TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 431.484 | Formula: C25H25N3O4
H donors: 2 H acceptors: 2 LogP: 3.27 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: NCCC(=O)Nc1ccc2c(c1)c(=O)c1c(n2Cc2cc(OC)cc(c2)OC)cccc1
InChi: 1S/C25H25N3O4/c1-31-18-11-16(12-19(14-18)32-2)15-28-22-6-4-3-5-20(22)25(30)21-13-17(7-8-23(21)28)27-24(29)9-10-26/h3-8,11-14H,9-10,15,26H2,1-2H3,(H,27,29)
InChiKey: BLANGKXWNFIVEJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Cathepsin L homolog	0.0126	0.1603	0.5789
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0821	0.0874
Schistosoma mansoni	ap endonuclease	0.0038	0.0037	0.0039
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0037	0.0231
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0126	0.1603	0.1702
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0198	0.2909	1
Brugia malayi	TAR-binding protein	0.0125	0.1593	0.1695
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1593	0.1695
Entamoeba histolytica	cysteine proteinase, putative	0.0073	0.0652	0.0648
Leishmania major	cathepsin L-like protease	0.0126	0.1603	0.5452
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0594	1	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0004	0.0004
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0036	0.0004	0.0026
Entamoeba histolytica	cysteine protease, putative	0.0073	0.0652	0.0648
Brugia malayi	RNA recognition motif domain containing protein	0.0125	0.1593	0.1695
Loa Loa (eye worm)	hypothetical protein	0.019	0.2766	0.2944
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0126	0.1603	0.1702
Plasmodium vivax	vivapain-3	0.0073	0.0652	0.4069
Giardia lamblia	Cathepsin B precursor	0.0198	0.2909	0.2906
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0126	0.1603	0.1599
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0036	0.0004	0.0026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0126	0.1603	0.5452
Onchocerca volvulus		0.0082	0.0821	0.2959
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0425	0.0859
Leishmania major	cathepsin L-like protease	0.0126	0.1603	0.5452
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0955	0.1016
Brugia malayi	Cathepsin L-like precursor	0.0126	0.1603	0.1706
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0126	0.1603	0.1599
Leishmania major	cathepsin L-like protease	0.0126	0.1603	0.5452
Brugia malayi	Cathepsin L-like precursor	0.0126	0.1603	0.1706
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0036	0.0004	0.0004
Brugia malayi	fibroinase precursor	0.0036	0.0004	0.0004
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0038	0.0037	0.0035
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0101	0.1166	0.1242
Trypanosoma cruzi	cruzipain precursor, putative	0.0126	0.1603	0.1706
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0036	0.0004	0.0004
Plasmodium vivax	vivapain-2	0.0126	0.1603	1
Entamoeba histolytica	cysteine proteinase, putative	0.0126	0.1603	0.1599
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0955	0.1016
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0425	0.0452
Onchocerca volvulus		0.019	0.2766	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0198	0.2909	1
Brugia malayi	Papain family cysteine protease containing protein	0.0036	0.0004	0.0004
Brugia malayi	Cathepsin L-like precursor	0.0089	0.0955	0.1016
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.1603	0.1599
Trypanosoma cruzi	cysteine peptidase, putative	0.0126	0.1603	0.1706
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.019	0.2766	0.2944
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0126	0.1603	0.1706
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0036	0.0004	0.0004
Entamoeba histolytica	cysteine protease, putative	0.0073	0.0652	0.0648
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.056	0.9395	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0036	0.0004	0.0004
Leishmania major	cathepsin L-like protease	0.0126	0.1603	0.5452
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0652	0.0694
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0594	1	1
Loa Loa (eye worm)	hypothetical protein	0.0126	0.1603	0.1706
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0594	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0126	0.1603	1
Entamoeba histolytica	cysteine protease, putative	0.0073	0.0652	0.0648
Loa Loa (eye worm)	hypothetical protein	0.056	0.9395	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0126	0.1603	0.1599
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0073	0.0652	0.0648
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0073	0.0652	0.0648
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.1603	0.1599
Brugia malayi	RNA binding protein	0.0125	0.1593	0.1695
Schistosoma mansoni	hypothetical protein	0.0069	0.0592	0.063
Echinococcus granulosus	tar DNA binding protein	0.0125	0.1593	0.1692
Loa Loa (eye worm)	ctsf protein	0.0126	0.1603	0.1706
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0036	0.0004	0.0004
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0101	0.1166	0.1242
Onchocerca volvulus		0.0126	0.1603	0.5789
Echinococcus granulosus	cathepsin b	0.056	0.9395	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0126	0.1603	0.1599
Brugia malayi	Cathepsin L-like precursor	0.0126	0.1603	0.1706
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.0592	0.063
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.1603	0.1599
Giardia lamblia	Cathepsin B precursor	0.0198	0.2909	0.2906
Trypanosoma cruzi	cysteine peptidase, putative	0.0126	0.1603	0.1706
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0037	0.0033
Brugia malayi	cathepsin F-like cysteine proteinase	0.0036	0.0004	0.0004
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.0425	0.0448
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0594	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.1603	0.1599
Loa Loa (eye worm)	ShTK domain-containing protein	0.019	0.2766	0.2944
Trypanosoma cruzi	major cysteine proteinase, putative	0.0036	0.0004	0.0004
Brugia malayi	Common central domain of tyrosinase family protein	0.019	0.2766	0.2944
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0036	0.0004	0.0004
Plasmodium vivax	unspecified product	0.0036	0.0004	0.0026
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0126	0.1603	0.1702
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0101	0.1166	0.1242
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0036	0.0004	0.0004
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0036	0.0004	0.0026
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0594	1	1
Entamoeba histolytica	cysteine protease, putative	0.0073	0.0652	0.0648
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0036	0.0004	0.0026
Schistosoma mansoni	cathepsin B (C01 family)	0.0036	0.0004	0.0004
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0198	0.2909	0.2906
Plasmodium vivax	serine-repeat antigen (SERA)	0.0036	0.0004	0.0026
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0594	1	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0073	0.0652	0.4054
Trypanosoma cruzi	cysteine proteinase, putative	0.0073	0.0652	0.0694
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0036	0.0004	0.0004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0126	0.1603	0.5452
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0126	0.1603	0.1599
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0198	0.2909	0.3096
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.0425	0.0448
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.056	0.9395	1
Brugia malayi	Papain family cysteine protease containing protein	0.0036	0.0004	0.0004
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.056	0.9395	1
Onchocerca volvulus		0.019	0.2766	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0036	0.0004	0.0004
Brugia malayi	exodeoxyribonuclease III family protein	0.0038	0.0037	0.0039
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.1603	0.1599
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0594	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.1603	0.1599
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0126	0.1603	0.1599
Schistosoma mansoni	tyrosinase precursor	0.019	0.2766	0.2944
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0036	0.0004	0.0026
Echinococcus multilocularis	cysteine protease	0.0126	0.1603	0.1702
Onchocerca volvulus		0.0126	0.1603	0.5789
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0073	0.0652	0.0694
Entamoeba histolytica	cysteine proteinase 1, putative	0.0073	0.0652	0.0648
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0036	0.0004	0.0004
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0073	0.0652	0.0694
Echinococcus multilocularis	cathepsin b	0.056	0.9395	1
Leishmania major	cysteine peptidase A (CPA)	0.0126	0.1603	0.5452
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0004	0.0004
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1593	0.1695
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0082	0.0821	0.0874
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0126	0.1603	1
Entamoeba histolytica	cysteine protease, putative	0.0073	0.0652	0.0648
Brugia malayi	Papain family cysteine protease containing protein	0.0073	0.0652	0.0694
Echinococcus granulosus	cathepsin L cysteine protease	0.0073	0.0652	0.069
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0038	0.0037	0.0035
Toxoplasma gondii	cathepsin B	0.0198	0.2909	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.0425	0.1351
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0037	0.0033
Toxoplasma gondii	cathepsin CPL	0.0126	0.1603	0.5504
Entamoeba histolytica	cysteine protease, putative	0.0073	0.0652	0.0648
Schistosoma mansoni	cathepsin F (C01 family)	0.0089	0.0955	0.1016
Entamoeba histolytica	cysteine protease, putative	0.0073	0.0652	0.0648
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0082	0.0821	0.087
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0004	0.0004
Brugia malayi	cathepsin L-like cysteine proteinase	0.0036	0.0004	0.0004
Echinococcus multilocularis	cathepsin L cysteine protease	0.0126	0.1603	0.1702
Entamoeba histolytica	cysteine protease, putative	0.0073	0.0652	0.0648
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0594	1	1
Brugia malayi	Cathepsin L-like precursor	0.0126	0.1603	0.1706
Onchocerca volvulus	Cathepsin F homolog	0.0126	0.1603	0.5789
Entamoeba histolytica	cysteine proteinase, putative	0.0089	0.0955	0.0951
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0425	0.0452
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0036	0.0004	0.0026
Brugia malayi	Papain family cysteine protease containing protein	0.0036	0.0004	0.0004
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0036	0.0004	0.0026
Onchocerca volvulus		0.0089	0.0955	0.3442
Onchocerca volvulus	Cathepsin L homolog	0.0126	0.1603	0.5789
Leishmania major	cathepsin L-like protease	0.0126	0.1603	0.5452
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0038	0.0037	0.0039
Loa Loa (eye worm)	RNA binding protein	0.0125	0.1593	0.1695
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0126	0.1603	0.5452
Trypanosoma cruzi	major cysteine proteinase, putative	0.0036	0.0004	0.0004
Onchocerca volvulus		0.019	0.2766	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0126	0.1603	0.1599
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.1603	0.1599
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.1603	0.1599
Schistosoma mansoni	cathepsin F (C01 family)	0.0126	0.1603	0.1706
Echinococcus multilocularis	tar DNA binding protein	0.0125	0.1593	0.1692
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.1603	0.1599
Loa Loa (eye worm)	cathepsin B	0.0198	0.2909	0.3096
Loa Loa (eye worm)	hypothetical protein	0.0101	0.1166	0.1242
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0036	0.0004	0.0004
Leishmania major	cathepsin L-like protease	0.0126	0.1603	0.5452
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0038	0.0037	0.0033
Entamoeba histolytica	cysteine protease, putative	0.0126	0.1603	0.1599
Schistosoma mansoni	cathepsin S (C01 family)	0.0036	0.0004	0.0004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0126	0.1603	0.5452
Onchocerca volvulus		0.019	0.2766	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.1603	0.1599
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0652	0.2142
Leishmania major	cathepsin L-like protease	0.0126	0.1603	0.5452
Schistosoma mansoni	cathepsin C	0.0036	0.0004	0.0004
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0089	0.0955	0.1016
Trypanosoma cruzi	cysteine protease, putative	0.0073	0.0652	0.0694
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0126	0.1603	0.5452
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.1603	0.1599
Echinococcus granulosus	cathepsin b	0.056	0.9395	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0126	0.1603	0.5452
Entamoeba histolytica	cysteine proteinase, putative	0.0073	0.0652	0.0648
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.0425	0.1449
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0126	0.1603	0.1702
Brugia malayi	Cathepsin L-like precursor	0.0089	0.0955	0.1016
Loa Loa (eye worm)	fibroinase	0.0126	0.1603	0.1706
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0126	0.1603	0.5452
Onchocerca volvulus		0.0126	0.1603	0.5789
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.029	0.4554	1
Brugia malayi	Papain family cysteine protease containing protein	0.0073	0.0652	0.0694
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.029	0.4554	0.5
Brugia malayi	ShTK domain containing protein	0.019	0.2766	0.2944
Loa Loa (eye worm)	ShTK domain-containing protein	0.019	0.2766	0.2944
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.0425	0.0859
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0089	0.0955	0.0951
Echinococcus multilocularis	cathepsin L	0.0073	0.0652	0.069
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0425	0.0859
Entamoeba histolytica	cysteine protease, putative	0.0073	0.0652	0.0648
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0082	0.0821	0.0874
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0036	0.0004	0.0004
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0036	0.0004	0.0004
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0594	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.1603	0.1599
Trypanosoma cruzi	cysteine peptidase, putative	0.0126	0.1603	0.1706
Schistosoma mansoni	ap endonuclease	0.0038	0.0037	0.0039
Entamoeba histolytica	cysteine proteinase 2	0.0073	0.0652	0.0648
Brugia malayi	Papain family cysteine protease containing protein	0.0126	0.1603	0.1706
Onchocerca volvulus		0.0126	0.1603	0.5789
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0089	0.0955	0.1016
Toxoplasma gondii	exonuclease III APE	0.0038	0.0037	0.0113
Giardia lamblia	Fructose-bisphosphate aldolase	0.0594	1	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0037	0.0206
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0038	0.0037	0.0033
Onchocerca volvulus		0.0126	0.1603	0.5789
Loa Loa (eye worm)	TAR-binding protein	0.0125	0.1593	0.1695
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0004	0.0004
Echinococcus multilocularis	cathepsin L cysteine protease	0.0126	0.1603	0.1702
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0004	0.0004
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0036	0.0004	0.0026
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0425	0.0859
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.1603	0.1599
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0038	0.0037	0.5
Leishmania major	cathepsin L-like protease	0.0126	0.1603	0.5452
Entamoeba histolytica	cysteine protease, putative	0.0073	0.0652	0.0648
Entamoeba histolytica	cysteine proteinase, putative	0.0126	0.1603	0.1599
Onchocerca volvulus		0.0126	0.1603	0.5789
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1593	0.1695
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0652	0.2142
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0126	0.1603	0.1599
Trypanosoma cruzi	cysteine peptidase, putative	0.0126	0.1603	0.1706
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0126	0.1603	0.5452
Trypanosoma cruzi	cysteine proteinase, putative	0.0073	0.0652	0.0694
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0125	0.1593	0.1695
Plasmodium vivax	serine-repeat antigen (SERA)	0.0036	0.0004	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0004	0.0004
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1593	0.1695
Onchocerca volvulus		0.0126	0.1603	0.5789
Brugia malayi	cathepsin L precursor	0.0036	0.0004	0.0004
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0036	0.0004	0.0004
Loa Loa (eye worm)	tyrosinase 1	0.019	0.2766	0.2944
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0126	0.1603	0.1599
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0073	0.0652	0.0694
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0126	0.1603	0.1599
Echinococcus granulosus	L aminoadipate semialdehyde	0.0082	0.0821	0.087
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0036	0.0004	0.0026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0126	0.1603	0.5452
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.056	0.9395	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.056	0.9395	1
Entamoeba histolytica	cysteine protease, putative	0.0073	0.0652	0.0648
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0036	0.0004	0.0004
Echinococcus granulosus	cathepsin l1	0.0126	0.1603	0.1702
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.019	0.2766	0.2944
Brugia malayi	Cathepsin L-like precursor	0.0126	0.1603	0.1706
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0089	0.0955	0.0951
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0126	0.1603	1
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.019	0.2766	0.2944
Echinococcus granulosus	cysteine protease	0.0073	0.0652	0.069
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0037	0.0039
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0126	0.1603	0.1706
Entamoeba histolytica	cysteine protease, putative	0.0073	0.0652	0.0648
Schistosoma mansoni	cathepsin F (C01 family)	0.0126	0.1603	0.1706
Plasmodium vivax	vivapain-2	0.0126	0.1603	1
Schistosoma mansoni	tyrosinase precursor	0.019	0.2766	0.2944
Echinococcus multilocularis	cathepsin b	0.056	0.9395	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0126	0.1603	0.1599
Brugia malayi	cathepsin L-like precursor	0.0089	0.0955	0.1016
Entamoeba histolytica	cysteine proteinase, putative	0.0073	0.0652	0.0648
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.029	0.4554	1
Brugia malayi	Cathepsin L-like precursor	0.0126	0.1603	0.1706
Brugia malayi	cathepsin B-like cysteine proteinase	0.056	0.9395	1
Entamoeba histolytica	cysteine protease, putative	0.0073	0.0652	0.0648
Entamoeba histolytica	cysteine proteinase, putative	0.0073	0.0652	0.0648
Echinococcus granulosus	cathepsin L	0.0073	0.0652	0.069
Plasmodium vivax	unspecified product	0.0073	0.0652	0.4069
Echinococcus multilocularis	cysteine protease	0.0126	0.1603	0.1702
Echinococcus granulosus	cathepsin l1	0.0089	0.0955	0.1012
Plasmodium vivax	vivapain-1	0.0073	0.0652	0.4069
Loa Loa (eye worm)	cysteine protease	0.0126	0.1603	0.1706
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0198	0.2909	0.3096
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0126	0.1603	0.5452
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0592	0.063
Loa Loa (eye worm)	hypothetical protein	0.019	0.2766	0.2944
Schistosoma mansoni	tar DNA-binding protein	0.0125	0.1593	0.1695
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0036	0.0004	0.0026
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0126	0.1603	0.1599
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.019	0.2766	0.2944
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0126	0.1603	0.5452
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0038	0.0037	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0955	0.1016
Giardia lamblia	Cathepsin B precursor	0.0198	0.2909	0.2906
Treponema pallidum	fructose-bisphosphate aldolase	0.0594	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0073	0.0652	0.0694

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1617967

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1474649