Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0058 | 0.6415 | 0.5 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 1 | 1 |
Trypanosoma cruzi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0053 | 0.5509 | 0.5531 |
Mycobacterium leprae | PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE DXS1 (1-DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE) (DXP SYNTHASE) (DXPS) | 0.0053 | 0.5509 | 1 |
Chlamydia trachomatis | transketolase | 0.0053 | 0.5509 | 0.5531 |
Brugia malayi | pyruvate dehydrogenase E1 component beta subunit, mitochondrial | 0.0076 | 0.9959 | 0.9959 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 1 | 1 |
Trypanosoma brucei | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0053 | 0.5509 | 0.5531 |
Echinococcus granulosus | pyruvate dehydrogenase | 0.0076 | 0.9959 | 0.9959 |
Brugia malayi | TAR-binding protein | 0.0076 | 1 | 1 |
Trypanosoma cruzi | transketolase, putative | 0.0053 | 0.5509 | 0.5531 |
Mycobacterium tuberculosis | Transketolase Tkt (TK) | 0.0053 | 0.5509 | 0.5 |
Trypanosoma brucei | pyruvate dehydrogenase E1 beta subunit, putative | 0.0076 | 0.9959 | 1 |
Plasmodium falciparum | 1-deoxy-D-xylulose 5-phosphate synthase | 0.0053 | 0.5509 | 0.5531 |
Trypanosoma brucei | chrX additional, unordered contigs | 0.0053 | 0.5509 | 0.5531 |
Trypanosoma cruzi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0053 | 0.5509 | 0.5531 |
Loa Loa (eye worm) | 2-oxoisovalerate dehydrogenase subunit beta | 0.0053 | 0.5509 | 0.5509 |
Schistosoma mansoni | pyruvate dehydrogenase (lipoamide) | 0.0076 | 0.9959 | 0.9959 |
Mycobacterium tuberculosis | Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs1 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) | 0.0053 | 0.5509 | 0.5 |
Plasmodium vivax | 1-deoxy-D-xylulose 5-phosphate synthase, putative | 0.0053 | 0.5509 | 0.5531 |
Echinococcus granulosus | transketolase | 0.0053 | 0.5509 | 0.5509 |
Chlamydia trachomatis | oxoisovalerate dehydrogenase subunits alpha/beta | 0.006 | 0.6761 | 0.6789 |
Entamoeba histolytica | transketolase, putative | 0.0053 | 0.5509 | 0.5 |
Trichomonas vaginalis | transketolase, putative | 0.0053 | 0.5509 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | transketolase | 0.0053 | 0.5509 | 0.5531 |
Leishmania major | transketolase | 0.0053 | 0.5509 | 0.5531 |
Schistosoma mansoni | transketolase | 0.0053 | 0.5509 | 0.5509 |
Brugia malayi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor | 0.0053 | 0.5509 | 0.5509 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Trypanosoma brucei | transketolase, putative | 0.0053 | 0.5509 | 0.5531 |
Chlamydia trachomatis | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0053 | 0.5509 | 0.5531 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Plasmodium vivax | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative | 0.0053 | 0.5509 | 0.5531 |
Brugia malayi | pyruvate dehydrogenase E1 component beta subunit, putative | 0.0076 | 0.9959 | 0.9959 |
Plasmodium falciparum | pyruvate dehydrogenase E1 component subunit beta | 0.0076 | 0.9959 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 1 | 1 |
Toxoplasma gondii | transketolase | 0.0053 | 0.5509 | 0.5531 |
Mycobacterium ulcerans | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0053 | 0.5509 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.5509 | 0.5509 |
Echinococcus multilocularis | transketolase | 0.0053 | 0.5509 | 0.5509 |
Trypanosoma brucei | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0053 | 0.5509 | 0.5531 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 1 | 1 |
Entamoeba histolytica | transketolase, chloroplast, putative | 0.0053 | 0.5509 | 0.5 |
Trypanosoma cruzi | pyruvate dehydrogenase E1 beta subunit, putative | 0.0076 | 0.9959 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.9959 | 0.9959 |
Echinococcus multilocularis | transketolase | 0.0053 | 0.5509 | 0.5509 |
Mycobacterium tuberculosis | Probable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB | 0.0053 | 0.5509 | 0.5 |
Schistosoma mansoni | transketolase | 0.0053 | 0.5509 | 0.5509 |
Mycobacterium ulcerans | pyruvate dehydrogenase E1 component subunit PdhB | 0.0053 | 0.5509 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.9959 | 0.9959 |
Leishmania major | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0053 | 0.5509 | 0.5531 |
Entamoeba histolytica | transketolase, putative | 0.0053 | 0.5509 | 0.5 |
Plasmodium vivax | pyruvate dehydrogenase E1 component subunit beta, putative | 0.0076 | 0.9959 | 1 |
Chlamydia trachomatis | pyruvate dehydrogenase subunit beta | 0.0076 | 0.9959 | 1 |
Echinococcus multilocularis | pyruvate dehydrogenase | 0.0076 | 0.9959 | 0.9959 |
Brugia malayi | transketolase | 0.0053 | 0.5509 | 0.5509 |
Echinococcus granulosus | transketolase | 0.0053 | 0.5509 | 0.5509 |
Entamoeba histolytica | transketolase, putative | 0.0053 | 0.5509 | 0.5 |
Toxoplasma gondii | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0053 | 0.5509 | 0.5531 |
Toxoplasma gondii | pyruvate dehydrogenase E1 component, beta subunit, putative | 0.0053 | 0.5509 | 0.5531 |
Wolbachia endosymbiont of Brugia malayi | pyruvate dehydrogenase subunit beta | 0.0076 | 0.9959 | 1 |
Leishmania major | pyruvate dehydrogenase E1 beta subunit, putative | 0.0076 | 0.9959 | 1 |
Plasmodium falciparum | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative | 0.0053 | 0.5509 | 0.5531 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Trypanosoma cruzi | pyruvate dehydrogenase E1 beta subunit, putative | 0.0076 | 0.9959 | 1 |
Mycobacterium ulcerans | transketolase | 0.0053 | 0.5509 | 1 |
Treponema pallidum | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0053 | 0.5509 | 0.5 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PD-HE1Beta | 0.0076 | 0.9959 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 1 | 1 |
Trypanosoma cruzi | transketolase, putative | 0.0053 | 0.5509 | 0.5531 |
Mycobacterium leprae | Probable transketolase Tkt (TK) | 0.0053 | 0.5509 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.