Detailed information for compound 1482316

Basic information

Technical information
  • TDR Targets ID: 1482316
  • Name: 2-(3,8-dimethylquinolin-2-yl)sulfanyl-N-(5-me thyl-1,2-oxazol-3-yl)acetamide
  • MW: 327.401 | Formula: C17H17N3O2S
  • H donors: 1 H acceptors: 3 LogP: 3.85 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1noc(c1)C)CSc1nc2c(C)cccc2cc1C
  • InChi: 1S/C17H17N3O2S/c1-10-5-4-6-13-7-11(2)17(19-16(10)13)23-9-15(21)18-14-8-12(3)22-20-14/h4-8H,9H2,1-3H3,(H,18,20,21)
  • InChiKey: SMWSXUCDWOKUGA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(3,8-dimethyl-2-quinolyl)sulfanyl]-N-(5-methylisoxazol-3-yl)acetamide
  • 2-[(3,8-dimethyl-2-quinolyl)thio]-N-(5-methyl-3-isoxazolyl)acetamide
  • 2-[(3,8-dimethyl-2-quinolyl)thio]-N-(5-methylisoxazol-3-yl)acetamide
  • 2-(3,8-dimethylquinolin-2-yl)sulfanyl-N-(5-methyl-1,2-oxazol-3-yl)ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major heat shock protein 83-1 0.0133 0.0326 0.1024
Giardia lamblia Cysteine protease 0.0258 0.0691 0.2686
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0065 0.0096
Schistosoma mansoni smad1 5 8 and 0.0027 0.0017 0.0025
Loa Loa (eye worm) hypothetical protein 0.0258 0.0691 0.102
Echinococcus multilocularis lamin dm0 0.0086 0.0189 0.0189
Giardia lamblia Hypothetical protein 0.0258 0.0691 0.2686
Echinococcus granulosus transcription factor Dp 1 0.0084 0.0182 0.0269
Brugia malayi jmjC domain containing protein 0.0039 0.0051 0.0076
Brugia malayi Bromodomain containing protein 0.0092 0.0207 0.0306
Trypanosoma cruzi cysteine peptidase, putative 0.1113 0.3185 0.4702
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0258 0.0691 0.2168
Schistosoma mansoni kinase 0.01 0.0229 0.0338
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0021 0.0001 0.0011
Echinococcus multilocularis cpg binding protein 0.0032 0.0033 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1113 0.3185 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0095 0.014
Echinococcus multilocularis tar DNA binding protein 0.0331 0.0903 0.0903
Giardia lamblia Cathepsin B precursor 0.0258 0.0691 0.2686
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.009 0.0133
Brugia malayi hypothetical protein 0.0028 0.0019 0.0028
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0039 0.0039
Echinococcus granulosus cathepsin l1 0.1113 0.3185 0.4702
Entamoeba histolytica cysteine protease, putative 0.0258 0.0691 0.2169
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0095 0.014
Echinococcus granulosus cathepsin L cysteine proteinase 0.1113 0.3185 0.4702
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.0095 0.014
Toxoplasma gondii preprocathepsin c precursor, putative 0.0258 0.0691 0.2168
Plasmodium vivax multidomain scavenger receptor, putative 0.0084 0.0184 0.0576
Schistosoma mansoni tar DNA-binding protein 0.0331 0.0903 0.1333
Loa Loa (eye worm) hypothetical protein 0.0107 0.025 0.037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0604 0.1702 0.5344
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0258 0.0691 0.2168
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1113 0.3185 0.4702
Schistosoma mansoni hypothetical protein 0.0052 0.009 0.0133
Schistosoma mansoni hypothetical protein 0.0084 0.0184 0.0272
Loa Loa (eye worm) hypothetical protein 0.0084 0.0184 0.0272
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0112 0.0165
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0068 0.1786
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0079 0.017 0.0532
Loa Loa (eye worm) oxidoreductase 0.0044 0.0068 0.01
Giardia lamblia Kinase, PLK 0.0195 0.0509 0.1977
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0258 0.0691 0.102
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0104 0.0327
Trypanosoma cruzi heat shock protein, putative 0.0079 0.017 0.025
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0046 0.0073 0.0227
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0113 0.0268 0.7061
Echinococcus granulosus Niemann Pick C1 protein 0.0279 0.0753 0.1112
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0044 0.0068 0.01
Echinococcus multilocularis serine:threonine protein phosphatase 2B 0.0046 0.0073 0.0073
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0068 0.1786
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0331 0.0903 0.1333
Leishmania major heat shock protein 83-1 0.0133 0.0326 0.1024
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0035 0.0039 0.0058
Loa Loa (eye worm) hypothetical protein 0.0059 0.0111 0.0164
Entamoeba histolytica heat shock transcription factor, putative 0.0108 0.0254 0.0797
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0183 0.0183
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0258 0.0691 0.2169
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0005 0.0017
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0051 0.0076
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.021 0.055 0.055
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0766 0.2174 0.3209
Schistosoma mansoni inositol monophosphatase 0.0037 0.0045 0.0067
Giardia lamblia Cathepsin L precursor 0.0258 0.0691 0.2686
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.009 0.009
Brugia malayi Hsp90 protein 0.0079 0.017 0.0251
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.012 0.0288 0.0903
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0034 0.0895
Plasmodium falciparum serine repeat antigen 1 0.0258 0.0691 0.2168
Brugia malayi AMP-binding enzyme family protein 0.0151 0.038 0.0561
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0478 0.15
Brugia malayi MH1 domain containing protein 0.0027 0.0017 0.0025
Brugia malayi MH2 domain containing protein 0.0027 0.0017 0.0025
Trypanosoma cruzi heat shock protein 85, putative 0.0133 0.0326 0.0482
Toxoplasma gondii cathepsin B 0.0903 0.2572 0.8076
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0104 0.0154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0604 0.1702 0.5344
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0044 0.0068 0.0213
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0045 0.0142
Loa Loa (eye worm) cathepsin B 0.0903 0.2572 0.3797
Plasmodium vivax unspecified product 0.0604 0.1702 0.5343
Entamoeba histolytica Ser/Thr protein phosphatase, putative 0.0046 0.0073 0.0227
Plasmodium vivax vivapain-2 0.1113 0.3185 1
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0055 0.0055
Brugia malayi CHE-14 protein 0.0084 0.0183 0.027
Brugia malayi cathepsin F-like cysteine proteinase 0.0347 0.095 0.1402
Plasmodium falciparum serine repeat antigen 8 0.0258 0.0691 0.2168
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0044 0.0068 0.1786
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0021 0.0001 0.0011
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0041 0.0059 0.0059
Trypanosoma cruzi serine/threonine protein phosphatase, putative 0.0046 0.0073 0.0107
Loa Loa (eye worm) hypothetical protein 0.0086 0.0189 0.0279
Brugia malayi Latrophilin receptor protein 2 0.0052 0.009 0.0133
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0035 0.0039 0.0039
Leishmania major 4-coumarate:coa ligase-like protein 0.0151 0.038 0.1192
Leishmania major acetyl-CoA synthetase, putative 0.0044 0.0068 0.0213
Entamoeba histolytica hypothetical protein 0.0187 0.0485 0.1523
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0104 0.0154
Trypanosoma cruzi heat shock protein 90, putative 0.0112 0.0264 0.039
Plasmodium vivax endoplasmin, putative 0.0133 0.0326 0.1023
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0019 0.0028
Plasmodium falciparum serine repeat antigen 9 0.0258 0.0691 0.2168
Leishmania major heat shock protein 83-1 0.0133 0.0326 0.1024
Leishmania major developmentally regulated phosphoprotein-like protein 0.0021 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1113 0.3185 1
Trichomonas vaginalis conserved hypothetical protein 0.0258 0.0691 0.2169
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0195 0.0509 0.0751
Leishmania major heat shock protein 83-1 0.0133 0.0326 0.1024
Schistosoma mansoni heat shock protein 0.0133 0.0326 0.0482
Loa Loa (eye worm) hypothetical protein 0.0044 0.0068 0.01
Onchocerca volvulus 0.1113 0.3185 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0005 0.0007
Schistosoma mansoni hypothetical protein 0.0112 0.0267 0.0393
Echinococcus granulosus heat shock protein 90 0.0133 0.0326 0.0482
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0044 0.0068 0.1786
Schistosoma mansoni lipoxygenase 0.0373 0.1027 0.1516
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0604 0.1702 0.2513
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0001 0.0001
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0213 0.0213
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0068 0.1786
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0088 0.0129
Echinococcus multilocularis microtubule associated protein 2 0.151 0.4345 0.4345
Schistosoma mansoni hypothetical protein 0.0321 0.0875 0.1291
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0022 0.0068
Brugia malayi cathepsin B-like cysteine proteinase 0.2343 0.6774 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0258 0.0691 0.2686
Echinococcus multilocularis endoplasmin 0.012 0.0288 0.0288
Brugia malayi Cathepsin L-like precursor 0.1113 0.3185 0.4702
Trypanosoma brucei Heat shock protein 83, putative 0.0133 0.0326 0.1024
Loa Loa (eye worm) intermediate filament protein 0.0086 0.0189 0.0279
Brugia malayi MAP kinase sur-1 0.0051 0.0088 0.0129
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.009 0.009
Echinococcus granulosus cathepsin l1 0.0766 0.2174 0.3209
Loa Loa (eye worm) hypothetical protein 0.0113 0.0268 0.0396
Onchocerca volvulus Huntingtin homolog 0.0268 0.0721 0.2263
Brugia malayi Cathepsin L-like precursor 0.1113 0.3185 0.4702
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0115 0.0169
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0079 0.017 0.0533
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0041 0.0059 0.0087
Trypanosoma cruzi cysteine peptidase, putative 0.1113 0.3185 0.4702
Trypanosoma cruzi DNA topoisomerase II, putative 0.0021 0.0001 0.0001
Trypanosoma cruzi cruzipain precursor, putative 0.1113 0.3185 0.4702
Schistosoma mansoni hypothetical protein 0.0187 0.0485 0.0716
Loa Loa (eye worm) hypothetical protein 0.0049 0.0082 0.0121
Loa Loa (eye worm) hypothetical protein 0.0108 0.0254 0.0375
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0035 0.0039 0.0121
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0478 0.15
Schistosoma mansoni hypothetical protein 0.0406 0.1122 0.1656
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0258 0.0691 0.2686
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.0761 0.2387
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0005 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0258 0.0691 0.2169
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0144 0.036 0.1129
Schistosoma mansoni endoplasmin 0.0133 0.0326 0.0482
Plasmodium falciparum heat shock protein 90 0.0133 0.0326 0.1023
Trichomonas vaginalis receptor histidine kinase, putative 0.0021 0.0001 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0221 0.0695
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0258 0.0691 0.102
Brugia malayi AMP-binding enzyme family protein 0.0151 0.038 0.0561
Loa Loa (eye worm) hypothetical protein 0.0164 0.0418 0.0618
Echinococcus granulosus survival motor neuron protein 1 0.0752 0.2133 0.3149
Trypanosoma cruzi Heat shock protein 83, putative 0.0133 0.0326 0.0482
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0044 0.0068 0.1786
Trypanosoma cruzi cruzipain precursor, putative 0.0347 0.095 0.1401
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0258 0.0691 0.2169
Brugia malayi RNA binding protein 0.0331 0.0903 0.1333
Entamoeba histolytica cysteine proteinase, putative 0.0766 0.2174 0.6825
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.0017 0.0025
Schistosoma mansoni heat shock protein 0.0079 0.017 0.0251
Giardia lamblia PHD finger protein 15 0.0029 0.0022 0.0086
Brugia malayi PHD-finger family protein 0.0029 0.0022 0.0033
Entamoeba histolytica heat shock protein 90, putative 0.0133 0.0326 0.1024
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0144 0.036 0.0531
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0258 0.0691 0.2169
Entamoeba histolytica cysteine protease, putative 0.0604 0.1702 0.5344
Brugia malayi Niemann-Pick C1 protein precursor 0.0195 0.0508 0.0751
Schistosoma mansoni ap endonuclease 0.0023 0.0005 0.0007
Echinococcus multilocularis protein dispatched 1 0.0096 0.0218 0.0218
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0021 0.0001 0.0001
Trypanosoma brucei heat shock protein, putative 0.0133 0.0326 0.1024
Leishmania major cathepsin L-like protease 0.1113 0.3185 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1113 0.3185 1
Giardia lamblia Cathepsin B precursor 0.0903 0.2572 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0093 0.0138
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0258 0.0691 0.2169
Onchocerca volvulus 0.0153 0.0386 0.1212
Onchocerca volvulus Glucosylceramidase homolog 0.0185 0.0478 0.15
Loa Loa (eye worm) hypothetical protein 0.1113 0.3185 0.4702
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0111 0.0111
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0088 0.0088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.0095 0.014
Loa Loa (eye worm) TOPoisomerase family member 0.0021 0.0001 0.0001
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0044 0.0068 0.01
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0022 0.0068
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0022 0.0033
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0154 0.0227
Schistosoma mansoni tar DNA-binding protein 0.0331 0.0903 0.1333
Plasmodium falciparum cysteine proteinase falcipain 3 0.1113 0.3185 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0373 0.1027 0.1516
Loa Loa (eye worm) hypothetical protein 0.0347 0.095 0.1402
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1113 0.3185 1
Mycobacterium tuberculosis Possible two component sensor kinase 0.0021 0.0001 0.0011
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0258 0.0691 0.2686
Entamoeba histolytica cysteine protease, putative 0.0604 0.1702 0.5344
Trypanosoma brucei heat shock protein, putative 0.0133 0.0326 0.1024
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0021 0.0001 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1113 0.3185 1
Plasmodium vivax serine/threonine protein phosphatase 2B catalytic subunit A, putative 0.0046 0.0073 0.0226
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0044 0.0068 0.0213
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0006 0.0017
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0045 0.0142
Giardia lamblia Heat shock protein HSP 90-alpha 0.0112 0.0264 0.1027
Echinococcus multilocularis isocitrate dehydrogenase 0.0035 0.0039 0.0039
Schistosoma mansoni bromodomain containing protein 0.0078 0.0166 0.0245
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0035 0.0039 0.103
Brugia malayi hypothetical protein 0.0084 0.0184 0.0272
Echinococcus multilocularis zinc finger protein 0.0025 0.0012 0.0012
Plasmodium falciparum LCCL domain-containing protein 0.0084 0.0184 0.0576
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0068 0.1786
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0044 0.0068 0.1777
Mycobacterium ulcerans DNA gyrase subunit B 0.0021 0.0001 0.0011
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0044 0.0068 0.1786
Plasmodium vivax vivapain-1 0.0604 0.1702 0.5343
Trypanosoma brucei developmentally regulated phosphoprotein 0.0021 0.0001 0.0001
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0144 0.036 0.0531
Echinococcus granulosus cpg binding protein 0.0032 0.0033 0.0049
Echinococcus multilocularis peregrin 0.0032 0.0031 0.0031
Giardia lamblia Hypothetical protein 0.0258 0.0691 0.2686
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1113 0.3185 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0104 0.0154
Echinococcus granulosus cysteine protease 0.0604 0.1702 0.2513
Plasmodium falciparum serine repeat antigen 4 0.0258 0.0691 0.2168
Toxoplasma gondii heat shock protein HSP90 0.0133 0.0326 0.1023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0258 0.0691 0.2169
Giardia lamblia Cathepsin B precursor 0.0258 0.0691 0.2686
Plasmodium falciparum serine repeat antigen 6 0.0258 0.0691 0.2168
Giardia lamblia Cathepsin L precursor 0.0258 0.0691 0.2686
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0095 0.014
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0258 0.0691 0.2168
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0039 0.0123
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0068 0.01
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0282 0.0761 0.1123
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0022 0.0022
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0006 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1113 0.3185 1
Trypanosoma cruzi cysteine peptidase, putative 0.1113 0.3185 0.4702
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0258 0.0691 0.2169
Schistosoma mansoni rab6-interacting 0.0084 0.0184 0.0272
Loa Loa (eye worm) MH2 domain-containing protein 0.0394 0.1088 0.1606
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0079 0.017 0.017
Onchocerca volvulus 0.1113 0.3185 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.009 0.009
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0144 0.036 0.1129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1113 0.3185 1
Schistosoma mansoni hypothetical protein 0.0081 0.0174 0.0257
Plasmodium falciparum serine repeat antigen 5 0.0258 0.0691 0.2168
Schistosoma mansoni smad1 5 8 and 0.0027 0.0017 0.0025
Trypanosoma brucei protein kinase, putative 0.0051 0.0088 0.0275
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0258 0.0691 0.102
Schistosoma mansoni cpg binding protein 0.0028 0.0021 0.0032
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2343 0.6774 1
Plasmodium falciparum acyl-CoA synthetase 0.0113 0.0268 0.084
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0347 0.095 0.1402
Leishmania major heat shock protein 83-1 0.0133 0.0326 0.1024
Schistosoma mansoni lipoxygenase 0.0221 0.0585 0.0863
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0258 0.0691 0.2168
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0258 0.0691 0.2169
Echinococcus multilocularis expressed conserved protein 0.0184 0.0474 0.0474
Echinococcus granulosus expressed conserved protein 0.0184 0.0474 0.07
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0258 0.0691 0.102
Trichomonas vaginalis heat shock protein, putative 0.012 0.0288 0.0903
Brugia malayi jmjC domain containing protein 0.0094 0.0213 0.0315
Echinococcus granulosus GPCR family 2 0.0052 0.009 0.0133
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Leishmania major heat shock protein 83-1 0.0133 0.0326 0.1024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0258 0.0691 0.2169
Echinococcus multilocularis protein patched 0.0084 0.0183 0.0183
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0113 0.0268 0.7061
Schistosoma mansoni protein phosphatase-2b 0.0046 0.0073 0.0107
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1113 0.3185 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2343 0.6774 1
Brugia malayi Bromodomain containing protein 0.0032 0.0031 0.0045
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0258 0.0691 0.2168
Mycobacterium ulcerans acyl-CoA synthetase 0.0151 0.038 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0258 0.0691 0.2168
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0021 0.0001 0.0011
Echinococcus granulosus tar DNA binding protein 0.0331 0.0903 0.1333
Echinococcus multilocularis serine:threonine protein phosphatase 2B 0.0046 0.0073 0.0073
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0006 0.0017
Schistosoma mansoni cathepsin C 0.0258 0.0691 0.102
Entamoeba histolytica heat shock transcription factor, putative 0.0108 0.0254 0.0797
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.0509 0.1597
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0258 0.0691 0.2168
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0021 0.0001 0.0002
Loa Loa (eye worm) isocitrate dehydrogenase 0.0035 0.0039 0.0058
Echinococcus granulosus peregrin 0.0032 0.0031 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0195 0.0509 0.0751
Echinococcus multilocularis cathepsin L 0.0258 0.0691 0.0691
Mycobacterium ulcerans acyl-CoA synthetase 0.0151 0.038 1
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0068 0.01
Leishmania major mitochondrial DNA topoisomerase II 0.0021 0.0001 0.0001
Schistosoma mansoni rab6-interacting 0.0084 0.0184 0.0272
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0022 0.0033
Schistosoma mansoni hypothetical protein 0.0052 0.009 0.0133
Trypanosoma cruzi cysteine proteinase, putative 0.0604 0.1702 0.2512
Echinococcus multilocularis cathepsin L 0.0604 0.1702 0.1702
Loa Loa (eye worm) hypothetical protein 0.0103 0.0238 0.0351
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1113 0.3185 1
Mycobacterium ulcerans acetyl-CoA synthetase 0.0044 0.0068 0.1786
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0088 0.0129
Trypanosoma brucei cysteine peptidase C (CPC) 0.0903 0.2572 0.8076
Schistosoma mansoni cathepsin B (C01 family) 0.0258 0.0691 0.102
Schistosoma mansoni DNA topoisomerase II 0.0021 0.0001 0.0001
Entamoeba histolytica Ser/Thr protein phosphatase, putative 0.0046 0.0073 0.0227
Loa Loa (eye worm) hypothetical protein 0.0151 0.038 0.0561
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0766 0.2174 0.6825
Giardia lamblia Cathepsin B precursor 0.0258 0.0691 0.2686
Schistosoma mansoni hypothetical protein 0.0052 0.009 0.0133
Plasmodium vivax serine-repeat antigen (SERA) 0.0258 0.0691 0.2168
Entamoeba histolytica hypothetical protein 0.0187 0.0485 0.1523
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.0017 0.0017
Schistosoma mansoni cpg binding protein 0.0032 0.0033 0.0049
Loa Loa (eye worm) hypothetical protein 0.0195 0.0508 0.0751
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0005 0.0014
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0151 0.038 1
Echinococcus multilocularis cathepsin L cysteine protease 0.1113 0.3185 0.3185
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0153 0.0386 0.057
Schistosoma mansoni cpg binding protein 0.0032 0.0033 0.0049
Schistosoma mansoni tar DNA-binding protein 0.0331 0.0903 0.1333
Echinococcus multilocularis heat shock protein 90 0.0133 0.0326 0.0326
Leishmania major heat shock protein 83-1 0.0133 0.0326 0.1024
Echinococcus multilocularis lamin 0.0086 0.0189 0.0189
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0011 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.0509 0.1597
Trichomonas vaginalis heat shock protein, putative 0.0093 0.0208 0.0654
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0044 0.0068 0.0212
Trypanosoma brucei heat shock protein 90, putative 0.0133 0.0326 0.1024
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0046 0.0073 0.0227
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0021 0.0001 0.0011
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0144 0.036 0.036
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0045 0.0142
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.0761 0.2387
Leishmania major cathepsin L-like protease 0.1113 0.3185 1
Trichomonas vaginalis heat shock protein, putative 0.0071 0.0146 0.0458
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0021 0.0001 0.0001
Brugia malayi Papain family cysteine protease containing protein 0.0258 0.0691 0.102
Brugia malayi cathepsin Z-like cysteine proteinase 0.0258 0.0691 0.102
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0021 0.0001 0.0001
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.012 0.0288 0.7573
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0019 0.0058
Schistosoma mansoni hypothetical protein 0.0029 0.0022 0.0033
Entamoeba histolytica DNA topoisomerase II, putative 0.0021 0.0001 0.0001
Brugia malayi Cathepsin L-like precursor 0.0347 0.095 0.1402
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.0761 0.2387
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0258 0.0691 0.2168
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1113 0.3185 1
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.009 0.0133
Echinococcus granulosus cathepsin b 0.2343 0.6774 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0044 0.0068 0.1786
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0045 0.0142
Schistosoma mansoni smad 0.0027 0.0017 0.0025
Leishmania major heat shock protein 83-1 0.0133 0.0326 0.1024
Echinococcus granulosus heat shock protein 90 0.0112 0.0264 0.039
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0021 0.0001 0.0002
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0079 0.017 0.0251
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.0017 0.0017
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0111 0.0111
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0021 0.0001 0.0011
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0006 0.0206
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0187 0.0485 0.0716
Entamoeba histolytica cysteine protease, putative 0.0604 0.1702 0.5344
Mycobacterium tuberculosis Probable two component sensor kinase 0.0021 0.0001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0155 0.0391 0.0577
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1113 0.3185 1
Brugia malayi Papain family cysteine protease containing protein 0.0604 0.1702 0.2513
Brugia malayi cathepsin L-like cysteine proteinase 0.0258 0.0691 0.102
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0258 0.0691 0.102
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0045 0.1191
Loa Loa (eye worm) hypothetical protein 0.0258 0.0691 0.102
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0021 0.0001 0.0001
Entamoeba histolytica serine/threonine protein kinase, putative 0.0195 0.0509 0.1597
Trypanosoma cruzi polo-like protein kinase, putative 0.0195 0.0509 0.0751
Loa Loa (eye worm) doublecortin family protein 0.0084 0.0184 0.0272
Echinococcus granulosus jumonji domain containing protein 0.004 0.0055 0.0082
Brugia malayi heat shock protein 90 0.0133 0.0326 0.0482
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1113 0.3185 1
Schistosoma mansoni Smad4 0.0027 0.0017 0.0025
Onchocerca volvulus 0.1113 0.3185 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0258 0.0691 0.2168
Entamoeba histolytica hypothetical protein 0.0187 0.0485 0.1523
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0258 0.0691 0.2169
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0258 0.0691 0.2169
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0021 0.0001 0.0011
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0144 0.036 0.0531
Trypanosoma cruzi heat shock protein 90, putative 0.0133 0.0326 0.0482
Brugia malayi Isocitrate dehydrogenase 0.0035 0.0039 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1113 0.3185 1
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.009 0.0133
Schistosoma mansoni zinc finger protein 0.0025 0.0012 0.0018
Onchocerca volvulus 0.0052 0.009 0.0283
Giardia lamblia Pms1-like protein 0.0021 0.0001 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0088 0.0275
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0104 0.2744
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0068 0.0213
Brugia malayi Papain family cysteine protease containing protein 0.0258 0.0691 0.102
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0088 0.0129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1113 0.3185 1
Echinococcus granulosus cathepsin L cysteine protease 0.0604 0.1702 0.2513
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0258 0.0691 0.2169
Trichomonas vaginalis heat shock protein, putative 0.0133 0.0326 0.1024
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.0072 0.0107
Leishmania major cathepsin L-like protease 0.1113 0.3185 1
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0021 0.0001 0.0011
Loa Loa (eye worm) hypothetical protein 0.0766 0.2174 0.3209
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0347 0.095 0.1402
Loa Loa (eye worm) hypothetical protein 0.0046 0.0074 0.0109
Mycobacterium ulcerans two component sensor kinase MprB 0.0021 0.0001 0.0011
Leishmania major heat shock protein 83-1 0.0133 0.0326 0.1024
Loa Loa (eye worm) hypothetical protein 0.0347 0.095 0.1402
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1113 0.3185 1
Trypanosoma cruzi heat shock protein 85, putative 0.0133 0.0326 0.0482
Echinococcus granulosus microtubule associated protein 2 0.151 0.4345 0.6413
Onchocerca volvulus 0.0086 0.0189 0.0592
Trypanosoma brucei heat shock protein, putative 0.0133 0.0326 0.1024
Leishmania major heat shock protein 83-1 0.0133 0.0326 0.1024
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0021 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0019 0.0028
Schistosoma mansoni lamin 0.0086 0.0189 0.0279
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0903 0.2572 0.3797
Loa Loa (eye worm) Smad1 0.0027 0.0017 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1113 0.3185 1
Loa Loa (eye worm) hypothetical protein 0.0258 0.0691 0.102
Loa Loa (eye worm) TAR-binding protein 0.0331 0.0903 0.1333
Loa Loa (eye worm) transcription factor SMAD2 0.0394 0.1088 0.1606
Brugia malayi cathepsin L-like precursor 0.0766 0.2174 0.3209
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0179 0.0179
Schistosoma mansoni loxhd1 0.0084 0.0184 0.0272
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1113 0.3185 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0006 0.0157
Plasmodium falciparum serine repeat antigen 2 0.0258 0.0691 0.2168
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0258 0.0691 0.2169
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.009 0.0133
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0006 0.0157
Toxoplasma gondii cathepsin CPC1 0.0258 0.0691 0.2168
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0144 0.036 0.0531
Giardia lamblia Cathepsin B precursor 0.0903 0.2572 1
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0021 0.0001 0.0011
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0044 0.0068 0.01
Echinococcus granulosus cathepsin L 0.0258 0.0691 0.102
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0903 0.2572 0.8076
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0144 0.036 0.1129
Echinococcus granulosus cathepsin L 0.0604 0.1702 0.2513
Brugia malayi hypothetical protein 0.0084 0.0184 0.0272
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0068 0.1786
Brugia malayi cathepsin F-like cysteine proteinase 0.0258 0.0691 0.102
Giardia lamblia Cathepsin B precursor 0.0903 0.2572 1
Brugia malayi Cathepsin L-like precursor 0.1113 0.3185 0.4702
Onchocerca volvulus 0.1113 0.3185 1
Giardia lamblia Cysteine protease 0.0258 0.0691 0.2686
Toxoplasma gondii propionate-CoA ligase 0.0044 0.0068 0.0212
Trypanosoma cruzi serine/threonine protein phosphatase 2B catalytic subunit A2, putative 0.0046 0.0073 0.0107
Plasmodium falciparum serine/threonine protein phosphatase 2B catalytic subunit A 0.0046 0.0073 0.0226
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0045 0.0067
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0104 0.2744
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.012 0.0288 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1113 0.3185 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0086 0.0189 0.0279
Entamoeba histolytica cysteine protease, putative 0.0258 0.0691 0.2169
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1113 0.3185 0.3185
Trichomonas vaginalis sensor histidine kinase, putative 0.0021 0.0001 0.0001
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0005 0.0013
Schistosoma mansoni transcription factor LCR-F1 0.0187 0.0485 0.0716
Leishmania major heat shock protein 83-1 0.0133 0.0326 0.1024
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0068 0.01
Trypanosoma cruzi major cysteine proteinase, putative 0.0258 0.0691 0.102
Plasmodium falciparum serine repeat antigen 3 0.0258 0.0691 0.2168
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0195 0.0509 0.1597
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0021 0.0001 0.0011
Brugia malayi Serine/threonine protein phosphatase 2B catalytic subunit 2 0.0046 0.0073 0.0107
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.0509 0.1597
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.0761 0.2387
Leishmania major heat shock protein 83-1 0.0133 0.0326 0.1024
Schistosoma mansoni endoplasmin 0.0133 0.0326 0.0482
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0183 0.027
Brugia malayi PHD-finger family protein 0.0032 0.0031 0.0046
Trypanosoma brucei heat shock protein 84, putative 0.0079 0.017 0.0532
Schistosoma mansoni heat shock protein 0.0133 0.0326 0.0482
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0151 0.038 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0023 0.0033
Entamoeba histolytica cysteine protease, putative 0.0604 0.1702 0.5344
Giardia lamblia Cathepsin L precursor 0.0258 0.0691 0.2686
Trypanosoma cruzi DNA topoisomerase II, putative 0.0021 0.0001 0.0001
Onchocerca volvulus 0.1113 0.3185 1
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0044 0.0068 0.1786
Entamoeba histolytica acyl-coA synthetase, putative 0.0151 0.038 0.1192
Echinococcus granulosus cathepsin b 0.2343 0.6774 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0088 0.0129
Onchocerca volvulus Cathepsin L homolog 0.1113 0.3185 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0021 0.0001 0.0002
Brugia malayi Cathepsin L-like precursor 0.1113 0.3185 0.4702
Trypanosoma brucei heat shock protein, putative 0.0133 0.0326 0.1024
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0045 0.0142
Onchocerca volvulus 0.0155 0.0391 0.1228
Entamoeba histolytica cysteine protease, putative 0.0258 0.0691 0.2169
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1113 0.3185 0.3185
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0044 0.0068 0.1786
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.0509 0.1597
Plasmodium vivax heat shock protein 86, putative 0.0133 0.0326 0.1023
Echinococcus granulosus endoplasmin 0.012 0.0288 0.0425
Onchocerca volvulus Huntingtin homolog 0.0268 0.0721 0.2263
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0021 0.0001 0.0001
Giardia lamblia Cathepsin B precursor 0.0258 0.0691 0.2686
Loa Loa (eye worm) hypothetical protein 0.0084 0.0184 0.0272
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1113 0.3185 1
Giardia lamblia Cathepsin L precursor 0.0258 0.0691 0.2686
Trypanosoma cruzi cysteine protease, putative 0.0604 0.1702 0.2512
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0068 0.1786
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0022 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1113 0.3185 1
Trypanosoma brucei protein phosphatase 2B, putative 0.0046 0.0073 0.0227
Echinococcus granulosus lamin 0.0086 0.0189 0.0279
Brugia malayi intermediate filament protein 0.0086 0.0189 0.0279
Plasmodium vivax heat shock protein 90, putative 0.0079 0.017 0.0531
Brugia malayi CXXC zinc finger family protein 0.0028 0.0021 0.0032
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0107 0.025 0.6586
Toxoplasma gondii cathepsin CPC2 0.0258 0.0691 0.2168
Schistosoma mansoni polycystin 1-related 0.0084 0.0184 0.0272
Trypanosoma cruzi heat shock protein 90, putative 0.0062 0.0119 0.0175
Entamoeba histolytica cysteine protease, putative 0.0258 0.0691 0.2169
Entamoeba histolytica cysteine protease, putative 0.0258 0.0691 0.2169
Plasmodium falciparum serine repeat antigen 7 0.0258 0.0691 0.2168
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0044 0.0068 0.1786
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0044 0.0068 0.1777
Loa Loa (eye worm) hypothetical protein 0.0258 0.0691 0.102
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0151 0.038 1
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0044 0.0068 0.0212
Leishmania major acetyl-CoA synthetase, putative 0.0044 0.0068 0.0213
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0088 0.034
Loa Loa (eye worm) hypothetical protein 0.0113 0.0268 0.0396
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0005 0.0118
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0021 0.0001 0.0001
Brugia malayi Cathepsin L-like precursor 0.0766 0.2174 0.3209
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0005 0.0007
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0258 0.0691 0.2168
Brugia malayi hypothetical protein 0.0155 0.0391 0.0577
Echinococcus granulosus dnaJ subfamily B 0.0406 0.1122 0.1656
Onchocerca volvulus 0.0151 0.038 0.1193
Leishmania major heat shock protein 83-1 0.0133 0.0326 0.1024
Trichomonas vaginalis heat shock protein, putative 0.012 0.0288 0.0903
Loa Loa (eye worm) hypothetical protein 0.0029 0.0022 0.0033
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0045 0.0067
Brugia malayi Inositol-1 0.0037 0.0045 0.0067
Schistosoma mansoni acetyl-CoA synthetase 0.0044 0.0068 0.01
Mycobacterium ulcerans two component regulator - sensor kinase 0.0021 0.0001 0.0011
Echinococcus granulosus lamin dm0 0.0086 0.0189 0.0279
Echinococcus granulosus lipoxygenase domain containing protein 0.0084 0.0184 0.0272
Schistosoma mansoni protein phosphatase-2b 0.0046 0.0073 0.0107
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0006 0.0146
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0088 0.0129
Loa Loa (eye worm) RNA binding protein 0.0331 0.0903 0.1333
Mycobacterium ulcerans putative regultory protein 0.0021 0.0001 0.0011
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0051 0.0076
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0021 0.0001 0.0001
Leishmania major cysteine peptidase A (CPA) 0.1113 0.3185 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1113 0.3185 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0151 0.038 0.1192
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0112 0.0264 0.039
Loa Loa (eye worm) hypothetical protein 0.0112 0.0267 0.0393
Plasmodium vivax vivapain-3 0.0604 0.1702 0.5343
Plasmodium falciparum phd finger protein, putative 0.0029 0.0022 0.0068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1113 0.3185 1
Brugia malayi mbt repeat family protein 0.0052 0.009 0.0133
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0258 0.0691 0.2169
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0005 0.0141
Brugia malayi Papain family cysteine protease containing protein 0.0258 0.0691 0.102
Leishmania major heat shock protein 83-1 0.0133 0.0326 0.1024
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0045 0.0045
Echinococcus granulosus Polycystic kidney disease protein 0.0084 0.0184 0.0272
Trichomonas vaginalis antibiotic synthetase, putative 0.0044 0.0068 0.0213
Entamoeba histolytica cysteine protease, putative 0.0604 0.1702 0.5344
Loa Loa (eye worm) hypothetical protein 0.0113 0.0268 0.0396
Plasmodium falciparum cysteine proteinase falcipain 1 0.0604 0.1702 0.5343
Brugia malayi Endoplasmin precursor 0.0133 0.0326 0.0482
Trypanosoma cruzi heat shock protein 85, putative 0.0112 0.0264 0.039
Giardia lamblia Cathepsin L-like protease 0.0258 0.0691 0.2686
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0021 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0903 0.2572 0.8076
Echinococcus multilocularis musashi 0.0086 0.0189 0.0189
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0478 0.15
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0044 0.0068 0.1786
Echinococcus multilocularis Niemann Pick C1 protein 0.0279 0.0753 0.0753
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0044 0.0068 0.1786
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0005 0.0014
Brugia malayi latrophilin 2 splice variant baaae 0.0112 0.0267 0.0393
Echinococcus multilocularis Niemann Pick C1 protein 0.0195 0.0508 0.0508
Entamoeba histolytica cysteine protease, putative 0.0258 0.0691 0.2169
Brugia malayi cathepsin L precursor 0.0258 0.0691 0.102
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0006 0.0192
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0088 0.0129
Onchocerca volvulus Alhambra homolog 0.0029 0.0022 0.007
Brugia malayi serine/threonine-protein kinase plk-2 0.0195 0.0509 0.0751
Trichomonas vaginalis conserved hypothetical protein 0.0258 0.0691 0.2169
Onchocerca volvulus Cathepsin L homolog 0.0258 0.0691 0.2169
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0023 0.0023
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0021 0.0001 0.0001
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0258 0.0691 0.102
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.0509 0.1597
Schistosoma mansoni hypothetical protein 0.0153 0.0386 0.057
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0604 0.1702 0.2513
Giardia lamblia Cysteine protease 0.0258 0.0691 0.2686
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0604 0.1702 0.5344
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0478 0.15
Trypanosoma cruzi major cysteine proteinase, putative 0.0258 0.0691 0.102
Brugia malayi Bromodomain containing protein 0.0046 0.0073 0.0108
Brugia malayi Cathepsin L-like cysteine proteinase 0.0766 0.2174 0.3209
Onchocerca volvulus 0.1113 0.3185 1
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0019 0.0058
Loa Loa (eye worm) heat shock protein 90 0.0133 0.0326 0.0482
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0107 0.025 0.6586
Echinococcus multilocularis lipoxygenase domain containing protein 0.0084 0.0184 0.0184
Echinococcus granulosus Niemann Pick C1 protein 0.0195 0.0508 0.0751
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0088 0.0273
Echinococcus granulosus intermediate filament protein 0.0086 0.0189 0.0279
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0044 0.0068 0.1786
Entamoeba histolytica cysteine proteinase, putative 0.0604 0.1702 0.5344
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1113 0.3185 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1113 0.3185 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0068 0.1786
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1113 0.3185 1
Onchocerca volvulus Cathepsin L homolog 0.1113 0.3185 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0604 0.1702 0.2513
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0104 0.0325
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0021 0.0001 0.0011
Leishmania major DNA topoisomerase ii 0.0021 0.0001 0.0001
Plasmodium falciparum heat shock protein 90, putative 0.0071 0.0146 0.0457
Brugia malayi TAR-binding protein 0.0331 0.0903 0.1333
Echinococcus multilocularis Smad4 0.0027 0.0017 0.0017
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0044 0.0068 0.1786
Echinococcus multilocularis transcription factor Dp 1 0.0084 0.0182 0.0182
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0151 0.038 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0044 0.0068 0.1786
Schistosoma mansoni hypothetical protein 0.0052 0.009 0.0133
Loa Loa (eye worm) cysteine protease 0.1113 0.3185 0.4702
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0039 0.0121
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0044 0.0068 0.01
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.0133
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0258 0.0691 0.2168
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0258 0.0691 0.102
Trichomonas vaginalis endoplasmin, putative 0.0093 0.0208 0.0654
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0144 0.036 0.0531
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.009 0.009
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0258 0.0691 0.102
Leishmania major 4-coumarate:coa ligase-like protein 0.0151 0.038 0.1192
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0005 0.0007
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0051 0.0076
Echinococcus multilocularis RUN 0.0084 0.0184 0.0184
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0051 0.0076
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0604 0.1702 0.2512
Mycobacterium ulcerans acyl-CoA synthetase 0.0151 0.038 1
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0021 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0041 0.0059 0.0087
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0195 0.0509 0.0509
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0046 0.0073 0.0227
Leishmania major 4-coumarate:coa ligase-like protein 0.0151 0.038 0.1192
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0017 0.0025
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0039 0.0039
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0006 0.0019
Echinococcus granulosus serine:threonine protein phosphatase 2B 0.0046 0.0073 0.0107
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0017 0.0025
Giardia lamblia Cathepsin L-like protease 0.0258 0.0691 0.2686
Leishmania major serine/threonine protein phosphatase, putative 0.0046 0.0073 0.0227
Entamoeba histolytica cysteine proteinase 2 0.0604 0.1702 0.5344
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0088 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1113 0.3185 1
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0221 0.0695
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0035 0.0039 0.0058
Entamoeba histolytica cysteine protease, putative 0.0604 0.1702 0.5344
Schistosoma mansoni lamin 0.0086 0.0189 0.0279
Loa Loa (eye worm) hypothetical protein 0.0766 0.2174 0.3209
Entamoeba histolytica cysteine protease, putative 0.0604 0.1702 0.5344
Schistosoma mansoni cathepsin F (C01 family) 0.1113 0.3185 0.4702
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0021 0.0001 0.0011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0107 0.025 0.6586
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0035 0.0039 0.0121
Schistosoma mansoni hypothetical protein 0.036 0.0989 0.1459
Trichomonas vaginalis DNA topoisomerase II, putative 0.0021 0.0001 0.0001
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0045 0.0067
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0044 0.0068 0.1786
Schistosoma mansoni hypothetical protein 0.0081 0.0174 0.0257
Leishmania major hypothetical protein, conserved 0.0028 0.0019 0.0059
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2343 0.6774 1
Leishmania major heat shock protein, putative 0.0079 0.017 0.0532
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0164 0.0418 0.0618
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0258 0.0691 0.2169
Giardia lamblia Encystation-specific protease 0.0258 0.0691 0.2686
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0021 0.0001 0.0011
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0195 0.0508 0.1596
Loa Loa (eye worm) hypothetical protein 0.0084 0.0184 0.0272
Echinococcus granulosus zinc finger protein 0.0025 0.0012 0.0018
Echinococcus multilocularis heat shock protein 0.0133 0.0326 0.0326
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.0761 0.2387
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0005 0.0005
Brugia malayi MH1 domain containing protein 0.0027 0.0017 0.0025
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0258 0.0691 0.2169
Loa Loa (eye worm) hypothetical protein 0.0752 0.2133 0.3149
Schistosoma mansoni cathepsin s 0.0347 0.095 0.1402
Entamoeba histolytica hypothetical protein 0.0023 0.0006 0.0019
Toxoplasma gondii exonuclease III APE 0.0023 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.0044 0.0068 0.01
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.012 0.0288 0.7576
Onchocerca volvulus 0.1113 0.3185 1
Onchocerca volvulus 0.0044 0.0068 0.0214
Brugia malayi hypothetical protein 0.0187 0.0485 0.0716
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0258 0.0691 0.2686
Schistosoma mansoni hypothetical protein 0.0081 0.0174 0.0257
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.009 0.0133
Plasmodium vivax unspecified product 0.0347 0.095 0.298
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0045 0.0141
Brugia malayi mbt repeat family protein 0.0052 0.009 0.0133
Entamoeba histolytica cysteine proteinase, putative 0.1113 0.3185 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0258 0.0691 0.2169
Echinococcus granulosus serine:threonine protein phosphatase 2B 0.0046 0.0073 0.0107
Loa Loa (eye worm) hypothetical protein 0.0268 0.0721 0.1064
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0144 0.036 0.0531
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1113 0.3185 1
Onchocerca volvulus 0.0766 0.2174 0.6825
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0046 0.0073 0.0227
Echinococcus granulosus geminin 0.036 0.0989 0.1459
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0034 0.0885
Brugia malayi Cathepsin L-like precursor 0.1113 0.3185 0.4702
Echinococcus multilocularis Polycystic kidney disease protein 0.0084 0.0184 0.0184
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0088 0.0275
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0258 0.0691 0.102
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0113 0.0268 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0045 0.1559
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.0017 0.0025
Brugia malayi Doublecortin family protein 0.0084 0.0184 0.0272
Entamoeba histolytica cysteine proteinase, putative 0.0604 0.1702 0.5344
Onchocerca volvulus Serine\/threonine kinase homolog 0.0195 0.0509 0.1598
Leishmania major serine/threonine protein phosphatase 2B catalytic subunit A2, putative 0.0046 0.0073 0.0227
Giardia lamblia Cysteine protease 0.0258 0.0691 0.2686
Loa Loa (eye worm) hypothetical protein 0.0084 0.0183 0.027
Echinococcus multilocularis cysteine protease 0.1113 0.3185 0.3185
Trypanosoma brucei heat shock protein 90, putative 0.0133 0.0326 0.1024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1113 0.3185 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0604 0.1702 0.5344
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0005 0.0141
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0903 0.2572 0.3797
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0258 0.0691 0.2169
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0258 0.0691 0.102
Loa Loa (eye worm) hypothetical protein 0.0268 0.0721 0.1064
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.004 0.004
Mycobacterium ulcerans heat shock protein 90 0.012 0.0288 0.7576
Loa Loa (eye worm) hypothetical protein 0.0258 0.0691 0.102
Echinococcus granulosus endonuclease exonuclease phosphatase 0.021 0.055 0.0812
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0157 0.0231
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0019 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.0507 0.1591
Loa Loa (eye worm) hypothetical protein 0.004 0.0055 0.0081
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0039 0.0121
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0068 0.01
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0088 0.0275
Schistosoma mansoni survival motor neuron protein 0.0153 0.0386 0.057
Onchocerca volvulus 0.0107 0.025 0.0786
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1113 0.3185 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0065 0.0065
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0282 0.0761 0.1123
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0068 0.1786
Brugia malayi cathepsin Z-like cysteine proteinase 0.0258 0.0691 0.102
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2343 0.6774 1
Brugia malayi AMP-binding enzyme family protein 0.0151 0.038 0.0561
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1113 0.3185 1
Brugia malayi Cathepsin L-like precursor 0.1113 0.3185 0.4702
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0044 0.0068 0.1786
Giardia lamblia Cathepsin L precursor 0.0258 0.0691 0.2686
Loa Loa (eye worm) hypothetical protein 0.0045 0.0071 0.0104
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0068 0.01
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0179 0.0265
Mycobacterium ulcerans hypothetical protein 0.0151 0.038 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1113 0.3185 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0068 0.1786
Leishmania major heat shock protein 83-1 0.0133 0.0326 0.1024
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0183 0.027
Trichomonas vaginalis receptor histidine kinase, putative 0.0021 0.0001 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.0509 0.1597
Trypanosoma brucei heat shock protein, putative 0.0133 0.0326 0.1024
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0044 0.0068 0.01
Onchocerca volvulus 0.0044 0.0068 0.0214
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0044 0.0068 0.01
Brugia malayi MH2 domain containing protein 0.0027 0.0017 0.0025
Mycobacterium tuberculosis Conserved protein 0.0021 0.0001 0.0011
Echinococcus granulosus heat shock protein 0.0133 0.0326 0.0482
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Entamoeba histolytica heat shock transcription factor, putative 0.0108 0.0254 0.0797
Onchocerca volvulus 0.0258 0.0691 0.2169
Trypanosoma cruzi cysteine peptidase, putative 0.0347 0.095 0.1401
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0164 0.0418 0.0618
Loa Loa (eye worm) hypothetical protein 0.2343 0.6774 1
Loa Loa (eye worm) inositol-1 0.0037 0.0045 0.0067
Leishmania major cathepsin L-like protease 0.1113 0.3185 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0088 0.0275
Entamoeba histolytica cysteine protease, putative 0.0604 0.1702 0.5344
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0021 0.0001 0.0001
Loa Loa (eye worm) endoplasmin 0.0133 0.0326 0.0482
Echinococcus multilocularis cathepsin b 0.2343 0.6774 0.6774
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0258 0.0691 0.102
Plasmodium vivax vivapain-2 0.1113 0.3185 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0019 0.0058
Leishmania major cathepsin L-like protease 0.1113 0.3185 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0258 0.0691 0.102
Toxoplasma gondii heat shock protein 75, putative 0.0079 0.017 0.0531
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0111 0.0164
Trichomonas vaginalis heat shock protein, putative 0.0112 0.0264 0.0829
Brugia malayi kinase, mitochondrial precursor 0.0021 0.0001 0.0001
Brugia malayi Calcitonin receptor-like protein seb-1 0.0164 0.0418 0.0618
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.009 0.0133
Giardia lamblia Cathepsin L precursor 0.0258 0.0691 0.2686
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0104 0.2744
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0022 0.0068
Onchocerca volvulus 0.0084 0.0184 0.0578
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.0766 0.2174 0.3209
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.0761 0.2387
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0023 0.0033
Entamoeba histolytica cysteine proteinase, putative 0.0604 0.1702 0.5344
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0006 0.0019
Loa Loa (eye worm) hypothetical protein 0.0053 0.0093 0.0138
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0039 0.0123
Loa Loa (eye worm) hypothetical protein 0.0083 0.0179 0.0265
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0035 0.0039 0.0058
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.0509 0.1597
Loa Loa (eye worm) hypothetical protein 0.0085 0.0188 0.0277
Loa Loa (eye worm) hypothetical protein 0.0347 0.095 0.1402
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0258 0.0691 0.2168
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.0072 0.0107
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0021 0.0001 0.0011
Brugia malayi AMP-binding enzyme family protein 0.0044 0.0068 0.01
Plasmodium vivax unspecified product 0.0258 0.0691 0.2168
Loa Loa (eye worm) hypothetical protein 0.004 0.0055 0.0081
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0373 0.1027 0.1027
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0258 0.0691 0.2168
Plasmodium falciparum heat shock protein 90, putative 0.0383 0.1057 0.3318
Plasmodium falciparum endoplasmin, putative 0.0093 0.0208 0.0652
Brugia malayi RNA recognition motif domain containing protein 0.0331 0.0903 0.1333
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0021 0.0001 0.0001
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.009 0.0133
Giardia lamblia Cathepsin B precursor 0.0258 0.0691 0.2686
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0179 0.0265
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0108 0.0254 0.0798
Onchocerca volvulus 0.0044 0.0068 0.0214
Trypanosoma cruzi serine/threonine protein phosphatase, putative 0.0046 0.0073 0.0107
Toxoplasma gondii heat shock protein 90, putative 0.0133 0.0326 0.1023
Loa Loa (eye worm) ctsf protein 0.1113 0.3185 0.4702
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.1122 0.1122
Trypanosoma cruzi cysteine peptidase, putative 0.0604 0.1702 0.2512
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0045 0.0142
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.009 0.0133
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0021 0.0001 0.0011
Echinococcus granulosus smad 0.0027 0.0017 0.0025
Plasmodium vivax acetyl-CoA synthetase, putative 0.0044 0.0068 0.0212
Brugia malayi isocitrate dehydrogenase 0.0035 0.0039 0.0058
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0151 0.038 1
Schistosoma mansoni cathepsin F (C01 family) 0.1113 0.3185 0.4702
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1113 0.3185 1
Entamoeba histolytica cysteine protease, putative 0.0604 0.1702 0.5344
Trypanosoma brucei heat shock protein, putative 0.0133 0.0326 0.1024
Schistosoma mansoni tar DNA-binding protein 0.0331 0.0903 0.1333
Loa Loa (eye worm) hypothetical protein 0.0052 0.009 0.0133
Giardia lamblia Grp94/Hsp90 0.012 0.0288 0.1118
Brugia malayi Cathepsin L-like precursor 0.0766 0.2174 0.3209
Echinococcus multilocularis cathepsin b 0.2343 0.6774 0.6774
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0038 0.005 0.1312
Loa Loa (eye worm) hypothetical protein 0.0258 0.0691 0.102
Leishmania major cathepsin L-like protease 0.1113 0.3185 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0005 0.0014
Echinococcus granulosus Smad4 0.0027 0.0017 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1113 0.3185 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0045 0.0067
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0039 0.0058
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0151 0.038 1
Schistosoma mansoni intermediate filament proteins 0.0086 0.0189 0.0279
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0088 0.0275
Brugia malayi Papain family cysteine protease containing protein 0.0604 0.1702 0.2513
Toxoplasma gondii protein phosphatase 2B catalytic subunit, calcineurin family phosphatse superfamily protein 0.0046 0.0073 0.0226
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0151 0.038 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0084 0.0184 0.0184
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0095 0.0095
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0179 0.0265
Trypanosoma cruzi cysteine proteinase, putative 0.0604 0.1702 0.2512
Echinococcus multilocularis smad 0.0027 0.0017 0.0017
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0111 0.0164
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0095 0.014
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0005 0.0014
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0151 0.038 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0082 0.0122
Trypanosoma brucei heat shock protein, putative 0.0133 0.0326 0.1024
Onchocerca volvulus Cathepsin F homolog 0.1113 0.3185 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0039 0.0039
Schistosoma mansoni microtubule-associated protein tau 0.151 0.4345 0.6413
Schistosoma mansoni tar DNA-binding protein 0.0331 0.0903 0.1333
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0095 0.0095
Echinococcus multilocularis GPCR, family 2 0.0052 0.009 0.009
Leishmania major hypothetical protein, conserved 0.0021 0.0001 0.0001
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0006 0.0192
Leishmania major cathepsin L-like protease 0.1113 0.3185 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.1113 0.3185 0.4702
Schistosoma mansoni ap endonuclease 0.0023 0.0005 0.0007
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0183 0.027
Echinococcus multilocularis survival motor neuron protein 1 0.0752 0.2133 0.2133
Onchocerca volvulus 0.0083 0.0179 0.0563
Onchocerca volvulus 0.0084 0.0184 0.0578
Entamoeba histolytica cysteine proteinase, putative 0.0604 0.1702 0.5344
Onchocerca volvulus 0.0086 0.0189 0.0592
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0198 0.0517 0.0764
Trypanosoma cruzi heat shock protein 85, putative 0.0133 0.0326 0.0482
Toxoplasma gondii Hsp90 domain-containing protein 0.0383 0.1057 0.3318
Entamoeba histolytica cysteine proteinase, putative 0.1113 0.3185 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0095 0.014
Entamoeba histolytica cysteine protease, putative 0.0604 0.1702 0.5344
Treponema pallidum heat shock protein 90 0.012 0.0288 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.009 0.0133
Schistosoma mansoni hypothetical protein 0.0025 0.0011 0.0016
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0021 0.0001 0.0011
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0088 0.0275
Echinococcus multilocularis geminin 0.036 0.0989 0.0989
Echinococcus multilocularis cathepsin L cysteine protease 0.1113 0.3185 0.3185
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0088 0.0129
Echinococcus multilocularis tumor protein p63 0.0731 0.207 0.207
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1113 0.3185 1
Toxoplasma gondii cathepsin CPL 0.1113 0.3185 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0258 0.0691 0.2169
Schistosoma mansoni smad1 5 8 and 0.0027 0.0017 0.0025
Schistosoma mansoni cathepsin S (C01 family) 0.0258 0.0691 0.102
Echinococcus multilocularis heat shock protein 90 0.0112 0.0264 0.0264
Plasmodium vivax heat shock protein, putative 0.0383 0.1057 0.3318
Entamoeba histolytica cysteine protease, putative 0.1113 0.3185 1
Brugia malayi Probable DNA topoisomerase II 0.0021 0.0001 0.0001
Echinococcus granulosus RUN 0.0084 0.0184 0.0272
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0021 0.0032
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0021 0.0001 0.0011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0005 0.0007
Brugia malayi Intermediate filament tail domain containing protein 0.0086 0.0189 0.0279
Schistosoma mansoni pyruvate dehydrogenase 0.0021 0.0001 0.0001
Leishmania major heat shock protein 83-1 0.0133 0.0326 0.1024
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0021 0.0001 0.0011
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0044 0.0068 0.1786
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0088 0.0129
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0044 0.0068 0.01
Loa Loa (eye worm) hypothetical protein 0.0113 0.0268 0.0396
Entamoeba histolytica hypothetical protein 0.0258 0.0691 0.2169
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0021 0.0001 0.0001
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0044 0.0068 0.0068
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0478 0.15
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0006 0.0017
Brugia malayi Papain family cysteine protease containing protein 0.1113 0.3185 0.4702
Brugia malayi HSF-type DNA-binding domain containing protein 0.0108 0.0254 0.0375
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0044 0.0068 0.0213
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0187 0.0485 0.0485
Entamoeba histolytica cysteine protease, putative 0.0604 0.1702 0.5344
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0005 0.0118
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.0507 0.1591
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0766 0.2174 0.6825
Trypanosoma cruzi cysteine peptidase, putative 0.1113 0.3185 0.4702
Onchocerca volvulus 0.0048 0.0079 0.0249
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0478 0.15
Entamoeba histolytica cysteine protease, putative 0.0604 0.1702 0.5344
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0044 0.0068 0.0212
Brugia malayi Smad1 0.0027 0.0017 0.0025
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1113 0.3185 0.4702
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0154 0.0154
Trypanosoma brucei heat shock protein, putative 0.0133 0.0326 0.1024
Plasmodium vivax acyl-CoA synthetase, putative 0.0113 0.0268 0.084
Loa Loa (eye worm) hypothetical protein 0.0151 0.038 0.0561
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0021 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0113 0.0268 0.0396
Trypanosoma brucei DNA topoisomerase ii 0.0021 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1113 0.3185 1
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0088 0.0275
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0107 0.025 0.6586
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0258 0.0691 0.2168
Echinococcus granulosus lipoxygenase domain containing protein 0.0084 0.0184 0.0272
Entamoeba histolytica cysteine proteinase 1, putative 0.0604 0.1702 0.5344
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0019 0.0059
Onchocerca volvulus 0.0028 0.0021 0.0067
Echinococcus granulosus tumor protein p63 0.0731 0.207 0.3056
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0195 0.0509 0.0751
Loa Loa (eye worm) fibroinase 0.1113 0.3185 0.4702
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0021 0.0001 0.0001
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0006 0.0157
Schistosoma mansoni patched 1 0.0084 0.0183 0.027
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0046 0.0073 0.0107
Schistosoma mansoni hypothetical protein 0.0081 0.0174 0.0257
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.009 0.0283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1113 0.3185 1
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0021 0.0001 0.0011
Entamoeba histolytica hypothetical protein 0.0187 0.0485 0.1523
Echinococcus multilocularis cysteine protease 0.1113 0.3185 0.3185
Leishmania major cathepsin L-like protease 0.1113 0.3185 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0133 0.0326 0.1268
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0021 0.0001 0.0001
Trichomonas vaginalis antibiotic synthetase, putative 0.0044 0.0068 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1113 0.3185 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0111 0.0164
Trypanosoma cruzi polo-like protein kinase, putative 0.0195 0.0509 0.0751
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0183 0.0574
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0068 0.1786
Brugia malayi fibroinase precursor 0.0258 0.0691 0.102
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0021 0.0001 0.0001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0151 0.038 0.1192
Loa Loa (eye worm) heat shock protein 75 0.0079 0.017 0.0251
Entamoeba histolytica heat shock protein 90, putative 0.0133 0.0326 0.1024
Entamoeba histolytica cysteine protease, putative 0.0604 0.1702 0.5344
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2343 0.6774 1
Leishmania major heat shock protein 83-1 0.0133 0.0326 0.1024
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0104 0.0104
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.0017 0.0025
Brugia malayi hypothetical protein 0.0752 0.2133 0.3149
Schistosoma mansoni cellular tumor antigen P53 0.0107 0.025 0.037
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0019 0.0058
Trypanosoma brucei polo-like protein kinase 0.0195 0.0509 0.1597
Schistosoma mansoni cathepsin F (C01 family) 0.0766 0.2174 0.3209
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0258 0.0691 0.102
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0035 0.0039 0.0123
Brugia malayi hypothetical protein 0.0268 0.0721 0.1064
Brugia malayi MH2 domain containing protein 0.0394 0.1088 0.1606
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0111 0.0164
Mycobacterium ulcerans acyl-CoA synthetase 0.0044 0.0068 0.1786
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0044 0.0068 0.1777
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.009 0.0133
Loa Loa (eye worm) MBCTL1 0.0059 0.0111 0.0164
Schistosoma mansoni hypothetical protein 0.036 0.0989 0.1459
Loa Loa (eye worm) hypothetical protein 0.0151 0.038 0.0561
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0021 0.0001 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0478 0.15
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0213 0.0315

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0828 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 4.7444 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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