Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0216 | 0.3277 | 0.5748 |
Schistosoma mansoni | hypothetical protein | 0.0142 | 0.1438 | 0.0495 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0161 | 0.1912 | 0.5033 |
Mycobacterium ulcerans | glutamine synthetase GlnA1 | 0.0315 | 0.5701 | 1 |
Plasmodium falciparum | V-type H(+)-translocating pyrophosphatase, putative | 0.0342 | 0.6369 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0161 | 0.1912 | 0.0554 |
Plasmodium falciparum | V-type K+-independent H+-translocating inorganic pyrophosphatase | 0.0342 | 0.6369 | 1 |
Schistosoma mansoni | glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) | 0.0489 | 1 | 1 |
Brugia malayi | glutamine synthetase | 0.0175 | 0.2251 | 0.5926 |
Echinococcus granulosus | carbonic anhydrase II | 0.0237 | 0.3799 | 0.2757 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0237 | 0.3799 | 0.6664 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0142 | 0.1438 | 0.3785 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0142 | 0.1438 | 0.3785 |
Entamoeba histolytica | glutamine synthetase, putative | 0.0123 | 0.0992 | 0.5 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 1 | 0.0342 | 0.6369 | 0.551 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0142 | 0.1438 | 0.0495 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0142 | 0.1438 | 0.2522 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0237 | 0.3799 | 0.3116 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0216 | 0.3277 | 0.2148 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0237 | 0.3799 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0142 | 0.1438 | 0.0495 |
Trichomonas vaginalis | glutamine synthetase, putative | 0.0123 | 0.0992 | 0.5 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 2, putative | 0.0342 | 0.6369 | 0.551 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0142 | 0.1438 | 0.3785 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0216 | 0.3277 | 0.8626 |
Leishmania major | glutamine synthetase, putative | 0.0489 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0142 | 0.1438 | 0.0495 |
Plasmodium falciparum | glutamine synthetase, putative | 0.0315 | 0.5701 | 0.8645 |
Trypanosoma cruzi | Vacuolar proton pyrophosphatase 1, putative | 0.0342 | 0.6369 | 0.551 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0237 | 0.3799 | 0.2333 |
Toxoplasma gondii | hypothetical protein | 0.0142 | 0.1438 | 0.1405 |
Echinococcus multilocularis | glutamine synthetase | 0.0489 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1438 | 0.2522 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0237 | 0.3799 | 0.6664 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0489 | 1 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0161 | 0.1912 | 0.1021 |
Loa Loa (eye worm) | Gln-2 protein | 0.0315 | 0.5701 | 1 |
Trypanosoma cruzi | vacuolar-type proton translocating pyrophosphatase 1 | 0.0342 | 0.6369 | 0.551 |
Onchocerca volvulus | Glutamine synthetase homolog | 0.0315 | 0.5701 | 1 |
Toxoplasma gondii | V-type H(+)-translocating pyrophosphatase VP1 | 0.0342 | 0.6369 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0142 | 0.1438 | 0.3785 |
Trypanosoma brucei | glutamine synthetase, putative | 0.0489 | 1 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0216 | 0.3277 | 0.2148 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1438 | 0.2522 |
Entamoeba histolytica | glutamine synthetase, putative | 0.0123 | 0.0992 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0142 | 0.1438 | 0.3785 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0237 | 0.3799 | 0.3116 |
Mycobacterium leprae | PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) | 0.0315 | 0.5701 | 0.5 |
Toxoplasma gondii | glutamine synthetase, type I, putative | 0.0315 | 0.5701 | 0.8836 |
Mycobacterium tuberculosis | Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) | 0.0315 | 0.5701 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1438 | 0.2522 |
Leishmania major | carbonic anhydrase-like protein | 0.0237 | 0.3799 | 0.2333 |
Plasmodium vivax | vacuolar-type H+ pumping pyrophosphatase, putative | 0.0342 | 0.6369 | 1 |
Mycobacterium ulcerans | glutamine synthetase | 0.0315 | 0.5701 | 1 |
Wolbachia endosymbiont of Brugia malayi | glutamine synthetase | 0.0123 | 0.0992 | 0.5 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0216 | 0.3277 | 0.2536 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0237 | 0.3799 | 0.2333 |
Plasmodium vivax | V-type H(+)-translocating pyrophosphatase, putative | 0.0342 | 0.6369 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0237 | 0.3799 | 1 |
Trichomonas vaginalis | glutamine synthetase-bacteria, putative | 0.0123 | 0.0992 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0142 | 0.1438 | 0.0495 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0161 | 0.1912 | 0.0554 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0489 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0237 | 0.3799 | 0.2757 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0237 | 0.3799 | 0.2333 |
Leishmania major | vacuolar-type proton translocating pyrophosphatase 1, putative | 0.0342 | 0.6369 | 0.551 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.2213 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 141.2538 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.