Detailed information for compound 1471261

Basic information

Technical information
  • TDR Targets ID: 1471261
  • Name: 4-[(9S,12S,15S,19S,21R,30S)-30-(2-amino-2-oxo ethyl)-21-carbamoyl-9-[(4-hydroxyphenyl)methy l]-12-(2-methylpropyl)-8,11,14,17,19,23,29,32 -octaoxo-19$l^{4}-thia-7,10,13,16,22,28,31-he ptazaspiro[5.26]dotriacontan-15-yl]butanoic a cid
  • MW: 934.067 | Formula: C42H63N9O13S
  • H donors: 12 H acceptors: 13 LogP: -0.72 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 4
  • SMILES: CC(C[C@@H]1NC(=O)[C@H](CCCC(=O)O)NC(=O)C[S@@+]([O-])C[C@H](NC(=O)CCCCNC(=O)[C@@H](NC(=O)C2(NC(=O)[C@@H](NC1=O)Cc1ccc(cc1)O)CCCCC2)CC(=O)N)C(=O)N)C
  • InChi: 1S/C42H63N9O13S/c1-24(2)19-28-39(61)49-29(20-25-12-14-26(52)15-13-25)40(62)51-42(16-5-3-6-17-42)41(63)50-30(21-32(43)53)37(59)45-18-7-4-10-33(54)47-31(36(44)58)22-65(64)23-34(55)46-27(38(60)48-28)9-8-11-35(56)57/h12-15,24,27-31,52H,3-11,16-23H2,1-2H3,(H2,43,53)(H2,44,58)(H,45,59)(H,46,55)(H,47,54)(H,48,60)(H,49,61)(H,50,63)(H,51,62)(H,56,57)/t27-,28-,29-,30-,31-,65-/m0/s1
  • InChiKey: YNWUNFGKJHUKJS-MWNZNSOUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[(9S,12S,15S,19S,21R,30S)-30-(2-amino-2-oxo-ethyl)-21-carbamoyl-9-[(4-hydroxyphenyl)methyl]-12-isobutyl-8,11,14,17,19,23,29,32-octaoxo-19$l^{4}-thia-7,10,13,16,22,28,31-heptazaspiro[5.26]dotriacontan-15-yl]butanoic acid
  • 4-[(9S,12S,15S,19S,21R,30S)-30-(2-amino-2-oxoethyl)-21-carbamoyl-9-[(4-hydroxyphenyl)methyl]-12-isobutyl-8,11,14,17,19,23,29,32-octaoxo-19$l^{4}-thia-7,10,13,16,22,28,31-heptazaspiro[5.26]dotriacontan-15-yl]butanoic acid
  • 4-[(9S,12S,15S,19S,21R,30S)-30-(2-amino-2-keto-ethyl)-21-carbamoyl-9-(4-hydroxybenzyl)-12-isobutyl-8,11,14,17,19,23,29,32-octaketo-19$l^{4}-thia-7,10,13,16,22,28,31-heptazaspiro[5.26]dotriacontan-15-yl]butyric acid
  • 4-[(9S,12S,15S,19S,21R,30S)-21-aminocarbonyl-30-(2-amino-2-oxo-ethyl)-9-[(4-hydroxyphenyl)methyl]-12-(2-methylpropyl)-8,11,14,17,19,23,29,32-octaoxo-19$l^{4}-thia-7,10,13,16,22,28,31-heptazaspiro[5.26]dotriacontan-15-yl]butanoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine protease, putative 0.0084 0.0882 0.1902
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0084 0.0882 0.0882
Brugia malayi hypothetical protein 0.0035 0.0219 0.0219
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0011 0.0011
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0007 0.0007
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0011 0.0011
Brugia malayi hypothetical protein 0.0019 0.0011 0.0011
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0019 0.0011 0.0011
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Trypanosoma cruzi cysteine peptidase, putative 0.0113 0.1272 0.0428
Brugia malayi hypothetical protein 0.0019 0.0007 0.0007
Plasmodium falciparum carbonic anhydrase 0.0093 0.1003 0.2152
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.076 1 1
Echinococcus multilocularis somatostatin receptor 0.0019 0.0011 0.0011
Onchocerca volvulus 0.0362 0.4634 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0011 0.0011
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.0981 0.1168
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0981 0.2116
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0575 0.0575
Schistosoma mansoni hypothetical protein 0.0164 0.1957 0.1957
Echinococcus granulosus 7TM GPCR rhodopsin 0.0019 0.0011 0.0011
Trypanosoma cruzi cysteine protease, putative 0.0197 0.2403 0.1668
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0019 0.0011 0.0011
Echinococcus multilocularis muscleblind protein 1 0.0144 0.1696 0.1696
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.3557 0.7675
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0011 0.0011
Plasmodium falciparum serine repeat antigen 1 0.0084 0.0882 0.189
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0084 0.0882 0.0882
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0084 0.0882 0.189
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0011 0.0011
Schistosoma mansoni carbonic anhydrase 0.0093 0.1003 0.1003
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0004 0.0004
Echinococcus multilocularis allatostatin A receptor 0.0019 0.0011 0.0011
Entamoeba histolytica cysteine protease, putative 0.0197 0.2403 0.5185
Schistosoma mansoni biogenic amine receptor 0.0019 0.0011 0.0011
Entamoeba histolytica cysteine proteinase, putative 0.0197 0.2403 0.5185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0249 0.3113 0.6717
Echinococcus granulosus cathepsin L 0.0084 0.0882 0.0882
Trypanosoma cruzi cysteine proteinase, putative 0.0197 0.2403 0.1668
Entamoeba histolytica cysteine protease, putative 0.0197 0.2403 0.5185
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0093 0.1003 0.1003
Schistosoma mansoni hypothetical protein 0.0019 0.0007 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0197 0.2403 0.3893
Leishmania major cathepsin L-like protease 0.0362 0.4634 1
Brugia malayi hypothetical protein 0.0019 0.0011 0.0011
Echinococcus granulosus neuropeptide s receptor 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0362 0.4634 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0362 0.4634 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0011 0.0011
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0084 0.0882 0.189
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0113 0.1272 0.1272
Echinococcus multilocularis serotonin receptor 0.0019 0.0011 0.0011
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0011 0.0011
Echinococcus granulosus cysteine protease 0.0197 0.2403 0.2403
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0084 0.0882 0.189
Echinococcus multilocularis cathepsin b 0.076 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0019 0.0011 0.0011
Onchocerca volvulus 0.0019 0.0011 0.0007
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0019 0.0011 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0981 0.2116
Schistosoma mansoni carbonic anhydrase-related 0.0093 0.1003 0.1003
Plasmodium falciparum serine repeat antigen 4 0.0084 0.0882 0.189
Brugia malayi Cathepsin L-like precursor 0.0362 0.4634 0.4634
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0084 0.0882 0.189
Loa Loa (eye worm) TYRA-2 protein 0.0019 0.0011 0.0011
Entamoeba histolytica cysteine protease, putative 0.0197 0.2403 0.5185
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.076 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0359 0.0775
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0981 0.2116
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0011 0.0011
Echinococcus multilocularis carbonic anhydrase II 0.0198 0.2417 0.2417
Schistosoma mansoni kinase 0.0046 0.0376 0.0376
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0359 0.0775
Schistosoma mansoni opsin-like receptor 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0362 0.4634 1
Schistosoma mansoni rab6-interacting 0.0019 0.0007 0.0007
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0084 0.0882 0.0882
Echinococcus granulosus cathepsin L cysteine proteinase 0.0362 0.4634 0.4634
Onchocerca volvulus 0.0019 0.0011 0.0007
Brugia malayi cathepsin L-like cysteine proteinase 0.0084 0.0882 0.0882
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.8737 0.8737
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0139 0.0139
Echinococcus granulosus carbonic anhydrase 0.0093 0.1003 0.1003
Echinococcus multilocularis carbonic anhydrase 0.0093 0.1003 0.1003
Loa Loa (eye worm) hypothetical protein 0.0362 0.4634 0.4634
Echinococcus granulosus muscleblind protein 0.0144 0.1696 0.1696
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0249 0.3113 0.3113
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0011 0.0011
Onchocerca volvulus 0.0019 0.0011 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0004 0.0004
Brugia malayi Muscleblind-like protein 0.0144 0.1696 0.1696
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0362 0.4634 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0981 0.0109
Entamoeba histolytica cysteine proteinase 1, putative 0.0197 0.2403 0.5185
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0019 0.0011 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0011 0.0011
Brugia malayi Cathepsin L-like cysteine proteinase 0.0249 0.3113 0.3113
Loa Loa (eye worm) hypothetical protein 0.076 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0019 0.0011 0.0011
Brugia malayi GnHR receptor homolog 0.0019 0.0011 0.0011
Brugia malayi putative neuropeptide receptor NPR1 0.0019 0.0011 0.0011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0011 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0362 0.4634 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0019 0.0011 0.0011
Echinococcus granulosus geminin 0.0164 0.1957 0.1957
Echinococcus granulosus microtubule associated protein 2 0.0667 0.8737 0.8737
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0198 0.2417 0.1684
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0362 0.4634 1
Brugia malayi Cathepsin L-like precursor 0.0362 0.4634 0.4634
Brugia malayi TAR-binding protein 0.0061 0.0575 0.0575
Echinococcus granulosus neuropeptide receptor 0.0019 0.0011 0.0011
Treponema pallidum fructose-bisphosphate aldolase 0.0282 0.3557 0.5
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0011 0.0011
Echinococcus granulosus carbonic anhydrase II 0.0198 0.2417 0.2417
Echinococcus granulosus neuropeptide receptor 0.0019 0.0011 0.0011
Echinococcus granulosus G protein coupled receptor 139 0.0019 0.0011 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0362 0.4634 1
Entamoeba histolytica hypothetical protein 0.0035 0.0219 0.0472
Echinococcus granulosus expressed protein 0.0361 0.4611 0.4611
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0981 0.2116
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0084 0.0882 0.0882
Schistosoma mansoni biogenic amine receptor 0.0019 0.0011 0.0011
Echinococcus multilocularis G-protein coupled receptor, putative 0.0019 0.0011 0.0011
Onchocerca volvulus Serine\/threonine kinase homolog 0.0091 0.0981 0.2104
Schistosoma mansoni hypothetical protein 0.0019 0.0011 0.0011
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.0497 0.0497
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0362 0.4634 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0882 0.1902
Brugia malayi hypothetical protein 0.0019 0.0007 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.3557 0.7675
Brugia malayi cathepsin L-like precursor 0.0249 0.3113 0.3113
Entamoeba histolytica cysteine protease, putative 0.0197 0.2403 0.5185
Entamoeba histolytica hypothetical protein 0.0035 0.0219 0.0472
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0362 0.4634 1
Brugia malayi RNA binding protein 0.0061 0.0575 0.0575
Schistosoma mansoni cathepsin F (C01 family) 0.0362 0.4634 0.4634
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0019 0.0011 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0362 0.4634 1
Schistosoma mansoni hypothetical protein 0.0164 0.1957 0.1957
Brugia malayi hypothetical protein 0.0019 0.0011 0.0011
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.076 1 1
Schistosoma mansoni hypothetical protein 0.0019 0.0011 0.0011
Plasmodium vivax serine-repeat antigen (SERA) 0.0084 0.0882 0.189
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0197 0.2403 0.3893
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0019 0.0011 0.0011
Trichomonas vaginalis set domain proteins, putative 0.0229 0.2835 0.6118
Loa Loa (eye worm) cathepsin B 0.0293 0.3702 0.3702
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0011 0.0011
Schistosoma mansoni cathepsin S (C01 family) 0.0084 0.0882 0.0882
Onchocerca volvulus 0.0362 0.4634 1
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0011 0.0011
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0007 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0139 0.0139
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0011 0.0011
Onchocerca volvulus Cathepsin L homolog 0.0362 0.4634 1
Echinococcus granulosus g-protein coupled receptor 0.0019 0.0011 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0011 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0011 0.0011
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0011 0.0011
Onchocerca volvulus 0.0362 0.4634 1
Schistosoma mansoni neuropeptide receptor 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0093 0.1003 0.1003
Onchocerca volvulus 0.0019 0.0011 0.0007
Entamoeba histolytica fatty acid elongase, putative 0.0046 0.0369 0.0797
Brugia malayi follicle stimulating hormone receptor 0.0242 0.3006 0.3006
Echinococcus multilocularis cathepsin L 0.0084 0.0882 0.0882
Brugia malayi Papain family cysteine protease containing protein 0.0084 0.0882 0.0882
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.3557 0.7675
Echinococcus multilocularis cathepsin L cysteine protease 0.0362 0.4634 0.4634
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0362 0.4634 1
Entamoeba histolytica cysteine proteinase, putative 0.0197 0.2403 0.5185
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0053 0.0469 0.0469
Echinococcus multilocularis serotonin receptor 0.0019 0.0011 0.0011
Trypanosoma cruzi cysteine peptidase, putative 0.0197 0.2403 0.1668
Onchocerca volvulus 0.0019 0.0011 0.0007
Plasmodium falciparum cysteine proteinase falcipain 3 0.0362 0.4634 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0575 0.0575
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0019 0.0011 0.0011
Entamoeba histolytica cysteine protease, putative 0.0197 0.2403 0.5185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0362 0.4634 1
Schistosoma mansoni amine GPCR 0.0019 0.0011 0.0011
Schistosoma mansoni lipoxygenase 0.0053 0.0469 0.0469
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.8737 0.8737
Toxoplasma gondii cathepsin B 0.0293 0.3702 0.7926
Onchocerca volvulus 0.0019 0.0011 0.0007
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0198 0.2417 0.2417
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Onchocerca volvulus 0.0019 0.0011 0.0007
Leishmania major cathepsin L-like protease 0.0362 0.4634 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Echinococcus granulosus carbonic anhydrase 0.0093 0.1003 0.1003
Echinococcus granulosus cathepsin L 0.0197 0.2403 0.2403
Brugia malayi Cathepsin L-like precursor 0.0249 0.3113 0.3113
Echinococcus multilocularis RUN 0.0019 0.0007 0.0007
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0084 0.0882 0.0882
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0084 0.0882 0.189
Brugia malayi G-protein coupled receptor 0.0019 0.0011 0.0011
Echinococcus multilocularis cysteine protease 0.0362 0.4634 0.4634
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.0981 0.0981
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0198 0.2417 0.2417
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0007 0.0007
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0084 0.0882 0.189
Plasmodium falciparum serine repeat antigen 7 0.0084 0.0882 0.189
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0011 0.0011
Schistosoma mansoni myosin xvIII 0.0019 0.0011 0.0011
Brugia malayi Cathepsin L-like precursor 0.0362 0.4634 0.4634
Echinococcus granulosus cathepsin l cysteine peptidase 0.0362 0.4634 0.4634
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.3557 0.7675
Echinococcus multilocularis neuropeptide receptor A26 0.0019 0.0011 0.0011
Leishmania major cathepsin L-like protease 0.0362 0.4634 1
Entamoeba histolytica cysteine protease, putative 0.0197 0.2403 0.5185
Schistosoma mansoni rab6-interacting 0.0019 0.0007 0.0007
Brugia malayi cathepsin F-like cysteine proteinase 0.0084 0.0882 0.0882
Trypanosoma cruzi cysteine peptidase, putative 0.0362 0.4634 0.4115
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.0981 0.0981
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0362 0.4634 1
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0981 0.2116
Loa Loa (eye worm) hypothetical protein 0.0084 0.0882 0.0882
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0011 0.0011
Entamoeba histolytica hypothetical protein 0.0084 0.0882 0.1902
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0497 0.0497
Entamoeba histolytica cysteine proteinase, putative 0.0362 0.4634 1
Entamoeba histolytica cysteine protease, putative 0.0197 0.2403 0.5185
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Schistosoma mansoni opsin-like receptor 0.0019 0.0011 0.0011
Brugia malayi larval opioid receptor 0.0019 0.0011 0.0011
Onchocerca volvulus 0.0362 0.4634 1
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0882 0.1902
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0093 0.1003 0.1003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0362 0.4634 1
Brugia malayi G-protein coupled receptor 0.0019 0.0011 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0362 0.4634 1
Onchocerca volvulus 0.0019 0.0011 0.0007
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0093 0.1003 0.1003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Brugia malayi cathepsin F-like cysteine proteinase 0.0113 0.1272 0.1272
Plasmodium falciparum cysteine proteinase falcipain 1 0.0197 0.2403 0.5178
Echinococcus granulosus cathepsin b 0.076 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Brugia malayi hypothetical protein 0.0019 0.0011 0.0011
Loa Loa (eye worm) RNA binding protein 0.0061 0.0575 0.0575
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0084 0.0882 0.0882
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0293 0.3702 0.3093
Echinococcus granulosus growth factor receptor bound protein 2 0.0152 0.1799 0.1799
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0575 0.0575
Brugia malayi Doublecortin family protein 0.0019 0.0007 0.0007
Plasmodium falciparum serine repeat antigen 5 0.0084 0.0882 0.189
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0011 0.0011
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0011 0.0011
Plasmodium falciparum serine repeat antigen 6 0.0084 0.0882 0.189
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.3557 0.7675
Echinococcus multilocularis orexin receptor type 2 0.0019 0.0011 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0011 0.0011
Echinococcus granulosus tachykinin peptides receptor 99D 0.0019 0.0011 0.0011
Onchocerca volvulus 0.0029 0.0139 0.0285
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.161 0.5
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0197 0.2403 0.1668
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0084 0.0882 0.1902
Brugia malayi Papain family cysteine protease containing protein 0.0197 0.2403 0.2403
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0198 0.2417 0.2417
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Schistosoma mansoni lipoxygenase 0.0019 0.0007 0.0007
Entamoeba histolytica fatty acid elongase, putative 0.0046 0.0369 0.0797
Echinococcus multilocularis expressed protein 0.0361 0.4611 0.4611
Brugia malayi Dopamine receptor 0.0019 0.0011 0.0011
Echinococcus multilocularis neuropeptide s receptor 0.0019 0.0011 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0362 0.4634 1
Brugia malayi putative neuropeptide receptor 0.0019 0.0011 0.0011
Entamoeba histolytica cysteine protease, putative 0.0084 0.0882 0.1902
Echinococcus granulosus 7tm_1 domain containing protein 0.0019 0.0011 0.0011
Brugia malayi neuropeptide F receptor 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Schistosoma mansoni cathepsin B (C01 family) 0.0084 0.0882 0.0882
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.3557 0.7675
Echinococcus multilocularis geminin 0.0164 0.1957 0.1957
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0575 0.0575
Onchocerca volvulus Cathepsin F homolog 0.0362 0.4634 1
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0198 0.2417 0.2417
Echinococcus granulosus neuropeptide FF receptor 2 0.0019 0.0011 0.0011
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0354 0.4517 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0011 0.0011
Leishmania major cathepsin L-like protease 0.0362 0.4634 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0293 0.3702 0.7746
Echinococcus granulosus g protein coupled receptor 0.0019 0.0011 0.0011
Entamoeba histolytica cysteine proteinase, putative 0.0197 0.2403 0.5185
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0019 0.0011 0.0011
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0093 0.1003 0.1003
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0354 0.4517 0.5
Schistosoma mansoni neuropeptide receptor 0.0019 0.0011 0.0011
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0113 0.1272 0.1272
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0362 0.4634 1
Brugia malayi Papain family cysteine protease containing protein 0.0084 0.0882 0.0882
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0019 0.0011 0.0011
Entamoeba histolytica cysteine protease, putative 0.0084 0.0882 0.1902
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0354 0.4517 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0055 0.0497 0.0497
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0242 0.3006 0.3006
Brugia malayi Cathepsin L-like precursor 0.0362 0.4634 0.4634
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0362 0.4634 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0011 0.0011
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0004 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0362 0.4634 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0084 0.0882 0.1902
Trypanosoma cruzi cysteine peptidase, putative 0.0362 0.4634 0.4115
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0354 0.4517 0.5
Onchocerca volvulus 0.0019 0.0011 0.0007
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0093 0.1003 0.1003
Schistosoma mansoni hypothetical protein 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0362 0.4634 1
Brugia malayi G protein-coupled receptor 0.0019 0.0011 0.0011
Brugia malayi Papain family cysteine protease containing protein 0.0084 0.0882 0.0882
Echinococcus granulosus somatostatin receptor 0.0019 0.0011 0.0011
Onchocerca volvulus Cathepsin L homolog 0.0362 0.4634 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0011 0.0011
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0139 0.0139
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0084 0.0882 0.189
Schistosoma mansoni opsin-like receptor 0.0019 0.0011 0.0011
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0011 0.0011
Echinococcus granulosus carbonic anhydrase 0.0093 0.1003 0.1003
Schistosoma mansoni hypothetical protein 0.0093 0.1003 0.1003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0362 0.4634 1
Brugia malayi Papain family cysteine protease containing protein 0.0197 0.2403 0.2403
Echinococcus granulosus allatostatin A receptor 0.0019 0.0011 0.0011
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0011 0.0011
Entamoeba histolytica cysteine protease, putative 0.0197 0.2403 0.5185
Giardia lamblia Cathepsin B precursor 0.0293 0.3702 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0019 0.0011 0.0011
Brugia malayi Dopamine receptor protein 2 0.0019 0.0011 0.0011
Echinococcus multilocularis g-protein coupled receptor 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Entamoeba histolytica cysteine proteinase, putative 0.0197 0.2403 0.5185
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0093 0.1003 0.1003
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0011 0.0011
Plasmodium falciparum serine repeat antigen 9 0.0084 0.0882 0.189
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0011 0.0011
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.161 0.2767
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0011 0.0011
Echinococcus granulosus RUN 0.0019 0.0007 0.0007
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0084 0.0882 0.1902
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0011 0.0011
Loa Loa (eye worm) cysteine protease 0.0362 0.4634 0.4634
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Schistosoma mansoni growth factor receptor-bound protein 0.0152 0.1799 0.1799
Echinococcus multilocularis growth factor receptor bound protein 2 0.0152 0.1799 0.1799
Brugia malayi hypothetical protein 0.0019 0.0011 0.0011
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0084 0.0882 0.0882
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0293 0.3702 0.3702
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0084 0.0882 0.0882
Onchocerca volvulus 0.0249 0.3113 0.6712
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0011 0.0011
Brugia malayi Papain family cysteine protease containing protein 0.0362 0.4634 0.4634
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0125 0.0125
Echinococcus granulosus hypothetical protein 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0882 0.1902
Schistosoma mansoni neuropeptide f receptor 76f 0.0019 0.0011 0.0011
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0362 0.4634 1
Plasmodium vivax unspecified product 0.0084 0.0882 0.189
Loa Loa (eye worm) fibroinase 0.0362 0.4634 0.4634
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0019 0.0011 0.0011
Onchocerca volvulus Neuropeptide F receptor homolog 0.0019 0.0011 0.0007
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0004 0.0004
Plasmodium falciparum serine repeat antigen 8 0.0084 0.0882 0.189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0362 0.4634 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Schistosoma mansoni neuropeptide receptor 0.0019 0.0011 0.0011
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.076 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0882 0.1902
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0007 0.0007
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0011 0.0011
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.0981 0.0109
Leishmania major cathepsin L-like protease 0.0362 0.4634 1
Brugia malayi fibroinase precursor 0.0084 0.0882 0.0882
Plasmodium vivax vivapain-2 0.0362 0.4634 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0219 0.0219
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0084 0.0882 0.1902
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0011 0.0011
Echinococcus multilocularis cathepsin L cysteine protease 0.0362 0.4634 0.4634
Echinococcus granulosus serotonin receptor 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0882 0.1902
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0113 0.1272 0.1272
Onchocerca volvulus 0.0019 0.0011 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0362 0.4634 1
Echinococcus granulosus cathepsin l1 0.0362 0.4634 0.4634
Entamoeba histolytica cysteine proteinase, putative 0.0249 0.3113 0.6717
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0882 0.1902
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0019 0.0011 0.0011
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0011 0.0011
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0007 0.0007
Echinococcus granulosus orexin receptor type 2 0.0019 0.0011 0.0011
Brugia malayi Sex muscle abnormal protein 5 0.0152 0.1799 0.1799
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0882 0.1902
Schistosoma mansoni amine GPCR 0.0019 0.0011 0.0011
Schistosoma mansoni carbonic anhydrase-related 0.0093 0.1003 0.1003
Brugia malayi hypothetical protein 0.0019 0.0011 0.0011
Onchocerca volvulus Cathepsin L homolog 0.0084 0.0882 0.189
Onchocerca volvulus 0.0084 0.0882 0.189
Loa Loa (eye worm) hypothetical protein 0.0084 0.0882 0.0882
Toxoplasma gondii cathepsin CPL 0.0362 0.4634 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0011 0.0011
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0084 0.0882 0.0882
Loa Loa (eye worm) hypothetical protein 0.0113 0.1272 0.1272
Brugia malayi hypothetical protein 0.0019 0.0011 0.0011
Entamoeba histolytica cysteine proteinase, putative 0.0362 0.4634 1
Echinococcus granulosus g protein coupled receptor 0.0019 0.0011 0.0011
Schistosoma mansoni cathepsin C 0.0084 0.0882 0.0882
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0084 0.0882 0.0882
Onchocerca volvulus 0.0019 0.0011 0.0007
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0007 0.0007
Leishmania major cathepsin L-like protease 0.0362 0.4634 1
Giardia lamblia Cathepsin B precursor 0.0293 0.3702 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0084 0.0882 0.1652
Loa Loa (eye worm) carbonic anhydrase 3 0.0198 0.2417 0.2417
Leishmania major cysteine peptidase A (CPA) 0.0362 0.4634 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0362 0.4634 1
Onchocerca volvulus 0.0362 0.4634 1
Echinococcus granulosus g protein coupled receptor 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Brugia malayi ORL1-like opioid receptor 0.0019 0.0011 0.0011
Echinococcus granulosus cathepsin l1 0.0249 0.3113 0.3113
Schistosoma mansoni histamine h1 receptor 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0249 0.3113 0.3113
Entamoeba histolytica cysteine protease, putative 0.0197 0.2403 0.5185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0362 0.4634 1
Onchocerca volvulus 0.0019 0.0011 0.0007
Trypanosoma cruzi cruzipain precursor, putative 0.0362 0.4634 0.4115
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0197 0.2403 0.5185
Trypanosoma cruzi cysteine peptidase, putative 0.0362 0.4634 0.4115
Brugia malayi hypothetical protein 0.0019 0.0011 0.0011
Echinococcus granulosus cathepsin b 0.076 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0019 0.0011 0.0011
Leishmania major cathepsin L-like protease 0.0362 0.4634 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0084 0.0882 0.1902
Schistosoma mansoni growth factor receptor-bound protein 0.0152 0.1799 0.1799
Echinococcus granulosus dro:myosuppressin receptor 0.0019 0.0011 0.0011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0011 0.0011
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.0981 0.0981
Schistosoma mansoni amine GPCR 0.0019 0.0011 0.0011
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0019 0.0011 0.0011
Echinococcus multilocularis dro:myosuppressin receptor 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0293 0.3702 0.7988
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0019 0.0011 0.0011
Loa Loa (eye worm) ctsf protein 0.0362 0.4634 0.4634
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.0981 0.2116
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0981 0.2116
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Brugia malayi Tachykinin-like peptides receptor 99D 0.0019 0.0011 0.0011
Trypanosoma cruzi cruzipain precursor, putative 0.0113 0.1272 0.0428
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Plasmodium vivax vivapain-2 0.0362 0.4634 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Leishmania major carbonic anhydrase-like protein 0.0198 0.2417 0.4641
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0019 0.0011 0.0011
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.3557 0.7675
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0011 0.0011
Echinococcus multilocularis carbonic anhydrase 0.0093 0.1003 0.1003
Onchocerca volvulus 0.0019 0.0011 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0093 0.1003 0.1003
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0354 0.4517 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0019 0.0011 0.0011
Entamoeba histolytica fatty acid elongase, putative 0.0046 0.0369 0.0797
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0139 0.0139
Entamoeba histolytica fatty acid elongase, putative 0.0046 0.0369 0.0797
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0011 0.0011
Brugia malayi RE15519p 0.0019 0.0011 0.0011
Entamoeba histolytica cysteine protease, putative 0.0084 0.0882 0.1902
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0011 0.0011
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.161 0.2767
Entamoeba histolytica cysteine protease, putative 0.0197 0.2403 0.5185
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0354 0.4517 0.9748
Onchocerca volvulus 0.0019 0.0011 0.0007
Giardia lamblia Cathepsin B precursor 0.0293 0.3702 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0084 0.0882 0.1902
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0575 0.0575
Schistosoma mansoni polycystin 1-related 0.0019 0.0007 0.0007
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0084 0.0882 0.0882
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0084 0.0882 0.189
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0084 0.0882 0.189
Entamoeba histolytica cysteine proteinase 2 0.0197 0.2403 0.5185
Toxoplasma gondii hypothetical protein 0.0093 0.1003 0.1922
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0362 0.4634 1
Loa Loa (eye worm) hypothetical protein 0.0249 0.3113 0.3113
Schistosoma mansoni adenoreceptor 0.0019 0.0011 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0981 0.2116
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0575 0.0575
Schistosoma mansoni alpha-1 adrenergic receptor 0.0019 0.0011 0.0011
Plasmodium falciparum serine repeat antigen 3 0.0084 0.0882 0.189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Brugia malayi hypothetical protein 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0882 0.1902
Schistosoma mansoni cathepsin F (C01 family) 0.0249 0.3113 0.3113
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.0497 0.0497
Entamoeba histolytica hypothetical protein 0.0035 0.0219 0.0472
Brugia malayi Pre-SET motif family protein 0.0029 0.0139 0.0139
Schistosoma mansoni carbonic anhydrase-related 0.0093 0.1003 0.1003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0362 0.4634 1
Echinococcus multilocularis carbonic anhydrase 0.0093 0.1003 0.1003
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0011 0.0011
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0447 0.0447
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0197 0.2403 0.2403
Trypanosoma cruzi cysteine proteinase, putative 0.0197 0.2403 0.1668
Brugia malayi neuropeptide F receptor 0.0019 0.0011 0.0011
Onchocerca volvulus 0.0019 0.0011 0.0007
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0084 0.0882 0.0882
Echinococcus granulosus fmrfamide receptor 0.0019 0.0011 0.0011
Echinococcus granulosus neuropeptide receptor A26 0.0019 0.0011 0.0011
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.076 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0084 0.0882 0.0882
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0198 0.2417 0.1684
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0362 0.4634 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0362 0.4634 1
Onchocerca volvulus 0.0019 0.0011 0.0007
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0084 0.0882 0.189
Loa Loa (eye worm) hypothetical protein 0.0084 0.0882 0.0882
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0084 0.0882 0.0882
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0354 0.4517 1
Schistosoma mansoni hypothetical protein 0.0035 0.0219 0.0219
Schistosoma mansoni loxhd1 0.0019 0.0007 0.0007
Onchocerca volvulus 0.0019 0.0011 0.0007
Loa Loa (eye worm) hypothetical protein 0.0144 0.1696 0.1696
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0029 0.0139 0.0139
Plasmodium vivax serine-repeat antigen (SERA) 0.0084 0.0882 0.189
Schistosoma mansoni amine GPCR 0.0019 0.0011 0.0011
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0011 0.0011
Leishmania major cathepsin L-like protease 0.0362 0.4634 1
Entamoeba histolytica fatty acid elongase, putative 0.0046 0.0369 0.0797
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0084 0.0882 0.1902
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Brugia malayi hypothetical protein 0.0019 0.0011 0.0011
Entamoeba histolytica cysteine protease, putative 0.0197 0.2403 0.5185
Echinococcus multilocularis cathepsin L 0.0197 0.2403 0.2403
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.3557 0.7675
Brugia malayi Cathepsin L-like precursor 0.0362 0.4634 0.4634
Plasmodium vivax vivapain-3 0.0197 0.2403 0.5178
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0197 0.2403 0.2403
Echinococcus granulosus tar DNA binding protein 0.0061 0.0575 0.0575
Onchocerca volvulus 0.0362 0.4634 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0084 0.0882 0.1902
Trypanosoma cruzi cysteine peptidase, putative 0.0362 0.4634 0.4115
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0362 0.4634 1
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0084 0.0882 0.189
Echinococcus granulosus alpha 1A adrenergic receptor 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0197 0.2403 0.5185
Schistosoma mansoni hypothetical protein 0.0019 0.0011 0.0011
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0019 0.0011 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0011 0.0011
Brugia malayi Cathepsin L-like precursor 0.0362 0.4634 0.4634
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0019 0.0011 0.0011
Brugia malayi Dopamine receptor protein 1 0.0019 0.0011 0.0011
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0575 0.0575
Brugia malayi Cathepsin L-like precursor 0.0249 0.3113 0.3113
Schistosoma mansoni cathepsin F (C01 family) 0.0362 0.4634 0.4634
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0139 0.0139
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0053 0.0469 0.0469
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0575 0.0575
Echinococcus granulosus cathepsin L cysteine protease 0.0197 0.2403 0.2403
Echinococcus multilocularis muscleblind protein 0.0144 0.1696 0.1696
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0084 0.0882 0.189
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0019 0.0011 0.0011
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0019 0.0011 0.0011
Brugia malayi cathepsin L precursor 0.0084 0.0882 0.0882
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.2461 0.2461
Schistosoma mansoni biogenic amine receptor 0.0019 0.0011 0.0011
Entamoeba histolytica cysteine protease, putative 0.0084 0.0882 0.1902
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0362 0.4634 1
Schistosoma mansoni amine GPCR 0.0019 0.0011 0.0011
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0004 0.0004
Entamoeba histolytica cysteine protease, putative 0.0084 0.0882 0.1902
Plasmodium vivax vivapain-1 0.0197 0.2403 0.5178
Brugia malayi cathepsin Z-like cysteine proteinase 0.0084 0.0882 0.0882
Onchocerca volvulus 0.0229 0.2835 0.6112
Brugia malayi Pre-SET motif family protein 0.0201 0.2461 0.2461
Plasmodium vivax SET domain protein, putative 0.0029 0.0139 0.0285
Giardia lamblia Fructose-bisphosphate aldolase 0.0282 0.3557 0.9485
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0035 0.0219 0.0472
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.3557 0.7675
Echinococcus granulosus sex peptide receptor 0.0019 0.0011 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0011 0.0011
Trypanosoma brucei cysteine peptidase C (CPC) 0.0293 0.3702 0.7448
Entamoeba histolytica cysteine protease, putative 0.0197 0.2403 0.5185
Echinococcus multilocularis cysteine protease 0.0362 0.4634 0.4634
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0084 0.0882 0.1902
Plasmodium vivax unspecified product 0.0113 0.1272 0.2733
Giardia lamblia Kinase, PLK 0.0091 0.0981 0.0351
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0084 0.0882 0.1902
Toxoplasma gondii cathepsin CPC2 0.0084 0.0882 0.1652
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0084 0.0882 0.189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0249 0.3113 0.6717
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0362 0.4634 1
Brugia malayi AKH receptor 0.0019 0.0011 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0011 0.0011
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0084 0.0882 0.0882
Schistosoma mansoni growth hormone secretagogue receptor 0.0019 0.0011 0.0011
Plasmodium falciparum serine repeat antigen 2 0.0084 0.0882 0.189
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0113 0.1272 0.1272
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0219 0.0219
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0019 0.0011 0.0011
Onchocerca volvulus 0.0362 0.4634 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0084 0.0882 0.1902
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0084 0.0882 0.1902
Brugia malayi Cathepsin L-like precursor 0.0113 0.1272 0.1272
Echinococcus multilocularis cathepsin b 0.076 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0139 0.0139
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0093 0.1003 0.1003
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0981 0.0981
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0362 0.4634 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0152 0.1799 0.1799
Brugia malayi Melatonin receptor type 1A 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0084 0.0882 0.0882
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0362 0.4634 0.4634
Loa Loa (eye worm) hypothetical protein 0.0144 0.1696 0.1696
Entamoeba histolytica cysteine protease, putative 0.0362 0.4634 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0362 0.4634 0.4634
Toxoplasma gondii cathepsin CPC1 0.0084 0.0882 0.1652
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0011 0.0011
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0362 0.4634 0.4634
Plasmodium vivax unspecified product 0.0197 0.2403 0.5178
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0011 0.0011
Brugia malayi Serotonin receptor 0.0019 0.0011 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0011 0.0011
Echinococcus multilocularis sex peptide receptor 0.0019 0.0011 0.0011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.3557 0.7675
Brugia malayi sulfakinin receptor protein 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0084 0.0882 0.0882
Schistosoma mansoni cathepsin s 0.0113 0.1272 0.1272
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0198 0.2417 0.2417
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0362 0.4634 1
Entamoeba histolytica cysteine protease, putative 0.0197 0.2403 0.5185
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0362 0.4634 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.0981 0.0981
Echinococcus granulosus peptide allatostatin:somatostatin 0.0019 0.0011 0.0011
Brugia malayi Serotonin receptor 0.0019 0.0011 0.0011
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0362 0.4634 0.4634
Echinococcus multilocularis G protein coupled receptor 139 0.0019 0.0011 0.0011
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0011 0.0011
Schistosoma mansoni neuropeptide receptor 0.0019 0.0011 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0011 0.0011
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0575 0.0575
Trypanosoma brucei carbonic anhydrase-like protein 0.0198 0.2417 0.3932
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0004 0.0004
Brugia malayi G protein-coupled receptor F59B2.13 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0362 0.4634 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0362 0.4634 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0249 0.3113 0.2447
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0011 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0084 0.0882 0.1902
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0354 0.4517 0.9748
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0197 0.2403 0.2403

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 77 uM Binding affinity to recombinant Grb2 SH2 domain by surface plasmon resonance analysis ChEMBL. 18821748

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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