 0.0187 | 0.3297 | 0.5 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0187 | 0.3297 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0075 | 0.0464 | 0.0584 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0075 | 0.0464 | 0.1406 |
Loa Loa (eye worm) | LGC-31 protein | 0.0075 | 0.0464 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.014 | 0.2117 | 0.5837 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.014 | 0.2117 | 0.6423 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Onchocerca volvulus | 0.037 | 0.7931 | 0.783 | |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.014 | 0.2117 | 0.2117 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.0187 | 0.3297 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.037 | 0.7931 | 1 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0075 | 0.0464 | 0.1406 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0075 | 0.0464 | 0.1406 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0075 | 0.0464 | 0.0464 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0187 | 0.3297 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0379 | 0.8153 | 0.5 |
Loa Loa (eye worm) | ACC-1 protein | 0.0075 | 0.0464 | 0.0464 |
Mycobacterium ulcerans | hypoxanthine-guanine phosphoribosyltransferase Hpt | 0.0187 | 0.3297 | 0.2964 |
Echinococcus multilocularis | nAChR subunit | 0.0075 | 0.0464 | 0.1406 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.2117 | 0.2117 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0379 | 0.8153 | 1 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0277 | 0.5582 | 0.6348 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0075 | 0.0464 | 0.0584 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Schistosoma mansoni | nAChR subunit | 0.0075 | 0.0464 | 0.0584 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0375 | 0.8048 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.014 | 0.2117 | 0.6423 |
Plasmodium vivax | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0187 | 0.3297 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.021 | 0.3867 | 0.3809 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.014 | 0.2117 | 0.5837 |
Loa Loa (eye worm) | hypothetical protein | 0.0452 | 1 | 1 |
Loa Loa (eye worm) | ACC-1 protein | 0.0075 | 0.0464 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Schistosoma mansoni | nAChR subunit | 0.0075 | 0.0464 | 0.0584 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0187 | 0.3297 | 0.4157 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Mycobacterium leprae | Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho | 0.0143 | 0.2189 | 0.1323 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0375 | 0.8048 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0336 | 0.7055 | 0.7055 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.037 | 0.7931 | 1 |
Onchocerca volvulus | 0.0452 | 1 | 1 | |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0075 | 0.0464 | 0.0464 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.014 | 0.2117 | 0.6423 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0075 | 0.0464 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Giardia lamblia | Guanine phosphoribosyltransferase | 0.0187 | 0.3297 | 0.5 |
Mycobacterium tuberculosis | Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor | 0.0143 | 0.2189 | 0.1323 |
Echinococcus multilocularis | hypoxanthine guanine phosphoribosyltransferase | 0.0187 | 0.3297 | 1 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0277 | 0.5582 | 0.6348 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Schistosoma mansoni | nAChR subunit | 0.0075 | 0.0464 | 0.0584 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0075 | 0.0464 | 0.1406 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0075 | 0.0464 | 0.0584 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0075 | 0.0464 | 0.1406 |
Trichomonas vaginalis | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0187 | 0.3297 | 1 |
Onchocerca volvulus | 0.037 | 0.7931 | 0.783 | |
Schistosoma mansoni | nAChR subunit | 0.0075 | 0.0464 | 0.0584 |
Leishmania major | xanthine phosphoribosyltransferase | 0.0187 | 0.3297 | 0.5 |
Leishmania major | hypoxanthine-guanine phosphoribosyltransferase | 0.0187 | 0.3297 | 0.5 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0075 | 0.0464 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.7931 | 0.7931 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0375 | 0.8048 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.021 | 0.3867 | 0.375 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0075 | 0.0464 | 0.1406 |
Echinococcus granulosus | hypoxanthine guanine phosphoribosyltransferase | 0.0187 | 0.3297 | 1 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0187 | 0.3297 | 0.4157 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0464 | 0.0464 |
Schistosoma mansoni | nAChR subunit | 0.0075 | 0.0464 | 0.0584 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.7931 | 0.7931 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.014 | 0.2117 | 0.5837 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0075 | 0.0464 | 0.1406 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0187 | 0.3297 | 0.5 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0187 | 0.3297 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0452 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.