Detailed information for compound 1482291

Basic information

Technical information
  • TDR Targets ID: 1482291
  • Name: 2-(4-bromophenyl)-5-[2-(4-chlorophenyl)sulfon ylethyl]-1,3,4-oxadiazole
  • MW: 427.7 | Formula: C16H12BrClN2O3S
  • H donors: 0 H acceptors: 4 LogP: 3.96 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)S(=O)(=O)CCc1nnc(o1)c1ccc(cc1)Br
  • InChi: 1S/C16H12BrClN2O3S/c17-12-3-1-11(2-4-12)16-20-19-15(23-16)9-10-24(21,22)14-7-5-13(18)6-8-14/h1-8H,9-10H2
  • InChiKey: QQEUIXRUOCPMJI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-bromophenyl)-5-{2-[(4-chlorophenyl)sulfonyl]ethyl}-1,3,4-oxadiazole
  • MLS000533491
  • SMR000140928
  • ZINC00990878

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.1171 0.4234 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1171 0.4234 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1171 0.4234 1
Brugia malayi Papain family cysteine protease containing protein 0.0636 0.1852 0.1852
Echinococcus granulosus cathepsin L cysteine protease 0.0636 0.1852 0.1852
Leishmania major cathepsin L-like protease 0.1171 0.4234 1
Trypanosoma cruzi cysteine peptidase, putative 0.1171 0.4234 0.4234
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0272 0.0227 0.0227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1171 0.4234 1
Trypanosoma cruzi cysteine proteinase, putative 0.0636 0.1852 0.1852
Onchocerca volvulus 0.0807 0.261 0.5946
Echinococcus granulosus cathepsin L 0.0272 0.0227 0.0227
Echinococcus granulosus cathepsin L cysteine proteinase 0.1171 0.4234 0.4234
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.095 0.325 0.325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1171 0.4234 1
Leishmania major cathepsin L-like protease 0.1171 0.4234 1
Brugia malayi Papain family cysteine protease containing protein 0.0272 0.0227 0.0227
Plasmodium vivax serine-repeat antigen (SERA) 0.0272 0.0227 0.0537
Loa Loa (eye worm) hypothetical protein 0.0807 0.261 0.261
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0272 0.0227 0.0227
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0636 0.1852 0.4054
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2466 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0636 0.1852 0.1852
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0272 0.0227 0.0227
Entamoeba histolytica cysteine protease, putative 0.0636 0.1852 0.4054
Brugia malayi Cathepsin L-like precursor 0.1171 0.4234 0.4234
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0272 0.0227 0.0227
Entamoeba histolytica cysteine protease, putative 0.0636 0.1852 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1171 0.4234 1
Brugia malayi Papain family cysteine protease containing protein 0.0272 0.0227 0.0227
Echinococcus granulosus cathepsin b 0.2466 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1171 0.4234 1
Brugia malayi Cathepsin L-like precursor 0.0365 0.0643 0.0643
Brugia malayi cathepsin Z-like cysteine proteinase 0.0272 0.0227 0.0227
Plasmodium falciparum serine repeat antigen 9 0.0272 0.0227 0.0537
Brugia malayi cathepsin L-like precursor 0.0807 0.261 0.261
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0272 0.0227 0.0227
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0272 0.0227 0.0227
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1171 0.4234 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0272 0.0227 0.0537
Entamoeba histolytica cysteine proteinase 2 0.0636 0.1852 0.4054
Echinococcus multilocularis cathepsin L cysteine protease 0.1171 0.4234 0.4234
Giardia lamblia Cathepsin B precursor 0.095 0.325 1
Onchocerca volvulus 0.1171 0.4234 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1171 0.4234 1
Leishmania major cysteine peptidase A (CPA) 0.1171 0.4234 1
Loa Loa (eye worm) hypothetical protein 0.2466 1 1
Echinococcus multilocularis cathepsin b 0.2466 1 1
Loa Loa (eye worm) hypothetical protein 0.0272 0.0227 0.0227
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0272 0.0227 0.0537
Plasmodium vivax unspecified product 0.0272 0.0227 0.0537
Toxoplasma gondii preprocathepsin c precursor, putative 0.0272 0.0227 0.0537
Entamoeba histolytica cysteine protease, putative 0.0636 0.1852 0.4054
Loa Loa (eye worm) hypothetical protein 0.0272 0.0227 0.0227
Toxoplasma gondii cathepsin CPL 0.1171 0.4234 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1171 0.4234 1
Giardia lamblia Cathepsin B precursor 0.095 0.325 1
Entamoeba histolytica cysteine proteinase, putative 0.0636 0.1852 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.1171 0.4234 1
Entamoeba histolytica cysteine proteinase, putative 0.1171 0.4234 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1171 0.4234 0.4234
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1171 0.4234 1
Entamoeba histolytica cysteine protease, putative 0.0636 0.1852 0.4054
Plasmodium vivax serine-repeat antigen (SERA) 0.0272 0.0227 0.0537
Onchocerca volvulus 0.1171 0.4234 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0272 0.0227 0.0227
Entamoeba histolytica cysteine protease, putative 0.0636 0.1852 0.4054
Brugia malayi Cathepsin L-like cysteine proteinase 0.0807 0.261 0.261
Brugia malayi Cathepsin L-like precursor 0.0807 0.261 0.261
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1171 0.4234 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0272 0.0227 0.0537
Trypanosoma cruzi cruzipain precursor, putative 0.0365 0.0643 0.0643
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.095 0.325 0.325
Loa Loa (eye worm) hypothetical protein 0.1171 0.4234 0.4234
Plasmodium falciparum cysteine proteinase falcipain 3 0.1171 0.4234 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0636 0.1852 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0636 0.1852 0.4054
Onchocerca volvulus 0.1171 0.4234 1
Entamoeba histolytica cysteine proteinase, putative 0.0636 0.1852 0.4054
Giardia lamblia Cathepsin B precursor 0.095 0.325 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1171 0.4234 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0272 0.0227 0.0537
Entamoeba histolytica cysteine protease, putative 0.0636 0.1852 0.4054
Loa Loa (eye worm) hypothetical protein 0.0272 0.0227 0.0227
Toxoplasma gondii cathepsin B 0.095 0.325 0.7675
Loa Loa (eye worm) hypothetical protein 0.0807 0.261 0.261
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1171 0.4234 1
Schistosoma mansoni cathepsin C 0.0272 0.0227 0.0227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1171 0.4234 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0636 0.1852 0.1852
Loa Loa (eye worm) hypothetical protein 0.0272 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0365 0.0643 0.0643
Trypanosoma brucei cysteine peptidase C (CPC) 0.095 0.325 0.7675
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0807 0.261 0.5946
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0272 0.0227 0.0537
Brugia malayi Papain family cysteine protease containing protein 0.0272 0.0227 0.0227
Onchocerca volvulus 0.1171 0.4234 1
Leishmania major cathepsin L-like protease 0.1171 0.4234 1
Brugia malayi Cathepsin L-like precursor 0.1171 0.4234 0.4234
Schistosoma mansoni cathepsin F (C01 family) 0.1171 0.4234 0.4234
Plasmodium vivax vivapain-1 0.0636 0.1852 0.4373
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2466 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1171 0.4234 1
Entamoeba histolytica cysteine proteinase, putative 0.0807 0.261 0.5946
Plasmodium vivax unspecified product 0.0636 0.1852 0.4373
Loa Loa (eye worm) hypothetical protein 0.0272 0.0227 0.0227
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0272 0.0227 0.0537
Schistosoma mansoni cathepsin F (C01 family) 0.1171 0.4234 0.4234
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.095 0.325 0.7543
Loa Loa (eye worm) ctsf protein 0.1171 0.4234 0.4234
Echinococcus granulosus cathepsin L 0.0636 0.1852 0.1852
Entamoeba histolytica cysteine protease, putative 0.0636 0.1852 0.4054
Onchocerca volvulus 0.1171 0.4234 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0272 0.0227 0.0227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1171 0.4234 1
Loa Loa (eye worm) cathepsin B 0.095 0.325 0.325
Loa Loa (eye worm) hypothetical protein 0.0365 0.0643 0.0643
Leishmania major cathepsin L-like protease 0.1171 0.4234 1
Leishmania major cathepsin L-like protease 0.1171 0.4234 1
Plasmodium vivax unspecified product 0.0365 0.0643 0.1518
Brugia malayi Cathepsin L-like precursor 0.1171 0.4234 0.4234
Loa Loa (eye worm) cysteine protease 0.1171 0.4234 0.4234
Entamoeba histolytica cysteine protease, putative 0.0636 0.1852 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1171 0.4234 1
Entamoeba histolytica cysteine protease, putative 0.1171 0.4234 1
Onchocerca volvulus 0.1171 0.4234 1
Echinococcus multilocularis cathepsin L 0.0636 0.1852 0.1852
Schistosoma mansoni cathepsin F (C01 family) 0.0807 0.261 0.261
Plasmodium vivax vivapain-2 0.1171 0.4234 1
Echinococcus granulosus cathepsin b 0.2466 1 1
Leishmania major cathepsin L-like protease 0.1171 0.4234 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0365 0.0643 0.0643
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0272 0.0227 0.0537
Entamoeba histolytica cysteine proteinase, putative 0.0636 0.1852 0.4054
Echinococcus granulosus cathepsin l1 0.0807 0.261 0.261
Trypanosoma cruzi cysteine peptidase, putative 0.1171 0.4234 0.4234
Brugia malayi cathepsin F-like cysteine proteinase 0.0272 0.0227 0.0227
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2466 1 1
Plasmodium falciparum serine repeat antigen 3 0.0272 0.0227 0.0537
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0272 0.0227 0.0227
Onchocerca volvulus Cathepsin L homolog 0.1171 0.4234 1
Loa Loa (eye worm) hypothetical protein 0.0365 0.0643 0.0643
Entamoeba histolytica cysteine protease, putative 0.0636 0.1852 0.4054
Brugia malayi Cathepsin L-like precursor 0.1171 0.4234 0.4234
Echinococcus granulosus cathepsin l1 0.1171 0.4234 0.4234
Trypanosoma cruzi cysteine protease, putative 0.0636 0.1852 0.1852
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0272 0.0227 0.0537
Loa Loa (eye worm) hypothetical protein 0.0807 0.261 0.261
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1171 0.4234 0.4234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1171 0.4234 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0272 0.0227 0.0227
Echinococcus granulosus cysteine protease 0.0636 0.1852 0.1852
Schistosoma mansoni cathepsin S (C01 family) 0.0272 0.0227 0.0227
Trypanosoma cruzi cruzipain precursor, putative 0.1171 0.4234 0.4234
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0272 0.0227 0.0537
Echinococcus granulosus cathepsin l cysteine peptidase 0.1171 0.4234 0.4234
Brugia malayi fibroinase precursor 0.0272 0.0227 0.0227
Schistosoma mansoni cathepsin B (C01 family) 0.0272 0.0227 0.0227
Brugia malayi cathepsin Z-like cysteine proteinase 0.0272 0.0227 0.0227
Toxoplasma gondii cathepsin CPC1 0.0272 0.0227 0.0537
Toxoplasma gondii cathepsin CPC2 0.0272 0.0227 0.0537
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0636 0.1852 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1171 0.4234 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0272 0.0227 0.0537
Plasmodium falciparum serine repeat antigen 5 0.0272 0.0227 0.0537
Brugia malayi cathepsin F-like cysteine proteinase 0.0365 0.0643 0.0643
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0272 0.0227 0.0537
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0272 0.0227 0.0537
Brugia malayi cathepsin L precursor 0.0272 0.0227 0.0227
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0272 0.0227 0.0227
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1171 0.4234 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0272 0.0227 0.0227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1171 0.4234 1
Trypanosoma cruzi cysteine peptidase, putative 0.1171 0.4234 0.4234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1171 0.4234 1
Brugia malayi Cathepsin L-like precursor 0.1171 0.4234 0.4234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0636 0.1852 0.4373
Plasmodium falciparum cysteine proteinase falcipain 1 0.0636 0.1852 0.4373
Trypanosoma cruzi cysteine peptidase, putative 0.0365 0.0643 0.0643
Brugia malayi Cathepsin L-like precursor 0.0807 0.261 0.261
Plasmodium falciparum serine repeat antigen 6 0.0272 0.0227 0.0537
Entamoeba histolytica cysteine protease, putative 0.0636 0.1852 0.4054
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0807 0.261 0.261
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1171 0.4234 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1171 0.4234 0.4234
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1171 0.4234 1
Brugia malayi Cathepsin L-like precursor 0.1171 0.4234 0.4234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1171 0.4234 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0272 0.0227 0.0227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1171 0.4234 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1171 0.4234 1
Echinococcus multilocularis cysteine protease 0.1171 0.4234 0.4234
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0636 0.1852 0.1852
Schistosoma mansoni cathepsin s 0.0365 0.0643 0.0643
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1171 0.4234 1
Echinococcus multilocularis cysteine protease 0.1171 0.4234 0.4234
Plasmodium falciparum serine repeat antigen 1 0.0272 0.0227 0.0537
Onchocerca volvulus 0.1171 0.4234 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1171 0.4234 1
Echinococcus multilocularis cathepsin b 0.2466 1 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.095 0.325 0.7675
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0636 0.1852 0.4373
Plasmodium vivax vivapain-2 0.1171 0.4234 1
Entamoeba histolytica cysteine protease, putative 0.0636 0.1852 0.4054
Plasmodium falciparum serine repeat antigen 8 0.0272 0.0227 0.0537
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1171 0.4234 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1171 0.4234 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0365 0.0643 0.0643
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1171 0.4234 1
Trypanosoma cruzi cysteine proteinase, putative 0.0636 0.1852 0.1852
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0272 0.0227 0.0537
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1171 0.4234 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1171 0.4234 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0272 0.0227 0.0227
Trypanosoma cruzi cysteine peptidase, putative 0.1171 0.4234 0.4234
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1171 0.4234 0.4234
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0636 0.1852 0.1852
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2466 1 1
Echinococcus multilocularis cathepsin L 0.0272 0.0227 0.0227
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0272 0.0227 0.0227
Onchocerca volvulus Cathepsin L homolog 0.1171 0.4234 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1171 0.4234 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2466 1 1
Plasmodium falciparum serine repeat antigen 4 0.0272 0.0227 0.0537
Brugia malayi Papain family cysteine protease containing protein 0.1171 0.4234 0.4234
Onchocerca volvulus Cathepsin F homolog 0.1171 0.4234 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1171 0.4234 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1171 0.4234 1
Leishmania major cathepsin L-like protease 0.1171 0.4234 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0807 0.261 0.5946
Echinococcus multilocularis cathepsin L cysteine protease 0.1171 0.4234 0.4234
Plasmodium falciparum serine repeat antigen 7 0.0272 0.0227 0.0537
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0272 0.0227 0.0227
Plasmodium vivax vivapain-3 0.0636 0.1852 0.4373
Loa Loa (eye worm) fibroinase 0.1171 0.4234 0.4234
Brugia malayi Papain family cysteine protease containing protein 0.0636 0.1852 0.1852
Plasmodium falciparum serine repeat antigen 2 0.0272 0.0227 0.0537
Entamoeba histolytica cysteine protease, putative 0.0636 0.1852 0.4054
Entamoeba histolytica cysteine protease, putative 0.0636 0.1852 0.4054
Loa Loa (eye worm) hypothetical protein 0.0272 0.0227 0.0227
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0636 0.1852 0.1852
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1171 0.4234 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.6213 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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