Detailed information for compound 1471821

Basic information

Technical information
  • TDR Targets ID: 1471821
  • Name: 5-(4-dimethylaminophenyl)-N-[(5-methylpyrazin -2-yl)methyl]pyrimidin-4-amine
  • MW: 320.392 | Formula: C18H20N6
  • H donors: 1 H acceptors: 4 LogP: 2.06 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cnc(cn1)CNc1ncncc1c1ccc(cc1)N(C)C
  • InChi: 1S/C18H20N6/c1-13-8-21-15(9-20-13)10-22-18-17(11-19-12-23-18)14-4-6-16(7-5-14)24(2)3/h4-9,11-12H,10H2,1-3H3,(H,19,22,23)
  • InChiKey: DLUJEJCUMFBYLX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(4-dimethylaminophenyl)-N-[(5-methyl-2-pyrazinyl)methyl]-4-pyrimidinamine
  • dimethyl-[4-[4-[(5-methylpyrazin-2-yl)methylamino]pyrimidin-5-yl]phenyl]amine
  • NCGC00011579
  • PCOP-539284

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens CDC-like kinase 4 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Giardia lamblia Kinase, CMGC CLK Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Plasmodium knowlesi serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum Serine/threonine-protein kinase Doa, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma brucei kinetoplastid kinetochore protein 10 Get druggable targets OG5_126990 All targets in OG5_126990
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Cryptosporidium parvum serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium yoelii protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium berghei serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei kinetoplastid kinetochore protein 19 Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) CMGC/CLK protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum expressed protein Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium vivax serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium falciparum protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium hominis serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Neospora caninum hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Babesia bovis protein serine/threonine kinase 1 Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126990 All targets in OG5_126990
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax hypothetical protein, conserved 0.0359 1 1
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0128 0.3018 1
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0359 1 1
Leishmania major hypothetical protein, conserved 0.0128 0.3018 1
Schistosoma mansoni fusion 0.0128 0.3018 0.2014
Echinococcus granulosus ring and YY1 binding protein 0.0128 0.3018 0.2014
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.1116 0.1116
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0128 0.3018 0.2014
Trypanosoma cruzi hypothetical protein, conserved 0.0128 0.3018 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9831 0.9804
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9831 0.9804
Trypanosoma brucei hypothetical protein, conserved 0.0128 0.3018 1
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0128 0.3018 0.2014
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0073 0.1371 0.4541
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.4375 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0359 1 1
Brugia malayi SWIB/MDM2 domain containing protein 0.0359 1 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0128 0.3018 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9831 0.9804
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0128 0.3018 0.1909
Echinococcus granulosus dual specificity protein kinase clk2 0.0073 0.1371 0.0129
Leishmania major hypothetical protein, conserved 0.0128 0.3018 1
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0072 0.1354 0.1354
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.4375 1
Leishmania major hypothetical protein, conserved 0.0128 0.3018 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.9831 0.5
Schistosoma mansoni hypothetical protein 0.0128 0.3018 0.2014
Brugia malayi YY1-associated factor 2 0.0128 0.3018 0.3018
Loa Loa (eye worm) hypothetical protein 0.0128 0.3018 0.3018
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0128 0.3018 0.3018
Loa Loa (eye worm) hypothetical protein 0.0128 0.3018 0.3018
Echinococcus multilocularis SWI:SNF matrix associated 0.0359 1 1
Trypanosoma cruzi WLM domain containing protein, putative 0.0128 0.3018 1
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0073 0.1371 0.4541
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0359 1 1
Leishmania major hypothetical protein, conserved 0.0128 0.3018 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.3018 0.3018
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0128 0.3018 0.3018
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0073 0.1371 0.4541
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0128 0.3018 0.3018
Schistosoma mansoni zinc finger protein 0.0128 0.3018 0.2014
Echinococcus multilocularis dual specificity protein kinase clk2 0.0073 0.1371 0.0129
Schistosoma mansoni hypothetical protein 0.0359 1 1
Echinococcus granulosus zinc finger protein Ran binding 0.0128 0.3018 0.2014
Echinococcus granulosus hypothetical protein 0.0072 0.1354 0.011
Loa Loa (eye worm) hypothetical protein 0.0128 0.3018 0.3018
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0359 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0128 0.3018 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.9831 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.1257 0.2874
Trichomonas vaginalis conserved hypothetical protein 0.0359 1 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.1371 0.1371
Schistosoma mansoni TRABID protein (C64 family) 0.0128 0.3018 0.2014
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0359 1 1
Leishmania major protein kinase, putative 0.0073 0.1371 0.4541
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0359 1 1
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.9831 0.5
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0128 0.3018 0.2014
Echinococcus multilocularis SWI:SNF matrix associated 0.0359 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0128 0.3018 1
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0128 0.3018 1
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0073 0.1371 0.4541
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.1257 0.2874
Echinococcus granulosus Zinc finger RanBP2 type 0.0128 0.3018 0.2014
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.1371 0.0129
Echinococcus multilocularis zinc finger protein Ran binding 0.0128 0.3018 0.2014
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.1257 0.1257
Chlamydia trachomatis DNA topoisomerase I 0.0359 1 0.5
Brugia malayi brahma associated protein 60 kDa 0.0359 1 1
Schistosoma mansoni hypothetical protein 0.0359 1 1
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0073 0.1371 0.4541
Schistosoma mansoni brg-1 associated factor 0.0359 1 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.1257 0.4166
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0128 0.3018 1
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0073 0.1371 0.1371
Loa Loa (eye worm) hypothetical protein 0.0128 0.3018 0.3018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9831 0.9804
Echinococcus multilocularis ring and YY1 binding protein 0.0128 0.3018 0.2014
Trypanosoma cruzi WLM domain containing protein, putative 0.0128 0.3018 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9831 0.9804
Chlamydia trachomatis SWIB complex protein 0.0359 1 0.5
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0128 0.3018 1
Trypanosoma cruzi hypothetical protein, conserved 0.0128 0.3018 1
Leishmania major hypothetical protein, conserved 0.0128 0.3018 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0128 0.3018 0.3018
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0073 0.1371 0.4541
Loa Loa (eye worm) brahma associated protein 0.0359 1 1
Onchocerca volvulus 0.0359 1 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.9831 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.4375 0.5
Brugia malayi Cytochrome P450 family protein 0.004 0.0377 0.0377
Echinococcus multilocularis 0.0072 0.1354 0.011
Echinococcus granulosus SWI:SNF matrix associated 0.0359 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.1371 0.0129
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0359 1 1
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0359 1 1
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0128 0.3018 0.1909
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9831 0.9804
Leishmania major protein kinase, putative 0.0073 0.1371 0.4541
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9831 0.9804
Schistosoma mansoni hypothetical protein 0.0359 1 1
Toxoplasma gondii ran binding protein 0.0128 0.3018 0.1909
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0128 0.3018 1
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0128 0.3018 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.9831 0.9804
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0359 1 1
Schistosoma mansoni RNA binding protein 0.0128 0.3018 0.2014

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 1.995262315 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 3.16227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (ADMET) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of CDC-like Kinase 4 (Kinase-Glo Assay). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of CDC-like Kinase 4 (ADP-Glo Assay). (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 19.9054 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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