TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 437.359 | Formula: C22H26Cl2N2O3
H donors: 1 H acceptors: 2 LogP: 5.17 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: ClCC(=O)N(C(C(=O)NCCc1ccccc1)C(C)C)c1ccc(c(c1)Cl)OC
InChi: 1S/C22H26Cl2N2O3/c1-15(2)21(22(28)25-12-11-16-7-5-4-6-8-16)26(20(27)14-23)17-9-10-19(29-3)18(24)13-17/h4-10,13,15,21H,11-12,14H2,1-3H3,(H,25,28)
InChiKey: IYTRAPWDEQLLQK-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine kinase	0.0049	0.0063	0.0031
Trypanosoma cruzi	cysteine peptidase, putative	0.2428	0.4732	0.41
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.2428	0.4732	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0045	0.0054	0.0054
Brugia malayi	Papain family cysteine protease containing protein	0.1319	0.2555	0.2531
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2428	0.4732	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0045	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0031	0.0031
Brugia malayi	Papain family cysteine protease containing protein	0.0563	0.1071	0.1043
Plasmodium vivax	vivapain-3	0.1319	0.2555	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0563	0.1071	0.1071
Entamoeba histolytica	cysteine protease, putative	0.1319	0.2555	0.5355
Leishmania major	cathepsin L-like protease	0.2428	0.4732	1
Entamoeba histolytica	cysteine proteinase 2	0.1319	0.2555	0.5355
Entamoeba histolytica	cysteine proteinase, putative	0.1319	0.2555	0.5355
Loa Loa (eye worm)	hypothetical protein	0.1672	0.3247	0.3247
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2428	0.4732	1
Entamoeba histolytica	cysteine protease, putative	0.0563	0.1071	0.2188
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2428	0.4732	1
Entamoeba histolytica	cysteine proteinase, putative	0.2428	0.4732	1
Loa Loa (eye worm)	hypothetical protein	0.0563	0.1071	0.1071
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0075	0.0113	0.0113
Entamoeba histolytica	cysteine proteinase, putative	0.1319	0.2555	0.5355
Brugia malayi	protein-tyrosine kinase	0.0045	0.0054	0.0023
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.2428	0.4732	1
Echinococcus granulosus	cathepsin l1	0.2428	0.4732	0.4732
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1319	0.2555	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0756	0.145	0.145
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0563	0.1071	0.1071
Entamoeba histolytica	cysteine protease, putative	0.1319	0.2555	0.5355
Echinococcus multilocularis		0.002	0.0006	0.0006
Plasmodium vivax	vivapain-2	0.2428	0.4732	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0307	0.0569	0.0569
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2428	0.4732	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0563	0.1071	0.1043
Echinococcus multilocularis	cathepsin L cysteine protease	0.2428	0.4732	0.4732
Loa Loa (eye worm)	hypothetical protein	0.0563	0.1071	0.1071
Brugia malayi	cathepsin F-like cysteine proteinase	0.0756	0.145	0.1423
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0563	0.1071	0.1043
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.2428	0.4732	1
Entamoeba histolytica	cysteine protease, putative	0.1319	0.2555	0.5355
Schistosoma mansoni	cathepsin S (C01 family)	0.0563	0.1071	0.1043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2428	0.4732	1
Brugia malayi	Papain family cysteine protease containing protein	0.0563	0.1071	0.1043
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0563	0.1071	0.1043
Schistosoma mansoni	cathepsin C	0.0563	0.1071	0.1043
Loa Loa (eye worm)	hypothetical protein	0.2428	0.4732	0.4732
Brugia malayi	Cathepsin L-like cysteine proteinase	0.1672	0.3247	0.3226
Plasmodium vivax	vivapain-2	0.2428	0.4732	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2428	0.4732	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.2428	0.4732	0.4732
Schistosoma mansoni	cathepsin s	0.0756	0.145	0.1423
Leishmania major	cathepsin L-like protease	0.2428	0.4732	1
Onchocerca volvulus		0.2428	0.4732	1
Loa Loa (eye worm)	hypothetical protein	0.0563	0.1071	0.1071
Echinococcus multilocularis	cathepsin L	0.0563	0.1071	0.1071
Loa Loa (eye worm)	cysteine protease	0.2428	0.4732	0.4732
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.5111	1	1
Echinococcus granulosus	epidermal growth factor receptor	0.0075	0.0113	0.0113
Trypanosoma cruzi	cysteine peptidase, putative	0.1319	0.2555	0.1662
Onchocerca volvulus	Cathepsin F homolog	0.2428	0.4732	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2428	0.4732	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1672	0.3247	0.5946
Brugia malayi	Papain family cysteine protease containing protein	0.1319	0.2555	0.2531
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0039	0.0042	0.0042
Entamoeba histolytica	cysteine protease, putative	0.1319	0.2555	0.5355
Brugia malayi	Protein kinase domain containing protein	0.0284	0.0524	0.0494
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2428	0.4732	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.2428	0.4732	0.4732
Entamoeba histolytica	cysteine proteinase, putative	0.2428	0.4732	1
Loa Loa (eye worm)	TK protein kinase	0.004	0.0045	0.0045
Toxoplasma gondii	cathepsin B	0.1969	0.3832	0.7543
Trypanosoma cruzi	cysteine proteinase, putative	0.1319	0.2555	0.1662
Echinococcus granulosus	cysteine protease	0.1319	0.2555	0.2555
Onchocerca volvulus		0.2428	0.4732	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.2428	0.4732	0.4732
Leishmania major	cathepsin L-like protease	0.2428	0.4732	1
Brugia malayi	Cathepsin L-like precursor	0.2428	0.4732	0.4715
Echinococcus multilocularis	cysteine protease	0.2428	0.4732	0.4732
Onchocerca volvulus		0.2428	0.4732	1
Entamoeba histolytica	cysteine protease, putative	0.1319	0.2555	0.5355
Schistosoma mansoni	tyrosine kinase	0.0075	0.0113	0.0082
Brugia malayi	cathepsin L-like precursor	0.1672	0.3247	0.3226
Schistosoma mansoni	cathepsin F (C01 family)	0.2428	0.4732	0.4715
Trypanosoma brucei	cysteine peptidase C (CPC)	0.1969	0.3832	0.5868
Trypanosoma cruzi	cysteine peptidase, putative	0.0756	0.145	0.0425
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2428	0.4732	1
Onchocerca volvulus		0.2428	0.4732	1
Echinococcus multilocularis	cathepsin L	0.1319	0.2555	0.2555
Onchocerca volvulus		0.0163	0.0286	0.0542
Onchocerca volvulus		0.2428	0.4732	1
Trypanosoma cruzi	cysteine protease, putative	0.1319	0.2555	0.1662
Entamoeba histolytica	cysteine protease, putative	0.1319	0.2555	0.5355
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0563	0.1071	0.1043
Loa Loa (eye worm)	hypothetical protein	0.0756	0.145	0.145
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1969	0.3832	0.3813
Brugia malayi	cathepsin L-like cysteine proteinase	0.0563	0.1071	0.1043
Onchocerca volvulus	Cathepsin L homolog	0.2428	0.4732	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2428	0.4732	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0049	0.0063	0.0063
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2428	0.4732	1
Onchocerca volvulus		0.2428	0.4732	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0563	0.1071	0.1043
Loa Loa (eye worm)	hypothetical protein	0.1672	0.3247	0.3247
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0049	0.0063	0.0063
Brugia malayi	Cathepsin L-like precursor	0.1672	0.3247	0.3226
Leishmania major	cysteine peptidase A (CPA)	0.2428	0.4732	1
Brugia malayi	Protein kinase domain containing protein	0.009	0.0143	0.0112
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0049	0.0063	0.0063
Schistosoma mansoni	tyrosine kinase	0.0069	0.0102	0.0071
Loa Loa (eye worm)	hypothetical protein	0.5111	1	1
Leishmania major	cathepsin L-like protease	0.2428	0.4732	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0184	0.0326	0.0296
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0563	0.1071	0.1043
Loa Loa (eye worm)	hypothetical protein	0.0563	0.1071	0.1071
Brugia malayi	Papain family cysteine protease containing protein	0.0563	0.1071	0.1043
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2428	0.4732	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0284	0.0523	0.0523
Trypanosoma cruzi	cruzipain precursor, putative	0.0756	0.145	0.0425
Loa Loa (eye worm)	fibroinase	0.2428	0.4732	0.4732
Entamoeba histolytica	cysteine protease, putative	0.2428	0.4732	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.2428	0.4732	0.4732
Loa Loa (eye worm)	hypothetical protein	0.0563	0.1071	0.1071
Loa Loa (eye worm)	cathepsin B	0.1969	0.3832	0.3832
Echinococcus multilocularis	MAM	0.0033	0.0031	0.0031
Onchocerca volvulus		0.2428	0.4732	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0172	0.0303	0.0579
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0075	0.0113	0.0113
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2428	0.4732	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.004	0.0045	0.0045
Echinococcus granulosus	tyrosine kinase	0.0045	0.0054	0.0054
Plasmodium vivax	unspecified product	0.1319	0.2555	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2428	0.4732	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0075	0.0113	0.0113
Echinococcus granulosus	insulin receptor	0.016	0.0279	0.0279
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0756	0.145	0.145
Echinococcus multilocularis	cathepsin b	0.5111	1	1
Schistosoma mansoni	tyrosine kinase	0.016	0.0279	0.0249
Brugia malayi	Protein kinase domain containing protein	0.0307	0.0569	0.0539
Loa Loa (eye worm)	hypothetical protein	0.1672	0.3247	0.3247
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2428	0.4732	1
Schistosoma mansoni	tyrosine kinase	0.016	0.0279	0.0249
Entamoeba histolytica	cysteine protease, putative	0.1319	0.2555	0.5355
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.5111	1	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0563	0.1071	0.1043
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0563	0.1071	0.2188
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0049	0.0063	0.0063
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0049	0.0063	0.0063
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0049	0.0063	0.0063
Echinococcus multilocularis	cysteine protease	0.2428	0.4732	0.4732
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0563	0.1071	0.2188
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.5111	1	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0049	0.0063	0.0063
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0039	0.0042	0.0042
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2428	0.4732	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.1319	0.2555	0.1662
Echinococcus multilocularis	tyrosine protein kinase HCK	0.004	0.0045	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0031	0.0031
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2428	0.4732	1
Schistosoma mansoni	cathepsin F (C01 family)	0.2428	0.4732	0.4715
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0045	0.0054	0.0054
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.016	0.0279	0.0279
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2428	0.4732	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2428	0.4732	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2428	0.4732	1
Echinococcus granulosus	cathepsin b	0.5111	1	1
Giardia lamblia	Cathepsin B precursor	0.1969	0.3832	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.2428	0.4732	0.4732
Loa Loa (eye worm)	ctsf protein	0.2428	0.4732	0.4732
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2428	0.4732	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0049	0.0063	0.0063
Loa Loa (eye worm)	TK/INSR protein kinase	0.016	0.0279	0.0279
Trypanosoma cruzi	cysteine peptidase, putative	0.2428	0.4732	0.41
Echinococcus granulosus	MAM	0.0033	0.0031	0.0031
Brugia malayi	Cathepsin L-like precursor	0.2428	0.4732	0.4715
Echinococcus multilocularis	insulin receptor	0.016	0.0279	0.0279
Leishmania major	cathepsin L-like protease	0.2428	0.4732	1
Brugia malayi	Cathepsin L-like precursor	0.2428	0.4732	0.4715
Entamoeba histolytica	cysteine proteinase 1, putative	0.1319	0.2555	0.5355
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0446	0.0446
Schistosoma mansoni	tyrosine kinase	0.0075	0.0113	0.0082
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2428	0.4732	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0563	0.1071	0.1043
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0563	0.1071	0.1043
Echinococcus granulosus	cathepsin L	0.0563	0.1071	0.1071
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.1672	0.3247	0.2438
Loa Loa (eye worm)	TK protein kinase	0.0045	0.0054	0.0054
Onchocerca volvulus	Cathepsin L homolog	0.0563	0.1071	0.2211
Entamoeba histolytica	cysteine protease, putative	0.1319	0.2555	0.5355
Entamoeba histolytica	cysteine protease, putative	0.1319	0.2555	0.5355
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2428	0.4732	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0563	0.1071	0.1043
Entamoeba histolytica	cysteine protease, putative	0.0563	0.1071	0.2188
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0563	0.1071	0.1043
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0049	0.0063	0.0063
Plasmodium falciparum	cysteine proteinase falcipain 3	0.2428	0.4732	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2428	0.4732	1
Onchocerca volvulus	Cathepsin L homolog	0.2428	0.4732	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0049	0.0063	0.0063
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0756	0.145	0.1423
Brugia malayi	Protein kinase domain containing protein	0.016	0.0279	0.0249
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0049	0.0063	0.0063
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0049	0.0063	0.0063
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2428	0.4732	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0563	0.1071	0.1043
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.5111	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.1672	0.3247	0.3226
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0049	0.0063	0.0063
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0049	0.0063	0.0063
Entamoeba histolytica	cysteine protease, putative	0.0563	0.1071	0.2188
Onchocerca volvulus		0.0563	0.1071	0.2211
Brugia malayi	Cathepsin L-like precursor	0.0756	0.145	0.1423
Brugia malayi	Furin-like cysteine rich region family protein	0.0075	0.0113	0.0082
Entamoeba histolytica	cysteine protease, putative	0.1319	0.2555	0.5355
Echinococcus multilocularis	protein tyrosine kinase	0.0303	0.0562	0.0562
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2428	0.4732	1
Brugia malayi	Papain family cysteine protease containing protein	0.2428	0.4732	0.4715
Brugia malayi	cathepsin L precursor	0.0563	0.1071	0.1043
Entamoeba histolytica	cysteine protease, putative	0.0563	0.1071	0.2188
Schistosoma mansoni	tyrosine kinase	0.0069	0.0102	0.0071
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1319	0.2555	0.2531
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2428	0.4732	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0049	0.0063	0.0063
Echinococcus granulosus	cathepsin b	0.5111	1	1
Echinococcus granulosus	cathepsin L	0.1319	0.2555	0.2555
Entamoeba histolytica	cysteine protease, putative	0.0563	0.1071	0.2188
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1672	0.3247	0.5946
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1319	0.2555	0.2531
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2428	0.4732	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0075	0.0113	0.0113
Echinococcus granulosus	epidermal growth factor receptor	0.0075	0.0113	0.0113
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2428	0.4732	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2428	0.4732	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0563	0.1071	0.1043
Trypanosoma cruzi	cysteine proteinase, putative	0.1319	0.2555	0.1662
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.1969	0.3832	0.7543
Echinococcus granulosus	tyrosine protein kinase Blk	0.0045	0.0054	0.0054
Entamoeba histolytica	cysteine proteinase, putative	0.1319	0.2555	0.5355
Schistosoma mansoni	tyrosine kinase	0.0069	0.0102	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0131	0.0131
Echinococcus granulosus	cathepsin l1	0.1672	0.3247	0.3247
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0049	0.0063	0.0063
Brugia malayi	Cathepsin L-like precursor	0.2428	0.4732	0.4715
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1319	0.2555	0.4054
Entamoeba histolytica	cysteine protease, putative	0.1319	0.2555	0.5355
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0563	0.1071	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0756	0.145	0.145
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1969	0.3832	0.3093
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0184	0.0326	0.0326
Entamoeba histolytica	cysteine proteinase, putative	0.1672	0.3247	0.6833
Trypanosoma cruzi	cysteine peptidase, putative	0.2428	0.4732	0.41
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0031	0.0031
Echinococcus multilocularis	cathepsin b	0.5111	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.2428	0.4732	0.41
Entamoeba histolytica	hypothetical protein	0.0563	0.1071	0.2188
Loa Loa (eye worm)	SRC-1	0.0049	0.0063	0.0063
Brugia malayi	Cathepsin L-like precursor	0.1672	0.3247	0.3226
Echinococcus granulosus	cathepsin l cysteine peptidase	0.2428	0.4732	0.4732
Giardia lamblia	Cathepsin B precursor	0.1969	0.3832	1
Schistosoma mansoni	tyrosine kinase	0.0049	0.0063	0.0031
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0563	0.1071	0.1043
Toxoplasma gondii	cathepsin CPL	0.2428	0.4732	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2428	0.4732	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.1319	0.2555	0.4054
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0045	0.0054	0.0054
Echinococcus granulosus	cathepsin L cysteine proteinase	0.2428	0.4732	0.4732
Entamoeba histolytica	cysteine proteinase, putative	0.1319	0.2555	0.5355
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2428	0.4732	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.016	0.0279	0.0279
Plasmodium vivax	unspecified product	0.0756	0.145	0.1037
Leishmania major	cathepsin L-like protease	0.2428	0.4732	1
Schistosoma mansoni	tyrosine kinase	0.0075	0.0113	0.0082
Brugia malayi	SRC-1	0.0049	0.0063	0.0031
Onchocerca volvulus		0.1672	0.3247	0.6842
Echinococcus granulosus	protein tyrosine kinase	0.0303	0.0562	0.0562
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.2428	0.4732	1
Giardia lamblia	Cathepsin B precursor	0.1969	0.3832	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1319	0.2555	0.2531
Echinococcus granulosus	cathepsin L cysteine protease	0.1319	0.2555	0.2555
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2428	0.4732	1
Brugia malayi	Cathepsin L-like precursor	0.2428	0.4732	0.4715
Trypanosoma cruzi	cruzipain precursor, putative	0.2428	0.4732	0.41
Schistosoma mansoni	tyrosine kinase	0.0303	0.0562	0.0532
Entamoeba histolytica	cysteine protease, putative	0.1319	0.2555	0.5355
Plasmodium vivax	vivapain-1	0.1319	0.2555	0.4054
Leishmania major	cathepsin L-like protease	0.2428	0.4732	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0049	0.0063	0.0063
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0563	0.1071	0.1071
Brugia malayi	fibroinase precursor	0.0563	0.1071	0.1043
Leishmania major	cathepsin L-like protease	0.2428	0.4732	1
Brugia malayi	Cathepsin L-like precursor	0.2428	0.4732	0.4715
Entamoeba histolytica	cysteine protease, putative	0.0563	0.1071	0.2188
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2428	0.4732	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.5111	1	1
Entamoeba histolytica	cysteine protease, putative	0.1319	0.2555	0.5355

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1717347

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1482281