Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | histone deacetylase, putative | 0.0471 | 0.539 | 0.8462 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.1653 | 0.2688 |
Echinococcus granulosus | histone deacetylase | 0.0471 | 0.539 | 0.8762 |
Entamoeba histolytica | histone deacetylase, putative | 0.0534 | 0.6151 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0235 | 0.0382 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0249 | 0.0405 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.036 | 0.4034 | 1 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0048 | 0.0249 | 0.0405 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0289 | 0.3172 | 0.5157 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.0134 | 0.0134 |
Toxoplasma gondii | prolyl endopeptidase | 0.0278 | 0.3045 | 0.2826 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0127 | 0.1202 | 1 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0055 | 0.033 | 0.033 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0534 | 0.6151 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.036 | 0.4034 | 0.4034 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0534 | 0.6151 | 1 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0055 | 0.033 | 0.0537 |
Trypanosoma brucei | histone deacetylase 2 | 0.0291 | 0.3201 | 0.4954 |
Giardia lamblia | Histone deacetylase | 0.0534 | 0.6151 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.006 | 0.0396 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0306 | 0.0306 |
Trypanosoma brucei | histone deacetylase 4 | 0.0471 | 0.539 | 0.8698 |
Loa Loa (eye worm) | MBCTL1 | 0.0055 | 0.033 | 0.033 |
Leishmania major | histone deacetylase, putative | 0.0534 | 0.6151 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.2093 | 0.2093 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0138 | 0.1346 | 0.2189 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0055 | 0.033 | 0.0537 |
Echinococcus granulosus | prolyl endopeptidase | 0.0278 | 0.3045 | 0.495 |
Echinococcus multilocularis | serotonin receptor | 0.0272 | 0.2972 | 0.4832 |
Trypanosoma brucei | RNA helicase, putative | 0.0301 | 0.332 | 0.5157 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.036 | 0.4034 | 0.6559 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0534 | 0.6151 | 1 |
Trypanosoma brucei | prolyl oligopeptidase, putative | 0.0127 | 0.1202 | 0.1533 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.1653 | 0.1653 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0048 | 0.0249 | 0.0405 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.036 | 0.4034 | 0.6559 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0471 | 0.539 | 0.8762 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0048 | 0.0249 | 0.0249 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0048 | 0.0249 | 0.0405 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.1078 | 0.1078 |
Brugia malayi | Histone deacetylase 1 | 0.0534 | 0.6151 | 0.6151 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0127 | 0.1202 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.033 | 0.033 |
Schistosoma mansoni | hypothetical protein | 0.0293 | 0.3222 | 0.5238 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0289 | 0.3172 | 0.7863 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0534 | 0.6151 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.1653 | 0.1653 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0272 | 0.2972 | 0.4832 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0278 | 0.3045 | 0.3045 |
Loa Loa (eye worm) | histone deacetylase | 0.0471 | 0.539 | 0.539 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0164 | 0.0164 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0534 | 0.6151 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0491 | 0.5631 | 0.9155 |
Echinococcus granulosus | histone deacetylase 8 | 0.0291 | 0.3201 | 0.5205 |
Brugia malayi | Histone deacetylase family protein | 0.0471 | 0.539 | 0.539 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0053 | 0.0306 | 0.0306 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0291 | 0.3201 | 0.2987 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0471 | 0.539 | 0.8698 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 0.3045 | 0.3045 |
Schistosoma mansoni | hypothetical protein | 0.0301 | 0.332 | 0.5397 |
Echinococcus granulosus | histone deacetylase 3 | 0.0534 | 0.6151 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0491 | 0.5631 | 0.9155 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0278 | 0.3045 | 0.495 |
Trypanosoma brucei | oligopeptidase b | 0.0127 | 0.1202 | 0.1533 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0135 | 0.0135 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0138 | 0.1346 | 0.178 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0534 | 0.6151 | 1 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0534 | 0.6151 | 0.6029 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0289 | 0.3172 | 0.3172 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0138 | 0.1346 | 0.178 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0291 | 0.3201 | 0.5205 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0534 | 0.6151 | 0.6151 |
Trypanosoma cruzi | oligopeptidase b | 0.0127 | 0.1202 | 0.1533 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0053 | 0.0306 | 0.0497 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0851 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.1653 | 0.2688 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0127 | 0.1202 | 0.5001 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0471 | 0.539 | 0.8762 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0278 | 0.3045 | 0.495 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0053 | 0.0306 | 0.0497 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.2972 | 0.2972 |
Brugia malayi | Histone deacetylase family protein | 0.0471 | 0.539 | 0.539 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.006 | 0.0396 | 0.0644 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0249 | 0.0249 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0534 | 0.6151 | 0.6151 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0534 | 0.6151 | 1 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0055 | 0.033 | 0.0537 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0851 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0471 | 0.539 | 0.539 |
Trypanosoma brucei | serine peptidase, clan SC, family S9A-like protein | 0.0127 | 0.1202 | 0.1533 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0534 | 0.6151 | 1 |
Trypanosoma cruzi | oligopeptidase B-like protein, putative | 0.0127 | 0.1202 | 0.1533 |
Mycobacterium tuberculosis | Probable peptidase | 0.0127 | 0.1202 | 0.5001 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0048 | 0.0249 | 0.0405 |
Schistosoma mansoni | histone deacetylase | 0.0534 | 0.6151 | 1 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0048 | 0.0249 | 0.0405 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0534 | 0.6151 | 1 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0249 | 0.0249 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0105 | 0.017 |
Trypanosoma brucei | histone deacetylase, putative | 0.0471 | 0.539 | 0.8698 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0291 | 0.3201 | 0.5205 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0471 | 0.539 | 0.8762 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0053 | 0.0306 | 0.0497 |
Loa Loa (eye worm) | hypothetical protein | 0.0291 | 0.3201 | 0.3201 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.1653 | 0.2688 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0289 | 0.3172 | 0.5157 |
Trypanosoma cruzi | oligopeptidase b | 0.0127 | 0.1202 | 0.1533 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0138 | 0.1346 | 0.1073 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.1653 | 0.2688 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.019 | 0.197 | 0.3203 |
Trypanosoma brucei | histone deacetylase 3 | 0.0471 | 0.539 | 0.8698 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0138 | 0.1346 | 0.2189 |
Brugia malayi | Bromodomain containing protein | 0.0076 | 0.0584 | 0.0584 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0138 | 0.1346 | 0.1346 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.023 | 0.2464 | 0.4007 |
Plasmodium falciparum | histone deacetylase 2 | 0.0471 | 0.539 | 0.8698 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0138 | 0.1346 | 0.178 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.1653 | 0.1653 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.1078 | 0.1078 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0471 | 0.539 | 0.5244 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0278 | 0.3045 | 0.7548 |
Loa Loa (eye worm) | hypothetical protein | 0.0559 | 0.6463 | 0.6463 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0235 | 0.0382 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0534 | 0.6151 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.019 | 0.197 | 0.3203 |
Leishmania major | histone deacetylase, putative | 0.0471 | 0.539 | 0.8462 |
Onchocerca volvulus | 0.0048 | 0.0249 | 0.0617 | |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0291 | 0.3201 | 0.7936 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0278 | 0.3045 | 0.3724 |
Brugia malayi | hypothetical protein | 0.0086 | 0.0704 | 0.0704 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0289 | 0.3172 | 0.5157 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0534 | 0.6151 | 0.6029 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0048 | 0.0249 | 0.0405 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0471 | 0.539 | 0.8698 |
Plasmodium vivax | histone deacetylase, putative | 0.0851 | 1 | 1 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0138 | 0.1346 | 0.2189 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0055 | 0.033 | 0.0537 |
Echinococcus granulosus | histone deacetylase 1 | 0.0534 | 0.6151 | 1 |
Giardia lamblia | Ceramide glucosyltransferase | 0.0131 | 0.1254 | 0.1623 |
Onchocerca volvulus | 0.0047 | 0.0235 | 0.0583 | |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0291 | 0.3201 | 0.5205 |
Echinococcus granulosus | histone deacetylase 6 | 0.0471 | 0.539 | 0.8762 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0291 | 0.3201 | 0.4954 |
Echinococcus multilocularis | serotonin receptor | 0.0272 | 0.2972 | 0.4832 |
Plasmodium falciparum | histone deacetylase 1 | 0.0534 | 0.6151 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0534 | 0.6151 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0225 | 0.2403 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0471 | 0.539 | 0.5244 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0278 | 0.3045 | 0.4686 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0471 | 0.539 | 0.8762 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0306 | 0.0306 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0491 | 0.5631 | 0.9155 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0187 | 0.0187 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0291 | 0.3201 | 0.4954 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0534 | 0.6151 | 0.6151 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0138 | 0.1346 | 0.0292 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.1653 | 0.1653 |
Brugia malayi | hypothetical protein | 0.023 | 0.2464 | 0.2464 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0471 | 0.539 | 0.8762 |
Trypanosoma cruzi | serine peptidase, clan SC, family S9A-like protein, putative | 0.0127 | 0.1202 | 0.1533 |
Echinococcus multilocularis | histone deacetylase | 0.0471 | 0.539 | 0.8762 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.1653 | 0.2688 |
Brugia malayi | mbt repeat family protein | 0.0048 | 0.0249 | 0.0249 |
Leishmania major | histone deacetylase, putative | 0.0534 | 0.6151 | 1 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0272 | 0.2972 | 0.4832 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0048 | 0.0249 | 0.0617 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0534 | 0.6151 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0704 | 0.0704 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.1852 | 0.1852 |
Loa Loa (eye worm) | hypothetical protein | 0.0534 | 0.6151 | 0.6151 |
Schistosoma mansoni | histone deacetylase | 0.0534 | 0.6151 | 1 |
Trypanosoma brucei | prolyl endopeptidase | 0.0278 | 0.3045 | 0.4686 |
Echinococcus multilocularis | acylamino acid releasing enzyme | 0.0053 | 0.0306 | 0.0497 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0471 | 0.539 | 0.8698 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.023 | 0.2464 | 0.4007 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0053 | 0.0306 | 0.0497 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0053 | 0.0306 | 0.0306 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0534 | 0.6151 | 0.6151 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0105 | 0.017 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.1078 | 0.1078 |
Echinococcus granulosus | histone deacetylase 7 | 0.0471 | 0.539 | 0.8762 |
Plasmodium falciparum | histone deacetylase, putative | 0.0471 | 0.539 | 0.8698 |
Plasmodium vivax | histone deacetylase, putative | 0.0471 | 0.539 | 0.5244 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0278 | 0.3045 | 0.495 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0138 | 0.1346 | 0.178 |
Schistosoma mansoni | acylaminoacyl-peptidase (S09 family) | 0.0053 | 0.0306 | 0.0497 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0534 | 0.6151 | 0.6029 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.1653 | 0.1653 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.1653 | 0.2688 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0053 | 0.0306 | 0.0306 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0055 | 0.033 | 0.0537 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0532 | 0.0532 |
Brugia malayi | Ceramide glucosyltransferase | 0.0289 | 0.3172 | 0.3172 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.2464 | 0.2464 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0289 | 0.3172 | 0.5157 |
Brugia malayi | prolyl oligopeptidase family protein | 0.036 | 0.4034 | 0.4034 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.2972 | 0.2972 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.1653 | 0.2688 |
Echinococcus granulosus | histone deacetylase 6 | 0.0471 | 0.539 | 0.8762 |
Echinococcus granulosus | acylamino acid releasing enzyme | 0.0053 | 0.0306 | 0.0497 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.1653 | 0.1653 |
Schistosoma mansoni | bromodomain containing protein | 0.0064 | 0.044 | 0.0716 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.036 | 0.4034 | 0.6559 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0235 | 0.0235 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0534 | 0.6151 | 1 |
Trypanosoma brucei | histone deacetylase 1 | 0.0534 | 0.6151 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.