Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | histone deacetylase 8 | 0.0291 | 0.3201 | 0.5205 |
Echinococcus granulosus | histone deacetylase 6 | 0.0491 | 0.5631 | 0.9155 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0164 | 0.0164 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0534 | 0.6151 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.1653 | 0.1653 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0289 | 0.3172 | 0.7863 |
Schistosoma mansoni | hypothetical protein | 0.0293 | 0.3222 | 0.5238 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0534 | 0.6151 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.0471 | 0.539 | 0.539 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0278 | 0.3045 | 0.3045 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0272 | 0.2972 | 0.4832 |
Echinococcus granulosus | histone deacetylase 3 | 0.0534 | 0.6151 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0301 | 0.332 | 0.5397 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.3045 | 0.3045 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0053 | 0.0306 | 0.0306 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0291 | 0.3201 | 0.2987 |
Brugia malayi | Histone deacetylase family protein | 0.0471 | 0.539 | 0.539 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0471 | 0.539 | 0.8698 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0048 | 0.0249 | 0.0405 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.036 | 0.4034 | 0.6559 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0127 | 0.1202 | 0.1533 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0534 | 0.6151 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.036 | 0.4034 | 0.6559 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.1653 | 0.1653 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0127 | 0.1202 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.033 | 0.033 |
Brugia malayi | Histone deacetylase 1 | 0.0534 | 0.6151 | 0.6151 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0048 | 0.0249 | 0.0249 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0048 | 0.0249 | 0.0405 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0471 | 0.539 | 0.8762 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.1078 | 0.1078 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0055 | 0.033 | 0.0537 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0534 | 0.6151 | 1 |
Trypanosoma brucei | histone deacetylase 2 | 0.0291 | 0.3201 | 0.4954 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0055 | 0.033 | 0.033 |
Toxoplasma gondii | prolyl endopeptidase | 0.0278 | 0.3045 | 0.2826 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0127 | 0.1202 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.036 | 0.4034 | 0.4034 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0534 | 0.6151 | 1 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0055 | 0.033 | 0.0537 |
Echinococcus granulosus | prolyl endopeptidase | 0.0278 | 0.3045 | 0.495 |
Trypanosoma brucei | RNA helicase, putative | 0.0301 | 0.332 | 0.5157 |
Echinococcus multilocularis | serotonin receptor | 0.0272 | 0.2972 | 0.4832 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.006 | 0.0396 | 0.0644 |
Leishmania major | histone deacetylase, putative | 0.0534 | 0.6151 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0306 | 0.0306 |
Trypanosoma brucei | histone deacetylase 4 | 0.0471 | 0.539 | 0.8698 |
Loa Loa (eye worm) | MBCTL1 | 0.0055 | 0.033 | 0.033 |
Giardia lamblia | Histone deacetylase | 0.0534 | 0.6151 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0138 | 0.1346 | 0.2189 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.2093 | 0.2093 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0249 | 0.0405 |
Entamoeba histolytica | histone deacetylase, putative | 0.0534 | 0.6151 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0235 | 0.0382 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.1653 | 0.2688 |
Leishmania major | histone deacetylase, putative | 0.0471 | 0.539 | 0.8462 |
Echinococcus granulosus | histone deacetylase | 0.0471 | 0.539 | 0.8762 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.0134 | 0.0134 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0289 | 0.3172 | 0.5157 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0048 | 0.0249 | 0.0405 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.036 | 0.4034 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0534 | 0.6151 | 1 |
Mycobacterium tuberculosis | Probable peptidase | 0.0127 | 0.1202 | 0.5001 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0249 | 0.0405 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0127 | 0.1202 | 0.1533 |
Trypanosoma cruzi | oligopeptidase b | 0.0127 | 0.1202 | 0.1533 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0289 | 0.3172 | 0.5157 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.1653 | 0.2688 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0138 | 0.1346 | 0.1073 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0105 | 0.017 |
Trypanosoma brucei | histone deacetylase, putative | 0.0471 | 0.539 | 0.8698 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0534 | 0.6151 | 1 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0249 | 0.0249 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0048 | 0.0249 | 0.0405 |
Schistosoma mansoni | histone deacetylase | 0.0534 | 0.6151 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0291 | 0.3201 | 0.3201 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0053 | 0.0306 | 0.0497 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0291 | 0.3201 | 0.5205 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0471 | 0.539 | 0.8762 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0053 | 0.0306 | 0.0497 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0278 | 0.3045 | 0.495 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.006 | 0.0396 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0249 | 0.0249 |
Brugia malayi | Histone deacetylase family protein | 0.0471 | 0.539 | 0.539 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.2972 | 0.2972 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.1653 | 0.2688 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0127 | 0.1202 | 0.5001 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0471 | 0.539 | 0.8762 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0055 | 0.033 | 0.0537 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0851 | 1 | 1 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0127 | 0.1202 | 0.1533 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0471 | 0.539 | 0.539 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0534 | 0.6151 | 0.6151 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0534 | 0.6151 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0291 | 0.3201 | 0.5205 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0138 | 0.1346 | 0.178 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0534 | 0.6151 | 1 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0289 | 0.3172 | 0.3172 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0534 | 0.6151 | 0.6029 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0851 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0053 | 0.0306 | 0.0497 |
Trypanosoma cruzi | oligopeptidase b | 0.0127 | 0.1202 | 0.1533 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0534 | 0.6151 | 0.6151 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0278 | 0.3045 | 0.495 |
Trypanosoma brucei | oligopeptidase b | 0.0127 | 0.1202 | 0.1533 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0491 | 0.5631 | 0.9155 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0138 | 0.1346 | 0.178 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0135 | 0.0135 |
Echinococcus multilocularis | histone deacetylase | 0.0471 | 0.539 | 0.8762 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0127 | 0.1202 | 0.1533 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0249 | 0.0249 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.1653 | 0.2688 |
Brugia malayi | hypothetical protein | 0.023 | 0.2464 | 0.2464 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0471 | 0.539 | 0.8762 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0138 | 0.1346 | 0.0292 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.1653 | 0.1653 |
Echinococcus multilocularis | serotonin receptor | 0.0272 | 0.2972 | 0.4832 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0471 | 0.539 | 0.5244 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0225 | 0.2403 | 1 |
Plasmodium falciparum | histone deacetylase 1 | 0.0534 | 0.6151 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0534 | 0.6151 | 1 |
Giardia lamblia | Ceramide glucosyltransferase | 0.0131 | 0.1254 | 0.1623 |
Echinococcus granulosus | histone deacetylase 1 | 0.0534 | 0.6151 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0291 | 0.3201 | 0.4954 |
Onchocerca volvulus | 0.0047 | 0.0235 | 0.0583 | |
Echinococcus granulosus | histone deacetylase 6 | 0.0471 | 0.539 | 0.8762 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0291 | 0.3201 | 0.5205 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0291 | 0.3201 | 0.4954 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0534 | 0.6151 | 0.6151 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0471 | 0.539 | 0.8762 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0278 | 0.3045 | 0.4686 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0187 | 0.0187 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0491 | 0.5631 | 0.9155 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0306 | 0.0306 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0278 | 0.3045 | 0.3724 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0291 | 0.3201 | 0.7936 |
Onchocerca volvulus | 0.0048 | 0.0249 | 0.0617 | |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0278 | 0.3045 | 0.7548 |
Loa Loa (eye worm) | hypothetical protein | 0.0559 | 0.6463 | 0.6463 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0471 | 0.539 | 0.5244 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.019 | 0.197 | 0.3203 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0534 | 0.6151 | 1 |
Leishmania major | histone deacetylase, putative | 0.0471 | 0.539 | 0.8462 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0235 | 0.0382 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0055 | 0.033 | 0.0537 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0048 | 0.0249 | 0.0405 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0534 | 0.6151 | 0.6029 |
Brugia malayi | hypothetical protein | 0.0086 | 0.0704 | 0.0704 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0289 | 0.3172 | 0.5157 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0138 | 0.1346 | 0.2189 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0471 | 0.539 | 0.8698 |
Plasmodium vivax | histone deacetylase, putative | 0.0851 | 1 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0138 | 0.1346 | 0.2189 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0138 | 0.1346 | 0.1346 |
Brugia malayi | Bromodomain containing protein | 0.0076 | 0.0584 | 0.0584 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.1653 | 0.2688 |
Trypanosoma brucei | histone deacetylase 3 | 0.0471 | 0.539 | 0.8698 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.019 | 0.197 | 0.3203 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.1078 | 0.1078 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.1653 | 0.1653 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.023 | 0.2464 | 0.4007 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0138 | 0.1346 | 0.178 |
Plasmodium falciparum | histone deacetylase 2 | 0.0471 | 0.539 | 0.8698 |
Echinococcus granulosus | histone deacetylase 6 | 0.0471 | 0.539 | 0.8762 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.1653 | 0.2688 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0534 | 0.6151 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0235 | 0.0235 |
Trypanosoma brucei | histone deacetylase 1 | 0.0534 | 0.6151 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0064 | 0.044 | 0.0716 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.036 | 0.4034 | 0.6559 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.0053 | 0.0306 | 0.0497 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.1653 | 0.1653 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0278 | 0.3045 | 0.495 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0138 | 0.1346 | 0.178 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.0053 | 0.0306 | 0.0497 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0532 | 0.0532 |
Brugia malayi | Ceramide glucosyltransferase | 0.0289 | 0.3172 | 0.3172 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0055 | 0.033 | 0.0537 |
Brugia malayi | prolyl oligopeptidase family protein | 0.036 | 0.4034 | 0.4034 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.2972 | 0.2972 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0289 | 0.3172 | 0.5157 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.2464 | 0.2464 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.1653 | 0.1653 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0534 | 0.6151 | 0.6029 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0053 | 0.0306 | 0.0306 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.1653 | 0.2688 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0053 | 0.0306 | 0.0497 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0053 | 0.0306 | 0.0306 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0534 | 0.6151 | 0.6151 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0105 | 0.017 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.023 | 0.2464 | 0.4007 |
Plasmodium vivax | histone deacetylase, putative | 0.0471 | 0.539 | 0.5244 |
Plasmodium falciparum | histone deacetylase, putative | 0.0471 | 0.539 | 0.8698 |
Echinococcus granulosus | histone deacetylase 7 | 0.0471 | 0.539 | 0.8762 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.1078 | 0.1078 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0534 | 0.6151 | 1 |
Leishmania major | histone deacetylase, putative | 0.0534 | 0.6151 | 1 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0048 | 0.0249 | 0.0617 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0272 | 0.2972 | 0.4832 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0471 | 0.539 | 0.8698 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.0053 | 0.0306 | 0.0497 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.1852 | 0.1852 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0704 | 0.0704 |
Trypanosoma brucei | prolyl endopeptidase | 0.0278 | 0.3045 | 0.4686 |
Schistosoma mansoni | histone deacetylase | 0.0534 | 0.6151 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0534 | 0.6151 | 0.6151 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.