Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | transketolase | 0.0035 | 0.6302 | 0.6302 |
Toxoplasma gondii | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0035 | 0.6302 | 0.6302 |
Mycobacterium tuberculosis | Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs1 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) | 0.0035 | 0.6302 | 0.5 |
Leishmania major | pyruvate dehydrogenase E1 beta subunit, putative | 0.0046 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 1 | 1 |
Trypanosoma cruzi | transketolase, putative | 0.0035 | 0.6302 | 0.6302 |
Entamoeba histolytica | transketolase, chloroplast, putative | 0.0035 | 0.6302 | 0.5 |
Echinococcus multilocularis | pyruvate dehydrogenase | 0.0046 | 1 | 1 |
Trypanosoma cruzi | pyruvate dehydrogenase E1 beta subunit, putative | 0.0046 | 1 | 1 |
Plasmodium vivax | 1-deoxy-D-xylulose 5-phosphate synthase, putative | 0.0035 | 0.6302 | 0.6302 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PD-HE1Beta | 0.0046 | 1 | 1 |
Chlamydia trachomatis | oxoisovalerate dehydrogenase subunits alpha/beta | 0.0039 | 0.7735 | 0.7735 |
Plasmodium falciparum | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative | 0.0035 | 0.6302 | 0.6302 |
Leishmania major | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0035 | 0.6302 | 0.6302 |
Trypanosoma brucei | transketolase, putative | 0.0035 | 0.6302 | 0.6302 |
Echinococcus multilocularis | transketolase | 0.0035 | 0.6302 | 0.6302 |
Trichomonas vaginalis | transketolase, putative | 0.0035 | 0.6302 | 0.5 |
Plasmodium falciparum | 1-deoxy-D-xylulose 5-phosphate synthase | 0.0035 | 0.6302 | 0.6302 |
Wolbachia endosymbiont of Brugia malayi | transketolase | 0.0035 | 0.6302 | 0.6302 |
Entamoeba histolytica | transketolase, putative | 0.0035 | 0.6302 | 0.5 |
Echinococcus multilocularis | transketolase | 0.0035 | 0.6302 | 0.6302 |
Toxoplasma gondii | pyruvate dehydrogenase E1 component, beta subunit, putative | 0.0035 | 0.6302 | 0.6302 |
Onchocerca volvulus | 0.0034 | 0.5945 | 0.5 | |
Mycobacterium leprae | PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE DXS1 (1-DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE) (DXP SYNTHASE) (DXPS) | 0.0035 | 0.6302 | 1 |
Entamoeba histolytica | transketolase, putative | 0.0035 | 0.6302 | 0.5 |
Trypanosoma brucei | chrX additional, unordered contigs | 0.0035 | 0.6302 | 0.6302 |
Trypanosoma brucei | pyruvate dehydrogenase E1 beta subunit, putative | 0.0046 | 1 | 1 |
Mycobacterium ulcerans | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0035 | 0.6302 | 1 |
Trypanosoma cruzi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0035 | 0.6302 | 0.6302 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.6302 | 0.6302 |
Trypanosoma cruzi | transketolase, putative | 0.0035 | 0.6302 | 0.6302 |
Mycobacterium tuberculosis | Transketolase Tkt (TK) | 0.0035 | 0.6302 | 0.5 |
Trypanosoma cruzi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0035 | 0.6302 | 0.6302 |
Brugia malayi | pyruvate dehydrogenase E1 component beta subunit, putative | 0.0046 | 1 | 1 |
Brugia malayi | transketolase | 0.0035 | 0.6302 | 0.6302 |
Entamoeba histolytica | transketolase, putative | 0.0035 | 0.6302 | 0.5 |
Echinococcus granulosus | pyruvate dehydrogenase | 0.0046 | 1 | 1 |
Chlamydia trachomatis | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0035 | 0.6302 | 0.6302 |
Trypanosoma brucei | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0035 | 0.6302 | 0.6302 |
Plasmodium vivax | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial, putative | 0.0035 | 0.6302 | 0.6302 |
Leishmania major | transketolase | 0.0035 | 0.6302 | 0.6302 |
Plasmodium falciparum | pyruvate dehydrogenase E1 component subunit beta | 0.0046 | 1 | 1 |
Treponema pallidum | 1-deoxy-D-xylulose-5-phosphate synthase | 0.0035 | 0.6302 | 0.5 |
Chlamydia trachomatis | transketolase | 0.0035 | 0.6302 | 0.6302 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 1 | 1 |
Brugia malayi | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor | 0.0035 | 0.6302 | 0.6302 |
Toxoplasma gondii | transketolase | 0.0035 | 0.6302 | 0.6302 |
Schistosoma mansoni | transketolase | 0.0035 | 0.6302 | 0.6302 |
Mycobacterium leprae | Probable transketolase Tkt (TK) | 0.0035 | 0.6302 | 1 |
Schistosoma mansoni | pyruvate dehydrogenase (lipoamide) | 0.0046 | 1 | 1 |
Mycobacterium tuberculosis | Probable branched-chain keto acid dehydrogenase E1 component, beta subunit BkdB | 0.0035 | 0.6302 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | pyruvate dehydrogenase subunit beta | 0.0046 | 1 | 1 |
Chlamydia trachomatis | pyruvate dehydrogenase subunit beta | 0.0046 | 1 | 1 |
Mycobacterium ulcerans | pyruvate dehydrogenase E1 component subunit PdhB | 0.0035 | 0.6302 | 1 |
Trypanosoma brucei | 2-oxoisovalerate dehydrogenase beta subunit, mitochondrial precursor, putative | 0.0035 | 0.6302 | 0.6302 |
Schistosoma mansoni | transketolase | 0.0035 | 0.6302 | 0.6302 |
Trypanosoma cruzi | pyruvate dehydrogenase E1 beta subunit, putative | 0.0046 | 1 | 1 |
Mycobacterium ulcerans | transketolase | 0.0035 | 0.6302 | 1 |
Loa Loa (eye worm) | 2-oxoisovalerate dehydrogenase subunit beta | 0.0035 | 0.6302 | 0.6302 |
Echinococcus granulosus | transketolase | 0.0035 | 0.6302 | 0.6302 |
Plasmodium vivax | pyruvate dehydrogenase E1 component subunit beta, putative | 0.0046 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of Mdm2 -p53 protein interaction by ELISA | ChEMBL. | 21314128 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.