Detailed information for compound 148619

Basic information

Technical information
  • TDR Targets ID: 148619
  • Name: disodium [(2,6-dimethylphenoxy)-oxidophosphor yl]formate
  • MW: 274.118 | Formula: C9H9Na2O5P
  • H donors: 0 H acceptors: 4 LogP: 1.91 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-]C(=O)P(=O)(Oc1c(C)cccc1C)[O-].[Na+].[Na+]
  • InChi: 1S/C9H11O5P.2Na/c1-6-4-3-5-7(2)8(6)14-15(12,13)9(10)11;;/h3-5H,1-2H3,(H,10,11)(H,12,13);;/q;2*+1/p-2
  • InChiKey: RXRPOMKANXQNMI-UHFFFAOYSA-L  


Substructure search Similarity search

Network

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Synonyms

  • disodium [(2,6-dimethylphenoxy)-oxido-phosphoryl]formate
  • disodium [(2,6-dimethylphenoxy)-oxidanidyl-phosphoryl]methanoate
  • disodium [(2,6-dimethylphenoxy)-oxido-phosphoryl]methanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) ACC-1 protein 0.0027 0.0159 0.0154
Trichomonas vaginalis alpha-glucosidase, putative 0.0137 0.1548 0.2451
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0027 0.0159 0.0168
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0027 0.0159 0.0154
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0027 0.0159 0.0154
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.6152 1
Echinococcus multilocularis lamin 0.0057 0.0546 0.0542
Schistosoma mansoni glutaminase 0.0264 0.3139 0.3418
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0027 0.0159 0.0154
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.0159 0.0154
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0027 0.0159 0.0154
Trichomonas vaginalis glucosylceramidase, putative 0.0331 0.3976 0.6433
Onchocerca volvulus 0.0177 0.2051 0.3353
Echinococcus multilocularis musashi 0.0057 0.0546 0.0542
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0723 0.1098
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0072 0.0723 0.4481
Trichomonas vaginalis alpha-glucosidase, putative 0.0137 0.1548 0.2451
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0027 0.0159 0.0154
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0027
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0494 0.0489
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0751 0.0814
Echinococcus granulosus bloom syndrome protein 0.0021 0.0084 0.0079
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0027 0.0159 0.0154
Brugia malayi Glycosyl hydrolases family 31 protein 0.0137 0.1548 0.1544
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.0159 0.0154
Brugia malayi Cation transporter family protein 0.0027 0.0159 0.0154
Echinococcus multilocularis non lysosomal glucosylceramidase 0.0201 0.2348 0.2345
Loa Loa (eye worm) hypothetical protein 0.0028 0.0173 0.0169
Loa Loa (eye worm) hypothetical protein 0.0027 0.016 0.0155
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0494 0.0489
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0494 0.0489
Schistosoma mansoni alpha-glucosidase 0.0745 0.9175 1
Trypanosoma cruzi hypothetical protein, conserved 0.0137 0.1548 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0027 0.0159 0.0154
Loa Loa (eye worm) RecQ helicase 0.0021 0.0084 0.0079
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0137 0.1548 1
Schistosoma mansoni nAChR subunit 0.0027 0.0159 0.0168
Onchocerca volvulus 0.0027 0.0159 0.0252
Trichomonas vaginalis maltase-glucoamylase, putative 0.0137 0.1548 0.2451
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.1571 0.1567
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0027 0.0159 0.0154
Schistosoma mansoni nAChR subunit 0.0027 0.0159 0.0168
Onchocerca volvulus 0.0501 0.6108 1
Trypanosoma brucei glucosidase, putative 0.0137 0.1548 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0751 0.0747
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0053 0.0048
Schistosoma mansoni alpha glucosidase 0.0137 0.1548 0.1683
Trichomonas vaginalis glucosylceramidase, putative 0.0331 0.3976 0.6433
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0053 0.0048
Brugia malayi TAR-binding protein 0.0074 0.0751 0.0747
Trichomonas vaginalis glucosylceramidase, putative 0.0331 0.3976 0.6433
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0027 0.0159 0.0154
Loa Loa (eye worm) glutaminase 2 0.0264 0.3139 0.3136
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0211 0.0207
Trichomonas vaginalis glucosylceramidase, putative 0.0331 0.3976 0.6433
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0027 0.0159 0.0154
Echinococcus multilocularis lysosomal alpha glucosidase 0.0811 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0494 0.0533
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0027 0.0159 0.0154
Schistosoma mansoni lamin 0.0057 0.0546 0.0591
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.6152 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0811 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0494 0.0489
Brugia malayi Cation transporter family protein 0.0177 0.2051 0.2048
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0751 0.0814
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0027 0.0159 0.0154
Echinococcus granulosus bile acid beta glucosidase 0.0201 0.2348 0.2345
Schistosoma mansoni nAChR subunit 0.0027 0.0159 0.0168
Brugia malayi MH2 domain containing protein 0.0139 0.1571 0.1567
Trichomonas vaginalis glucosylceramidase, putative 0.0349 0.42 0.6799
Brugia malayi Ceramide glucosyltransferase 0.0461 0.5608 0.5606
Echinococcus multilocularis glycine receptor subunit beta 0.0027 0.0159 0.0154
Loa Loa (eye worm) hypothetical protein 0.0136 0.1528 0.1524
Echinococcus granulosus neutral alpha glucosidase AB 0.0137 0.1548 0.1544
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0137 0.1548 0.2451
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0211 0.0207
Echinococcus granulosus lamin 0.0057 0.0546 0.0542
Echinococcus granulosus glycogen debranching enzyme 0.0125 0.1396 0.1392
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Trichomonas vaginalis glucosylceramidase, putative 0.0331 0.3976 0.6433
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0027 0.0159 0.0168
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0027 0.0159 0.0154
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0494 0.0489
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0053 0.5
Schistosoma mansoni hypothetical protein 0.0161 0.1845 0.2007
Brugia malayi hypothetical protein 0.0028 0.0178 0.0173
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0723 0.1098
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0027 0.0159 0.0154
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0072 0.0723 0.4481
Brugia malayi intermediate filament protein 0.0057 0.0546 0.0542
Loa Loa (eye worm) hypothetical protein 0.0057 0.0546 0.0542
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0027 0.0159 0.0154
Echinococcus multilocularis geminin 0.038 0.4595 0.4593
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0173 0.0169
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0125 0.1396 0.2202
Onchocerca volvulus 0.0057 0.0546 0.0887
Onchocerca volvulus 0.0177 0.2051 0.3353
Echinococcus granulosus lysosomal alpha glucosidase 0.0811 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0751 0.0814
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0811 1 1
Giardia lamblia Ceramide glucosyltransferase 0.0209 0.2447 1
Onchocerca volvulus 0.0177 0.2051 0.3353
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.0159 0.0154
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.0159 0.0154
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0177 0.2051 0.2232
Echinococcus granulosus nAChR subunit 0.0027 0.0159 0.0154
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0027 0.0159 0.0168
Echinococcus multilocularis glycine receptor subunit beta 0.0027 0.0159 0.0154
Trichomonas vaginalis glutaminase, putative 0.0264 0.3139 0.506
Onchocerca volvulus Putative nachr subunit 0.0027 0.0159 0.0252
Schistosoma mansoni ap endonuclease 0.0018 0.0053 0.0053
Echinococcus granulosus glycine receptor subunit alpha 1 0.0027 0.0159 0.0154
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0053 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0137 0.1548 0.1544
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0072 0.0723 0.1098
Mycobacterium ulcerans glutaminase 0.0264 0.3139 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0053 0.0048
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0177 0.2051 0.2232
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0723 0.1098
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0084 0.0079
Schistosoma mansoni lamin 0.0057 0.0546 0.0591
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0723 0.1098
Loa Loa (eye worm) hypothetical protein 0.0177 0.2051 0.2048
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0027 0.0159 0.0154
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0027 0.0159 0.0154
Schistosoma mansoni ap endonuclease 0.0018 0.0053 0.0053
Schistosoma mansoni nAChR subunit 0.0027 0.0159 0.0168
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0751 0.0814
Onchocerca volvulus Ceramide glucosyltransferase homolog 0.0461 0.5608 0.9182
Onchocerca volvulus Glucosylceramidase homolog 0.0331 0.3976 0.6507
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0053 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.0159 0.0154
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.6152 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0173 0.0169
Schistosoma mansoni bile acid beta-glucosidase-related 0.0201 0.2348 0.2556
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0027 0.0159 0.0154
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0027 0.0159 0.0154
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0027 0.0159 0.0154
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0546 0.0542
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0053 0.5
Entamoeba histolytica glycogen debranching enzyme, putative 0.0125 0.1396 0.9017
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0027 0.0159 0.0154
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0751 0.0747
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0027 0.0159 0.0154
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0053 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Brugia malayi Cation transporter family protein 0.0027 0.0159 0.0154
Echinococcus multilocularis ceramide glucosyltransferase 0.0461 0.5608 0.5606
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Echinococcus multilocularis lamin dm0 0.0057 0.0546 0.0542
Giardia lamblia 4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase 0.0125 0.1396 0.5611
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0027 0.0159 0.0154
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0027 0.0159 0.0154
Loa Loa (eye worm) hypothetical protein 0.0177 0.2051 0.2048
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0027 0.0159 0.0154
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0027 0.0159 0.0154
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0504 0.6152 0.615
Schistosoma mansoni hypothetical protein 0.009 0.096 0.1042
Trichomonas vaginalis alpha-glucosidase, putative 0.0137 0.1548 0.2451
Echinococcus granulosus glycine receptor subunit beta 0.0027 0.0159 0.0154
Trichomonas vaginalis glucosylceramidase, putative 0.0331 0.3976 0.6433
Loa Loa (eye worm) ceramide glucosyltransferase 0.0461 0.5608 0.5606
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.6152 1
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0072 0.0723 0.1177
Brugia malayi excitatory GABA receptor EXP-1A 0.0027 0.0159 0.0154
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0137 0.1548 1
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0631 0.0948
Brugia malayi Amylo-alpha-1,6-glucosidase family protein 0.0125 0.1396 0.1392
Echinococcus granulosus non lysosomal glucosylceramidase 0.0201 0.2348 0.2345
Trypanosoma brucei glycosyl hydrolase-like protein 0.0072 0.0723 0.4481
Loa Loa (eye worm) glutaminase 0.0264 0.3139 0.3136
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0137 0.1548 0.2451
Echinococcus multilocularis nAChR subunit 0.0027 0.0159 0.0154
Schistosoma mansoni nAChR subunit 0.0027 0.0159 0.0168
Loa Loa (eye worm) hypothetical protein 0.0027 0.016 0.0155
Echinococcus granulosus intermediate filament protein 0.0057 0.0546 0.0542
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0751 0.0747
Loa Loa (eye worm) ACC-1 protein 0.0027 0.0159 0.0154
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0027 0.0159 0.0154
Schistosoma mansoni nAChR subunit 0.0027 0.0159 0.0168
Trichomonas vaginalis glucosylceramidase, putative 0.0349 0.42 0.6799
Loa Loa (eye worm) hypothetical protein 0.0125 0.1396 0.1392
Trichomonas vaginalis glucosylceramidase, putative 0.0331 0.3976 0.6433
Echinococcus multilocularis neutral alpha glucosidase AB 0.0137 0.1548 0.1544
Schistosoma mansoni ceramide glucosyltransferase 0.0461 0.5608 0.6111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0494 0.0533
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0072 0.0723 0.4654
Brugia malayi glutaminase DH11.1 0.0264 0.3139 0.3136
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0027 0.0159 0.0154
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0751 0.0747
Schistosoma mansoni nAChR subunit 0.0027 0.0159 0.0168
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0027 0.0159 0.0154
Onchocerca volvulus 0.0027 0.0159 0.0252
Echinococcus granulosus lamin dm0 0.0057 0.0546 0.0542
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0029 0.0027
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0027 0.0159 0.0154
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0494 0.0533
Echinococcus granulosus glycine receptor subunit alpha 1 0.0027 0.0159 0.0154
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0072 0.0723 0.1098
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0546 0.0542
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Trichomonas vaginalis maltase-glucoamylase, putative 0.0072 0.0723 0.1098
Trypanosoma cruzi hypothetical protein, conserved 0.0137 0.1548 1
Onchocerca volvulus 0.0027 0.0159 0.0252
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0084 0.005
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0027 0.0159 0.0154
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0053 0.0313
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0084 0.005
Schistosoma mansoni alpha-glucosidase 0.0745 0.9175 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0723 0.0718
Echinococcus granulosus tar DNA binding protein 0.0074 0.0751 0.0747
Echinococcus multilocularis glycogen debranching enzyme 0.0125 0.1396 0.1392
Toxoplasma gondii Amylo-alpha-1,6-glucosidase 0.0125 0.1396 0.8985
Echinococcus granulosus ceramide glucosyltransferase 0.0461 0.5608 0.5606
Trichomonas vaginalis sucrase-isomaltase, putative 0.0137 0.1548 0.2451
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0084 0.0079
Loa Loa (eye worm) hypothetical protein 0.0056 0.0533 0.0529
Schistosoma mansoni ceramide glucosyltransferase 0.0461 0.5608 0.6111
Leishmania major alpha glucosidase II subunit, putative 0.0137 0.1548 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0027 0.0159 0.0154
Schistosoma mansoni bile acid beta-glucosidase-related 0.0201 0.2348 0.2556
Brugia malayi RNA binding protein 0.0074 0.0751 0.0747
Schistosoma mansoni hypothetical protein 0.038 0.4595 0.5006
Echinococcus granulosus geminin 0.038 0.4595 0.4593
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0494 0.0489
Schistosoma mansoni intermediate filament proteins 0.0057 0.0546 0.0591
Loa Loa (eye worm) LGC-31 protein 0.0027 0.0159 0.0154
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Echinococcus granulosus glycine receptor subunit beta 0.0027 0.0159 0.0154
Trichomonas vaginalis alpha-glucosidase, putative 0.0072 0.0723 0.1098
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0504 0.6152 0.615
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.1571 0.1567
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0027 0.0159 0.0154
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0027 0.0159 0.0168
Loa Loa (eye worm) RNA binding protein 0.0074 0.0751 0.0747
Trichomonas vaginalis alpha-glucosidase, putative 0.0137 0.1548 0.2451
Loa Loa (eye worm) hypothetical protein 0.0165 0.1898 0.1894
Brugia malayi Glycosyl hydrolases family 31 protein 0.0072 0.0723 0.0718
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.6152 1
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0546 0.0542
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.6152 1
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0027 0.0159 0.0154
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0027 0.0159 0.0154
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0137 0.1548 1
Trichomonas vaginalis glycogen debranching enzyme, putative 0.0125 0.1396 0.2202
Leishmania major glycosyl hydrolase-like protein 0.0072 0.0723 0.4481
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0751 0.0814
Onchocerca volvulus 0.0057 0.0546 0.0887
Loa Loa (eye worm) hypothetical protein 0.0027 0.0159 0.0154
Trichomonas vaginalis alpha-glucosidase, putative 0.0137 0.1548 0.2451
Loa Loa (eye worm) amylo-alpha-1,6-glucosidase 0.0061 0.059 0.0585
Schistosoma mansoni hypothetical protein 0.038 0.4595 0.5006
Echinococcus granulosus glycine receptor subunit alpha 1 0.0027 0.0159 0.0154
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0053 0.0048
Echinococcus multilocularis bile acid beta glucosidase 0.0201 0.2348 0.2345

Activities

Activity type Activity value Assay description Source Reference
Effect (functional) 0 Evaluated for antiviral activity against cutaneous HSV-1 C42 infections in guinea pig; Active ChEMBL. 6298425
IC50 (binding) > 500 uM Inhibition of HSV-1 DNA polymerase in HSV-1 C42 plaque reduction assay ChEMBL. 6298425
IC50 (binding) > 500 uM Inhibition of HSV-1 DNA polymerase in HSV-1 C42 plaque reduction assay ChEMBL. 6298425

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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