TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 259.362 | Formula: C17H22FN
H donors: 0 H acceptors: 0 LogP: 4.58 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: C[C@H]1[C@H](/N=C/c2ccc(cc2)F)C[C@@H]2C[C@H]1C2(C)C
InChi: 1S/C17H22FN/c1-11-15-8-13(17(15,2)3)9-16(11)19-10-12-4-6-14(18)7-5-12/h4-7,10-11,13,15-16H,8-9H2,1-3H3/b19-10+/t11-,13+,15-,16-/m1/s1
InChiKey: DHARHFOBIHYEQZ-TXWONSHXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	zinc finger protein	0.0021	0.0087	0.0263
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0021	0.0087	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0265	0.0515
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.039	0.0762
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0087	0.0087
Brugia malayi	follicle stimulating hormone receptor	0.0235	0.2799	0.5465
Mycobacterium leprae	PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD	0.0035	0.0265	1
Schistosoma mansoni	hypothetical protein	0.0125	0.1397	0.4206
Mycobacterium tuberculosis	Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase)	0.0022	0.0093	0.0121
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0045	0.0391	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0391	0.0762
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0136	0.1546	1
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0136	0.1546	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0045	0.0391	0.0391
Schistosoma mansoni	thyroid hormone receptor	0.017	0.1973	0.594
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0391	0.0762
Brugia malayi	nuclear receptor NHR-67	0.0021	0.0087	0.017
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0087	0.0167
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0045	0.0391	0.1179
Loa Loa (eye worm)	IRE protein kinase	0.0418	0.5121	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.039	0.0759
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0045	0.0391	0.0762
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0024	0.012	0.012
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.0407
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0058	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0087	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0087	0.0167
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0045	0.0391	0.0764
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0045	0.0391	0.0391
Brugia malayi	nuclear hormone receptor	0.0045	0.0391	0.0764
Echinococcus multilocularis	nuclear receptor nhr 48	0.0021	0.0087	0.0087
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0045	0.0391	0.0764
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0021	0.0087	0.0263
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0087	0.0167
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0017	0.0032
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0125	0.1397	0.2727
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0045	0.0391	0.1179
Schistosoma mansoni	coup transcription factor	0.0045	0.0391	0.1179
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0136	0.1546	0.3017
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0021	0.0087	0.0087
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0045	0.0391	0.0391
Brugia malayi	nuclear receptor NHR-88	0.0045	0.0391	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0087	0.0167
Brugia malayi	glutaminase DH11.1	0.0276	0.3321	0.6485
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0045	0.0391	0.1179
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0031	0.021	0.041
Schistosoma mansoni	carbonic anhydrase-related	0.0031	0.021	0.0633
Brugia malayi	steroid hormone receptor	0.0045	0.0391	0.0764
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.039	0.039
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.039	0.1175
Brugia malayi	photoreceptor-specific nuclear receptor	0.0045	0.0391	0.0764
Trichomonas vaginalis	glutaminase, putative	0.0276	0.3321	1
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0067	0.0662	0.0662
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0045	0.0391	0.0764
Loa Loa (eye worm)	steroid hormone receptor	0.0045	0.0391	0.0762
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.0407
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0045	0.0391	0.0764
Loa Loa (eye worm)	glutaminase	0.0276	0.3321	0.6483
Plasmodium falciparum	carbonic anhydrase	0.0031	0.021	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0021	0.0087	0.017
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0045	0.0391	0.1179
Onchocerca volvulus	Bile acid receptor homolog	0.0045	0.0391	1
Brugia malayi	ecdysteroid receptor	0.0045	0.0391	0.0764
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0045	0.0391	0.0391
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0074	0.076	0.1484
Mycobacterium tuberculosis	Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at)	0.0022	0.0093	0.0121
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.039	0.0762
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0126	0.1419	0.2771
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0045	0.0391	0.0764
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0058	0.0058
Brugia malayi	Steroid receptor seven-up type 2	0.0045	0.0391	0.0764
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0024	0.012	0.0361
Brugia malayi	4-aminobutyrate aminotransferase, mitochondrial precursor	0.0245	0.2925	0.5712
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0136	0.1546	0.3019
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0045	0.0391	0.0764
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0021	0.0087	0.0087
Trichomonas vaginalis	conserved hypothetical protein	0.0213	0.2519	0.7543
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0031	0.021	0.041
Mycobacterium ulcerans	glutaminase	0.0276	0.3321	1
Echinococcus granulosus	Ankyrin	0.0015	0.0002	0.0003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0045	0.0391	0.0762
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0058	0.0113
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0067	0.0662	0.406
Echinococcus multilocularis	Aminotransferase class III	0.0022	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0024	0.012	0.0231
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.039	0.039
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0058	0.011
Echinococcus multilocularis	ornithine aminotransferase	0.0022	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0058	0.011
Trichomonas vaginalis	acetylornithine aminotransferase, putative	0.0022	0.0093	0.0106
Brugia malayi	Nuclear hormone receptor E75	0.0021	0.0087	0.017
Echinococcus multilocularis	succinate semialdehyde dehydrogenase	0.0035	0.0265	0.0265
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.012	0.0234
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0022	0.0093	0.0106
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0024	0.012	0.0361
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0045	0.0391	0.0764
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0045	0.0391	0.0764
Brugia malayi	Succinate semialdehyde dehydrogenase, mitochondrial precursor	0.0035	0.0265	0.0518
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0126	0.1419	0.9148
Toxoplasma gondii	hypothetical protein	0.0031	0.021	0.0885
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0391	0.0762
Brugia malayi	hypothetical protein	0.0024	0.012	0.0234
Schistosoma mansoni	serine/threonine protein kinase	0.0214	0.2536	0.7636
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0058	0.5
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0136	0.1546	0.4655
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0136	0.1546	0.3019
Echinococcus multilocularis	ecdysone induced protein 78C	0.0045	0.0391	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0391	0.0762
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	0.0022	0.0093	0.0121
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0087	0.0263
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0087	0.0263
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0045	0.0391	0.0762
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0087	0.0167
Mycobacterium ulcerans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	0.0022	0.0093	0.0106
Mycobacterium ulcerans	succinate-semialdehyde dehydrogenase	0.0035	0.0265	0.0635
Brugia malayi	orphan nuclear receptor NR2E1	0.0021	0.0087	0.017
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0045	0.0391	0.0764
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0045	0.0391	0.0764
Schistosoma mansoni	RAR-like nuclear receptor	0.0045	0.0391	0.1179
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0067	0.0662	0.1293
Brugia malayi	nuclear receptor RXR	0.0021	0.0087	0.017
Brugia malayi	nuclear hormone receptor family member odr-7	0.0021	0.0087	0.017
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0067	0.0662	0.406
Mycobacterium tuberculosis	Probable acetylornithine aminotransferase ArgD	0.0022	0.0093	0.0121
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0087	0.017
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0045	0.0391	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0087	0.0167
Brugia malayi	Nuclear hormone receptor-like 1	0.0045	0.0391	0.0764
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0126	0.1419	0.4171
Brugia malayi	hypothetical protein	0.0021	0.0087	0.017
Mycobacterium ulcerans	ornithine aminotransferase RocD1 and RocD2	0.0022	0.0093	0.0106
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0067	0.0662	0.406
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0087	0.0167
Brugia malayi	nuclear receptor RXR	0.0024	0.012	0.0234
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0126	0.1419	0.4747
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0022	0.0093	0.0106
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0126	0.1419	0.1419
Echinococcus multilocularis	FTZ F1 alpha	0.0045	0.0391	0.0391
Entamoeba histolytica	protein kinase, putative	0.0418	0.5121	1
Mycobacterium ulcerans	glutamate-1-semialdehyde aminotransferase	0.0022	0.0093	0.0106
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0074	0.076	0.076
Loa Loa (eye worm)	hypothetical protein	0.0024	0.012	0.0231
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0045	0.0391	0.0391
Schistosoma mansoni	carbonic anhydrase	0.0031	0.021	0.0633
Echinococcus multilocularis	thyroid hormone receptor alpha	0.017	0.1973	0.1973
Brugia malayi	Ribonuclease 2-5A family protein	0.0418	0.5121	1
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0067	0.0662	0.406
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0015	0.0002	0.0005
Toxoplasma gondii	NADP-dependent succinate-semialdehyde dehydrogenase	0.0035	0.0265	0.1299
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0058	0.0175
Brugia malayi	tailless protein	0.0021	0.0087	0.017
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0045	0.0391	0.0764
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.039	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0031	0.021	0.0407
Echinococcus granulosus	transcription factor Dp 1	0.0039	0.0306	0.0597
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0067	0.0662	0.129
Brugia malayi	conserved hypotetical protein	0.0021	0.0087	0.017
Schistosoma mansoni	nuclear hormone receptor	0.0045	0.0391	0.1179
Echinococcus granulosus	thyroid hormone receptor alpha	0.0021	0.0087	0.017
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+])	0.0035	0.0265	0.0722
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0045	0.0391	0.0764
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0058	0.0058
Echinococcus granulosus	nuclear receptor nhr 48	0.0021	0.0087	0.017
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0031	0.021	0.041
Echinococcus granulosus	carbonic anhydrase	0.0031	0.021	0.041
Wolbachia endosymbiont of Brugia malayi	acetylornithine transaminase protein	0.0022	0.0093	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0235	0.2799	0.5463
Loa Loa (eye worm)	DR-78	0.0021	0.0087	0.0167
Schistosoma mansoni	nuclear receptor	0.0021	0.0087	0.0263
Echinococcus multilocularis	carbonic anhydrase	0.0031	0.021	0.021
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0021	0.0087	0.017
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0058	0.0175
Loa Loa (eye worm)	nuclear hormone receptor	0.0021	0.0087	0.0167
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.039	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0391	0.0762
Echinococcus multilocularis	carbonic anhydrase	0.0031	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0391	0.0762
Loa Loa (eye worm)	hypothetical protein	0.0024	0.012	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0024	0.012	0.0231
Mycobacterium ulcerans	acetylornithine aminotransferase	0.0022	0.0093	0.0106
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	0.0035	0.0265	0.0722
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0126	0.1419	0.4171
Mycobacterium tuberculosis	Probable aminotransferase	0.0022	0.0093	0.0121
Echinococcus granulosus	carbonic anhydrase II	0.0136	0.1546	0.3019
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0087	0.0167
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.012	0.0234
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0058	0.0113
Schistosoma mansoni	glutaminase	0.0276	0.3321	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0021	0.0087	0.0167
Schistosoma mansoni	thyroid hormone receptor	0.017	0.1973	0.594
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0045	0.0391	0.0762
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0021	0.0087	0.0263
Onchocerca volvulus		0.0045	0.0391	1
Leishmania major	carbonic anhydrase-like protein	0.0136	0.1546	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0021	0.0087	0.0167
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0045	0.0391	0.0762
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0087	0.0167
Echinococcus multilocularis	carbonic anhydrase II	0.0136	0.1546	0.1546
Loa Loa (eye worm)	hypothetical protein	0.0024	0.012	0.0231
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.039	0.0762
Schistosoma mansoni	retinoic acid receptor RXR	0.0045	0.0391	0.1179
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0087	0.0167
Chlamydia trachomatis	glutamate-1-semialdehyde-2,1-aminomutase	0.0022	0.0093	0.5
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0058	0.0058
Onchocerca volvulus	Protein ultraspiracle homolog	0.0045	0.0391	1
Schistosoma mansoni	nuclear receptor	0.0021	0.0087	0.0263
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0045	0.0391	0.0391
Mycobacterium tuberculosis	Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase)	0.0245	0.2925	1
Echinococcus granulosus	serine:threonine protein kinase:endoribonuclease	0.0418	0.5121	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0045	0.0391	0.1179
Echinococcus granulosus	succinate semialdehyde dehydrogenase	0.0035	0.0265	0.0518
Plasmodium vivax	ornithine aminotransferase, putative	0.0022	0.0093	0.5
Echinococcus granulosus	dna polymerase eta	0.0019	0.0058	0.0113
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0058	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0087	0.0167
Echinococcus granulosus	Aminotransferase class III	0.0022	0.0093	0.0181
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0045	0.0391	0.1179
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0126	0.1419	0.4171
Mycobacterium ulcerans	hypothetical protein	0.0022	0.0093	0.0106
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0024	0.012	0.0231
Schistosoma mansoni	succinate semialdehyde dehydrogenase	0.0035	0.0265	0.0798
Echinococcus multilocularis	carbonic anhydrase	0.0031	0.021	0.021
Mycobacterium ulcerans	NAD-dependent aldehyde dehydrogenase AldA	0.0035	0.0265	0.0635
Echinococcus multilocularis	Ankyrin	0.0015	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0087	0.0167
Trypanosoma brucei	aldehyde dehydrogenase, putative	0.0035	0.0265	0.1392
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0391	0.0762
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0031	0.021	0.0407
Brugia malayi	ecdysone receptor	0.0021	0.0087	0.017
Schistosoma mansoni	carbonic anhydrase-related	0.0031	0.021	0.0633
Echinococcus granulosus	ecdysone induced protein 78C	0.0045	0.0391	0.0764
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0067	0.0662	0.1994
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0136	0.1546	0.4655
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0031	0.021	0.041
Echinococcus granulosus	carbonic anhydrase	0.0031	0.021	0.041
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0021	0.0087	0.017
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0045	0.0391	0.0764
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0045	0.0391	0.0764
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0031	0.021	0.041
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0045	0.0391	0.1179
Echinococcus granulosus	FTZ F1 alpha	0.0045	0.0391	0.0764
Toxoplasma gondii	aldehyde dehydrogenase	0.0126	0.1419	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0045	0.0391	0.0764
Mycobacterium ulcerans	L-lysine aminotransferase	0.0245	0.2925	0.8787
Echinococcus multilocularis	ornithine aminotransferase	0.0022	0.0093	0.0093
Schistosoma mansoni	ornithine--oxo-acid transaminase	0.0022	0.0093	0.0279
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0045	0.0391	1
Brugia malayi	nuclear hormone receptor	0.0021	0.0087	0.017
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0021	0.0087	0.017
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0087	0.017
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0021	0.0087	0.0087
Trypanosoma brucei	carbonic anhydrase-like protein	0.0136	0.1546	1
Echinococcus granulosus	ornithine aminotransferase	0.0022	0.0093	0.0181
Leishmania major	aldehyde dehydrogenase, putative	0.0035	0.0265	0.1392
Brugia malayi	hypothetical protein	0.0024	0.012	0.0234
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0024	0.012	0.0234
Loa Loa (eye worm)	carbonic anhydrase 3	0.0136	0.1546	0.3017
Trichomonas vaginalis	serine threonine-protein kinase, putative	0.0213	0.2519	0.7543
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0067	0.0662	0.1293
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0045	0.0391	0.0762
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0045	0.0391	0.0764
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0045	0.0391	0.0762
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0391	0.0762
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0045	0.0391	0.0764
Echinococcus multilocularis	succinate semialdehyde dehydrogenase	0.0035	0.0265	0.0265
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0045	0.0391	0.0764
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0125	0.1397	0.1397
Schistosoma mansoni	nuclear receptor nhr-48	0.0021	0.0087	0.0263
Schistosoma mansoni	carbonic anhydrase-related	0.0031	0.021	0.0633
Loa Loa (eye worm)	glutaminase 2	0.0276	0.3321	0.6483
Entamoeba histolytica	protein kinase, putative	0.0418	0.5121	1
Echinococcus granulosus	carbonic anhydrase	0.0031	0.021	0.041
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0067	0.0662	0.1193
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0265	0.0515
Brugia malayi	hypothetical protein	0.0021	0.0087	0.017
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0021	0.0087	0.017
Echinococcus multilocularis	transcription factor Dp 1	0.0039	0.0306	0.0306
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0058	0.0113
Schistosoma mansoni	aldehyde dehydrogenase	0.0126	0.1419	0.4273
Mycobacterium ulcerans	NAD-dependent aldehyde dehydrogenase AldA	0.0035	0.0265	0.0635
Schistosoma mansoni	hypothetical protein	0.0031	0.021	0.0633
Echinococcus multilocularis	serine:threonine protein kinase:endoribonuclease	0.0418	0.5121	0.5121
Brugia malayi	Nuclear hormone receptor E75	0.0021	0.0087	0.017
Schistosoma mansoni	aldehyde dehydrogenase	0.0126	0.1419	0.4273
Trypanosoma cruzi	aldehyde dehydrogenase, putative	0.0035	0.0265	0.1392

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1651756

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1487984