Detailed information for compound 1483795

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 341.336 | Formula: C18H16FN3O3
  • H donors: 1 H acceptors: 3 LogP: 3.45 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1nnc(o1)c1ccc(c(c1)C)C)COc1ccccc1F
  • InChi: 1S/C18H16FN3O3/c1-11-7-8-13(9-12(11)2)17-21-22-18(25-17)20-16(23)10-24-15-6-4-3-5-14(15)19/h3-9H,10H2,1-2H3,(H,20,22,23)
  • InChiKey: VOUMDFQXSXRKCI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens calcium channel, voltage-dependent, T type, alpha 1H subunit Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog Get druggable targets OG5_129328 All targets in OG5_129328
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129328 All targets in OG5_129328
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129328 All targets in OG5_129328
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MH2 domain containing protein 0.012 0.1126 0.1303
Brugia malayi steroid hormone receptor 0.0032 0.0189 0.0209
Loa Loa (eye worm) hypothetical protein 0.0021 0.0068 0.0068
Schistosoma mansoni chromobox protein 0.0072 0.0617 0.0709
Leishmania major trypanothione reductase 0.0085 0.0747 0.0841
Plasmodium vivax importin-beta 2, putative 0.003 0.0165 0.016
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0824 0.8574 1
Giardia lamblia Kinase, CMGC MAPK 0.0104 0.0956 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.028 0.0952
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0066 0.0045
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0105 0.0126
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0105 0.0091
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0105 0.0126
Treponema pallidum ribonucleotide-diphosphate reductase subunit beta 0.0076 0.0652 0.0689
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0339 0.033
Loa Loa (eye worm) glutathione reductase 0.0085 0.0747 0.0861
Echinococcus granulosus cyclins 0.0017 0.0035 0.0025
Mycobacterium tuberculosis Probable transcriptional regulatory protein NrdR 0.0071 0.0605 0.0742
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0079
Schistosoma mansoni hypothetical protein 0.003 0.0171 0.0188
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.016 0.0176
Loa Loa (eye worm) hypothetical protein 0.028 0.2811 0.3271
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0104 0.0956 0.1086
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0171 0.0188
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0956 0.1105
Schistosoma mansoni hypothetical protein 0.0129 0.122 0.1414
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.016 0.0155
Plasmodium falciparum importin beta, putative 0.003 0.0165 0.016
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0109 0.1 0.1272
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0079
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0048 0.0363 0.0349
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0339 0.0385
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0109 0.1 0.1157
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit beta 0.0026 0.0122 0.0072
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0297 0.0287
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0078 0.0676 0.0667
Brugia malayi glutathione reductase 0.0085 0.0747 0.0861
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0189 0.0179
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0297 0.0287
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0057 0.0056
Echinococcus multilocularis lysosomal alpha glucosidase 0.049 0.5035 0.503
Loa Loa (eye worm) hypothetical protein 0.0066 0.0545 0.0626
Loa Loa (eye worm) hypothetical protein 0.0409 0.4182 0.4872
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0068 0.0068
Giardia lamblia PHD finger protein 15 0.003 0.0171 0.1477
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0048 0.0363 0.043
Trypanosoma cruzi cdc2-related kinase 3 0.0043 0.031 0.033
Echinococcus granulosus chromobox protein 1 0.0072 0.0617 0.0608
Brugia malayi Pre-SET motif family protein 0.0031 0.0176 0.0194
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0339 0.033
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0078 0.008
Plasmodium falciparum thioredoxin reductase 0.0085 0.0747 0.0841
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0068 0.0068
Trichomonas vaginalis alpha-glucosidase, putative 0.0109 0.1 0.1272
Mycobacterium ulcerans glutaminase 0.0276 0.2775 0.3494
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.016 0.0155
Entamoeba histolytica cell division protein kinase 2, putative 0.0043 0.031 0.2847
Loa Loa (eye worm) hypothetical protein 0.0032 0.0189 0.0209
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0066 0.0045
Trichomonas vaginalis cyclin A, putative 0.0017 0.0035 0.0036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0339 0.0385
Trypanosoma brucei unspecified product 0.0021 0.0068 0.0079
Loa Loa (eye worm) hypothetical protein 0.0221 0.2187 0.2542
Mycobacterium tuberculosis Probable reductase 0.0193 0.1896 0.2398
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0172 0.1675 0.1944
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0234 0.0225
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0189 0.0179
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0104 0.0956 0.1086
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0189 0.0209
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0189 0.0179
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit beta 0.0076 0.0652 0.0756
Trichomonas vaginalis cyclins, putative 0.0017 0.0035 0.0036
Toxoplasma gondii exonuclease III APE 0.002 0.0066 0.0045
Echinococcus granulosus neutral alpha glucosidase AB 0.0109 0.1 0.0992
Leishmania major cyclin 0.0017 0.0035 0.0008
Trichomonas vaginalis alpha-glucosidase, putative 0.0109 0.1 0.1272
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.016 0.0155
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.016 0.0122
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.016 0.0151
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0028 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0189 0.0209
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0048 0.0363 0.0392
Plasmodium vivax hypothetical protein, conserved 0.003 0.0171 0.0168
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0492 0.0563
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0125 0.0114
Schistosoma mansoni DNA polymerase eta 0.0021 0.0068 0.0068
Brugia malayi Calcitonin receptor-like protein seb-1 0.0409 0.4182 0.4872
Schistosoma mansoni microtubule-associated protein tau 0.0696 0.7225 0.8425
Leishmania major DNA polymerase kappa, putative 0.0021 0.0068 0.0047
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0068 0.0078
Loa Loa (eye worm) hypothetical protein 0.0172 0.1675 0.1944
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0066 0.0045
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.016 0.0171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0189 0.0209
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0824 0.8574 0.8573
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0081 0.0507
Loa Loa (eye worm) latrophilin receptor protein 2 0.0129 0.122 0.1414
Schistosoma mansoni importin beta-1 0.003 0.0165 0.0181
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0029 0.0022
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.1126 0.1303
Echinococcus granulosus importin subunit beta 1 0.003 0.0165 0.0155
Echinococcus granulosus ribonucleoside diphosphate reductase subunit 0.0076 0.0652 0.0643
Brugia malayi Thioredoxin reductase 0.0085 0.0747 0.0861
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0029 0.0022
Echinococcus multilocularis snurportin 1 0.0318 0.3212 0.3206
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0189 0.0179
Loa Loa (eye worm) hypothetical protein 0.0032 0.0189 0.0209
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0066 0.0325
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0068 0.0079
Schistosoma mansoni ran 0.0022 0.0081 0.0084
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0532 0.061
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0318 0.3212 0.374
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0189 0.0209
Loa Loa (eye worm) RNA binding protein 0.0064 0.0532 0.061
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0165 0.0192
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0189 0.0179
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.016 0.0155
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0189 0.0631
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.031 0.0388
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0221 0.2187 0.2542
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.016 0.0155
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0104 0.0956 0.1086
Loa Loa (eye worm) hypothetical protein 0.0031 0.0176 0.0194
Echinococcus multilocularis neuropeptide receptor A26 0.0958 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0176 0.0194
Plasmodium vivax ribonucleotide reductase small subunit, putative 0.0026 0.0122 0.011
Trypanosoma brucei trypanothione reductase 0.0085 0.0747 0.0871
Entamoeba histolytica hypothetical protein 0.0036 0.0234 0.2065
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0824 0.8574 1
Schistosoma mansoni hypothetical protein 0.0036 0.0234 0.0262
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0029 0.0022
Leishmania major importin beta-1 subunit, putative 0.0024 0.0105 0.0091
Echinococcus multilocularis lysosomal alpha glucosidase 0.049 0.5035 0.503
Schistosoma mansoni hypothetical protein 0.04 0.4083 0.4756
Echinococcus multilocularis cpg binding protein 0.003 0.0164 0.0154
Trichomonas vaginalis cyclin B, putative 0.0017 0.0035 0.0036
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0532 0.061
Plasmodium vivax SET domain protein, putative 0.0031 0.0176 0.0173
Brugia malayi Cyclin, N-terminal domain containing protein 0.0237 0.2357 0.274
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0104 0.0956 0.1086
Trypanosoma cruzi cdc2-related kinase 3 0.0043 0.031 0.033
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0129 0.122 0.1212
Onchocerca volvulus 0.0017 0.0035 0.0089
Trypanosoma brucei cdc2-related kinase 1 0.0043 0.031 0.0361
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0029 0.0022
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.016 0.0187
Onchocerca volvulus 0.0032 0.0187 0.0625
Echinococcus multilocularis ribonucleoside diphosphate reductase subunit 0.0076 0.0652 0.0643
Echinococcus multilocularis mitogen activated protein kinase 3 0.0104 0.0956 0.0947
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0011 0.0006
Echinococcus granulosus X box binding protein 1 0.0291 0.2929 0.2922
Echinococcus granulosus cyclin dependent kinase 1 0.0043 0.031 0.03
Leishmania major alpha glucosidase II subunit, putative 0.0109 0.1 0.1138
Echinococcus multilocularis short transient receptor potential channel 6 0.0134 0.1271 0.1263
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0824 0.8574 1
Echinococcus multilocularis cyclin B 0.0017 0.0035 0.0025
Mycobacterium tuberculosis Probable dehydrogenase 0.0193 0.1896 0.2398
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0189 0.0209
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0043 0.031 0.035
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.031 0.035
Onchocerca volvulus 0.0043 0.0301 0.1027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0043 0.0046
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0181
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0076 0.0652 0.0731
Loa Loa (eye worm) hypothetical protein 0.0032 0.0189 0.0209
Trypanosoma cruzi cdc2-related kinase 1 0.0043 0.031 0.033
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0189 0.0179
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0081 0.0072
Plasmodium falciparum cyclin 0.0017 0.0035 0.0008
Loa Loa (eye worm) hypothetical protein 0.0052 0.04 0.0456
Brugia malayi Glycosyl hydrolases family 31 protein 0.049 0.5035 0.5867
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0068 0.0068
Brugia malayi hypothetical protein 0.0017 0.0029 0.0022
Trypanosoma brucei mitotic cyclin 6 0.0017 0.0035 0.004
Echinococcus multilocularis short transient receptor potential channel 6 0.0134 0.1271 0.1263
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0171 0.0161
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0081 0.0084
Brugia malayi isocitrate dehydrogenase 0.0017 0.0028 0.0021
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain, putative 0.0076 0.0652 0.0761
Loa Loa (eye worm) hypothetical protein 0.0032 0.0187 0.0207
Brugia malayi Cyclin, N-terminal domain containing protein 0.0017 0.0035 0.0029
Brugia malayi jmjC domain containing protein 0.0038 0.0255 0.0287
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.016 0.0155
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0278 0.0348
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0068 0.0079
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.031 0.0388
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0104 0.0956 0.1115
Onchocerca volvulus 0.0032 0.0189 0.0631
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0824 0.8574 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0154 0.0189
Toxoplasma gondii thioredoxin reductase 0.0085 0.0747 0.0841
Leishmania major DNA polymerase eta, putative 0.0021 0.0068 0.0047
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0171 0.0188
Echinococcus granulosus TRP transient receptor potential channel 0.0078 0.0676 0.0667
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0189 0.0209
Trichomonas vaginalis cyclin B3, putative 0.0017 0.0035 0.0036
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0043 0.0046
Trypanosoma cruzi cyclin, putative 0.0017 0.0035 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0189 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0189 0.0209
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0066 0.034
Echinococcus multilocularis cyclins 0.0017 0.0035 0.0025
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0081 0.0063
Brugia malayi cell division control protein 2 homolog 0.0043 0.031 0.035
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0017 0.0035 0.0008
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0068 0.0052
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.2083 0.2421
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0171 0.0168
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0189 0.0209
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.016 0.0122
Loa Loa (eye worm) hypothetical protein 0.0032 0.0189 0.0209
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0824 0.8574 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0029
Giardia lamblia Kinase, CMGC CDK 0.0043 0.031 0.2985
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0076 0.0652 0.0761
Onchocerca volvulus 0.024 0.2391 0.8388
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0028 0.0032
Brugia malayi Latrophilin receptor protein 2 0.0129 0.122 0.1414
Schistosoma mansoni ap endonuclease 0.002 0.0066 0.0066
Entamoeba histolytica hypothetical protein 0.0024 0.0105 0.0728
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0189 0.0209
Trichomonas vaginalis alpha-glucosidase, putative 0.0109 0.1 0.1272
Echinococcus multilocularis cyclin dependent kinase 5 0.0043 0.031 0.03
Echinococcus multilocularis cyclin dependent kinase 1 0.0043 0.031 0.03
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0068 0.0058
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0043 0.0046
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0189 0.0209
Echinococcus granulosus dna polymerase eta 0.0021 0.0068 0.0058
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit beta 0.0076 0.0652 0.0585
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0079
Echinococcus granulosus peregrin 0.003 0.0171 0.0161
Echinococcus multilocularis cyclin B3 1 0.0017 0.0035 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0154 0.0189
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0109 0.1 1
Giardia lamblia Kinase, CMGC CDK 0.0043 0.031 0.2985
Leishmania major glycosyl hydrolase-like protein 0.004 0.0278 0.0293
Entamoeba histolytica hypothetical protein 0.0036 0.0234 0.2065
Echinococcus multilocularis cyclin b3 0.0017 0.0035 0.0025
Schistosoma mansoni transient receptor potential channel 4 0.02 0.1967 0.2286
Echinococcus multilocularis dna polymerase eta 0.0021 0.0068 0.0058
Echinococcus granulosus cyclins 0.0017 0.0035 0.0025
Schistosoma mansoni hypothetical protein 0.0129 0.122 0.1414
Echinococcus granulosus cyclins 0.0017 0.0035 0.0025
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.1126 0.1303
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0078 0.008
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0109 0.1 1
Loa Loa (eye worm) hypothetical protein 0.0248 0.2481 0.2885
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0193 0.1896 0.2398
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0532 0.061
Brugia malayi hypothetical protein 0.0152 0.1465 0.1699
Schistosoma mansoni transient receptor potential channel 0.0134 0.1271 0.1473
Echinococcus granulosus dnaJ subfamily B 0.04 0.4083 0.4077
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0028 0.0032
Echinococcus granulosus tar DNA binding protein 0.0064 0.0532 0.0523
Loa Loa (eye worm) hypothetical protein 0.0017 0.0029 0.0022
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.016 0.0155
Brugia malayi CXXC zinc finger family protein 0.0028 0.0147 0.016
Loa Loa (eye worm) hypothetical protein 0.0042 0.0295 0.0333
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0081 0.0072
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0043 0.031 0.033
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.016 0.0122
Trichomonas vaginalis cyclins, putative 0.0017 0.0035 0.0036
Echinococcus granulosus neuropeptide receptor A26 0.0958 1 1
Schistosoma mansoni hypothetical protein 0.0318 0.3212 0.374
Trypanosoma brucei glucosidase, putative 0.0109 0.1 0.1166
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0278 0.0348
Trypanosoma cruzi cyclin, putative 0.0017 0.0035 0.0008
Loa Loa (eye worm) glutaminase 2 0.0276 0.2775 0.3229
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.031 0.035
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0189 0.0209
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0752 0.7818 1
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0189 0.0209
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0176 0.0166
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.016 0.0197
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0193 0.1896 0.2398
Brugia malayi Pre-SET motif family protein 0.0211 0.2083 0.2421
Trichomonas vaginalis set domain proteins, putative 0.024 0.2391 0.3052
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0605 0.0629
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0278 0.0348
Brugia malayi Protein kinase domain containing protein 0.0043 0.031 0.035
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.0901 0.0893
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0189 0.0179
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0312 0.1067
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0043 0.0046
Loa Loa (eye worm) cyclin domain-containing protein 0.0237 0.2357 0.274
Echinococcus granulosus cyclin B 0.0017 0.0035 0.0025
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) 0.0076 0.0652 0.0802
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0312 0.0392
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0234 0.0262
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0513 0.0588
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0068 0.0002
Schistosoma mansoni glutaminase 0.0276 0.2775 0.3229
Chlamydia trachomatis transcriptional repressor NrdR 0.0071 0.0605 0.0529
Schistosoma mansoni cyclin B 0.0017 0.0035 0.0029
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.016 0.0155
Schistosoma mansoni transient receptor potential channel 0.0134 0.1271 0.1473
Schistosoma mansoni cyclin B3 0.0017 0.0035 0.0029
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0066 0.0076
Echinococcus multilocularis X box binding protein 1 0.0291 0.2929 0.2922
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0081 0.0063
Loa Loa (eye worm) cyclin domain-containing protein 0.0017 0.0035 0.0029
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.016 0.0155
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0048 0.0363 0.0392
Giardia lamblia DINP protein human, muc B family 0.0021 0.0068 0.0358
Schistosoma mansoni chromobox protein 0.0072 0.0617 0.0709
Mycobacterium leprae conserved hypothetical protein 0.0048 0.0363 0.0313
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0189 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0189 0.0209
Echinococcus granulosus L aminoadipate semialdehyde 0.0172 0.1675 0.1667
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0215 0.2124 0.2602
Trypanosoma cruzi CYC2-like cyclin, putative 0.0017 0.0035 0.0008
Trypanosoma brucei hypothetical protein, conserved 0.0048 0.0363 0.0423
Loa Loa (eye worm) hypothetical protein 0.0032 0.0189 0.0209
Schistosoma mansoni hypothetical protein 0.0129 0.122 0.1414
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0028 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0189 0.0209
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0824 0.8574 1
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0752 0.7818 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0035 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0189 0.0209
Trichomonas vaginalis cyclin D, putative 0.0017 0.0035 0.0036
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0409 0.4182 0.4872
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0278 0.2521
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0189 0.0209
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0079
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0068 0.0002
Trichomonas vaginalis alpha-glucosidase, putative 0.0109 0.1 0.1272
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0956 0.1215
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0193 0.1896 0.2305
Trichomonas vaginalis maltase-glucoamylase, putative 0.0109 0.1 0.1272
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0189 0.0179
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0066 0.0066
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0824 0.8574 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0043 0.0046
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0066 0.0049
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0125 0.0114
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0532 0.061
Brugia malayi ecdysteroid receptor 0.0032 0.0189 0.0209
Echinococcus granulosus dna polymerase kappa 0.0021 0.0068 0.0058
Echinococcus granulosus cyclin b3 0.0017 0.0035 0.0025
Schistosoma mansoni hypothetical protein 0.0129 0.122 0.1414
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0068 0.0078
Echinococcus granulosus GPCR family 2 0.0129 0.122 0.1212
Loa Loa (eye worm) hypothetical protein 0.0248 0.2481 0.2885
Schistosoma mansoni hypothetical protein 0.0346 0.3514 0.4092
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.031 0.0388
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0189 0.0209
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0189 0.0631
Trypanosoma brucei glycosyl hydrolase-like protein 0.004 0.0278 0.0324
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0409 0.4182 0.4872
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0312 0.0392
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0068 0.0047
Trichomonas vaginalis cyclins, putative 0.0017 0.0035 0.0036
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0048 0.0363 0.0392
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0278 0.0348
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0617 0.0782
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0189 0.0209
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0043 0.031 0.033
Loa Loa (eye worm) hypothetical protein 0.0078 0.0676 0.0778
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0189 0.0179
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0189 0.0179
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0824 0.8574 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0068 0.0047
Trypanosoma cruzi trypanothione reductase, putative 0.0085 0.0747 0.0841
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0029 0.0019
Schistosoma mansoni cpg binding protein 0.0028 0.0147 0.016
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0048 0.0363 0.0383
Echinococcus granulosus cyclins 0.0017 0.0035 0.0025
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0157 0.0148
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0129 0.122 0.1212
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0105 0.0126
Brugia malayi Importin beta-1 subunit 0.003 0.0165 0.0181
Echinococcus granulosus cyclin dependent kinase 5 0.0043 0.031 0.03
Onchocerca volvulus 0.0152 0.1465 0.5126
Brugia malayi Heterochromatin protein 1 0.0072 0.0617 0.0709
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0068 0.0068
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0271 0.2715 0.3449
Echinococcus multilocularis thioredoxin glutathione reductase 0.0085 0.0752 0.0743
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.016 0.0151
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0339 0.033
Onchocerca volvulus 0.0172 0.1675 0.5865
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0171 0.0168
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0081 0.0063
Echinococcus multilocularis neuropeptide s receptor 0.0958 1 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0109 0.1 0.1272
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0066 0.0045
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0028 0.0018
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0171 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0189 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0189 0.0209
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0956 0.1215
Onchocerca volvulus Huntingtin homolog 0.0248 0.2481 0.8704
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0172 0.1675 0.1944
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0035 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0011 0.0006
Loa Loa (eye worm) thioredoxin reductase 0.0085 0.0747 0.0861
Plasmodium falciparum protein kinase 5 0.0043 0.031 0.033
Schistosoma mansoni cpg binding protein 0.003 0.0164 0.018
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0076 0.0652 0.0731
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0231 0.2294 0.2652
Treponema pallidum NADH oxidase 0.0029 0.016 0.0111
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0189 0.0209
Trypanosoma cruzi cdc2-related kinase 1 0.0043 0.031 0.033
Loa Loa (eye worm) glutaminase 0.0276 0.2775 0.3229
Brugia malayi RNA, U transporter 1 0.0085 0.0745 0.0859
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0085 0.0747 0.0923
Echinococcus granulosus transient receptor potential gamma protein 0.02 0.1967 0.1959
Trichomonas vaginalis cyclin D, putative 0.0017 0.0035 0.0036
Loa Loa (eye worm) hypothetical protein 0.0122 0.114 0.1321
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.016 0.0155
Echinococcus granulosus microtubule associated protein 2 0.0696 0.7225 0.7223
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0068 0.0079
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0165 0.016
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.1 0.1138
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0066 0.0066
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.016 0.0176
Brugia malayi glutaminase DH11.1 0.0276 0.2775 0.3229
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.016 0.0155
Plasmodium falciparum glutathione reductase 0.0029 0.016 0.0155
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.016 0.0155
Echinococcus granulosus transient receptor potential ion channel A 0.0188 0.1836 0.1829
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0301 0.034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.016 0.0155
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0068 0.0068
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0189 0.0631
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0104 0.0956 0.1105
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0109 0.1 0.1272
Brugia malayi Glycosyl hydrolases family 31 protein 0.0109 0.1 0.1157
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.049 0.5035 0.5867
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0193 0.1896 0.2398
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0125 0.0114
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0234 0.0225
Echinococcus multilocularis GPCR, family 2 0.0129 0.122 0.1212
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0255 0.0246
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0043 0.031 0.033
Echinococcus granulosus mitogen activated protein kinase 3 0.0104 0.0956 0.0947
Mycobacterium ulcerans transcriptional regulator NrdR 0.0071 0.0605 0.0696
Echinococcus granulosus short transient receptor potential channel 6 0.0134 0.1271 0.1263
Echinococcus multilocularis chromobox protein 1 0.0072 0.0617 0.0608
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0189 0.0209
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.016 0.0187
Echinococcus granulosus thioredoxin glutathione reductase 0.0085 0.0752 0.0743
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.1 0.1138
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0129 0.122 0.1212
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0617 0.0709
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0189 0.0209
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0043 0.031 0.035
Echinococcus multilocularis cyclins 0.0017 0.0035 0.0025
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0255 0.0287
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.0901 0.0893
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0339 0.033
Echinococcus multilocularis cyclin dependent kinase 1 0.0043 0.031 0.03
Echinococcus granulosus short transient receptor potential channel 6 0.0134 0.1271 0.1263
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0278 0.0348
Echinococcus multilocularis dnaJ subfamily B 0.04 0.4083 0.4077
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0824 0.8574 1
Echinococcus multilocularis peregrin 0.003 0.0171 0.0161
Entamoeba histolytica cell division protein kinase 2, putative 0.0043 0.031 0.2847
Plasmodium vivax thioredoxin reductase, putative 0.0085 0.0747 0.0841
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0215 0.2124 0.2691
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0424 0.0464
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0125 0.0114
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0824 0.8574 0.8573
Echinococcus multilocularis cyclin dependent kinase 0.0043 0.031 0.03
Loa Loa (eye worm) hypothetical protein 0.0017 0.0029 0.0022
Echinococcus granulosus cpg binding protein 0.003 0.0164 0.0154
Loa Loa (eye worm) hypothetical protein 0.0032 0.0189 0.0209
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0189 0.0179
Echinococcus granulosus snurportin 1 0.0318 0.3212 0.3206
Onchocerca volvulus Alhambra homolog 0.003 0.0171 0.0568
Trichomonas vaginalis cyclins, putative 0.0017 0.0035 0.0036
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0076 0.0652 0.0731
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0028 0.0018
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.016 0.0122
Schistosoma mansoni cpg binding protein 0.003 0.0164 0.018
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0685 0.0789
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0066 0.0045
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0068 0.0342
Plasmodium vivax protein kinase Crk2 0.0043 0.031 0.033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0189 0.0209
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0026 0.0122 0.011
Trichomonas vaginalis cyclin B, putative 0.0017 0.0035 0.0036
Loa Loa (eye worm) hypothetical protein 0.0017 0.0029 0.0022
Echinococcus multilocularis geminin 0.0346 0.3514 0.3508
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0189 0.0209
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.016 0.0122
Brugia malayi Bromodomain containing protein 0.003 0.0171 0.0188
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0165 0.0192
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0956 0.1215
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0081 0.0084
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0752 0.7818 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0043 0.0046
Brugia malayi hypothetical protein 0.0017 0.0027 0.0021
Loa Loa (eye worm) hypothetical protein 0.0032 0.0189 0.0209
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0189 0.0179
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0068 0.0047
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0068 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.2056 0.2624
Plasmodium vivax glutathione reductase, putative 0.0085 0.0747 0.0841
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.028 0.035
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.016 0.0155
Echinococcus multilocularis transient receptor potential gamma protein 0.02 0.1967 0.1959
Echinococcus multilocularis cyclins 0.0017 0.0035 0.0025
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0029 0.0022
Schistosoma mansoni hypothetical protein 0.0346 0.3514 0.4092
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0104 0.0956 0.1086
Loa Loa (eye worm) hypothetical protein 0.02 0.1967 0.2286
Trypanosoma brucei protein kinase, putative 0.0104 0.0956 0.1115
Echinococcus multilocularis chromobox protein 1 0.0072 0.0617 0.0608
Brugia malayi MAP kinase sur-1 0.0104 0.0956 0.1105
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0043 0.031 0.03
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.016 0.0187
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0043 0.031 0.035
Brugia malayi RNA binding protein 0.0064 0.0532 0.061
Echinococcus granulosus mitogen activated protein kinase 0.0104 0.0956 0.0947
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0176 0.0166
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0617 0.0782
Onchocerca volvulus 0.0028 0.0147 0.0484
Entamoeba histolytica hypothetical protein 0.0048 0.0363 0.3399
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0238 0.0229
Entamoeba histolytica Ran family GTPase 0.0022 0.0081 0.0484
Brugia malayi Cyclin, N-terminal domain containing protein 0.0017 0.0035 0.0029
Brugia malayi hypothetical protein 0.0036 0.0234 0.0262
Echinococcus multilocularis cyclins 0.0017 0.0035 0.0025
Loa Loa (eye worm) hypothetical protein 0.0152 0.1465 0.1699
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.004 0.0278 0.0946
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0339 0.0385
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0125 0.0146
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0104 0.0956 0.1086
Brugia malayi TAR-binding protein 0.0064 0.0532 0.061
Entamoeba histolytica hypothetical protein 0.0036 0.0234 0.2065
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.016 0.0155
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0026 0.0122 0.0142
Brugia malayi jmjC domain containing protein 0.0099 0.0901 0.1041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0189 0.0209
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0068 0.0052
Trichomonas vaginalis cyclin B, putative 0.0017 0.0035 0.0036
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0028 0.0021
Trichomonas vaginalis alpha-glucosidase, putative 0.0109 0.1 0.1272
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0189 0.0179
Echinococcus multilocularis L aminoadipate semialdehyde 0.0172 0.1675 0.1667
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.016 0.1365
Onchocerca volvulus Huntingtin homolog 0.0248 0.2481 0.8704
Schistosoma mansoni cyclins 0.0017 0.0035 0.0029
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0066 0.0077
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0028 0.0021
Loa Loa (eye worm) hypothetical protein 0.0041 0.028 0.0316
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0048 0.0363 0.0241
Loa Loa (eye worm) hypothetical protein 0.004 0.0278 0.0314
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0189 0.0179
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.016 0.0197
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0079
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0147 0.016
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0076 0.0652 0.0731
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0068 0.0047
Echinococcus multilocularis importin subunit beta 1 0.003 0.0165 0.0155
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0752 0.7818 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0079
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0824 0.8574 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0189 0.0209
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0068 0.0058
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0532 0.061
Echinococcus multilocularis mitogen activated protein kinase 0.0104 0.0956 0.0947
Echinococcus multilocularis microtubule associated protein 2 0.0696 0.7225 0.7223
Echinococcus multilocularis neutral alpha glucosidase AB 0.0109 0.1 0.0992
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0028 0.0018
Trichomonas vaginalis cyclins, putative 0.0017 0.0035 0.0036
Brugia malayi nuclear receptor NHR-88 0.0032 0.0189 0.0209
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0048 0.0363 0.0383
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0048 0.0363 0.0383
Schistosoma mansoni alpha-glucosidase 0.0421 0.4313 0.5024
Trypanosoma brucei cdc2-related kinase 3 0.0043 0.031 0.0361
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0129 0.122 0.1414
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0068 0.0079
Echinococcus granulosus cyclin dependent kinase 0.0043 0.031 0.03
Brugia malayi chromobox protein homolog 3 0.0041 0.028 0.0316
Brugia malayi latrophilin 2 splice variant baaae 0.028 0.2811 0.3271
Echinococcus granulosus cyclins 0.0017 0.0035 0.0025
Leishmania major hypothetical protein, conserved 0.0026 0.0125 0.0114
Trichomonas vaginalis cyclin B, putative 0.0017 0.0035 0.0036
Echinococcus granulosus cyclin B3 1 0.0017 0.0035 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0043 0.0046
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0176 0.0166
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0255 0.0287
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0081 0.0063
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0752 0.7818 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.016 0.0187
Schistosoma mansoni alpha glucosidase 0.0109 0.1 0.1157
Echinococcus granulosus geminin 0.0346 0.3514 0.3508
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0189 0.0179
Onchocerca volvulus 0.0283 0.2848 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0043 0.0046
Entamoeba histolytica hypothetical protein 0.0036 0.0234 0.2065
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0278 0.0348
Leishmania major GTP-binding protein, putative 0.0022 0.0081 0.0063
Schistosoma mansoni hypothetical protein 0.028 0.2811 0.3271
Loa Loa (eye worm) ribonucleotide reductase M2 B 0.0076 0.0652 0.075
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0076 0.0652 0.0761
Toxoplasma gondii ribonucleoside-diphosphate reductase small subunit 0.0076 0.0652 0.0731
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0255 0.0287
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0125 0.0114
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0028 0.0018
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0215 0.2124 0.2691
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0109 0.1 0.1138
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0048 0.0363 0.0392
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0028 0.0021
Brugia malayi Transient-receptor-potential like protein 0.0078 0.0676 0.0778
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0532 0.061
Echinococcus multilocularis transient receptor potential ion channel A 0.0188 0.1836 0.1829
Loa Loa (eye worm) hypothetical protein 0.003 0.0171 0.0188
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0189 0.0209
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0278 0.0348
Echinococcus multilocularis cyclins 0.0017 0.0035 0.0025
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) 0.0076 0.0652 0.0802
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.016 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0189 0.0209
Echinococcus multilocularis cyclins 0.0017 0.0035 0.0025
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0532 0.0523
Plasmodium falciparum glutathione reductase 0.0085 0.0747 0.0841
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0079
Echinococcus multilocularis cyclins 0.0017 0.0035 0.0025
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0129 0.122 0.1212
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0339 0.0385
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0017 0.0035 0.0025
Schistosoma mansoni ran 0.0022 0.0081 0.0084
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0081 0.0095
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0339 0.0385
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0189 0.0209
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0532 0.061
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0066 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.028 0.035
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0029 0.0019
Trichomonas vaginalis glutaminase, putative 0.0276 0.2775 0.3544
Trichomonas vaginalis cyclin B, putative 0.0017 0.0035 0.0036
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0081 0.0063
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.016 0.0155
Schistosoma mansoni ribonucleoside-diphosphate reductase small chain 0.0076 0.0652 0.075
Leishmania major phosphopantetheinyl transferase-like protein 0.0048 0.0363 0.0392
Loa Loa (eye worm) hypothetical protein 0.0032 0.0189 0.0209
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0956 0.1215
Loa Loa (eye worm) hypothetical protein 0.0129 0.122 0.1414
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0079
Schistosoma mansoni alpha-glucosidase 0.0421 0.4313 0.5024
Brugia malayi hypothetical protein 0.0017 0.0029 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0532 0.061
Brugia malayi Cyclin, N-terminal domain containing protein 0.0017 0.0035 0.0029
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0278 0.0314
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0189 0.0179
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.016 0.0155
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0066 0.0057
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0189 0.0209
Brugia malayi hypothetical protein 0.0248 0.2481 0.2885
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0017 0.0035 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0189 0.0209
Trichomonas vaginalis ran, putative 0.0022 0.0081 0.0096
Brugia malayi PHD-finger family protein 0.003 0.0171 0.0188
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0189 0.0179
Loa Loa (eye worm) hypothetical protein 0.0017 0.0029 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0079
Schistosoma mansoni hypothetical protein 0.0291 0.2929 0.3409
Brugia malayi hypothetical protein 0.0026 0.0125 0.0135
Trypanosoma cruzi cyclin 6, putative 0.0017 0.0035 0.0008
Brugia malayi nuclear hormone receptor 0.0032 0.0189 0.0209
Plasmodium falciparum thioredoxin reductase 0.0029 0.016 0.0155
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0176 0.0194
Loa Loa (eye worm) hypothetical protein 0.0026 0.0125 0.0135
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0176 0.0173
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.004 0.0278 0.0293
Brugia malayi ribonucleotide reductase 2 0.0076 0.0652 0.075
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0125 0.0114
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0824 0.8574 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.004 0.0278 0.0293
Loa Loa (eye worm) hypothetical protein 0.0017 0.0029 0.0022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0176 0.0194
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.016 0.0155
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0189 0.0209
Mycobacterium tuberculosis Probable oxidoreductase 0.0215 0.2124 0.2691
Schistosoma mansoni coup transcription factor 0.0032 0.0189 0.0209
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.004 0.0036
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0066 0.0057
Plasmodium vivax ribonucleoside-diphosphate reductase small chain, putative 0.0076 0.0652 0.0731
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0079
Echinococcus granulosus chromobox protein 1 0.0072 0.0617 0.0608
Schistosoma mansoni transient receptor potential channel 0.02 0.1967 0.2286
Plasmodium falciparum phd finger protein, putative 0.003 0.0171 0.0168
Echinococcus granulosus lysosomal alpha glucosidase 0.049 0.5035 0.503
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0278 0.0348
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0076 0.0652 0.0731
Brugia malayi nuclear receptor RXR 0.0017 0.0029 0.0022
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0076 0.0652 0.0761
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0193 0.1896 0.2398
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0068 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0189 0.0209
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0104 0.0956 0.1086
Schistosoma mansoni ap endonuclease 0.002 0.0066 0.0066
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0068 0.0058
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0189 0.0179

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 2.3 uM PUBCHEM_BIOASSAY: Inhibitors of T-Type Calcium Channels (SynthLib1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID449739, AID463087, AID489005, AID493041, AID504579, AID504584, AID504619, AID504628] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.