Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ribonucleoside diphosphate reductase large | 0.0932 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.1164 | 0.1089 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0096 | 0.0163 | 0.0163 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0141 | 0.0694 | 0.0539 |
Echinococcus granulosus | adam | 0.0196 | 0.1342 | 0.1198 |
Trypanosoma cruzi | ribonucleoside-diphosphate reductase large chain, putative | 0.0932 | 1 | 1 |
Mycobacterium ulcerans | glutaminase | 0.0266 | 0.2163 | 0.2478 |
Echinococcus granulosus | adam 17 protease | 0.0201 | 0.14 | 0.1257 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0115 | 0.0385 | 0.0225 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0326 | 0.2867 | 0.2867 |
Toxoplasma gondii | ribonucleoside-diphosphate reductase large chain | 0.0932 | 1 | 0.5 |
Trypanosoma brucei | ribonucleoside-diphosphate reductase large chain | 0.0932 | 1 | 0.5 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0196 | 0.1342 | 0.1342 |
Loa Loa (eye worm) | matrixin family protein | 0.0188 | 0.1245 | 0.1171 |
Mycobacterium tuberculosis | Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) | 0.0283 | 0.2359 | 0.2719 |
Wolbachia endosymbiont of Brugia malayi | ribonucleotide-diphosphate reductase subunit alpha | 0.0786 | 0.8281 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0137 | 0.0647 | 0.0492 |
Schistosoma mansoni | glutaminase | 0.0266 | 0.2163 | 0.2163 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0587 | 0.5936 | 0.5916 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0148 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0214 | 0.0131 |
Brugia malayi | glutaminase DH11.1 | 0.0266 | 0.2163 | 0.2123 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0172 | 0.1062 | 0.878 |
Treponema pallidum | ribonucleotide-diphosphate reductase subunit alpha | 0.0932 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0974 | 0.0974 |
Loa Loa (eye worm) | hypothetical protein | 0.0587 | 0.5936 | 0.5902 |
Echinococcus multilocularis | ribonucleoside diphosphate reductase large | 0.0932 | 1 | 1 |
Leishmania major | ribonucleoside-diphosphate reductase large chain, putative | 0.0932 | 1 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0172 | 0.1062 | 0.878 |
Brugia malayi | Matrixin family protein | 0.0188 | 0.1245 | 0.12 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0326 | 0.2867 | 0.2748 |
Plasmodium vivax | ribonucleoside-diphosphate reductase large chain, putative | 0.0932 | 1 | 0.5 |
Echinococcus multilocularis | adam | 0.0196 | 0.1342 | 0.1198 |
Mycobacterium leprae | conserved hypothetical protein | 0.0146 | 0.0755 | 0.0746 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0141 | 0.0694 | 0.0694 |
Plasmodium falciparum | ribonucleoside-diphosphate reductase large subunit, putative | 0.0932 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.3553 | 0.3499 |
Schistosoma mansoni | ribonucleoside-diphosphate reductase alpha subunit | 0.0932 | 1 | 1 |
Onchocerca volvulus | Papilin homolog | 0.0181 | 0.1164 | 1 |
Echinococcus granulosus | geminin | 0.0165 | 0.0974 | 0.0824 |
Loa Loa (eye worm) | ribonucleoside-diphosphate reductase large subunit | 0.0932 | 1 | 1 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0095 | 0.0148 | 0.0098 |
Loa Loa (eye worm) | glutaminase 2 | 0.0266 | 0.2163 | 0.2097 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0096 | 0.0163 | 0.0163 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0141 | 0.0694 | 0.0646 |
Mycobacterium tuberculosis | Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) | 0.0786 | 0.8281 | 1 |
Echinococcus multilocularis | geminin | 0.0165 | 0.0974 | 0.0824 |
Echinococcus multilocularis | adam 17 protease | 0.0183 | 0.1186 | 0.1039 |
Schistosoma mansoni | hypothetical protein | 0.011 | 0.0331 | 0.0331 |
Loa Loa (eye worm) | acetyltransferase | 0.0141 | 0.0694 | 0.0615 |
Trichomonas vaginalis | ribonucleoside-diphosphate reductase alpha chain, putative | 0.0786 | 0.8281 | 1 |
Brugia malayi | Hemopexin family protein | 0.011 | 0.0331 | 0.0282 |
Mycobacterium ulcerans | transcriptional regulator NrdR | 0.0146 | 0.0755 | 0.0746 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0115 | 0.0385 | 0.0225 |
Brugia malayi | ADAMTS-like protease | 0.0189 | 0.1263 | 0.1218 |
Brugia malayi | hypothetical protein | 0.0196 | 0.1342 | 0.1298 |
Loa Loa (eye worm) | glutaminase | 0.0266 | 0.2163 | 0.2097 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0974 | 0.0974 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0326 | 0.2867 | 0.2748 |
Mycobacterium leprae | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) | 0.0786 | 0.8281 | 1 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein NrdR | 0.0146 | 0.0755 | 0.0746 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.1127 | 0.1052 |
Brugia malayi | angiogenesis inhibito | 0.0189 | 0.1263 | 0.1218 |
Loa Loa (eye worm) | reprolysin | 0.0096 | 0.0163 | 0.008 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0183 | 0.1186 | 0.1186 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0282 | 0.2358 | 0.2231 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0282 | 0.2358 | 0.2231 |
Mycobacterium ulcerans | ribonucleotide-diphosphate reductase subunit alpha | 0.0786 | 0.8281 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0163 | 0.008 |
Chlamydia trachomatis | ribonucleoside-diphosphate reductase subunit alpha | 0.0932 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0172 | 0.1062 | 0.0986 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.