TDR Targets

Basic information

Technical information

TDR Targets ID: 1483617
Name: N-[2-(1-cyclohexenyl)ethyl]-3-(2-sulfanyliden e-1,3-benzoxazol-3-yl)propanamide
MW: 330.444 | Formula: C18H22N2O2S
H donors: 1 H acceptors: 1 LogP: 3.22 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(CCn1c(=S)oc2c1cccc2)NCCC1=CCCCC1
InChi: 1S/C18H22N2O2S/c21-17(19-12-10-14-6-2-1-3-7-14)11-13-20-15-8-4-5-9-16(15)22-18(20)23/h4-6,8-9H,1-3,7,10-13H2,(H,19,21)
InChiKey: CFELNGBBSNAZOX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-(1-cyclohexenyl)ethyl]-3-(2-thioxo-1,3-benzoxazol-3-yl)propanamide
N-[2-(1-cyclohexenyl)ethyl]-3-(2-thioxo-1,3-benzoxazol-3-yl)propionamide
MLS000686791
N-(2-cyclohex-1-en-1-ylethyl)-3-(2-thioxo-1,3-benzoxazol-3(2H)-yl)propanamide
SMR000339798

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	chromobox homolog 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	heterochromatin protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus granulosus	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus granulosus	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	chromobox protein	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Brugia malayi	Heterochromatin protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Onchocerca volvulus	Heterochromatin protein 1 homolog	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus multilocularis	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma japonicum	Chromobox protein homolog 5, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus multilocularis	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Theileria parva	hypothetical protein	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Onchocerca volvulus		Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	chromobox protein	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	cysteine proteinase 1, putative	0.0128	0.1717	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0055	0.0084	0.0205
Leishmania major	cathepsin L-like protease	0.0235	0.4112	1
Brugia malayi	Papain family cysteine protease containing protein	0.0128	0.1717	0.1647
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0128	0.1717	0.4176
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0084	0.0205
Entamoeba histolytica	cysteine proteinase, putative	0.0128	0.1717	0.4054
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0128	0.1717	0.1647
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0235	0.4112	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0084	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0162	0.2479	0.2415
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0235	0.4112	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0235	0.4112	1
Loa Loa (eye worm)	hypothetical protein	0.0235	0.4112	0.4062
Onchocerca volvulus		0.0235	0.4112	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0235	0.4112	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0235	0.4112	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0498	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0055	0.0084	0.0205
Trypanosoma cruzi	cysteine peptidase, putative	0.0235	0.4112	0.4062
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0235	0.4112	1
Echinococcus multilocularis	cathepsin b	0.0498	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0084	0.0205
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1717	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0235	0.4112	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0235	0.4112	1
Echinococcus multilocularis	cysteine protease	0.0235	0.4112	0.4062
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0084	0.0205
Brugia malayi	Cathepsin L-like precursor	0.0235	0.4112	0.4062
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0128	0.1717	0.1647
Brugia malayi	Cathepsin L-like precursor	0.0073	0.0499	0.0418
Leishmania major	cathepsin L-like protease	0.0235	0.4112	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0235	0.4112	0.4062
Entamoeba histolytica	cysteine proteinase, putative	0.0128	0.1717	0.4054
Loa Loa (eye worm)	fibroinase	0.0235	0.4112	0.4062
Toxoplasma gondii	cathepsin CPL	0.0235	0.4112	1
Echinococcus granulosus	cathepsin b	0.0498	1	1
Giardia lamblia	Cathepsin B precursor	0.0192	0.3151	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0128	0.1717	0.1647
Trypanosoma cruzi	cruzipain precursor, putative	0.0235	0.4112	0.4062
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0235	0.4112	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0235	0.4112	1
Plasmodium vivax	unspecified product	0.0073	0.0499	0.103
Leishmania major	cathepsin L-like protease	0.0235	0.4112	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0235	0.4112	1
Plasmodium vivax	vivapain-3	0.0128	0.1717	0.4054
Schistosoma mansoni	chromobox protein	0.0084	0.0746	0.0667
Plasmodium vivax	vivapain-2	0.0235	0.4112	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0235	0.4112	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0235	0.4112	0.4062
Brugia malayi	Cathepsin L-like precursor	0.0162	0.2479	0.2415
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0235	0.4112	1
Loa Loa (eye worm)	cysteine protease	0.0235	0.4112	0.4062
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0235	0.4112	0.4062
Trypanosoma cruzi	cysteine peptidase, putative	0.0235	0.4112	0.4062
Echinococcus granulosus	chromobox protein 1	0.0084	0.0746	0.0667
Loa Loa (eye worm)	hypothetical protein	0.0162	0.2479	0.2415
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.0084	0.0205
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0235	0.4112	0.4062
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0499	0.0418
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0128	0.1717	0.1647
Entamoeba histolytica	cysteine proteinase 2	0.0128	0.1717	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0235	0.4112	0.4062
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0235	0.4112	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0055	0.0084	0.0205
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0235	0.4112	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0084	0.0205
Leishmania major	cysteine peptidase A (CPA)	0.0235	0.4112	1
Onchocerca volvulus	Cathepsin L homolog	0.0055	0.0084	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0499	0.0418
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.0746	0.1814
Onchocerca volvulus		0.0055	0.0084	0.0205
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1717	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0055	0.0084	0.0205
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0235	0.4112	0.4062
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0055	0.0084	0.0205
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0055	0.0084	0.0205
Onchocerca volvulus		0.0235	0.4112	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0055	0.0084	0.0205
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0235	0.4112	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0073	0.0499	0.0418
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0128	0.1717	0.4054
Leishmania major	cathepsin L-like protease	0.0235	0.4112	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0235	0.4112	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0162	0.2479	0.2415
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0128	0.1717	0.4176
Brugia malayi	Cathepsin L-like precursor	0.0235	0.4112	0.4062
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0235	0.4112	1
Echinococcus multilocularis	chromobox protein 1	0.0084	0.0746	0.0667
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0128	0.1717	0.1647
Loa Loa (eye worm)	ctsf protein	0.0235	0.4112	0.4062
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0055	0.0084	0.0205
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0235	0.4112	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0498	1	1
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1717	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0162	0.2479	0.2415
Brugia malayi	Cathepsin L-like precursor	0.0235	0.4112	0.4062
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.0746	0.1814
Schistosoma mansoni	cathepsin F (C01 family)	0.0235	0.4112	0.4062
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0498	1	1
Echinococcus granulosus	cathepsin L	0.0128	0.1717	0.1647
Echinococcus granulosus	cathepsin l1	0.0162	0.2479	0.2415
Entamoeba histolytica	cysteine protease, putative	0.0235	0.4112	1
Brugia malayi	Papain family cysteine protease containing protein	0.0235	0.4112	0.4062
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0235	0.4112	1
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1717	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0235	0.4112	0.4062
Onchocerca volvulus		0.0235	0.4112	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0235	0.4112	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0235	0.4112	1
Echinococcus multilocularis	chromobox protein 1	0.0084	0.0746	0.0667
Trypanosoma cruzi	cruzipain precursor, putative	0.0073	0.0499	0.0418
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0192	0.3151	0.5987
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0235	0.4112	1
Entamoeba histolytica	cysteine proteinase, putative	0.0128	0.1717	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0235	0.4112	1
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1717	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0235	0.4112	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0235	0.4112	0.4062
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0055	0.0084	0.0205
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0192	0.3151	0.3093
Trypanosoma cruzi	cysteine protease, putative	0.0128	0.1717	0.1647
Leishmania major	cathepsin L-like protease	0.0235	0.4112	1
Brugia malayi	cathepsin L-like precursor	0.0162	0.2479	0.2415
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1717	0.4054
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0498	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0235	0.4112	0.4062
Entamoeba histolytica	cysteine proteinase, putative	0.0235	0.4112	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0073	0.0499	0.0418
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0235	0.4112	1
Onchocerca volvulus		0.0235	0.4112	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0499	0.0418
Schistosoma mansoni	cathepsin s	0.0073	0.0499	0.0418
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0192	0.3151	0.3093
Schistosoma mansoni	cathepsin F (C01 family)	0.0162	0.2479	0.2415
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1717	0.4054
Leishmania major	cathepsin L-like protease	0.0235	0.4112	1
Brugia malayi	Cathepsin L-like precursor	0.0235	0.4112	0.4062
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0162	0.2479	0.2415
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0162	0.2479	0.6029
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0235	0.4112	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0128	0.1717	0.1647
Leishmania major	cathepsin L-like protease	0.0235	0.4112	1
Brugia malayi	Papain family cysteine protease containing protein	0.0128	0.1717	0.1647
Toxoplasma gondii	cathepsin B	0.0192	0.3151	0.7614
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1717	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1717	0.4054
Loa Loa (eye worm)	heterochromatin protein 1	0.0084	0.0746	0.0667
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.0084	0.0205
Loa Loa (eye worm)	cathepsin B	0.0192	0.3151	0.3093
Onchocerca volvulus	Cathepsin L homolog	0.0235	0.4112	1
Onchocerca volvulus		0.0235	0.4112	1
Echinococcus multilocularis	cathepsin L	0.0128	0.1717	0.1647
Plasmodium vivax	vivapain-2	0.0235	0.4112	1
Echinococcus granulosus	cysteine protease	0.0128	0.1717	0.1647
Onchocerca volvulus		0.0162	0.2479	0.6029
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0235	0.4112	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0235	0.4112	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0235	0.4112	0.4062
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0235	0.4112	1
Plasmodium vivax	unspecified product	0.0128	0.1717	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0235	0.4112	1
Entamoeba histolytica	cysteine proteinase, putative	0.0128	0.1717	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0192	0.3151	0.7663
Leishmania major	cathepsin L-like protease	0.0235	0.4112	1
Echinococcus granulosus	chromobox protein 1	0.0084	0.0746	0.0667
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0499	0.0418
Echinococcus multilocularis	cathepsin L cysteine protease	0.0235	0.4112	0.4062
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0073	0.0499	0.0418
Echinococcus granulosus	cathepsin b	0.0498	1	1
Echinococcus multilocularis	cathepsin b	0.0498	1	1
Onchocerca volvulus	Cathepsin F homolog	0.0235	0.4112	1
Onchocerca volvulus		0.0235	0.4112	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0235	0.4112	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0235	0.4112	1
Giardia lamblia	Cathepsin B precursor	0.0192	0.3151	1
Schistosoma mansoni	chromobox protein	0.0084	0.0746	0.0667
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0235	0.4112	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0162	0.2479	0.6029
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0055	0.0084	0.0205
Brugia malayi	Heterochromatin protein 1	0.0084	0.0746	0.0667
Brugia malayi	Cathepsin L-like precursor	0.0235	0.4112	0.4062
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0055	0.0084	0.0205
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0055	0.0084	0.0205
Trypanosoma cruzi	cysteine peptidase, putative	0.0235	0.4112	0.4062
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0498	1	1
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1717	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0128	0.1717	0.1647
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0235	0.4112	1
Loa Loa (eye worm)	hypothetical protein	0.0498	1	1
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1717	0.4054
Plasmodium vivax	vivapain-1	0.0128	0.1717	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0162	0.2479	0.5946
Echinococcus granulosus	cathepsin l1	0.0235	0.4112	0.4062
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0235	0.4112	1
Brugia malayi	Cathepsin L-like precursor	0.0162	0.2479	0.2415
Giardia lamblia	Cathepsin B precursor	0.0192	0.3151	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0235	0.4112	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0235	0.4112	1
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1717	0.4054
Onchocerca volvulus		0.0235	0.4112	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0235	0.4112	1
Entamoeba histolytica	cysteine protease, putative	0.0128	0.1717	0.4054
Trypanosoma cruzi	cysteine proteinase, putative	0.0128	0.1717	0.1647
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0235	0.4112	1
Echinococcus multilocularis	cysteine protease	0.0235	0.4112	0.4062
Onchocerca volvulus	Cathepsin L homolog	0.0235	0.4112	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	7.0795 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	29.081 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1719291

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1483617